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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ardecreases activityISOAR (Homo sapiens)6480464CTDArsenic Trioxide results in decreased activity of AR proteinPMID:19131511
Ardecreases expressionISOAr (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of AR proteinPMID:28956719
Ardecreases expressionISOAR (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of AR mRNAPMID:19769630
Armultiple interactionsISOAR (Homo sapiens)6480464CTDArsenic Trioxide inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]]PMID:19131511
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