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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:prolonged QT interval
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Accession:MP:0003233 term browser browse the term
Definition:increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave
Comment:A prolonged QT interval is a risk factor for ventricular tachyarrhythmias and sudden death. It varies with heart rate and for clinical relevance requires a correction for this, giving the QTc.
Synonyms:exact_synonym: increased QT interval;   widened QT interval
 related_synonym: long QT syndrome


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prolonged QT interval term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank2 ankyrin 2, brain IAGP MGI PMID:37182735 NCBI chr 3:126,715,256...127,293,996
Ensembl chr 3:126,715,261...127,292,999 		JBrowse link
G Ap1s3 adaptor-related protein complex AP-1, sigma 3 IEA MGI NCBI chr 1:79,584,593...79,649,736
Ensembl chr 1:79,584,593...79,649,689 		JBrowse link
G Atg5 autophagy related 5 IAGP MGI PMID:29438013 NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287 		JBrowse link
G Btnl4 butyrophilin-like 4 IEA MGI NCBI chr17:34,687,320...34,696,402
Ensembl chr17:34,685,536...34,696,292 		JBrowse link
G Calm1 calmodulin 1 IAGP MGI PMID:37589122 NCBI chr12:100,165,694...100,176,083
Ensembl chr12:100,165,694...100,176,073 		JBrowse link
G Cap2 cyclase associated actin cytoskeleton regulatory protein 2 IAGP MGI PMID:22945801 PMID:26616005 NCBI chr13:46,655,379...46,803,757
Ensembl chr13:46,655,324...46,803,757 		JBrowse link
G Cdc42 cell division cycle 42 IAGP MGI PMID:21690310 NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031 		JBrowse link
G Chat choline acetyltransferase IAGP MGI PMID:28159985 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946 		JBrowse link
G Clcf1 cardiotrophin-like cytokine factor 1 IEA MGI NCBI chr19:4,264,479...4,273,548
Ensembl chr19:4,264,292...4,273,544 		JBrowse link
G Cnot1 CCR4-NOT transcription complex, subunit 1 IAGP MGI PMID:29438013 NCBI chr 8:96,445,559...96,534,741
Ensembl chr 8:96,446,079...96,534,092 		JBrowse link
G Cnot3 CCR4-NOT transcription complex, subunit 3 IAGP MGI PMID:29438013 NCBI chr 7:3,646,717...3,664,108
Ensembl chr 7:3,648,267...3,664,108 		JBrowse link
G Col6a3 collagen, type VI, alpha 3 IEA MGI NCBI chr 1:90,694,582...90,771,710
Ensembl chr 1:90,693,645...90,771,693 		JBrowse link
G Dennd5b DENN domain containing 5B IEA MGI NCBI chr 6:148,889,566...149,003,178
Ensembl chr 6:148,889,569...149,003,178 		JBrowse link
G Egfr epidermal growth factor receptor IAGP MGI PMID:10700187 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 IAGP MGI PMID:12072561 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 IAGP MGI PMID:15863464 NCBI chr 1:68,071,063...69,147,756
Ensembl chr 1:68,071,345...69,147,218 		JBrowse link
G Esrrg estrogen-related receptor gamma IAGP MGI PMID:17618853 NCBI chr 1:187,340,707...187,947,082
Ensembl chr 1:187,340,988...187,947,082 		JBrowse link
G Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) IEA MGI NCBI chr 2:122,424,954...122,441,758
Ensembl chr 2:122,424,948...122,441,784 		JBrowse link
G Gja1 gap junction protein, alpha 1 IAGP MGI PMID:15282340 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gja5 gap junction protein, alpha 5 IAGP MGI PMID:9501069 PMID:9501070 NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732 		JBrowse link
G Grm7 glutamate receptor, metabotropic 7 IAGP MGI PMID:22423102 NCBI chr 6:110,622,304...111,544,191
Ensembl chr 6:110,622,542...111,544,191 		JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:29257745 PMID:31833196 NCBI chr 6:113,044,389...113,054,205
Ensembl chr 6:113,043,843...113,054,294 		JBrowse link
G Hcn3 hyperpolarization-activated, cyclic nucleotide-gated K+ 3 IAGP MGI PMID:21903939 NCBI chr 3:89,054,082...89,067,538
Ensembl chr 3:89,053,381...89,067,503 		JBrowse link
G Hopx HOP homeobox IAGP MGI PMID:15790958 NCBI chr 5:77,234,831...77,262,970
Ensembl chr 5:77,234,835...77,262,968 		JBrowse link
G Iah1 isoamyl acetate-hydrolyzing esterase 1 homolog IEA MGI NCBI chr12:21,366,363...21,373,608
Ensembl chr12:21,366,390...21,373,820 		JBrowse link
G Kcne1 potassium voltage-gated channel, Isk-related subfamily, member 1 IAGP MGI PMID:11438691 NCBI chr16:92,142,889...92,156,356
Ensembl chr16:92,142,870...92,156,356 		JBrowse link
G Kcne3 potassium voltage-gated channel, Isk-related subfamily, gene 3 IAGP MGI PMID:24225147 NCBI chr 7:99,825,714...99,834,076
Ensembl chr 7:99,825,709...99,834,076 		JBrowse link
G Kcne4 potassium voltage-gated channel, Isk-related subfamily, gene 4 IAGP MGI PMID:26399785 NCBI chr 1:78,794,628...78,797,749
Ensembl chr 1:78,794,475...78,797,745 		JBrowse link
G Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 IAGP MGI PMID:11226272 PMID:15498462 NCBI chr 7:142,660,614...142,980,787
Ensembl chr 7:142,660,099...142,980,779 		JBrowse link
G Klf16 Kruppel-like transcription factor 16 IEA MGI NCBI chr10:80,402,955...80,413,130
Ensembl chr10:80,402,958...80,413,155 		JBrowse link
G Klhl29 kelch-like 29 IEA MGI NCBI chr12:5,127,465...5,425,682
Ensembl chr12:5,127,472...5,425,682 		JBrowse link
G Lmod2 leiomodin 2 (cardiac) IAGP MGI PMID:27274810 NCBI chr 6:24,597,770...24,605,413
Ensembl chr 6:24,597,761...24,605,413 		JBrowse link
G Mbnl1 muscleblind like splicing regulator 1 IAGP MGI PMID:24293317 NCBI chr 3:60,380,209...60,537,171
Ensembl chr 3:60,380,251...60,537,171 		JBrowse link
G Mbnl2 muscleblind like splicing factor 2 IAGP MGI PMID:24293317 NCBI chr14:120,513,077...120,669,110
Ensembl chr14:120,513,081...120,669,109 		JBrowse link
G Mecp2 methyl CpG binding protein 2 IAGP MGI PMID:25634563 PMID:28159985 NCBI chr  X:73,070,198...73,129,296
Ensembl chr  X:73,070,198...73,129,296 		JBrowse link
G Mir1a-1 microRNA 1a-1 IAGP MGI PMID:24252873 NCBI chr 2:180,030,841...180,030,917
Ensembl chr 2:180,030,841...180,030,917 		JBrowse link
G Mir1a-2 microRNA 1a-2 IAGP MGI PMID:24252873 NCBI chr18:10,785,481...10,785,552
Ensembl chr18:10,785,481...10,785,552 		JBrowse link
G Mnx1 motor neuron and pancreas homeobox 1 IAGP MGI PMID:22423102 NCBI chr 5:29,678,821...29,683,468
Ensembl chr 5:29,678,032...29,683,468 		JBrowse link
G Mob1a MOB kinase activator 1A IEA MGI NCBI chr 6:83,303,016...83,320,758
Ensembl chr 6:83,302,998...83,320,758 		JBrowse link
G Mto1 mitochondrial tRNA translation optimization 1 IAGP MGI PMID:25506927 NCBI chr 9:78,355,372...78,381,447
Ensembl chr 9:78,355,490...78,382,630 		JBrowse link
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha IAGP MGI PMID:18362229 NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384 		JBrowse link
G Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow IAGP MGI PMID:12072561 PMID:15863464 NCBI chr 5:122,230,787...122,251,536
Ensembl chr 5:122,239,014...122,251,535 		JBrowse link
G Nkx2-5 NK2 homeobox 5 IAGP MGI PMID:21690310 PMID:34333993 NCBI chr17:27,057,638...27,063,962
Ensembl chr17:27,057,638...27,063,983 		JBrowse link
G Nos1ap nitric oxide synthase 1 (neuronal) adaptor protein IAGP MGI PMID:27170476 NCBI chr 1:170,143,039...170,417,371
Ensembl chr 1:170,130,237...170,417,430 		JBrowse link
G Ntf5 neurotrophin 5 IEA MGI NCBI chr 7:45,063,119...45,066,603
Ensembl chr 7:45,063,119...45,066,603 		JBrowse link
G Pla2g10 phospholipase A2, group X IEA MGI NCBI chr16:13,532,921...13,548,863
Ensembl chr16:13,532,921...13,548,847 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 IAGP MGI PMID:10700187 NCBI chr 5:121,268,596...121,329,460
Ensembl chr 5:121,268,596...121,329,460 		JBrowse link
G Rbm20 RNA binding motif protein 20 IAGP MGI PMID:33110103 NCBI chr19:53,649,422...53,855,514
Ensembl chr19:53,665,737...53,855,511 		JBrowse link
G Rxfp2 relaxin/insulin-like family peptide receptor 2 IEA MGI NCBI chr 5:149,941,487...150,006,015
Ensembl chr 5:149,942,140...150,005,649 		JBrowse link
G Scn1a sodium channel, voltage-gated, type I, alpha IAGP MGI PMID:24155976 NCBI chr 2:66,101,125...66,271,181
Ensembl chr 2:66,101,122...66,271,184 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha IAGP MGI PMID:11533705 PMID:15809371 PMID:17145985 PMID:22287583 PMID:30144447 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082 		JBrowse link
G Sh3tc1 SH3 domain and tetratricopeptide repeats 1 IEA MGI NCBI chr 5:35,854,524...35,897,331
Ensembl chr 5:35,854,524...35,897,331 		JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 IAGP MGI PMID:10521591 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444 		JBrowse link
G Smarcd3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 IAGP MGI PMID:29183906 NCBI chr 5:24,797,620...24,829,649
Ensembl chr 5:24,795,816...24,829,409 		JBrowse link
G Smn1 survival motor neuron 1 IAGP MGI PMID:22423102 NCBI chr13:100,259,713...100,274,206
Ensembl chr13:100,261,360...100,274,198 		JBrowse link
G Srsf4 serine and arginine-rich splicing factor 4 IAGP MGI PMID:34333993 NCBI chr 4:131,600,841...131,629,036
Ensembl chr 4:131,600,928...131,629,017 		JBrowse link
G Srsf5 serine and arginine-rich splicing factor 5 IAGP MGI PMID:34622152 NCBI chr12:80,992,308...80,997,277
Ensembl chr12:80,992,278...80,997,281 		JBrowse link
G Ssh2 slingshot protein phosphatase 2 IEA MGI NCBI chr11:77,107,020...77,351,046
Ensembl chr11:77,107,113...77,351,046 		JBrowse link
G Sun5 Sad1 and UNC84 domain containing 5 IEA MGI NCBI chr 2:153,698,108...153,713,281
Ensembl chr 2:153,698,108...153,713,004 		JBrowse link
G Syne1 spectrin repeat containing, nuclear envelope 1 IAGP MGI PMID:19008300 NCBI chr10:4,970,192...5,501,013
Ensembl chr10:4,970,917...5,501,482 		JBrowse link
G Thra thyroid hormone receptor alpha IAGP MGI PMID:9430637 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Tmem60 transmembrane protein 60 IEA MGI NCBI chr 5:21,087,451...21,091,868
Ensembl chr 5:21,087,189...21,091,868 		JBrowse link
G Tnf tumor necrosis factor IAGP MGI PMID:29618659 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnnt2 troponin T2, cardiac IAGP MGI PMID:17556660 PMID:18612386 NCBI chr 1:135,763,933...135,780,006
Ensembl chr 1:135,764,092...135,779,998 		JBrowse link
G Vdac3 voltage-dependent anion channel 3 IEA MGI NCBI chr 8:23,067,091...23,083,829
Ensembl chr 8:23,067,102...23,083,774 		JBrowse link
G Vegfa vascular endothelial growth factor A IAGP MGI PMID:10229225 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor IAGP MGI PMID:22977222 NCBI chr 6:113,600,955...113,608,595
Ensembl chr 6:113,600,920...113,608,594 		JBrowse link
G Wdr1 WD repeat domain 1 IAGP MGI PMID:24840128 NCBI chr 5:38,684,149...38,720,265
Ensembl chr 5:38,684,156...38,720,564 		JBrowse link
G Xirp1 xin actin-binding repeat containing 1 IAGP MGI PMID:17766470 NCBI chr 9:119,842,821...119,852,660
Ensembl chr 9:119,842,821...119,852,664 		JBrowse link
G Xirp2 xin actin-binding repeat containing 2 IAGP MGI PMID:29306897 NCBI chr 2:67,276,343...67,356,964
Ensembl chr 2:67,004,178...67,356,959 		JBrowse link
G Ypel2 yippee like 2 IEA MGI NCBI chr11:86,827,251...86,884,629
Ensembl chr11:86,827,251...86,884,533 		JBrowse link
G Zfp804a zinc finger protein 804A IEA MGI NCBI chr 2:81,880,473...82,090,223
Ensembl chr 2:81,883,566...82,090,223 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16762
    cardiovascular system phenotype 4134
      abnormal cardiovascular system physiology 2340
        abnormal impulse conducting system conduction 420
          abnormal heart electrocardiography waveform feature 395
            abnormal QT interval 99
              prolonged QT interval 72
paths to the root