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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:34826
Term: M1
Definition: A carbamate ester that has formula C12H11Cl2NO4.
Chemical ID: MESH:C101851
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Armultiple interactionsEXP 6480464CTD2-(((3,5-dichlorophenyl)carbamoyl)oxy)-2-methyl-3-butenoic acid binds to and affects the activity of AR protein; 2-(((3,5-dichlorophenyl)carbamoyl)oxy)-2-methyl-3-butenoic acid binds to and results in decreased activity of AR proteinPMID:10188192 PMID:16417039
Ardecreases activityISOAR (Homo sapiens)6480464CTD2-(((3,5-dichlorophenyl)carbamoyl)oxy)-2-methyl-3-butenoic acid results in decreased activity of AR proteinPMID:11403899
Armultiple interactionsISOAR (Homo sapiens)6480464CTD2-(((3,5-dichlorophenyl)carbamoyl)oxy)-2-methyl-3-butenoic acid binds to and results in decreased activity of AR protein; 2-(((3,5-dichlorophenyl)carbamoyl)oxy)-2-methyl-3-butenoic acid inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]PMID:11861974 PMID:16417039 PMID:16750840
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