RGD Reference Report - Androgen receptor gene CAG length polymorphism in women with polycystic ovary syndrome. - Rat Genome Database

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Androgen receptor gene CAG length polymorphism in women with polycystic ovary syndrome.

Authors: Jaaskelainen, J  Korhonen, S  Voutilainen, R  Hippelainen, M  Heinonen, S 
Citation: Jaaskelainen J, etal., Fertil Steril. 2005 Jun;83(6):1724-8.
RGD ID: 1578688
Pubmed: PMID:15950642   (View Abstract at PubMed)
DOI: DOI:10.1016/j.fertnstert.2004.11.080   (Journal Full-text)

OBJECTIVE: To determine whether the CAG repeat length of the androgen receptor (AR) gene contributes to individual differences in the susceptibility to the development of polycystic ovary syndrome (PCOS). DESIGN: Retrospective case-control study. SETTING: University-based clinic. PATIENT(S): One hundred six nondiabetic women with PCOS and 112 nonhirsute fertile controls. INTERVENTION(S): Androgen receptor gene CAG repeat length was analyzed in women with PCOS and their controls. MAIN OUTCOME MEASURE(S): Androgen receptor gene CAG repeat length in both groups. RESULT(S): The mean CAGn was 21.5 repeats in both groups (NS; t-test). Furthermore, when the CAGn lengths were divided into three categories (CAGn < or =18, 19-24, > or =25), the distribution was similar in both groups (NS; chi2 test). However, all five women carrying < or =15 CAG repeats belonged to the PCOS group. In the PCOS group, CAGn did not correlate with body mass index or serum testosterone concentration. CONCLUSION(S): Androgen receptor CAGn is not a major determinant of PCOS. However, it may be a significant modulator of androgen-related diseases in some individuals.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
polycystic ovary syndrome no_associationIAGP 1578688 RGD 
polycystic ovary syndrome no_associationISOAR (Homo sapiens)1578688; 1578688 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ar  (androgen receptor)

Genes (Mus musculus)
Ar  (androgen receptor)

Genes (Homo sapiens)
AR  (androgen receptor)


Additional Information