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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:3620
Term: chlornitrofen
Definition: An aromatic ether that has formula C12H6Cl3NO3.
Chemical ID: MESH:C010422
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Araffects bindingISOAR (Homo sapiens)6480464CTD2,4,6-trichlorophenyl 4-nitrophenyl ether binds to AR proteinPMID:12676605
Armultiple interactionsISOAR (Homo sapiens)6480464CTD2,4,6-trichlorophenyl 4-nitrophenyl ether binds to and results in increased activity of AR protein; 2,4,6-trichlorophenyl 4-nitrophenyl ether inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Dihydrotestosterone inhibits the reaction [2,4,6-trichlorophenyl 4-nitrophenyl ether results in increased activity of AR protein]PMID:12676605 PMID:15064155
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