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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:28854
Term: 2,4-D
Definition: A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.
Chemical ID: MESH:D015084
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Armultiple interactionsISOAr (Mus musculus)6480464CTD[Sucrose co-treated with Dietary Fats co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of AR mRNAPMID:37516258
Armultiple interactionsISOAR (Homo sapiens)6480464CTD2,4-Dichlorophenoxyacetic Acid inhibits the reaction [Androgens binds to AR protein]; 2,4-Dichlorophenoxyacetic Acid promotes the reaction [Dihydrotestosterone results in increased localization of and results in increased activity of AR protein]PMID:16107550
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