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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ardecreases activityISOAR (Homo sapiens)6480464CTDDoxorubicin results in decreased activity of AR proteinPMID:25257666
Ardecreases expressionISOAR (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of AR mRNAPMID:29803840
Arincreases activityISOAR (Homo sapiens)6480464CTDDoxorubicin results in increased activity of AR proteinPMID:25257666
Armultiple interactionsISOAR (Homo sapiens)6480464CTDDoxorubicin binds to and results in decreased activity of AR protein; Doxorubicin binds to and results in increased activity of AR proteinPMID:25752796
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