Dennd5b (DENN domain containing 5B) - Rat Genome Database

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Gene: Dennd5b (DENN domain containing 5B) Mus musculus
Analyze
Symbol: Dennd5b
Name: DENN domain containing 5B
RGD ID: 1617988
MGI Page MGI
Description: Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in positive regulation of triglyceride transport. Predicted to be located in membrane. Orthologous to human DENND5B (DENN domain containing 5B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9330160C06Rik; AI852444; D030011O10Rik; DENN domain-containing protein 5B; DENN/MADD domain containing 5B; ENSMUSG00000072657; expressed sequence AI852444; Gm17524; RAB6IP1-like protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396148,889,566 - 149,003,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6148,889,569 - 149,003,178 (-)EnsemblGRCm39 Ensembl
GRCm386148,988,069 - 149,101,680 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6148,988,071 - 149,101,680 (-)EnsemblGRCm38mm10GRCm38
MGSCv376148,936,591 - 149,050,202 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366148,971,158 - 149,058,708 (-)NCBIMGSCv36mm8
Celera6152,026,106 - 152,141,735 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map678.71NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal body mass index  (IAGP)
abnormal bone structure  (IEA)
abnormal circulating lipid level  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal intestine physiology  (IAGP)
abnormal seminal vesicle morphology  (IEA)
abnormal small intestine morphology  (IAGP)
abnormal spleen morphology  (IEA)
abnormal sternum morphology  (IEA)
decreased body fat mass  (IAGP)
decreased bone mineral content  (IEA)
decreased bone mineral density  (IEA)
decreased circulating cholesterol level  (IEA)
decreased circulating glucose level  (IEA)
decreased circulating HDL cholesterol level  (IAGP)
decreased circulating total protein level  (IEA)
decreased circulating triglyceride level  (IEA)
decreased exploration in new environment  (IEA)
decreased heart rate  (IEA)
decreased liver cholesterol level  (IAGP)
decreased liver free fatty acids level  (IAGP)
decreased red blood cell distribution width  (IEA)
decreased susceptibility to atherosclerosis  (IAGP)
decreased susceptibility to weight gain  (IAGP)
decreased total body fat amount  (IEA)
distended duodenum  (IAGP)
distended ileum  (IAGP)
distended jejunum  (IAGP)
improved glucose tolerance  (IEA)
increased circulating alkaline phosphatase level  (IEA)
increased circulating VLDL triglyceride level  (IAGP)
increased freezing behavior  (IEA)
increased grip strength  (IEA)
increased lean body mass  (IAGP)
increased leukocyte cell number  (IEA)
increased lymphocyte cell number  (IEA)
increased small intestine length  (IAGP)
prolonged PR interval  (IEA)
prolonged QT interval  (IEA)
prolonged RR interval  (IEA)
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:18799693   PMID:21677750  
PMID:21873635   PMID:30837651   PMID:32325033   PMID:32496646   PMID:36243100   PMID:38187761   PMID:38355793  


Genomics

Comparative Map Data
Dennd5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396148,889,566 - 149,003,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6148,889,569 - 149,003,178 (-)EnsemblGRCm39 Ensembl
GRCm386148,988,069 - 149,101,680 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6148,988,071 - 149,101,680 (-)EnsemblGRCm38mm10GRCm38
MGSCv376148,936,591 - 149,050,202 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366148,971,158 - 149,058,708 (-)NCBIMGSCv36mm8
Celera6152,026,106 - 152,141,735 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map678.71NCBI
DENND5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381231,382,226 - 31,591,136 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1231,382,226 - 31,591,136 (-)EnsemblGRCh38hg38GRCh38
GRCh371231,535,160 - 31,744,070 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361231,426,424 - 31,635,219 (-)NCBINCBI36Build 36hg18NCBI36
Celera1211,356,369 - 11,566,294 (-)NCBICelera
Cytogenetic Map12p11.21NCBI
HuRef1231,287,816 - 31,496,409 (-)NCBIHuRef
CHM1_11231,500,166 - 31,708,943 (-)NCBICHM1_1
T2T-CHM13v2.01231,258,770 - 31,467,670 (-)NCBIT2T-CHM13v2.0
Dennd5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84183,688,039 - 183,821,012 (-)NCBIGRCr8
mRatBN7.24181,959,597 - 182,089,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4181,961,386 - 182,089,362 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.04183,476,093 - 183,604,940 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4183,476,093 - 183,544,850 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04247,608,015 - 247,704,356 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4170,433,402 - 170,556,221 (-)NCBICelera
Cytogenetic Map4q44NCBI
Dennd5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555054,208,320 - 4,295,112 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555054,134,686 - 4,295,112 (+)NCBIChiLan1.0ChiLan1.0
DENND5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21065,179,861 - 65,390,784 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11265,176,281 - 65,387,177 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01254,650,609 - 54,858,862 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11257,236,855 - 57,444,819 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1257,236,973 - 57,444,819 (+)Ensemblpanpan1.1panPan2
DENND5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12717,250,526 - 17,366,021 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2717,044,309 - 17,361,570 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2729,051,206 - 29,250,680 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02717,348,446 - 17,549,134 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2717,348,446 - 17,548,801 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12717,159,010 - 17,358,756 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02717,191,053 - 17,389,619 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02729,204,343 - 29,403,719 (-)NCBIUU_Cfam_GSD_1.0
Dennd5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494577,825,694 - 77,945,439 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366074,663,703 - 4,775,956 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366074,598,370 - 4,777,241 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DENND5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl542,643,115 - 42,879,729 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1542,642,676 - 42,870,980 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2545,983,366 - 46,005,315 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DENND5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11130,858,764 - 31,060,928 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1130,859,822 - 31,060,633 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660693,926,033 - 4,127,804 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dennd5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247784,680,389 - 4,873,418 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247784,680,320 - 4,870,818 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dennd5b
4766 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1823
Count of miRNA genes:797
Interacting mature miRNAs:1036
Transcripts:ENSMUST00000111557, ENSMUST00000127727, ENSMUST00000129539, ENSMUST00000145555, ENSMUST00000150436
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
10449437Pas15_mpulmonary adenoma susceptibility 15 (mouse)6128180868149588044Mouse
1301686Trmq1_mT cell ratio modifier QTL 1 (mouse)Not determined6129330484149588044Mouse
1301620Insq8_minsulin QTL 8 (mouse)Not determined6129534979149588044Mouse
10053680Lith25_mlithogenic gene 25 (mouse)Not determined6128601582149588044Mouse
4141974Skmw14_mskeletal muscle weight 14 (mouse)Not determined6129330484149588044Mouse
1301084Bpq5_mblood pressure QTL 5 (mouse)Not determined6129330484149588044Mouse
14746990Manh61_mmandible shape 61 (mouse)6130156355149588044Mouse
1301027Hdlq12_mHDL QTL 12 (mouse)Not determined6128601582149588044Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
10766452Sle23_msystematic lupus erythematosus susceptibility 23 (mouse)6128601582149588044Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
14746999Mancz6_mmandible centroid size 6 (mouse)6130156355149588044Mouse
1558959Eamcd2_mexperimental autoimmune myocarditis 2 (mouse)Not determined6129953954149588044Mouse
1302089Wta2_mweight adult 2 (mouse)Not determined6125269523149588044Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120416806149588044Mouse

Markers in Region
AI852444  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386148,988,130 - 148,988,240UniSTSGRCm38
MGSCv376148,936,652 - 148,936,762UniSTSGRCm37
Celera6152,026,167 - 152,026,277UniSTS
Cytogenetic Map6G3UniSTS
Whitehead/MRC_RH61499.43UniSTS
D11Bhm20  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F1UniSTS
Cytogenetic Map5E2UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map19D1UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map12D1UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map7B4UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map4E1UniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map16C1.1UniSTS
Cytogenetic Map3BUniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map2E2UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map4C7UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map10A3UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map1C1.3UniSTS
Cytogenetic Map13D2UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map6A2UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map16C4UniSTS
Cytogenetic Map3G1UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map7B1-B2UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic Map11B1.1UniSTS
Cytogenetic Map15B3.1UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic Map10D2UniSTS
Cytogenetic Map15E3UniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map7E3UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXC-DUniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map11A3.2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map16B4UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map19BUniSTS
cM Map1144.15UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_177192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006507063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017321643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030255459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036166229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036166230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC132412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC140327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK038858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB656426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN537548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU207334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV558497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000111557   ⟹   ENSMUSP00000107182
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6148,889,569 - 149,003,178 (-)Ensembl
GRCm38.p6 Ensembl6148,988,071 - 149,101,680 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127727   ⟹   ENSMUSP00000123568
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6148,970,078 - 149,003,082 (-)Ensembl
GRCm38.p6 Ensembl6149,068,580 - 149,101,584 (-)Ensembl
Ensembl Acc Id: ENSMUST00000129539
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6148,915,348 - 148,918,686 (-)Ensembl
GRCm38.p6 Ensembl6149,013,850 - 149,017,188 (-)Ensembl
Ensembl Acc Id: ENSMUST00000145555   ⟹   ENSMUSP00000127731
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6148,970,055 - 148,982,793 (-)Ensembl
GRCm38.p6 Ensembl6149,068,557 - 149,081,295 (-)Ensembl
Ensembl Acc Id: ENSMUST00000150436
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6148,915,486 - 149,003,036 (-)Ensembl
GRCm38.p6 Ensembl6149,013,988 - 149,101,538 (-)Ensembl
Ensembl Acc Id: ENSMUST00000204030
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6148,983,883 - 148,986,861 (-)Ensembl
GRCm38.p6 Ensembl6149,082,385 - 149,085,363 (-)Ensembl
Ensembl Acc Id: ENSMUST00000204583
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6148,939,593 - 148,944,371 (-)Ensembl
GRCm38.p6 Ensembl6149,038,095 - 149,042,873 (-)Ensembl
RefSeq Acc Id: NM_177192   ⟹   NP_796166
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396148,889,567 - 149,003,178 (-)NCBI
GRCm386148,988,069 - 149,101,680 (-)NCBI
MGSCv376148,936,591 - 149,050,202 (-)RGD
Celera6152,026,106 - 152,141,735 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006507063   ⟹   XP_006507126
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396148,889,566 - 149,003,040 (-)NCBI
GRCm386148,990,531 - 149,101,560 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017321643   ⟹   XP_017177132
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396148,892,535 - 148,986,434 (-)NCBI
GRCm386148,990,351 - 149,084,936 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030255459   ⟹   XP_030111319
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396148,892,798 - 149,002,765 (-)NCBI
GRCm386148,990,531 - 149,101,267 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036166229   ⟹   XP_036022122
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396148,892,798 - 149,002,770 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036166230   ⟹   XP_036022123
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396148,892,798 - 149,002,765 (-)NCBI
Sequence:
RefSeq Acc Id: NP_796166   ⟸   NM_177192
- UniProtKB: Q8BII7 (UniProtKB/Swiss-Prot),   Q8BWK2 (UniProtKB/Swiss-Prot),   A2RSQ0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006507126   ⟸   XM_006507063
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017177132   ⟸   XM_017321643
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_030111319   ⟸   XM_030255459
- Peptide Label: isoform X3
Ensembl Acc Id: ENSMUSP00000127731   ⟸   ENSMUST00000145555
Ensembl Acc Id: ENSMUSP00000107182   ⟸   ENSMUST00000111557
Ensembl Acc Id: ENSMUSP00000123568   ⟸   ENSMUST00000127727
RefSeq Acc Id: XP_036022122   ⟸   XM_036166229
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036022123   ⟸   XM_036166230
- Peptide Label: isoform X4
Protein Domains
cDENN   dDENN   PLAT   RUN   uDENN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A2RSQ0-F1-model_v2 AlphaFold A2RSQ0 1-1274 view protein structure

Promoters
RGD ID:6839179
Promoter ID:MM_KWN:48326
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000082629
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366148,965,736 - 148,966,236 (-)MPROMDB
RGD ID:6839155
Promoter ID:MM_KWN:48332
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   Spleen
Transcripts:NM_177192,   OTTMUST00000056366,   UC009ETU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366149,049,779 - 149,050,279 (-)MPROMDB
RGD ID:6891574
Promoter ID:EPDNEW_M9238
Type:initiation region
Name:Dennd5b_2
Description:Mus musculus DENN/MADD domain containing 5B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9239  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386149,101,546 - 149,101,606EPDNEW
RGD ID:6891576
Promoter ID:EPDNEW_M9239
Type:multiple initiation site
Name:Dennd5b_1
Description:Mus musculus DENN/MADD domain containing 5B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9238  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386149,101,680 - 149,101,740EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2444273 AgrOrtholog
Ensembl Genes ENSMUSG00000030313 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000111557 ENTREZGENE
  ENSMUST00000111557.8 UniProtKB/Swiss-Prot
  ENSMUST00000127727.2 UniProtKB/TrEMBL
  ENSMUST00000145555.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.900 UniProtKB/Swiss-Prot
  3.30.450.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.11500 UniProtKB/Swiss-Prot
  PLAT/LH2 domain UniProtKB/Swiss-Prot
InterPro cDENN_dom UniProtKB/Swiss-Prot
  dDENN_dom UniProtKB/Swiss-Prot
  DEN5A/B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DENN_C UniProtKB/Swiss-Prot
  PLAT/LH2_dom UniProtKB/Swiss-Prot
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot
  PLAT_RAB6IP1 UniProtKB/Swiss-Prot
  RUN1_DENND5B UniProtKB/Swiss-Prot
  RUN2_DENND5B UniProtKB/Swiss-Prot
  Run_dom UniProtKB/Swiss-Prot
  Run_dom_sf UniProtKB/Swiss-Prot
  Tripartite_DENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  uDENN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:320560 UniProtKB/Swiss-Prot
MGD MGI:2444273 ENTREZGENE
NCBI Gene 320560 ENTREZGENE
PANTHER DENN DOMAIN-CONTAINING PROTEIN 5B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PINSTRIPE, ISOFORM A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam dDENN UniProtKB/Swiss-Prot
  DENN UniProtKB/Swiss-Prot
  PLAT UniProtKB/Swiss-Prot
  RUN UniProtKB/Swiss-Prot
  uDENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dennd5b PhenoGen
PROSITE DENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot
  RUN UniProtKB/Swiss-Prot
SMART dDENN UniProtKB/Swiss-Prot
  DENN UniProtKB/Swiss-Prot
  RUN UniProtKB/Swiss-Prot
  uDENN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF140741 UniProtKB/Swiss-Prot
  SSF49723 UniProtKB/Swiss-Prot
UniProt A2RSQ0 ENTREZGENE
  B8JKU3_MOUSE UniProtKB/TrEMBL
  DEN5B_MOUSE UniProtKB/Swiss-Prot
  E9Q0R9_MOUSE UniProtKB/TrEMBL
  Q3UPW6_MOUSE UniProtKB/TrEMBL
  Q8BII7 ENTREZGENE
  Q8BWK2 ENTREZGENE
UniProt Secondary Q8BII7 UniProtKB/Swiss-Prot
  Q8BWK2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-11-29 Dennd5b  DENN domain containing 5B  Dennd5b  DENN/MADD domain containing 5B  Symbol and/or name change 5135510 APPROVED
2016-04-05 Dennd5b  DENN/MADD domain containing 5B  AI852444  expressed sequence AI852444  Data merged from RGD:1608519 737654 PROVISIONAL