RGD Reference Report - Blockade of androgen receptor in the medial amygdala inhibits noncontact erections in male rats. - Rat Genome Database

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Blockade of androgen receptor in the medial amygdala inhibits noncontact erections in male rats.

Authors: Bialy, Michal  Nikolaev-Diak, Anna  Kalata, Urszula  Nikolaev, Evgeni 
Citation: Bialy M, etal., Physiol Behav. 2011 Jun 1;103(3-4):295-301. doi: 10.1016/j.physbeh.2011.02.003. Epub 2011 Feb 20.
RGD ID: 11576237
Pubmed: PMID:21315100   (View Abstract at PubMed)
DOI: DOI:10.1016/j.physbeh.2011.02.003   (Journal Full-text)

Our previous work demonstrated that androgens in the medial amygdala (MeA) of castrated male rats maintained noncontact erections (NCEs), which occur during exposure to an inaccessible receptive female, for one week after implantation. The present experiments investigated the effects of implantation into the MeA of either flutamide (F), a blocker of androgen receptors, or of 1,4,6-androstatrien-3,17-dione (ATD), which blocks aromatization of testosterone. One day after implantation of F, fewer males displayed NCEs, and had longer latencies to the first NCE and fewer NCEs, and spent less total time in genital grooming, compared to the control group. ATD had only weak facilitative effects on some measures of NCEs. These results suggest that androgen receptors in the MeA play a major role in the regulation of NCEs and that the MeA is one of the neuronal structures that regulate male sexual arousal. Furthermore, it is sensitive to relatively fast changes in the level of androgen receptors stimulation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of penile erection  IMP 11576237 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ar  (androgen receptor)


Additional Information