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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:34575
Term: bisphenol F
Definition: A bisphenol that is methane in which two of the hydrogens have been replaced by 4-hydroxyphenyl groups.
Chemical ID: MESH:C008745
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Araffects bindingEXP 6480464CTDbisphenol F binds to AR proteinPMID:31836225
Ardecreases expressionEXP 6480464CTDbisphenol F results in decreased expression of AR mRNA; bisphenol F results in decreased expression of AR proteinPMID:35803362
Ardecreases activityISOAR (Homo sapiens)6480464CTD4,4'-bisphenol F results in decreased activity of AR proteinPMID:15110108 PMID:24563381
Armultiple interactionsISOAR (Homo sapiens)6480464CTD4,4'-bisphenol F inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; 4,4'-bisphenol F inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; 4,4'-bisphenol F inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; 4,4'-bisphenol F inhibits the reaction [Testosterone binds to and results in increased activity of AR protein]; 4,4'-bisphenol F inhibits the reaction [Testosterone results in increased activity of AR protein]PMID:18973785 PMID:25576683 PMID:27561732 PMID:29392883 PMID:30582956
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