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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:27585
Term: selenomethionine
Definition: A selenoamino acid that is the selenium analogue of methionine.
Chemical ID: MESH:D012645
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ardecreases activityISOAR (Homo sapiens)6480464CTDSelenomethionine results in decreased activity of AR proteinPMID:16239064
Armultiple interactionsISOAR (Homo sapiens)6480464CTDAR protein promotes the reaction [Selenomethionine results in decreased expression of KLK3 protein]; AR protein promotes the reaction [Selenomethionine results in increased expression of TP53 mRNA]PMID:17205524
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