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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ardecreases expressionISOAr (Mus musculus)6480464CTDdiallyl trisulfide results in decreased expression of AR mRNA; diallyl trisulfide results in decreased expression of AR proteinPMID:19622577
Ardecreases expressionISOAR (Homo sapiens)6480464CTDdiallyl trisulfide results in decreased expression of AR mRNA; diallyl trisulfide results in decreased expression of AR proteinPMID:19622577
Armultiple interactionsISOAR (Homo sapiens)6480464CTDdiallyl trisulfide inhibits the reaction [Metribolone affects the localization of AR protein]PMID:19622577
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