GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ar | affects binding | EXP | | 6480464 | CTD | Dehydroepiandrosterone binds to AR protein | PMID:14565775 | Ar | increases response to substance | ISO | AR (Homo sapiens) | 6480464 | CTD | AR protein mutant form results in increased susceptibility to Dehydroepiandrosterone | PMID:27473015 | Ar | multiple interactions | ISO | AR (Homo sapiens) | 6480464 | CTD | [AR protein mutant form results in increased susceptibility to Dehydroepiandrosterone] which results in increased activity of AR protein mutant form; [bicalutamide binds to and results in decreased activity of AR protein] inhibits the reaction [Dehydroepiandrosterone results in decreased expression of CYP1A2 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein]; Dehydroepiandrosterone binds to and results in decreased activity of AR protein; Dehydroepiandrosterone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Dehydroepiandrosterone promotes the reaction [AR protein binds to MIR21 promoter] | PMID:15994348 PMID:23603339 PMID:25969534 PMID:27239218 PMID:27473015 PMID:33049310 | | ||||||||||||||||||||||
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