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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147 Species: Rattus norvegicus RGD Object: Gene Symbol: Ar Name: androgen receptor

Acc ID: CHEBI:34696 Term: dieldrin Definition: An organochlorine insecticide that has formula C12H8Cl6O. CasRN: 60-57-1 Chemical ID: MESH:D004026

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:735652	6480464	CTD	Dihydrotestosterone inhibits the reaction [Dieldrin results in increased activity of AR protein]	PMID:15064155
multiple interactions	ISO	RGD:735652	6480464	CTD	Dieldrin inhibits the reaction [Metribolone results in increased activity of AR protein]	PMID:18324785
multiple interactions	ISO	RGD:735652	6480464	CTD	Dieldrin inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]	PMID:21295777