GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ar | affects binding | EXP | | 6480464 | CTD | Dibutyl Phthalate binds to AR protein | PMID:14565775 | Ar | decreases expression | EXP | | 6480464 | CTD | Dibutyl Phthalate results in decreased expression of AR mRNA; Dibutyl Phthalate results in decreased expression of AR protein | PMID:22027561 PMID:22273727 PMID:24067674 PMID:25213187 PMID:26514922 PMID:26948521 PMID:27079746 PMID:28341571 PMID:28919491 PMID:30053495 | Ar | increases expression | EXP | | 6480464 | CTD | Dibutyl Phthalate results in increased expression of AR mRNA; Dibutyl Phthalate results in increased expression of AR protein | PMID:15829613 PMID:19549552 PMID:23294617 | Ar | multiple interactions | EXP | | 6480464 | CTD | bisphenol A promotes the reaction [Dibutyl Phthalate results in increased expression of AR mRNA]; Dibutyl Phthalate promotes the reaction [bisphenol A results in increased expression of AR mRNA]; Dibutyl Phthalate results in decreased expression of and results in decreased localization of AR protein | PMID:23294617 PMID:38184977 | Ar | decreases activity | ISO | AR (Homo sapiens) | 6480464 | CTD | Dibutyl Phthalate results in decreased activity of AR protein | PMID:26867867 | Ar | increases activity | ISO | AR (Homo sapiens) | 6480464 | CTD | Dibutyl Phthalate results in increased activity of AR protein | PMID:19643168 | Ar | increases response to substance | ISO | Ar (Mus musculus) | 6480464 | CTD | AR protein results in increased susceptibility to Dibutyl Phthalate | PMID:25434310 | Ar | multiple interactions | ISO | Ar (Mus musculus) | 6480464 | CTD | Dibutyl Phthalate promotes the reaction [Dihydrotestosterone results in decreased localization of AR protein] | PMID:36308879 | Ar | multiple interactions | ISO | AR (Homo sapiens) | 6480464 | CTD | Dibutyl Phthalate inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Dibutyl Phthalate inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Dibutyl Phthalate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Dibutyl Phthalate results in decreased expression of and results in decreased localization of AR protein; Flutamide inhibits the reaction [Dibutyl Phthalate results in increased activity of AR protein]; TGFB1I1 protein inhibits the reaction [Dibutyl Phthalate results in decreased localization of AR protein] | PMID:15840436 PMID:19643168 PMID:20943248 PMID:28571686 PMID:33049310 PMID:38184977 | | ||||||||||||||||||||||
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