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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:4315
Term: danazol
Definition: A terminal acetylenic compound that has formula C22H27NO2.
Chemical ID: MESH:D003613
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arincreases activityISOAR (Homo sapiens)6480464CTDDanazol results in increased activity of AR proteinPMID:21543282
Armultiple interactionsISOAR (Homo sapiens)6480464CTDDanazol binds to and results in decreased activity of AR protein; Danazol binds to and results in increased activity of AR proteinPMID:12730620 PMID:25752796
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