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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:34696
Term: dieldrin
Definition: An organochlorine compound resulting from the epoxidation of the double bond of aldrin. It is the active metabolite of the proinsecticde aldrin.
Chemical ID: MESH:D004026
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Armultiple interactionsISOAR (Homo sapiens)6480464CTDDieldrin inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Dieldrin inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Dieldrin inhibits the reaction [Metribolone results in increased activity of AR protein]; Dihydrotestosterone inhibits the reaction [Dieldrin results in increased activity of AR protein]PMID:15064155 PMID:18324785 PMID:21295777 PMID:26022396
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