GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ar | affects binding | EXP | | 6480464 | CTD | vinclozolin binds to AR protein | PMID:14565775 | Ar | decreases expression | EXP | | 6480464 | CTD | vinclozolin results in decreased expression of AR mRNA | PMID:17980475 PMID:18629315 PMID:22285353 PMID:23034163 PMID:23160963 PMID:23410115 PMID:29863768 | Ar | increases expression | EXP | | 6480464 | CTD | vinclozolin results in increased expression of AR mRNA | PMID:15686871 PMID:17980475 PMID:31491443 | Ar | multiple interactions | EXP | | 6480464 | CTD | [Genistein co-treated with vinclozolin] affects the expression of AR mRNA; [Genistein co-treated with vinclozolin] results in decreased expression of AR mRNA; vinclozolin affects the localization of and affects the activity of AR protein; vinclozolin binds to and results in decreased activity of AR protein; vinclozolin inhibits the reaction [Testosterone affects the localization of and results in increased activity of AR protein]; vinclozolin metabolite binds to and affects the activity of AR protein | PMID:10188192 PMID:14687758 PMID:16417039 PMID:18315717 PMID:23410115 PMID:27684650 PMID:29863768 | Ar | affects binding | ISO | AR (Homo sapiens) | 6480464 | CTD | vinclozolin binds to AR protein | PMID:12676605 PMID:14579009 PMID:19564212 | Ar | decreases activity | ISO | AR (Homo sapiens) | 6480464 | CTD | vinclozolin metabolite results in decreased activity of AR protein; vinclozolin results in decreased activity of AR protein | PMID:11861975 PMID:20821581 PMID:21251949 PMID:26867867 PMID:9846162 | Ar | decreases expression | ISO | Ar (Mus musculus) | 6480464 | CTD | vinclozolin results in decreased expression of AR mRNA | PMID:18940246 PMID:31601345 PMID:34182078 | Ar | increases expression | ISO | AR (Homo sapiens) | 6480464 | CTD | vinclozolin results in increased expression of AR mRNA | PMID:21310686 | Ar | multiple interactions | ISO | AR (Homo sapiens) | 6480464 | CTD | [procymidone co-treated with prochloraz co-treated with vinclozolin] inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; [procymidone co-treated with vinclozolin] inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; [vinclozolin binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; AR protein affects the reaction [vinclozolin inhibits the reaction [Dihydrotestosterone results in increased expression of SRD5A1 mRNA]]; Dihydrotestosterone inhibits the reaction [vinclozolin results in increased activity of AR protein]; methoxyacetic acid inhibits the reaction [vinclozolin inhibits the reaction [Testosterone results in increased activity of AR protein]]; vinclozolin binds to and results in decreased activity of AR protein; vinclozolin inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; vinclozolin inhibits the reaction [Dihydrotestosterone affects the localization of and results in increased phosphorylation of AR protein]; vinclozolin inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; vinclozolin inhibits the reaction [Dihydrotestosterone binds to AR protein]; vinclozolin inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; vinclozolin inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; vinclozolin inhibits the reaction [Metribolone results in increased activity of AR protein]; vinclozolin inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]; vinclozolin inhibits the reaction [Stanozolol results in increased activity of AR protein]; vinclozolin inhibits the reaction [Testosterone results in increased activity of AR protein]; vinclozolin metabolite inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; vinclozolin metabolite inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; vinclozolin metabolite inhibits the reaction [Metribolone results in increased activity of AR protein]; vinclozolin results in decreased activity of [Dihydrotestosterone results in increased activity of AR protein] | PMID:10053169 PMID:11861974 PMID:11985887 PMID:12377982 PMID:12676605 PMID:12730620 PMID:14579009 PMID:15064155 PMID:15084347 PMID:15483189 PMID:16417039 PMID:16621434 PMID:16750840 PMID:18324785 PMID:18486176 PMID:19564212 PMID:20438827 PMID:21310686 PMID:23558297 PMID:25324206 PMID:26602169 PMID:28377212 PMID:28803809 PMID:29162470 PMID:33049310 | | ||||||||||||||||||||||
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