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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Araffects bindingEXP 6480464CTDTamoxifen binds to AR proteinPMID:14565775
Araffects bindingISOAR (Homo sapiens)6480464CTDTamoxifen binds to AR proteinPMID:14751673
Araffects expressionISOAR (Homo sapiens)6480464CTDTamoxifen affects the expression of AR mRNAPMID:27163517
Ardecreases activityISOAR (Homo sapiens)6480464CTDTamoxifen results in decreased activity of AR proteinPMID:15316697
Ardecreases expressionISOAR (Homo sapiens)6480464CTDTamoxifen results in decreased expression of AR proteinPMID:27163517
Ardecreases response to substanceISOAR (Homo sapiens)6480464CTDAR mRNA results in decreased susceptibility to TamoxifenPMID:19533338
Armultiple interactionsISOAr (Mus musculus)6480464CTDTamoxifen inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]PMID:20937368
Armultiple interactionsISOAR (Homo sapiens)6480464CTD[Tamoxifen co-treated with Estradiol] results in decreased expression of AR proteinPMID:27163517
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