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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:116509
Term: diuron
Definition: A member of the class of 3-(3,4-substituted-phenyl)-1,1-dimethylureas that is urea in which both of the hydrogens attached to one nitrogen are substituted by methyl groups, and one of the hydrogens attached to the other nitrogen is substituted by a 3,4-dichlorophenyl group.
Chemical ID: MESH:D004237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ardecreases expressionEXP 6480464CTDDiuron results in decreased expression of AR mRNAPMID:25152437
Armultiple interactionsISOAR (Homo sapiens)6480464CTDDihydrotestosterone inhibits the reaction [Diuron results in increased activity of AR protein]; Diuron inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Diuron inhibits the reaction [Metribolone results in increased activity of AR protein]PMID:15064155 PMID:18324785 PMID:33049310
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