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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:FasL mediated signaling pathway
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Accession:PW:0000681 term browser browse the term
Definition:Fas ligand binding to its receptor triggers a conformational change that allows the receptor to assemble a signaling complex known as DISC, followed by recruitment of pro-caspase-8 and activation of caspase-3 and -7. It is believed that Fas-mediated signaling to elicit apoptosis follows two routes.
Synonyms:related_synonym: Fas signaling pathway;   FasL/ CD95L signaling
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FasL mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200080 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bid BH3 interacting domain death agonist IEP
ISO 		PID
RGD		 PMID:18090083 PMID:19239902 PID:200080, RGD:2314002, RGD:4143196 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 ISO PID PID:200080 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 ISO PID PID:200080 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590 		JBrowse link
G Btk Bruton tyrosine kinase ISO PID PID:200080 NCBI chr  X:102,016,070...102,055,448
Ensembl chr  X:102,016,074...102,055,143 		JBrowse link
G Casp3 caspase 3 ISO PID
RGD		 PMID:19239902 PID:200080, RGD:4143196 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 ISO RGD PMID:19239902 RGD:4143196 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp8 caspase 8 IMP
ISO 		PID
RGD		 PMID:18090083 PMID:19239902 PID:200080, RGD:2314002, RGD:4143196 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator ISO
IEP 		PID
RGD		 PMID:19239902 PMID:19107989 PID:200080, RGD:4143196, RGD:8662854 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID PID:200080 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Cltc clathrin heavy chain ISO PID PID:200080 NCBI chr10:72,014,984...72,073,308
Ensembl chr10:72,014,986...72,070,691 		JBrowse link
G Ezr ezrin ISO PID PID:200080 NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573 		JBrowse link
G Fadd Fas associated via death domain ISO PID
RGD		 PMID:19239902 PID:200080, RGD:4143196 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976 		JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 ISO PID PID:200080 NCBI chr 7:132,512,095...132,539,192
Ensembl chr 7:132,512,210...132,538,026 		JBrowse link
G Fas Fas cell surface death receptor IEP
ISO 		PID
RGD		 PMID:18090083 PMID:19239902 PMID:19107989 PID:200080, RGD:2314002, RGD:4143196, RGD:8662854 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Faslg Fas ligand IEP
ISO 		PID
RGD		 PMID:18090083 PMID:19239902 PID:200080, RGD:2314002, RGD:4143196 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200080 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID PID:200080 NCBI chr  X:157,358,279...157,397,563
Ensembl chr  X:157,367,639...157,392,757 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO PID PID:200080 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 ISO PID PID:200080 NCBI chr12:7,389,032...7,398,377
Ensembl chr12:7,389,155...7,398,377 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200080 NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 ISO PID PID:200080 NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 ISO PID PID:200080 NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:122,098,121...122,105,038 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO PID PID:200080 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200080 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO PID PID:200080 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO PID PID:200080 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200080 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta ISO PID PID:200080 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta ISO PID PID:200080 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200080 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 ISO PID PID:200080 NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,699,448...18,709,665 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 ISO PID PID:200080 NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762 		JBrowse link
G Rfc1 replication factor C subunit 1 ISO PID PID:200080 NCBI chr14:43,319,768...43,395,028
Ensembl chr14:43,319,935...43,395,026 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO PID PID:200080 NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 ISO PID PID:200080 NCBI chr 1:169,304,772...169,308,615
Ensembl chr 1:169,304,708...169,308,614 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200080 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Syk spleen associated tyrosine kinase ISO PID PID:200080 NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,756,493...12,813,278 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      cytokine and chemokine mediated signaling pathway 570
        cytokine mediated signaling pathway 485
          tumor necrosis factor superfamily mediated signaling pathway 88
            FasL mediated signaling pathway 38
              altered FasL mediated signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3864
      cell death pathway 243
        programmed cell death pathway 243
          apoptotic cell death pathway 162
            extrinsic apoptotic pathway 88
              FasL mediated signaling pathway 38
                altered FasL mediated signaling pathway 0
paths to the root