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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Araffects bindingEXP 6480464CTDbisphenol A binds to AR proteinPMID:14565775 PMID:20371976 PMID:31836225
Araffects expressionEXP 6480464CTDbisphenol A affects the expression of AR proteinPMID:26658420
Ardecreases expressionEXP 6480464CTDbisphenol A analog results in decreased expression of AR mRNA; bisphenol A analog results in decreased expression of AR protein; bisphenol A results in decreased expression of AR; bisphenol A results in decreased expression of AR mRNA; bisphenol A results in decreased expression of AR proteinPMID:10822019 PMID:12810577 PMID:19837096 PMID:23528252 PMID:24566421 PMID:25181051 PMID:28928807 PMID:30755151 PMID:35810996 PMID:36803626
Arincreases expressionEXP 6480464CTDbisphenol A results in increased expression of AR mRNA; bisphenol A results in increased expression of AR proteinPMID:16406770 PMID:17589598 PMID:22285353 PMID:23294617 PMID:24257414 PMID:25575453 PMID:26260748 PMID:28641706 PMID:29097150 PMID:29323181 PMID:31369804 PMID:31771501 PMID:32753632 PMID:36136478
Armultiple interactionsEXP 6480464CTD[Gonadotropins, Equine co-treated with bisphenol A] results in increased expression of AR protein; bisphenol A inhibits the reaction [Testosterone affects the localization of and results in increased activity of AR protein]; bisphenol A promotes the reaction [Dibutyl Phthalate results in increased expression of AR mRNA]; Dibutyl Phthalate promotes the reaction [bisphenol A results in increased expression of AR mRNA]; Genistein inhibits the reaction [bisphenol A results in increased expression of AR protein]; indole-3-carbinol inhibits the reaction [bisphenol A results in increased expression of AR protein]PMID:23294617 PMID:24257414 PMID:26260748 PMID:27684650 PMID:28648634
Araffects activityISOAr (Mus musculus)6480464CTDbisphenol A affects the activity of AR proteinPMID:18294747
Araffects bindingISOAR (Homo sapiens)6480464CTDbisphenol A binds to AR proteinPMID:12161000 PMID:16893599 PMID:28751236 PMID:34706627
Araffects expressionISOAr (Mus musculus)6480464CTDbisphenol A affects the expression of ARPMID:23719926
Ardecreases activityISOAR (Homo sapiens)6480464CTDbisphenol A results in decreased activity of AR proteinPMID:11403899 PMID:15110108 PMID:16893599 PMID:24563381 PMID:26867867 PMID:9846162
Ardecreases expressionISOAr (Mus musculus)6480464CTDbisphenol A results in decreased expression of AR proteinPMID:29778459 PMID:34601267
Ardecreases expressionISOAR (Homo sapiens)6480464CTDbisphenol A results in decreased expression of AR proteinPMID:26922907
Ardecreases foldingISOAr (Mus musculus)6480464CTDbisphenol A results in decreased folding of AR proteinPMID:28645579
Arincreases activityISOAR (Homo sapiens)6480464CTDbisphenol A results in increased activity of AR proteinPMID:29427707 PMID:30951782
Arincreases expressionISOAr (Mus musculus)6480464CTDbisphenol A results in increased expression of AR mRNAPMID:17706920 PMID:26746108
Arincreases expressionISOAR (Homo sapiens)6480464CTDbisphenol A results in increased expression of AR mRNAPMID:15159206 PMID:20678512
Arincreases response to substanceISOAr (Mus musculus)6480464CTDAR protein results in increased susceptibility to bisphenol APMID:24265451 PMID:25434310
Armultiple interactionsISOAr (Mus musculus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] affects the expression of AR mRNA; [bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased expression of AR mRNA; [Dietary Fats co-treated with Dietary Sucrose] affects the reaction [[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] affects the expression of AR mRNA]; bisphenol A inhibits the reaction [Dihydrotestosterone binds to AR protein]; bisphenol A inhibits the reaction [Ovalbumin results in increased expression of AR mRNA]; bisphenol A promotes the reaction [NCOR1 protein binds to AR protein]; bisphenol A promotes the reaction [NCOR2 protein binds to AR protein]PMID:12805653 PMID:22828881 PMID:28645579 PMID:30722647 PMID:31788436
Armultiple interactionsISOAR (Homo sapiens)6480464CTD[bisphenol A binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to CNOT1 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to ITGB3BP protein modified form]; [bisphenol A binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOA1 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOA3 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOA4 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NCOR1 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NRIP1 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to PRAME protein modified form]; [bisphenol A binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to TRRAP protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to BRD8 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to CCND1 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to CREBBP protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to GSN protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to HELZ2 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to ILK protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to JMJD1C protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to KAT5 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to LCOR protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MED1 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NCOA6 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NR0B1 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NR0B2 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NSD1 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PNRC1 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PPARGC1A protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PRDM2 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to RBL2 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to RELA protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to SLC30A9 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRERF1 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to UBE3A protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to AR protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CHD9 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to DHX30 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to EP300 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to GNAQ protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to HR protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MGMT protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOR2 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NELFB protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NFKBIB protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PAK6 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PELP1 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PPRC1 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to RAD9A protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to TGFB1I1 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to TRIM24 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to TRIP4 protein modified form]; [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to ZNHIT3 protein modified form]; [bisphenol A binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; [bisphenol A binds to and results in decreased activity of AR protein] which results in decreased susceptibility to Metribolone; AR protein mutant form affects the reaction [bisphenol A results in decreased expression of ESR2 mRNA]; bicalutamide inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to AR protein]]; bisphenol A affects the reaction [Dihydrotestosterone binds to AR protein mutant form]; bisphenol A analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; bisphenol A binds to and affects the activity of AR protein; bisphenol A binds to and results in decreased activity of AR protein; bisphenol A inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; bisphenol A inhibits the reaction [AR protein results in decreased expression of KMT2C mRNA]; bisphenol A inhibits the reaction [Dihydrotestosterone affects the localization of AR protein]; bisphenol A inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; bisphenol A inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; bisphenol A inhibits the reaction [Dihydrotestosterone results in increased expression of and results in increased stability of AR protein]; bisphenol A inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; bisphenol A inhibits the reaction [ESR1 protein binds to AR protein]; bisphenol A inhibits the reaction [Metribolone results in increased activity of AR protein]; bisphenol A inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]; bisphenol A inhibits the reaction [Testosterone binds to and results in increased activity of AR protein]; bisphenol A inhibits the reaction [Testosterone results in increased activity of AR protein]; bisphenol A promotes the reaction [EGFR protein binds to AR protein]; Dihydrotestosterone inhibits the reaction [bisphenol A results in decreased activity of AR protein]; Fulvestrant inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to AR protein]]; Gefitinib inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to AR protein]]PMID:15084347 PMID:15665279 PMID:16169144 PMID:16893599 PMID:18007998 PMID:18324785 PMID:20943248 PMID:23562765 PMID:23714657 PMID:25576683 PMID:27436773 PMID:27561732 PMID:28009930 PMID:28377212 PMID:28728110 PMID:28751236 PMID:28803809 PMID:29162470 PMID:29383186 PMID:29389661 PMID:29392883 PMID:29427707 PMID:30408883 PMID:30582956 PMID:31415812 PMID:33049310 PMID:36803626
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