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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:77012
Term: methylseleninic acid
Definition: An organoselenium compound that is seleninic acid in which the hydrogen attached to selenium is replaced by a methyl group.
Chemical ID: MESH:C008493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Araffects response to substanceISOAR (Homo sapiens)6480464CTDAR protein affects the susceptibility to methylselenic acidPMID:16020662
Ardecreases activityISOAR (Homo sapiens)6480464CTDmethylselenic acid results in decreased activity of AR proteinPMID:16648561
Ardecreases expressionISOAR (Homo sapiens)6480464CTDmethylselenic acid results in decreased expression of AR mRNA; methylselenic acid results in decreased expression of AR proteinPMID:14617803 PMID:15141018 PMID:16020662 PMID:16928829
Arincreases degradationISOAR (Homo sapiens)6480464CTDmethylselenic acid results in increased degradation of AR mRNA; methylselenic acid results in increased degradation of AR proteinPMID:16648561
Armultiple interactionsISOAR (Homo sapiens)6480464CTDAR protein inhibits the reaction [methylselenic acid results in decreased expression of ABCC4 mRNA]; AR protein inhibits the reaction [methylselenic acid results in decreased expression of DHCR24 mRNA]; AR protein inhibits the reaction [methylselenic acid results in decreased expression of GUCY1A1 mRNA]; AR protein inhibits the reaction [methylselenic acid results in decreased expression of KLK2 mRNA]; AR protein inhibits the reaction [methylselenic acid results in decreased expression of KLK3 mRNA]; methylselenic acid inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 promoter]]; Superoxides promotes the reaction [methylselenic acid results in decreased expression of AR protein]PMID:16020662 PMID:16648561 PMID:16928829
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