PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: erythropoietin signaling pathway
Accession: PW:0000987
browse the term
Definition: Erythropoietin (EPO) signaling is crucial for the production of blood cell or erythropoiesis and also plays important roles in wound healing and responses to neural injury. EPO is a glycoprotein hormone and also a cytokine whose receptor belongs to type I cytokine receptor. The pathway engages the Jak-Stat intracellular cascade.
Synonyms: exact_synonym: EPO signaling pathway
related_synonym: PID:200183
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Bcl2
BCL2, apoptosis regulator
ISO
PID
PID:200183
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
ISO
PID
PID:200183
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Btk
Bruton tyrosine kinase
ISO
PID
PID:200183
NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853
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Cbl
Cbl proto-oncogene
ISO
PID
PID:200183
NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176
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Crkl
CRK like proto-oncogene, adaptor protein
ISO
PID
PID:200183
NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238
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Epo
erythropoietin
ISO
PID
PID:200183
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Epor
erythropoietin receptor
ISO
PID
PID:200183
NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
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Gab1
GRB2-associated binding protein 1
ISO
PID
PID:200183
NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236
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Grb2
growth factor receptor bound protein 2
ISO
PID
PID:200183
NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
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Hras
HRas proto-oncogene, GTPase
ISO
PID
PID:200183
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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Inpp5d
inositol polyphosphate-5-phosphatase D
ISO
PID
PID:200183
NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
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Irs2
insulin receptor substrate 2
ISO
PID
PID:200183
NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
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Jak2
Janus kinase 2
ISO
PID
PID:200183
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Lyn
LYN proto-oncogene, Src family tyrosine kinase
ISO
PID
PID:200183
NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
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Mapk14
mitogen activated protein kinase 14
ISO
PID
PID:200183
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mapk8
mitogen-activated protein kinase 8
ISO
PID
PID:200183
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Nfkb1
nuclear factor kappa B subunit 1
ISO
PID
PID:200183
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
ISO
PID
PID:200183
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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Plcg1
phospholipase C, gamma 1
ISO
PID
PID:200183
NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
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Plcg2
phospholipase C, gamma 2
ISO
PID
PID:200183
NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
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Ptpn11
protein tyrosine phosphatase, non-receptor type 11
ISO
PID
PID:200183
NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
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Ptpn6
protein tyrosine phosphatase, non-receptor type 6
ISO
PID
PID:200183
NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
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Rap1a
RAP1A, member of RAS oncogene family
ISO
PID
PID:200183
NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
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Rapgef1
Rap guanine nucleotide exchange factor 1
ISO
PID
PID:200183
NCBI chr 3:12,898,349...13,016,234
Ensembl chr 3:12,898,266...13,013,984
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Sh2b3
SH2B adaptor protein 3
ISO
PID
PID:200183
NCBI chr12:34,731,934...34,753,617
Ensembl chr12:34,731,911...34,753,616
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Shc1
SHC adaptor protein 1
ISO
PID
PID:200183
NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
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Socs3
suppressor of cytokine signaling 3
ISO
PID
PID:200183
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
ISO
PID
PID:200183
NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
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Stat1
signal transducer and activator of transcription 1
ISO
PID
PID:200183
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Stat5a
signal transducer and activator of transcription 5A
ISO
PID
PID:200183
NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
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Stat5b
signal transducer and activator of transcription 5B
ISO
PID
PID:200183
NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
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Tec
tec protein tyrosine kinase
ISO
PID
PID:200183
NCBI chr14:35,352,551...35,461,585
Ensembl chr14:35,352,829...35,461,557
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Trpc6
transient receptor potential cation channel, subfamily C, member 6
ISO
PID
PID:200183
NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
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Vav2
vav guanine nucleotide exchange factor 2
ISO
PID
PID:200183
NCBI chr 3:10,584,688...10,754,128
Ensembl chr 3:10,584,688...10,754,052
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