Rbm20 (RNA binding motif protein 20) - Rat Genome Database

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Gene: Rbm20 (RNA binding motif protein 20) Mus musculus
Analyze
Symbol: Rbm20
Name: RNA binding motif protein 20
RGD ID: 1616733
MGI Page MGI
Description: Enables pre-mRNA intronic binding activity. Involved in heart formation; regulation of RNA splicing; and spliceosome-depend formation of circular RNA. Located in cytoplasmic ribonucleoprotein granule. Is active in nucleus. Is expressed in several structures, including diaphragm; extraembryonic component; heart; limb segment; and skeletal musculature. Used to study atrial fibrillation and dilated cardiomyopathy 1DD. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and dilated cardiomyopathy 1DD. Orthologous to human RBM20 (RNA binding motif protein 20).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110018J23Rik; 2010003H22Rik; AI646761; probable RNA-binding protein 20; RNA-binding motif protein 20; RNA-binding protein 20
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391953,649,422 - 53,855,514 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1953,665,737 - 53,855,511 (+)EnsemblGRCm39 Ensembl
GRCm381953,660,989 - 53,867,083 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1953,677,306 - 53,867,080 (+)EnsemblGRCm38mm10GRCm38
MGSCv371953,751,796 - 53,941,570 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361953,730,363 - 53,919,025 (+)NCBIMGSCv36mm8
MGSCv361953,676,844 - 53,880,034 (+)NCBIMGSCv36mm8
Celera1955,870,376 - 56,061,918 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1948.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasmic ribonucleoprotein granule  (IDA,ISO)
nucleus  (IBA,IDA,IMP,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mutations in ribonucleic acid binding protein gene cause familial dilated cardiomyopathy. Brauch KM, etal., J Am Coll Cardiol. 2009 Sep 1;54(10):930-41. doi: 10.1016/j.jacc.2009.05.038.
2. RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Guo W, etal., Nat Med. 2012 May;18(5):766-73. doi: 10.1038/nm.2693.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:16107646   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635  
PMID:23886709   PMID:24470489   PMID:24584570   PMID:24599837   PMID:27139341   PMID:27470639   PMID:27524973   PMID:27531932   PMID:27630136   PMID:27889803   PMID:29567830   PMID:29650543  
PMID:29895960   PMID:29978560   PMID:30523116   PMID:31776291   PMID:32187365   PMID:32325033   PMID:32547410   PMID:33110103   PMID:35041844   PMID:35394688   PMID:35476669   PMID:36047761  
PMID:36198914   PMID:36367695   PMID:36417486   PMID:36555335   PMID:37219949   PMID:37272356   PMID:37349314   PMID:38288598   PMID:38355793   PMID:38847487   PMID:38950288  


Genomics

Comparative Map Data
Rbm20
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391953,649,422 - 53,855,514 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1953,665,737 - 53,855,511 (+)EnsemblGRCm39 Ensembl
GRCm381953,660,989 - 53,867,083 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1953,677,306 - 53,867,080 (+)EnsemblGRCm38mm10GRCm38
MGSCv371953,751,796 - 53,941,570 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361953,730,363 - 53,919,025 (+)NCBIMGSCv36mm8
MGSCv361953,676,844 - 53,880,034 (+)NCBIMGSCv36mm8
Celera1955,870,376 - 56,061,918 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1948.28NCBI
RBM20
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810110,643,245 - 110,839,468 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10110,644,336 - 110,839,471 (+)EnsemblGRCh38hg38GRCh38
GRCh3710112,404,094 - 112,599,226 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610112,394,203 - 112,589,217 (+)NCBINCBI36Build 36hg18NCBI36
Celera10106,135,726 - 106,330,820 (+)NCBICelera
Cytogenetic Map10q25.2NCBI
HuRef10106,033,283 - 106,228,064 (+)NCBIHuRef
CHM1_110112,685,947 - 112,881,061 (+)NCBICHM1_1
T2T-CHM13v2.010111,526,746 - 111,723,237 (+)NCBIT2T-CHM13v2.0
Rbm20
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81262,671,311 - 262,912,551 (+)NCBIGRCr8
mRatBN7.21252,683,760 - 252,907,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1252,683,771 - 252,886,060 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1260,872,977 - 261,075,647 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01267,579,046 - 267,781,723 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01260,234,755 - 260,437,091 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01274,391,932 - 274,589,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1274,391,932 - 274,589,816 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01281,783,646 - 282,003,053 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41259,905,545 - 260,144,190 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11260,300,378 - 260,352,579 (+)NCBI
Celera1248,402,941 - 248,600,603 (+)NCBICelera
Cytogenetic Map1q55NCBI
Rbm20
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955485586,373 - 769,635 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955485590,094 - 769,604 (-)NCBIChiLan1.0ChiLan1.0
RBM20
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28122,528,458 - 122,721,290 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110122,533,794 - 122,726,626 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010107,240,854 - 107,433,749 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110110,767,653 - 110,882,909 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10110,822,255 - 110,882,909 (+)Ensemblpanpan1.1panPan2
RBM20
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12821,971,424 - 22,162,798 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2821,971,504 - 22,161,476 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2822,243,625 - 22,314,911 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02822,616,330 - 22,687,337 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2822,496,586 - 22,687,315 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12822,175,756 - 22,246,804 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02822,182,299 - 22,253,611 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02822,316,433 - 22,387,379 (+)NCBIUU_Cfam_GSD_1.0
Rbm20
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721323,908,959 - 24,089,243 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364861,472,227 - 1,653,209 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364861,472,170 - 1,652,314 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBM20
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14121,210,666 - 121,269,823 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114121,058,896 - 121,269,824 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214131,944,861 - 132,146,766 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RBM20
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19103,583,722 - 103,775,391 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9103,703,569 - 103,777,934 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604864,923,022 - 64,982,689 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbm20
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473735,477,521 - 35,545,242 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473735,479,621 - 35,660,357 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rbm20
7899 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:2578
Count of miRNA genes:717
Interacting mature miRNAs:911
Transcripts:ENSMUST00000095969, ENSMUST00000161856, ENSMUST00000162910, ENSMUST00000164202
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
11667075Led3_mlate embryonic death 3 (mouse)195108837859123872Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
1300585Pgia12_mproteoglycan induced arthritis 12 (mouse)Not determined194258685961420004Mouse
4141412Acsns1_mAngiostrongylus costaricensis nematode susceptibility 1 (mouse)Not determined4789788055026545Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse

Markers in Region
AI646761  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381953,866,696 - 53,866,817UniSTSGRCm38
MGSCv371953,941,186 - 53,941,307UniSTSGRCm37
Celera1956,061,534 - 56,061,655UniSTS
Cytogenetic Map19D2UniSTS
D19Mit103  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381953,764,166 - 53,764,287UniSTSGRCm38
MGSCv371953,838,656 - 53,838,777UniSTSGRCm37
Celera1955,959,548 - 55,959,675UniSTS
Cytogenetic Map19D2UniSTS
cM Map1952.0UniSTS
Whitehead Genetic1940.4UniSTS
Whitehead/MRC_RH19563.07UniSTS
Whitehead_YAC19 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000161856   ⟹   ENSMUSP00000124363
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1953,831,641 - 53,855,511 (+)Ensembl
GRCm38.p6 Ensembl1953,843,210 - 53,867,080 (+)Ensembl
Ensembl Acc Id: ENSMUST00000162910   ⟹   ENSMUSP00000158014
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1953,781,739 - 53,802,004 (+)Ensembl
GRCm38.p6 Ensembl1953,793,308 - 53,813,573 (+)Ensembl
Ensembl Acc Id: ENSMUST00000164202   ⟹   ENSMUSP00000129447
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1953,665,737 - 53,853,811 (+)Ensembl
GRCm38.p6 Ensembl1953,677,306 - 53,865,380 (+)Ensembl
RefSeq Acc Id: NM_001170847   ⟹   NP_001164318
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391953,665,737 - 53,855,511 (+)NCBI
GRCm381953,677,306 - 53,867,080 (+)NCBI
MGSCv371953,751,796 - 53,941,570 (+)RGD
Celera1955,870,376 - 56,061,918 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006527385   ⟹   XP_006527448
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391953,781,445 - 53,855,514 (+)NCBI
GRCm381953,793,016 - 53,867,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011247371   ⟹   XP_011245673
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391953,649,422 - 53,855,514 (+)NCBI
GRCm381953,660,989 - 53,867,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011247372   ⟹   XP_011245674
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391953,712,564 - 53,855,514 (+)NCBI
GRCm381953,726,603 - 53,867,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036161706   ⟹   XP_036017599
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391953,789,211 - 53,855,514 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036161707   ⟹   XP_036017600
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391953,661,609 - 53,855,514 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001164318   ⟸   NM_001170847
- UniProtKB: E9PVK0 (UniProtKB/Swiss-Prot),   Q8CFS9 (UniProtKB/Swiss-Prot),   Q3UQS8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006527448   ⟸   XM_006527385
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011245673   ⟸   XM_011247371
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011245674   ⟸   XM_011247372
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSMUSP00000129447   ⟸   ENSMUST00000164202
Ensembl Acc Id: ENSMUSP00000158014   ⟸   ENSMUST00000162910
Ensembl Acc Id: ENSMUSP00000124363   ⟸   ENSMUST00000161856
RefSeq Acc Id: XP_036017600   ⟸   XM_036161707
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036017599   ⟸   XM_036161706
- Peptide Label: isoform X3
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3UQS8-F1-model_v2 AlphaFold Q3UQS8 1-1199 view protein structure

Promoters
RGD ID:13679790
Promoter ID:EPDNEW_M24044
Type:initiation region
Name:Rbm20_1
Description:Mus musculus RNA binding motif protein 20 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381953,677,371 - 53,677,431EPDNEW
RGD ID:6830361
Promoter ID:MM_KWN:27350
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000083634
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361953,867,986 - 53,868,486 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1920963 AgrOrtholog
Ensembl Genes ENSMUSG00000043639 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000161856.2 UniProtKB/TrEMBL
  ENSMUST00000162910.2 UniProtKB/TrEMBL
  ENSMUST00000164202 ENTREZGENE
  ENSMUST00000164202.9 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
InterPro Matrin/U1-C_Znf_C2H2 UniProtKB/Swiss-Prot
  Matrin/U1-like-C_Znf_C2H2 UniProtKB/Swiss-Prot
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RBM20_RRM UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report mmu:73713 UniProtKB/Swiss-Prot
MGD MGI:1920963 ENTREZGENE
NCBI Gene 73713 ENTREZGENE
PANTHER MATRIN 3/NUCLEAR PROTEIN 220-RELATED UniProtKB/Swiss-Prot
PhenoGen Rbm20 PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
  ZF_MATRIN UniProtKB/Swiss-Prot
SMART RRM UniProtKB/Swiss-Prot
  ZnF_U1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A494BAB4_MOUSE UniProtKB/TrEMBL
  E9PVK0 ENTREZGENE
  F6TAZ4_MOUSE UniProtKB/TrEMBL
  Q3UQS8 ENTREZGENE
  Q8CFS9 ENTREZGENE
  RBM20_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary E9PVK0 UniProtKB/Swiss-Prot
  Q8CFS9 UniProtKB/Swiss-Prot