MAMMALIAN PHENOTYPE - ANNOTATIONS
The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term: cardiovascular system phenotype
Accession: MP:0005385
browse the term
Definition: the observable morphological and physiological characteristics of the mammalian heart, blood vessels, or circulatory system that are manifested through development and lifespan
Synonyms: narrow_synonym: Abnormality of the cardiovascular system
xref: HP:0001626
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Apoe
apolipoprotein E
IMP
RGD
PMID:29166645
RGD:150520219
NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932
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Apoeem1Ejt
apolipoprotein E; TALEN induced mutant 1, Ejt
IMP
RGD
PMID:29166645
RGD:150520219
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Apoeem1Sage
apolipoprotein E; endonuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
IMP
RGD
PMID:29166645
RGD:150520219
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Lepr
leptin receptor
IAGP
DNA:mutations:cds: : (rat)
RGD
PMID:32710530
RGD:401960103
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
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Lepr
leptin receptor
IAGP
DNA:mutations:cds: : (rat)
RGD
PMID:32710530
RGD:401960103
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
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Abcb1a
ATP binding cassette subfamily B member 1A
IMP
RGD
PMID:22049154
RGD:8657330
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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Abcb1aem2Sage
ATP binding cassette subfamily B member 1A; ZFN induced mutant 2, Sage
IMP
RGD
PMID:22049154
RGD:8657330
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Abcc2
ATP binding cassette subfamily C member 2
IAGP
RGD
PMID:12663688
RGD:704399
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
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Crh
corticotropin releasing hormone
IDA
RGD
PMID:12663088
RGD:704425
NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919
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Tmem67
transmembrane protein 67
IAGP
RGD
PMID:30705305
RGD:14995942
NCBI chr 5:30,333,793...30,386,702
Ensembl chr 5:25,536,458...25,589,334
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Tmem67wpk
transmembrane protein 67; wpk mutant
IAGP
RGD
PMID:30705305
RGD:14995942
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Ttn
titin
IAGP
RGD
PMID:27869827
RGD:11565821
NCBI chr 3:82,059,648...82,332,130
Ensembl chr 3:61,652,439...61,924,741
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Ttnem1Sage
Titin; zinc finger nuclease induced mutant 1,Sigma Advanced Genetic Engineering Labs
IAGP
RGD
PMID:27869827
RGD:11565821
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Ttnem2Sage
Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs
IAGP
RGD
PMID:27869827
RGD:11565821
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Tnnt2
troponin T2, cardiac type
IDA
RGD
PMID:10946062
RGD:1580434
NCBI chr13:49,819,123...49,837,125
Ensembl chr13:47,267,204...47,285,388
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Kcnq1
potassium voltage-gated channel subfamily Q member 1
IAGP
DNA:deletion:exon (rat)
RGD
PMID:16368876
RGD:1581602
NCBI chr 1:207,721,134...208,054,073
Ensembl chr 1:198,291,766...198,624,669
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Kcnq1dfk
potassium voltage-gated channel subfamily Q member 1;deafness Kyoto
IAGP
RGD
PMID:16368876
RGD:1581602
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Cd36
CD36 molecule
IAGP
RGD
PMID:18288886
RGD:2307226
NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903
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Astn1
astrotactin 1
IMP
RGD
PMID:24714719
RGD:12792227
NCBI chr13:73,070,754...73,388,902
Ensembl chr13:70,537,703...70,855,440
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Brinp2
BMP/retinoic acid inducible neural specific 2
IMP
RGD
PMID:24714719
RGD:12792227
NCBI chr13:72,964,498...73,065,312
Ensembl chr13:70,431,010...70,531,810
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Cop1
COP1, E3 ubiquitin ligase
IMP
RGD
PMID:24714719
RGD:12792227
NCBI chr13:73,954,058...74,095,283
Ensembl chr13:71,429,961...71,538,890
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Pappa2
pappalysin 2
IMP
RGD
PMID:24714719
RGD:12792227
NCBI chr13:73,407,385...73,683,699
Ensembl chr13:70,876,794...71,147,779
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Tnr
tenascin R
IMP
RGD
PMID:24714719
RGD:12792227
NCBI chr13:74,285,141...74,706,174
Ensembl chr13:72,091,585...72,167,641
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Dmd
dystrophin
IMP
RGD
PMID:25310701
RGD:12880034
NCBI chr X:51,070,098...53,437,845
Ensembl chr X:47,272,331...49,504,207
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Dmdem1Ang
dystrophin; TALEN-induced mutant1, Ang
IMP
RGD
PMID:25310701
RGD:12880034
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Lepr
leptin receptor
treatment
IAGP
RGD
PMID:33568522
RGD:401965412
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
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Myh7b
myosin heavy chain 7B
IMP
RGD
PMID:32207065
RGD:126925946
NCBI chr 3:164,537,211...164,582,441
Ensembl chr 3:144,098,190...144,122,084
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Myh7bem1Blar
myosin heavy chain 7B; CRISPR/Cas9 induced mutant 1, Blar
IMP
RGD
PMID:32207065
RGD:126925946
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Gla
galactosidase, alpha
IMP
RGD
PMID:31253878
RGD:401976417
NCBI chr X:102,062,497...102,073,915
Ensembl chr X:97,768,996...97,780,664
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Glaem2Mcwi
galactosidase, alpha; CRISPR/Cas9 system induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:31253878
RGD:401976417
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Lrp5
LDL receptor related protein 5
IMP
RGD
PMID:32833527
RGD:40902996
NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:200,814,250...200,917,581
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Lrp5em1Vari
LDL receptor related protein 5;CRISPR/Cas9 induced mutant 1, Vari
IMP
RGD
PMID:32833527
RGD:40902996
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Lrp5em2Vari
LDL receptor related protein 5; CRISPR/Cas9 induced mutant 2, Vari
IMP
RGD
PMID:32833527
RGD:40902996
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Lrp5em3Vari
LDL receptor related protein 5; CRISPR/Cas9 induced mutant 3, Vari
IMP
RGD
PMID:32833527
RGD:40902996
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Lrp5
LDL receptor related protein 5
IMP
RGD
PMID:32833527
RGD:40902996
NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:200,814,250...200,917,581
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Lrp5em1Vari
LDL receptor related protein 5;CRISPR/Cas9 induced mutant 1, Vari
IMP
RGD
PMID:32833527
RGD:40902996
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Lrp5em2Vari
LDL receptor related protein 5; CRISPR/Cas9 induced mutant 2, Vari
IMP
RGD
PMID:32833527
RGD:40902996
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Lrp5em3Vari
LDL receptor related protein 5; CRISPR/Cas9 induced mutant 3, Vari
IMP
RGD
PMID:32833527
RGD:40902996
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Pde6b
phosphodiesterase 6B
IMP
compared to wild-type
RGD
PMID:31009522
RGD:40924664
NCBI chr14:1,468,302...1,511,435
Ensembl chr14:1,323,310...1,366,450
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Pde6bem1Baek
phosphodiesterase 6B; Cpf1-CRISPR induced mutant1, Baek
IMP
compared to wild-type
RGD
PMID:31009522
RGD:40924664
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Cryba1
crystallin, beta A1
IMP
RGD
PMID:17931883
RGD:2303652
NCBI chr10:63,106,465...63,113,020
Ensembl chr10:62,608,383...62,614,726
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Cryba1Nuc1Dbsa
crystallin, beta A1;Nuc1 mutant, Dbsa
IMP
RGD
PMID:17931883
RGD:2303652
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Kdr
kinase insert domain receptor
IDA
inhibition significantly reduces retinal neovascularization
RGD
PMID:15951738
RGD:1581593
NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018
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Cryba1
crystallin, beta A1
IAGP
DNA:insertion:exon
RGD
PMID:17931883
RGD:2303652
NCBI chr10:63,106,465...63,113,020
Ensembl chr10:62,608,383...62,614,726
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Spon2
spondin 2
IMP
RGD
PMID:25751394
RGD:329328927
NCBI chr14:81,713,070...81,742,510
Ensembl chr14:77,511,901...77,517,996
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Spon2em1Holi
spondin 2; TALEN induced mutant1, Holi
IMP
RGD
PMID:25751394
RGD:329328927
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Gpr182
G protein-coupled receptor 182
IDA
RGD
PMID:7592696
RGD:61533
NCBI chr 7:65,471,254...65,474,110
Ensembl chr 7:63,578,750...63,589,210
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Nfe2l2
NFE2 like bZIP transcription factor 2
IMP
RGD
PMID:26637559
RGD:11344212
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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Nfe2l2em1Mcwi
nuclear factor, erythroid 2-like 2; TALEN induced mutant 1, Medical College of Wisconsin
IMP
RGD
PMID:26637559
RGD:11344212
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Sod3
superoxide dismutase 3
IMP
DNA:missense mutation:CDS:p.E124D
RGD
PMID:24322611
RGD:38548929
NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990
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Sod3m1Mcwi
superoxide dismutase 3; mutation 1, Medical College of Wisconsin
IMP
RGD
PMID:24322611
RGD:38548929
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Ahr
aryl hydrocarbon receptor
IMP
RGD
PMID:23859880
RGD:13204753
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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Ahrem2Sage
aryl hydrocarbon receptor; ZFN induced mutant2, Sage
IMP
RGD
PMID:23859880
RGD:13204753
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Lepr
leptin receptor
IAGP
DNA:mutations:cds: : (rat)
RGD
PMID:10901178
RGD:401965414
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
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Mgp
matrix Gla protein
IDA
RGD
PMID:17138823
RGD:2293588
NCBI chr 4:171,497,472...171,500,888
Ensembl chr 4:169,766,279...169,769,667
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Myh7b
myosin heavy chain 7B
IMP
RGD
PMID:32207065
RGD:126925946
NCBI chr 3:164,537,211...164,582,441
Ensembl chr 3:144,098,190...144,122,084
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Myh7bem1Blar
myosin heavy chain 7B; CRISPR/Cas9 induced mutant 1, Blar
IMP
RGD
PMID:32207065
RGD:126925946
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Crebbp
CREB binding protein
IDA
RGD
PMID:12477714
RGD:1298794
NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,335,953...11,461,888
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Ep300
E1A binding protein p300
IDA
RGD
PMID:12477714
RGD:1298794
NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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Igf1
insulin-like growth factor 1
IDA
RGD
PMID:15996002
RGD:1580474
NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296
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Nppb
natriuretic peptide B
IMP
RGD
PMID:26063669
RGD:12910116
NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168
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Nppbem2Mcwi
natriuretic peptide B; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:26063669
RGD:12910116
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Npr2
natriuretic peptide receptor 2
IAGP
RGD
PMID:16537417
RGD:1601488
NCBI chr 5:62,678,197...62,697,360
Ensembl chr 5:57,883,171...57,901,580
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Ppp3ca
protein phosphatase 3 catalytic subunit alpha
IDA
RGD
PMID:16799071
RGD:1580700
NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:225,165,766...225,438,974
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Ppp3cb
protein phosphatase 3 catalytic subunit beta
IDA
RGD
PMID:16496058
RGD:1580703
NCBI chr15:3,809,182...3,854,204
Ensembl chr15:3,760,030...3,804,981
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Rcan1
regulator of calcineurin 1
IDA
RGD
PMID:15899894
RGD:1581475
NCBI chr11:45,108,123...45,188,065
Ensembl chr11:31,622,210...31,702,045
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S1pr1
sphingosine-1-phosphate receptor 1
IMP
RGD
PMID:11549339
RGD:1357201
NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:203,621,587...203,629,681
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test
test1
TAS
RGD
PMID:12446719
RGD:629553
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Ubd
ubiquitin D
IMP
associated with induced myocardial infarction
RGD
PMID:29438664
RGD:126925221
NCBI chr20:1,390,734...1,392,685
Ensembl chr20:1,385,864...1,408,639 Ensembl chr20:1,385,864...1,408,639
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Ubdem1
ubiquitin D; CRISPR/Cas9 induced mutant1
IMP
associated with induced myocardial infarction
RGD
PMID:29438664
RGD:126925221
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Zbtb16
zinc finger and BTB domain containing 16
ameliorates
IMP
RGD
PMID:28396530
RGD:150340623
NCBI chr 8:57,885,886...58,073,507
Ensembl chr 8:48,994,566...49,177,011
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Zbtb16em1Ipcv
zinc finger and BTB domain containing 16; TALEN induced mutant 1, Ipcv
ameliorates
IMP
RGD
PMID:28396530
RGD:150340623
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Agtr1a
angiotensin II receptor, type 1a
induces
IMP
RGD
PMID:32324784
RGD:127345089
NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946
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Agtr1aem5Mcwi
angiotensin II receptor, type 1a; zinc finger nuclease induced mutant 5, Medical College of Wisconsin
induces
IMP
RGD
PMID:32324784
RGD:127345089
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Wars2
tryptophanyl tRNA synthetase 2 (mitochondrial)
IMP
RGD
PMID:27389904
RGD:127338472
NCBI chr 2:186,459,744...186,543,581
Ensembl chr 2:186,459,444...186,543,571
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Gla
galactosidase, alpha
onset
IMP
compared to Wild type
RGD
PMID:29979634
RGD:401976416
NCBI chr X:102,062,497...102,073,915
Ensembl chr X:97,768,996...97,780,664
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Glaem2Mcwi
galactosidase, alpha; CRISPR/Cas9 system induced mutant 2, Medical College of Wisconsin
onset
IMP
compared to Wild type
RGD
PMID:29979634
RGD:401976416
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Ubd
ubiquitin D
IMP
associated with induced myocardial infarction
RGD
PMID:29438664
RGD:126925221
NCBI chr20:1,390,734...1,392,685
Ensembl chr20:1,385,864...1,408,639 Ensembl chr20:1,385,864...1,408,639
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Ubdem1
ubiquitin D; CRISPR/Cas9 induced mutant1
IMP
associated with induced myocardial infarction
RGD
PMID:29438664
RGD:126925221
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Ttn
titin
IAGP
RGD
PMID:27869827
RGD:11565821
NCBI chr 3:82,059,648...82,332,130
Ensembl chr 3:61,652,439...61,924,741
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Ttnem1Sage
Titin; zinc finger nuclease induced mutant 1,Sigma Advanced Genetic Engineering Labs
IAGP
RGD
PMID:27869827
RGD:11565821
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Ttnem2Sage
Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs
IAGP
RGD
PMID:27869827
RGD:11565821
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Ttn
titin
IAGP
RGD
PMID:27869827
RGD:11565821
NCBI chr 3:82,059,648...82,332,130
Ensembl chr 3:61,652,439...61,924,741
G
Ttnem2Sage
Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs
IAGP
RGD
PMID:27869827
RGD:11565821
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Wars2
tryptophanyl tRNA synthetase 2 (mitochondrial)
IMP
RGD
PMID:27389904
RGD:127338472
NCBI chr 2:186,459,744...186,543,581
Ensembl chr 2:186,459,444...186,543,571
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Gla
galactosidase, alpha
onset
IMP
compared to Wild type
RGD
PMID:29979634
RGD:401976416
NCBI chr X:102,062,497...102,073,915
Ensembl chr X:97,768,996...97,780,664
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Glaem2Mcwi
galactosidase, alpha; CRISPR/Cas9 system induced mutant 2, Medical College of Wisconsin
onset
IMP
compared to Wild type
RGD
PMID:29979634
RGD:401976416
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Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
IMP
RGD
PMID:31327268
RGD:18899561
NCBI chr 5:155,958,116...155,959,897
Ensembl chr 5:150,673,507...150,676,600
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Camk2n1em1Tja
calcium/calmodulin-dependent protein kinase II inhibitor 1; ZFN induced mutant 1, Tja
IMP
RGD
PMID:31327268
RGD:18899561
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Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
IAGP
RGD
PMID:11832364
RGD:727991
NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:106,838,590...106,845,004
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Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
IMP
compared to SS/JrHsdMcwi
RGD
PMID:28931751
RGD:38500204
NCBI chr10:96,489,329...96,520,745
Ensembl chr10:95,960,725...96,021,702
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Kcnj16em1Mcwi
potassium inwardly-rectifying channel, subfamily J, member 16; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
IMP
compared to SS/JrHsdMcwi
RGD
PMID:28931751
RGD:38500204
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Mc4r
melanocortin 4 receptor
IMP
compared with WI-MC4r^m1Hubr
RGD
PMID:24400148 PMID:24400148
RGD:13825242 , RGD:13825242
NCBI chr18:62,689,798...62,691,685
Ensembl chr18:60,419,832...60,421,719
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Mc4rm1Hubr
melanocortin 4 receptor; ENU induced mutation 1, Hubr
IMP
compared with WI-MC4r^m1Hubr
RGD
PMID:24400148 PMID:24400148
RGD:13825242 , RGD:13825242
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Rarres2
retinoic acid receptor responder 2
sexual_dimorphism
IMP
compared to male wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:77,522,535...77,525,556
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Rarres2em1Msu
retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu
sexual_dimorphism
IMP
compared to male wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
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Tnf
tumor necrosis factor
IAGP
RGD
PMID:9590569
RGD:1357163
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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Il36rn
interleukin 36 receptor antagonist
IMP
RGD
PMID:32048631
RGD:126925167
NCBI chr 3:27,442,679...27,449,306
Ensembl chr 3:7,044,406...7,051,016
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Il36rntm1(Myh6-cre)Mhzh
interleukin 36 receptor antagonist; tm1, Mhzh
IMP
RGD
PMID:32048631
RGD:126925167
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Sh2b3
SH2B adaptor protein 3
IMP
RGD
PMID:25628389
RGD:12904914
NCBI chr12:40,391,755...40,414,336
Ensembl chr12:34,731,911...34,753,616
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Sh2b3em2Mcwi
SH2B adaptor protein 3; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:25628389
RGD:12904914
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Clcn6
chloride voltage-gated channel 6
IMP
as compared to the wild-type
RGD
PMID:24006081
RGD:8662415
NCBI chr 5:158,434,299...158,465,174
Ensembl chr 5:158,434,299...158,465,059
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Dmd
dystrophin
IMP
RGD
PMID:25310701
RGD:12880034
NCBI chr X:51,070,098...53,437,845
Ensembl chr X:47,272,331...49,504,207
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Dmdem1Ang
dystrophin; TALEN-induced mutant1, Ang
IMP
RGD
PMID:25310701
RGD:12880034
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Nppc
natriuretic peptide C
IMP
compared to wild type
RGD
PMID:29566041
RGD:127284867
NCBI chr 9:94,767,986...94,772,186
Ensembl chr 9:87,320,051...87,324,251
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Nppcem3Kyo
natriuretic peptide C; ZFN induced mutant 3, Kyo
IMP
compared to wild type
RGD
PMID:29566041
RGD:127284867
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test
test1
TAS
fr str61106
RGD
PMID:9453331
RGD:619652
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Ttn
titin
IAGP
RGD
PMID:27869827
RGD:11565821
NCBI chr 3:82,059,648...82,332,130
Ensembl chr 3:61,652,439...61,924,741
G
Ttnem2Sage
Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs
IAGP
RGD
PMID:27869827
RGD:11565821
G
Il36rn
interleukin 36 receptor antagonist
IMP
RGD
PMID:32048631
RGD:126925167
NCBI chr 3:27,442,679...27,449,306
Ensembl chr 3:7,044,406...7,051,016
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Il36rntm1(Myh6-cre)Mhzh
interleukin 36 receptor antagonist; tm1, Mhzh
IMP
RGD
PMID:32048631
RGD:126925167
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Bmal1
basic helix-loop-helix ARNT like 1
IMP
compared to wild type
RGD
PMID:32306766
RGD:155598602
NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:167,331,633...167,430,231
G
Bmal1em1Mcwi
basic helix-loop-helix ARNT like 1;CRISPR/Cas9 induced mutant 1,Mcwi
IMP
compared to wild type
RGD
PMID:32306766
RGD:155598602
G
Cd247
Cd247 molecule
induced
IMP
compared to wild-type
RGD
PMID:24343121 PMID:24343121
RGD:13442481 , RGD:13442481
NCBI chr13:80,576,264...80,651,422
Ensembl chr13:78,043,307...78,122,263
G
Cd247em1Mcwi
Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
induced
IMP
compared to wild-type
RGD
PMID:24343121 PMID:24343121
RGD:13442481 , RGD:13442481
G
Cd36
CD36 molecule
IMP
RGD
PMID:22128087
RGD:6893560
NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903
G
Clcn6
chloride voltage-gated channel 6
IMP
as compared to the wild-type
RGD
PMID:24006081
RGD:8662415
NCBI chr 5:158,434,299...158,465,174
Ensembl chr 5:158,434,299...158,465,059
G
Gper1
G protein-coupled estrogen receptor 1
IMP
compared to wild type SS rat
RGD
PMID:30354811
RGD:39939000
NCBI chr12:20,331,073...20,336,527
Ensembl chr12:15,217,442...15,221,889
G
Gper1em1Bj
G protein-coupled estrogen receptor 1; CRISPR/Cas 9 induced mutant 1, Bj
IMP
compared to wild type SS rat
RGD
PMID:30354811
RGD:39939000
G
Hvcn1
hydrogen voltage-gated channel 1
IMP
RGD
PMID:24935944
RGD:14985214
NCBI chr12:34,341,673...34,370,010
Ensembl chr12:34,335,190...34,370,141
G
Mc4r
melanocortin 4 receptor
IMP
RGD
PMID:24400148
RGD:13825242
NCBI chr18:62,689,798...62,691,685
Ensembl chr18:60,419,832...60,421,719
G
Mc4rm1Hubr
melanocortin 4 receptor; ENU induced mutation 1, Hubr
IMP
RGD
PMID:24400148
RGD:13825242
G
Nox4
NADPH oxidase 4
induced
IMP
compared to SS/JrHsdMcwi
RGD
PMID:26644237 PMID:26644237
RGD:11085830 , RGD:11085830
NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406
G
Nox4em2Mcwi
NADPH oxidase 4; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
induced
IMP
compared to SS/JrHsdMcwi
RGD
PMID:26644237 PMID:26644237
RGD:11085830 , RGD:11085830
G
P2rx7
purinergic receptor P2X 7
IMP
RGD
PMID:31630543
RGD:14995937
NCBI chr12:39,550,531...39,594,984
Ensembl chr12:33,879,745...33,934,619
G
Rarres2
retinoic acid receptor responder 2
sexual_dimorphism
IMP
compared to female wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:77,522,535...77,525,556
G
Rarres2em1Msu
retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu
sexual_dimorphism
IMP
compared to female wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
G
Ren
renin
sexual_dimorphism
IMP
compared to wild type compared to wild type male
RGD
PMID:21242461 PMID:21242461
RGD:7771614 , RGD:7771614
NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489
G
Renem1Mcwi
renin; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
sexual_dimorphism
IMP
compared to wild type compared to wild type male
RGD
PMID:21242461 PMID:21242461
RGD:7771614 , RGD:7771614
G
Zbtb16
zinc finger and BTB domain containing 16
IMP
compared to wild type SHR/OlaIpcv;
RGD
PMID:28396530
RGD:150340623
NCBI chr 8:57,885,886...58,073,507
Ensembl chr 8:48,994,566...49,177,011
G
Zbtb16em1Ipcv
zinc finger and BTB domain containing 16; TALEN induced mutant 1, Ipcv
IMP
compared to wild type SHR/OlaIpcv;
RGD
PMID:28396530
RGD:150340623
G
Slc39a12
solute carrier family 39 member 12
IMP
RGD
PMID:26258299
RGD:10401832
NCBI chr17:82,262,303...82,348,974
Ensembl chr17:77,353,805...77,440,353
G
Slc39a12em77Tja
solute carrier family 39 (zinc transporter), member 12; zinc finger nuclease induced mutant 77, Timothy J. Aitman
IMP
RGD
PMID:26258299
RGD:10401832
G
Gper1
G protein-coupled estrogen receptor 1
IMP
compared to wild type SS rat
RGD
PMID:30354811
RGD:39939000
NCBI chr12:20,331,073...20,336,527
Ensembl chr12:15,217,442...15,221,889
G
Gper1em1Bj
G protein-coupled estrogen receptor 1; CRISPR/Cas 9 induced mutant 1, Bj
IMP
compared to wild type SS rat
RGD
PMID:30354811
RGD:39939000
G
Lepr
leptin receptor
IAGP
DNA:mutations::cds: : (rat)
RGD
PMID:10901178
RGD:401965414
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
G
Kcnj1
potassium inwardly-rectifying channel, subfamily J, member 1
IMP
RGD
PMID:23753405
RGD:13782272
NCBI chr 8:39,014,822...39,066,716
Ensembl chr 8:30,753,617...30,813,796
G
Kcnj1em1Kasu
potassium voltage-gated channel subfamily J member 1; ZFN induced mutant 1,Kasu
IMP
RGD
PMID:23753405
RGD:13782272
G
Ncf2
neutrophil cytosolic factor 2
induces
IMP
compared to wild-type littermates
RGD
PMID:22326221 PMID:22326221
RGD:9587793 , RGD:9587793
NCBI chr13:67,505,492...67,536,015
Ensembl chr13:64,955,503...64,986,277
G
Ncf2em1Mcwi
neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1,Mcwi
induces
IMP
compared to wild-type littermates
RGD
PMID:22326221 PMID:22326221
RGD:9587793 , RGD:9587793
G
Nox4
NADPH oxidase 4
induced
IMP
compared to SS/JrHsdMcwi
RGD
PMID:26644237 PMID:26644237
RGD:11085830 , RGD:11085830
NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406
G
Nox4em2Mcwi
NADPH oxidase 4; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
induced
IMP
compared to SS/JrHsdMcwi
RGD
PMID:26644237 PMID:26644237
RGD:11085830 , RGD:11085830
G
Plekha7
pleckstrin homology domain containing A7
IMP
compared to wild type
RGD
PMID:25136115 PMID:25136115
RGD:11079199 , RGD:11079199
NCBI chr 1:179,798,856...179,982,155
Ensembl chr 1:170,365,135...170,547,775
G
Plekha7em4Mcwi
pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin
IMP
compared to wild type
RGD
PMID:25136115 PMID:25136115
RGD:11079199 , RGD:11079199
G
Sh2b3
SH2B adaptor protein 3
IMP
RGD
PMID:25776069
RGD:13442483
NCBI chr12:40,391,755...40,414,336
Ensembl chr12:34,731,911...34,753,616
G
Sh2b3em1Mcwi
SH2B adaptor protein 3; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
IMP
RGD
PMID:25776069
RGD:13442483
G
Adamts16
ADAM metallopeptidase with thrombospondin type 1 motif, 16
IAGP
DNA:polymorphism
RGD
PMID:19423552
RGD:2312639
NCBI chr 1:34,258,899...34,388,952
Ensembl chr 1:32,430,436...32,560,494
G
Hmox1
heme oxygenase 1
IDA
RGD
PMID:12215473
RGD:1580453
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
G
Hvcn1
hydrogen voltage-gated channel 1
IMP
RGD
PMID:24935944
RGD:14985214
NCBI chr12:34,341,673...34,370,010
Ensembl chr12:34,335,190...34,370,141
G
Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
IMP
compared to SS/JrHsdMcwi
RGD
PMID:28931751
RGD:38500204
NCBI chr10:96,489,329...96,520,745
Ensembl chr10:95,960,725...96,021,702
G
Kcnj16em1Mcwi
potassium inwardly-rectifying channel, subfamily J, member 16; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
IMP
compared to SS/JrHsdMcwi
RGD
PMID:28931751
RGD:38500204
G
Adamts16
ADAM metallopeptidase with thrombospondin type 1 motif, 16
IMP
As compared to SS parents
RGD
PMID:23185005
RGD:9685162
NCBI chr 1:34,258,899...34,388,952
Ensembl chr 1:32,430,436...32,560,494
G
Adamts16em1Bj
ADAM metallopeptidase with thrombospondin type 1 motif, 16; ZFN mutant1,Bj
IMP
As compared to SS parents
RGD
PMID:23185005
RGD:9685162
G
Bmal1
basic helix-loop-helix ARNT like 1
IMP
compared to wild type
RGD
PMID:32306766
RGD:155598602
NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:167,331,633...167,430,231
G
Bmal1em1Mcwi
basic helix-loop-helix ARNT like 1;CRISPR/Cas9 induced mutant 1,Mcwi
IMP
compared to wild type
RGD
PMID:32306766
RGD:155598602
G
Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
IMP
RGD
PMID:31327268
RGD:18899561
NCBI chr 5:155,958,116...155,959,897
Ensembl chr 5:150,673,507...150,676,600
G
Camk2n1em1Tja
calcium/calmodulin-dependent protein kinase II inhibitor 1; ZFN induced mutant 1, Tja
IMP
RGD
PMID:31327268
RGD:18899561
G
Clcn6
chloride voltage-gated channel 6
IMP
as compared to the wild-type
RGD
PMID:24006081
RGD:8662415
NCBI chr 5:158,434,299...158,465,174
Ensembl chr 5:158,434,299...158,465,059
G
Gper1
G protein-coupled estrogen receptor 1
IMP
compared to wild type SS rat
RGD
PMID:30354811
RGD:39939000
NCBI chr12:20,331,073...20,336,527
Ensembl chr12:15,217,442...15,221,889
G
Gper1em1Bj
G protein-coupled estrogen receptor 1; CRISPR/Cas 9 induced mutant 1, Bj
IMP
compared to wild type SS rat
RGD
PMID:30354811
RGD:39939000
G
Rarres2
retinoic acid receptor responder 2
sexual_dimorphism
IMP
compared to female wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:77,522,535...77,525,556
G
Rarres2em1Msu
retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu
sexual_dimorphism
IMP
compared to female wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
G
Ren
renin
sexual_dimorphism
IMP
compared to wild type compared to wild type male
RGD
PMID:21242461 PMID:21242461
RGD:7771614 , RGD:7771614
NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489
G
Renem1Mcwi
renin; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
sexual_dimorphism
IMP
compared to wild type male
RGD
PMID:21242461 PMID:21242461
RGD:7771614 , RGD:7771614
G
test
test1
TAS IDA
fr str628908 fr str61106wastas
RGD
PMID:9453331 PMID:9453331
RGD:619652 , RGD:619652
G
Adamts16
ADAM metallopeptidase with thrombospondin type 1 motif, 16
IMP
As compared to SS parents
RGD
PMID:23185005
RGD:9685162
NCBI chr 1:34,258,899...34,388,952
Ensembl chr 1:32,430,436...32,560,494
G
Adamts16em1Bj
ADAM metallopeptidase with thrombospondin type 1 motif, 16; ZFN mutant1,Bj
IMP
As compared to SS parents
RGD
PMID:23185005
RGD:9685162
G
Bmal1
basic helix-loop-helix ARNT like 1
IMP
compared to wild type
RGD
PMID:32306766
RGD:155598602
NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:167,331,633...167,430,231
G
Bmal1em1Mcwi
basic helix-loop-helix ARNT like 1;CRISPR/Cas9 induced mutant 1,Mcwi
IMP
compared to wild type
RGD
PMID:32306766
RGD:155598602
G
Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
IMP
RGD
PMID:31327268
RGD:18899561
NCBI chr 5:155,958,116...155,959,897
Ensembl chr 5:150,673,507...150,676,600
G
Camk2n1em1Tja
calcium/calmodulin-dependent protein kinase II inhibitor 1; ZFN induced mutant 1, Tja
IMP
RGD
PMID:31327268
RGD:18899561
G
Cfb
complement factor B
IMP
compared to wild type SHR
RGD
PMID:28739975
RGD:127285403
NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,951,474...3,976,505
G
Cfbem1Tja
complement factor B, ZFN induced mutant 1, Tja
IMP
compared to wild type SHR
RGD
PMID:28739975
RGD:127285403
G
Gper1
G protein-coupled estrogen receptor 1
IMP
compared to wild type SS rat
RGD
PMID:30354811
RGD:39939000
NCBI chr12:20,331,073...20,336,527
Ensembl chr12:15,217,442...15,221,889
G
Gper1em1Bj
G protein-coupled estrogen receptor 1; CRISPR/Cas 9 induced mutant 1, Bj
IMP
compared to wild type SS rat
RGD
PMID:30354811
RGD:39939000
G
Rarres2
retinoic acid receptor responder 2
sexual_dimorphism
IMP
compared to female wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:77,522,535...77,525,556
G
Rarres2em1Msu
retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu
sexual_dimorphism
IMP
compared to female wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
G
Ren
renin
sexual_dimorphism
IMP
compared to wild type compared to wild type male
RGD
PMID:21242461 PMID:21242461
RGD:7771614 , RGD:7771614
NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489
G
Renem1Mcwi
renin; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
sexual_dimorphism
IMP
compared to wild type male
RGD
PMID:21242461 PMID:21242461
RGD:7771614 , RGD:7771614
G
test
test1
TAS IDA
fr str628908 fr str61106wastas
RGD
PMID:9453331 PMID:9453331
RGD:619652 , RGD:619652
G
Plekha7
pleckstrin homology domain containing A7
induces
IMP
compared to wild type
RGD
PMID:25136115 PMID:25136115
RGD:11079199 , RGD:11079199
NCBI chr 1:179,798,856...179,982,155
Ensembl chr 1:170,365,135...170,547,775
G
Plekha7em4Mcwi
pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin
induces
IMP
compared to wild type
RGD
PMID:25136115 PMID:25136115
RGD:11079199 , RGD:11079199
G
Add3
adducin 3
IMP
RGD
PMID:32029431
RGD:150340736
NCBI chr 1:262,152,722...262,260,504
Ensembl chr 1:252,147,386...252,255,124
G
Mmp2
matrix metallopeptidase 2
ameliorates
IMP
associated with Experimental Diabetes Mellitus, compared to wild type SS
RGD
PMID:37643020
RGD:401827835
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
G
Mmp2em2Mcwi
matrix metallopeptidase 2; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
ameliorates
IMP
associated with Experimental Diabetes Mellitus, compared to wild type SS
RGD
PMID:37643020
RGD:401827835
G
Add3
adducin 3
induces
IMP
compared to WT
RGD
PMID:32029431
RGD:150340736
NCBI chr 1:262,152,722...262,260,504
Ensembl chr 1:252,147,386...252,255,124
G
Add3em1Mcwi
adducin 3; ZFN induced mutant1, Mcwi
induces
IMP
compared to wild-type
RGD
PMID:32029431
RGD:150340736
G
Add3em2Mcwi
adducin 3; ZFN induced mutant2, Mcwi
induces
IMP
compared to WT
RGD
PMID:32029431
RGD:150340736
G
Dusp5
dual specificity phosphatase 5
IMP
compared to FHH.1BN
RGD
PMID:25397684
RGD:13446412
NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:252,538,449...252,551,818
G
Dusp5em1Mcwi
dual specificity phosphatase 5; ZFN induced mutant1, Mcwi
IMP
compared to FHH.1BN
RGD
PMID:25397684
RGD:13446412
G
Mc4r
melanocortin 4 receptor
IMP
RGD
PMID:24400148
RGD:13825242
NCBI chr18:62,689,798...62,691,685
Ensembl chr18:60,419,832...60,421,719
G
Mc4rm1Hubr
melanocortin 4 receptor; ENU induced mutation 1, Hubr
IMP
RGD
PMID:24400148
RGD:13825242
G
Slc6a4
solute carrier family 6 member 4
IMP
RGD
PMID:18263707
RGD:4889513
NCBI chr10:62,322,688...62,357,060
Ensembl chr10:61,826,123...61,858,384
G
Kcnk3
potassium two pore domain channel subfamily K member 3
IMP
RGD
PMID:31347976
RGD:151347452
NCBI chr 6:31,483,129...31,519,061
Ensembl chr 6:25,763,228...25,799,153
G
Kcnk3em1Ang
potassium two pore domain channel subfamily K member 3; CRISPR/Cas9 induced mutant1, Ang
IMP
RGD
PMID:31347976
RGD:151347452
G
Mir29b1
microRNA 29b-1
IMP
RGD
PMID:29374012
RGD:13702880
NCBI chr 4:60,618,334...60,618,414
Ensembl chr 4:59,650,986...59,651,067
G
Mir29b1em1Mcwi
microRNA 29b-1; TALEN induced mutant 1, Medical College of Wisconsin
IMP
RGD
PMID:29374012
RGD:13702880
G
Nfe2l2
NFE2 like bZIP transcription factor 2
IMP
compared to SD
RGD
PMID:26637559
RGD:11344212
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
G
Nfe2l2em1Mcwi
nuclear factor, erythroid 2-like 2; TALEN induced mutant 1, Medical College of Wisconsin
IMP
compared to SD
RGD
PMID:26637559
RGD:11344212
G
Sod3
superoxide dismutase 3
IMP
compared to SS/JrHsdMcwi;DNA:missense mutation:cds:p.E124D
RGD
PMID:24322611
RGD:38548929
NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990
G
Sod3m1Mcwi
superoxide dismutase 3; mutation 1, Medical College of Wisconsin
IMP
compared to SS/JrHsdMcwi;DNA:missense mutation:cds:p.E124D
RGD
PMID:24322611
RGD:38548929
G
Ednra
endothelin receptor type A
IDA
RGD
PMID:16157796
RGD:1581830
NCBI chr19:47,137,360...47,207,961
Ensembl chr19:30,233,571...30,297,049
G
Egfr
epidermal growth factor receptor
IDA
RGD
PMID:12624003
RGD:1580955
NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
G
Lepr
leptin receptor
treatment
IAGP
RGD
PMID:33568522
RGD:401965412
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
G
Myh7b
myosin heavy chain 7B
IMP
RGD
PMID:32207065
RGD:126925946
NCBI chr 3:164,537,211...164,582,441
Ensembl chr 3:144,098,190...144,122,084
G
Myh7bem1Blar
myosin heavy chain 7B; CRISPR/Cas9 induced mutant 1, Blar
IMP
RGD
PMID:32207065
RGD:126925946
G
Sod3
superoxide dismutase 3
IMP
compared to SS/JrHsdMcwi
RGD
PMID:31972339
RGD:150573712
NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990
G
Sod3m1Mcwi
superoxide dismutase 3; mutation 1, Medical College of Wisconsin
IMP
compared to SS/JrHsdMcwi
RGD
PMID:31972339
RGD:150573712
G
F8
coagulation factor VIII
treatment
IMP
RGD
PMID:27060449 PMID:31899798
RGD:150520059 , RGD:150520060
NCBI chr18:155,237...187,186
Ensembl chr18:140,955...171,857
G
F8em1Sage
coagulation factor VIII, procoagulant component; zinc finger nuclease induced mutant1, Sage
treatment
IMP
RGD
PMID:31899798 PMID:27060449
RGD:150520060 , RGD:150520059
G
F8em1Mcwi
coagulation factor VIII, procoagulant component; CRISPR/Cas9 induced mutant1, Mcwi
treatment
IMP
RGD
PMID:31899798
RGD:150520060
G
F8
coagulation factor VIII
IMP
RGD
PMID:24931420
RGD:11530071
NCBI chr18:155,237...187,186
Ensembl chr18:140,955...171,857
G
F8em1Sage
coagulation factor VIII, procoagulant component; zinc finger nuclease induced mutant1, Sage
IMP
RGD
PMID:24931420
RGD:11530071
G
Lepr
leptin receptor
IMP IAGP
DNA:mutations:cds: : (rat)
RGD
PMID:27465994 PMID:30278832
RGD:12911217 , RGD:401960095
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
G
Nppb
natriuretic peptide B
IMP
RGD
PMID:26063669
RGD:12910116
NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168
G
Nppbem2Mcwi
natriuretic peptide B; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:26063669
RGD:12910116
G
Ddah1
dimethylarginine dimethylaminohydrolase 1
exacerbates induces
IMP
compared to wild type
RGD
PMID:31402164 PMID:31402164
RGD:151347602 , RGD:151347602
NCBI chr 2:237,327,812...237,460,624
Ensembl chr 2:234,667,491...234,799,339
G
Ddah1em1Ywxu
dimethylarginine dimethylaminohydrolase 1; CRISPR/Cas9 induced mutant 1, Ywxu
induces exacerbates
IMP
compared to wild type
RGD
PMID:31402164 PMID:31402164
RGD:151347602 , RGD:151347602
G
Myh7b
myosin heavy chain 7B
IMP
RGD
PMID:32207065
RGD:126925946
NCBI chr 3:164,537,211...164,582,441
Ensembl chr 3:144,098,190...144,122,084
G
Myh7bem1Blar
myosin heavy chain 7B; CRISPR/Cas9 induced mutant 1, Blar
IMP
RGD
PMID:32207065
RGD:126925946
G
Il1rl2
interleukin 1 receptor-like 2
IMP
compared to Wild Type in cardiopulmonary bypass model
RGD
PMID:32048631
RGD:126925167
NCBI chr 9:42,591,658...42,639,351
Ensembl chr 9:42,591,934...42,636,667
G
Il1rl2tm1(Myh6-cre)Mhzh
interleukin 1 receptor-like 2; tm1 (Myh6-cre), Mhzh
IMP
compared to Wild Type in cardiopulmonary bypass model
RGD
PMID:32048631
RGD:126925167
G
Plekha7
pleckstrin homology domain containing A7
IMP
compared to wild type
RGD
PMID:25136115 PMID:25136115
RGD:11079199 , RGD:11079199
NCBI chr 1:179,798,856...179,982,155
Ensembl chr 1:170,365,135...170,547,775
G
Plekha7em4Mcwi
pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin
IMP
compared to wild type
RGD
PMID:25136115 PMID:25136115
RGD:11079199 , RGD:11079199
G
Plekha7
pleckstrin homology domain containing A7
induces
IMP
compared to wild type
RGD
PMID:25136115 PMID:25136115
RGD:11079199 , RGD:11079199
NCBI chr 1:179,798,856...179,982,155
Ensembl chr 1:170,365,135...170,547,775
G
Plekha7em4Mcwi
pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin
induces
IMP
compared to wild type
RGD
PMID:25136115 PMID:25136115
RGD:11079199 , RGD:11079199
G
Lepr
leptin receptor
IAGP
DNA:mutations:cds: : (rat)
RGD
PMID:32710530
RGD:401960103
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
G
Myh7b
myosin heavy chain 7B
IMP
RGD
PMID:32207065
RGD:126925946
NCBI chr 3:164,537,211...164,582,441
Ensembl chr 3:144,098,190...144,122,084
G
Myh7bem1Blar
myosin heavy chain 7B; CRISPR/Cas9 induced mutant 1, Blar
IMP
RGD
PMID:32207065
RGD:126925946
G
Lepr
leptin receptor
IAGP
DNA:mutations:cds: : (rat)
RGD
PMID:32710530
RGD:401960103
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
G
Bmal1
basic helix-loop-helix ARNT like 1
sexual_dimorphism
IMP
in female
RGD
PMID:32306766
RGD:155598602
NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:167,331,633...167,430,231
G
Bmal1em1Mcwi
basic helix-loop-helix ARNT like 1;CRISPR/Cas9 induced mutant 1,Mcwi
sexual_dimorphism
IMP
in female
RGD
PMID:32306766
RGD:155598602
G
Glp1r
glucagon-like peptide 1 receptor
IDA
RGD
PMID:12093887
RGD:625448
NCBI chr20:8,973,393...9,011,622
Ensembl chr20:8,972,004...9,010,241
G
Kcnk3
potassium two pore domain channel subfamily K member 3
IMP
RGD
PMID:31347976
RGD:151347452
NCBI chr 6:31,483,129...31,519,061
Ensembl chr 6:25,763,228...25,799,153
G
Kcnk3em1Ang
potassium two pore domain channel subfamily K member 3; CRISPR/Cas9 induced mutant1, Ang
IMP
RGD
PMID:31347976
RGD:151347452
G
Ren
renin
IMP
compared to wild type
RGD
PMID:21242461
RGD:7771614
NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489
G
Renem1Mcwi
renin; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
IMP
compared to wild type
RGD
PMID:21242461
RGD:7771614
G
Ddah1
dimethylarginine dimethylaminohydrolase 1
exacerbates
IMP
RGD
PMID:31402164
RGD:151347602
NCBI chr 2:237,327,812...237,460,624
Ensembl chr 2:234,667,491...234,799,339
G
Ddah1em1Ywxu
dimethylarginine dimethylaminohydrolase 1; CRISPR/Cas9 induced mutant 1, Ywxu
exacerbates
IMP
RGD
PMID:31402164
RGD:151347602
G
Nr2f2
nuclear receptor subfamily 2, group F, member 2
IMP
compared to SS/JrHsdMcw
RGD
PMID:25687237
RGD:10401852
NCBI chr 1:133,419,161...133,434,290
Ensembl chr 1:124,009,181...124,022,031
G
Nr2f2em1Mcwi
nuclear receptor subfamily 2, group F, member 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
IMP
compared to SS/JrHsdMcw
RGD
PMID:25687237
RGD:10401852
G
Dmd
dystrophin
IMP
RGD
PMID:25005781
RGD:11040981
NCBI chr X:51,070,098...53,437,845
Ensembl chr X:47,272,331...49,504,207
G
Dmdem1Kykn
dystrophin; CRISPR/Cas9 system induced mutant 1, Keitaro Yamanouchi
IMP
RGD
PMID:25005781
RGD:11040981
G
Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
IMP
compared to wild type
RGD
PMID:26077568
RGD:13800514
NCBI chr19:50,307,569...50,312,812
Ensembl chr19:33,397,656...33,402,899
G
Hsd11b2em1Jmul
hydroxysteroid 11-beta dehydrogenase 2; ZFN induced mutant1, Jmul
IMP
compared to wild type
RGD
PMID:26077568
RGD:13800514
G
Lamp2
lysosomal-associated membrane protein 2
IMP
in hemizygote mutant male (LAMP2y/-)
RGD
PMID:29720683
RGD:13703117
NCBI chr X:122,038,734...122,087,745
Ensembl chr X:117,057,606...117,260,522
G
Lamp2em1
lysosomal-associated membrane protein 2; TALEN induced mutant1
IMP
in hemizygote mutant male (LAMP2y/-)
RGD
PMID:29720683
RGD:13703117
G
Mc4r
melanocortin 4 receptor
IMP
RGD
PMID:24400148
RGD:13825242
NCBI chr18:62,689,798...62,691,685
Ensembl chr18:60,419,832...60,421,719
G
Mc4rm1Hubr
melanocortin 4 receptor; ENU induced mutation 1, Hubr
IMP
RGD
PMID:24400148
RGD:13825242
G
Mthfr
methylenetetrahydrofolate reductase
IMP
as compared to the wild-type
RGD
PMID:24006081
RGD:8662415
NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797
G
Nppa
natriuretic peptide A
IMP
as compared to the wild-type
RGD
PMID:24006081
RGD:8662415
NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351
G
Lepr
leptin receptor
IAGP
DNA:mutations:cds: : (rat)
RGD
PMID:32710530
RGD:401960103
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
G
Il1rl2
interleukin 1 receptor-like 2
IMP
compared to Wild Type in cardiopulmonary bypass model
RGD
PMID:32048631
RGD:126925167
NCBI chr 9:42,591,658...42,639,351
Ensembl chr 9:42,591,934...42,636,667
G
Il1rl2tm1(Myh6-cre)Mhzh
interleukin 1 receptor-like 2; tm1 (Myh6-cre), Mhzh
IMP
compared to Wild Type in cardiopulmonary bypass model
RGD
PMID:32048631
RGD:126925167
G
Alms1
ALMS1, centrosome and basal body associated protein
exacerbates
IMP
compared to wild type
RGD
PMID:30385718
RGD:151361229
NCBI chr 4:119,683,085...119,783,471
Ensembl chr 4:118,125,607...118,226,005
G
Alms1em1Mcwi
Alstrom syndrome 1 homolog (human); zinc finger nuclease induced mutant 1, Medical College of Wisconsin
exacerbates
IMP
compared to wild type
RGD
PMID:30385718
RGD:151361229
G
Lepr
leptin receptor
IAGP
DNA:mutations:cds: : (rat)
RGD
PMID:32710530
RGD:401960103
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
G
Nppa
natriuretic peptide A
IMP
as compared to the wild-type
RGD
PMID:24006081
RGD:8662415
NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351
G
Rag1
recombination activating 1
IMP
on 4% NaCl diet
RGD
PMID:23364523
RGD:7207429
NCBI chr 3:108,372,087...108,383,184
Ensembl chr 3:87,917,004...87,928,291
G
Rag1em1Mcwi
recombination activating gene 1; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
IMP
on 4% NaCl diet
RGD
PMID:23364523
RGD:7207429
G
Rag1em2Mcwi
recombination activating gene 1; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
on 4% NaCl diet
RGD
PMID:23364523
RGD:7207429
G
Rarres2
retinoic acid receptor responder 2
sexual_dimorphism
IMP
compared to male wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:77,522,535...77,525,556
G
Rarres2em1Msu
retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu
sexual_dimorphism
IMP
compared to male wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
G
Sod3
superoxide dismutase 3
onset
IMP
compared to SS/JrHsdMcwi
RGD
PMID:31972339
RGD:150573712
NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990
G
Sod3m1Mcwi
superoxide dismutase 3; mutation 1, Medical College of Wisconsin
onset
IMP
compared to SS/JrHsdMcwi
RGD
PMID:31972339
RGD:150573712
G
Tmem67
transmembrane protein 67
IAGP
RGD
PMID:11095650
RGD:1300514
NCBI chr 5:30,333,793...30,386,702
Ensembl chr 5:25,536,458...25,589,334
G
Tmem67wpk
transmembrane protein 67; wpk mutant
IAGP
RGD
PMID:11095650
RGD:1300514
G
Myh7b
myosin heavy chain 7B
IMP
RGD
PMID:32207065
RGD:126925946
NCBI chr 3:164,537,211...164,582,441
Ensembl chr 3:144,098,190...144,122,084
G
Myh7bem1Blar
myosin heavy chain 7B; CRISPR/Cas9 induced mutant 1, Blar
IMP
RGD
PMID:32207065
RGD:126925946
G
Ubd
ubiquitin D
IMP
associated with induced myocardial infarction
RGD
PMID:29438664
RGD:126925221
NCBI chr20:1,390,734...1,392,685
Ensembl chr20:1,385,864...1,408,639 Ensembl chr20:1,385,864...1,408,639
G
Ubdem1
ubiquitin D; CRISPR/Cas9 induced mutant1
IMP
associated with induced myocardial infarction
RGD
PMID:29438664
RGD:126925221
G
Kcnk3
potassium two pore domain channel subfamily K member 3
IMP
RGD
PMID:31347976
RGD:151347452
NCBI chr 6:31,483,129...31,519,061
Ensembl chr 6:25,763,228...25,799,153
G
Kcnk3em1Ang
potassium two pore domain channel subfamily K member 3; CRISPR/Cas9 induced mutant1, Ang
IMP
RGD
PMID:31347976
RGD:151347452
G
Rarres2
retinoic acid receptor responder 2
sexual_dimorphism
IMP
compared to male wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:77,522,535...77,525,556
G
Rarres2em1Msu
retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu
sexual_dimorphism
IMP
compared to male wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
G
Lepr
leptin receptor
IAGP
DNA:mutations::cds: : (rat)
RGD
PMID:10901178
RGD:401965414
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
G
Ahr
aryl hydrocarbon receptor
ameliorates
IMP
compared to wild type littermates
RGD
PMID:33836606
RGD:401940192
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
G
Ahrem1Iexas
aryl hydrocarbon receptor; CRISPR/Cas9 induced mutant1, Iexas
ameliorates
IMP
compared to wild type littermates
RGD
PMID:33836606
RGD:401940192
G
Ddah1
dimethylarginine dimethylaminohydrolase 1
induces
IMP
compared to wild type
RGD
PMID:31402164
RGD:151347602
NCBI chr 2:237,327,812...237,460,624
Ensembl chr 2:234,667,491...234,799,339
G
Ddah1em1Ywxu
dimethylarginine dimethylaminohydrolase 1; CRISPR/Cas9 induced mutant 1, Ywxu
induces
IMP
compared to wild type
RGD
PMID:31402164
RGD:151347602
G
Kcnk3
potassium two pore domain channel subfamily K member 3
onset
IMP
RGD
PMID:31347976
RGD:151347452
NCBI chr 6:31,483,129...31,519,061
Ensembl chr 6:25,763,228...25,799,153
G
Kcnk3em1Ang
potassium two pore domain channel subfamily K member 3; CRISPR/Cas9 induced mutant1, Ang
onset
IMP
RGD
PMID:31347976
RGD:151347452
G
Apoe
apolipoprotein E
IMP
RGD
PMID:29166645
RGD:150520219
NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932
G
Apoeem1Ejt
apolipoprotein E; TALEN induced mutant 1, Ejt
IMP
RGD
PMID:29166645
RGD:150520219
G
Apoeem1Sage
apolipoprotein E; endonuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
IMP
RGD
PMID:29166645
RGD:150520219
G
Ddx52
DExD-box helicase 52
IAGP
DNA:polymorphism
RGD
PMID:17218081
RGD:1599269
NCBI chr10:69,322,062...69,344,856
Ensembl chr10:68,824,645...68,848,266
G
Ednrb
endothelin receptor type B
IDA
RGD
PMID:16179487
RGD:1581856
NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115
G
Glp1r
glucagon-like peptide 1 receptor
IDA
RGD
PMID:12093887
RGD:625448
NCBI chr20:8,973,393...9,011,622
Ensembl chr20:8,972,004...9,010,241
G
Kcnmb1
potassium calcium-activated channel subfamily M regulatory beta subunit 1
IDA
RGD
PMID:14551242
RGD:1298970
NCBI chr10:19,062,014...19,119,005
Ensembl chr10:18,557,904...18,565,798
G
Npr1
natriuretic peptide receptor 1
IAGP
RGD
PMID:7629399
RGD:1357231
NCBI chr 2:178,231,766...178,247,591
Ensembl chr 2:175,934,181...175,949,505
G
Ren
renin
IAGP
RGD
PMID:8567976
RGD:61046
NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489
G
Tnf
tumor necrosis factor
IAGP
RGD
PMID:9590569
RGD:1357163
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Nppa
natriuretic peptide A
IMP
as compared to the wild-type
RGD
PMID:24006081
RGD:8662415
NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351
G
Npr1
natriuretic peptide receptor 1
IAGP
RGD
PMID:12511524
RGD:628585
NCBI chr 2:178,231,766...178,247,591
Ensembl chr 2:175,934,181...175,949,505
G
Rarres2
retinoic acid receptor responder 2
sexual_dimorphism
IMP
RGD
PMID:29906243
RGD:38596340
NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:77,522,535...77,525,556
G
Rarres2em1Msu
retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu
sexual_dimorphism
IMP
RGD
PMID:29906243
RGD:38596340
G
Sod3
superoxide dismutase 3
onset
IMP
compared to SS/JrHsdMcwi
RGD
PMID:31972339
RGD:150573712
NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990
G
Sod3m1Mcwi
superoxide dismutase 3; mutation 1, Medical College of Wisconsin
onset
IMP
compared to SS/JrHsdMcwi
RGD
PMID:31972339
RGD:150573712
G
Add1
adducin 1
IAGP
RGD
PMID:15474463
RGD:1302895
NCBI chr14:80,333,242...80,401,641
Ensembl chr14:76,108,654...76,167,182
G
Adora2b
adenosine A2B receptor
IMP
RGD
PMID:26385692
RGD:11533328
NCBI chr10:47,439,712...47,456,092
Ensembl chr10:46,940,384...46,956,772
G
Adora2bem2Mcwi
adenosine A2B receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:26385692
RGD:11533328
G
Alms1
ALMS1, centrosome and basal body associated protein
exacerbates
IMP
compared to wild type
RGD
PMID:30385718
RGD:151361229
NCBI chr 4:119,683,085...119,783,471
Ensembl chr 4:118,125,607...118,226,005
G
Alms1em1Mcwi
Alstrom syndrome 1 homolog (human); zinc finger nuclease induced mutant 1, Medical College of Wisconsin
exacerbates
IMP
compared to wild type
RGD
PMID:30385718
RGD:151361229
G
Cyp11b1
cytochrome P450, family 11, subfamily b, polypeptide 1
IAGP
RGD
PMID:7981756
RGD:69709
NCBI chr 7:108,653,385...108,660,062
Ensembl chr 7:106,718,274...106,779,278
G
Ednra
endothelin receptor type A
IDA
RGD
PMID:16157796
RGD:1581830
NCBI chr19:47,137,360...47,207,961
Ensembl chr19:30,233,571...30,297,049
G
Egln1
egl-9 family hypoxia-inducible factor 1
IAGP
DNA:duplication
RGD
PMID:20231529
RGD:11251783
NCBI chr19:69,765,276...69,804,681
Ensembl chr19:52,869,486...52,907,777
G
Kcnq1
potassium voltage-gated channel subfamily Q member 1
IAGP
DNA:deletion:exon (rat)
RGD
PMID:16368876
RGD:1581602
NCBI chr 1:207,721,134...208,054,073
Ensembl chr 1:198,291,766...198,624,669
G
Kcnq1dfk
potassium voltage-gated channel subfamily Q member 1;deafness Kyoto
IAGP
RGD
PMID:16368876
RGD:1581602
G
Lepr
leptin receptor
treatment onset
IAGP IMP
compared to treated compared to SS/JrHsdMcwi
RGD
PMID:23154293 PMID:33568522 PMID:27465994
RGD:13432147 , RGD:401965412 , RGD:12911217
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
G
Leprem2Mcwi
leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
onset
IMP
compared to SS/JrHsdMcwi
RGD
PMID:27465994
RGD:12911217
G
Leprfa
leptin receptor; fa mutant
IAGP
RGD
PMID:23154293
RGD:13432147
G
Nppa
natriuretic peptide A
IMP
as compared to the wild-type
RGD
PMID:24006081
RGD:8662415
NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351
G
Plod1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
IMP
as compared to the wild-type
RGD
PMID:24006081
RGD:8662415
NCBI chr 5:163,623,847...163,650,737
Ensembl chr 5:158,340,490...158,367,620
G
Rarres2
retinoic acid receptor responder 2
sexual_dimorphism
IMP
compared to male wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:77,522,535...77,525,556
G
Rarres2em1Msu
retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu
sexual_dimorphism
IMP
compared to male wild-type
RGD
PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340
G
Sod3
superoxide dismutase 3
onset
IMP
compared to SS/JrHsdMcwi
RGD
PMID:31972339
RGD:150573712
NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990
G
Sod3m1Mcwi
superoxide dismutase 3; mutation 1, Medical College of Wisconsin
onset
IMP
compared to SS/JrHsdMcwi
RGD
PMID:31972339
RGD:150573712
G
Adora2b
adenosine A2B receptor
IMP
RGD
PMID:26385692
RGD:11533328
NCBI chr10:47,439,712...47,456,092
Ensembl chr10:46,940,384...46,956,772
G
Adora2bem2Mcwi
adenosine A2B receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:26385692
RGD:11533328
G
Mc4r
melanocortin 4 receptor
IMP
RGD
PMID:24400148
RGD:13825242
NCBI chr18:62,689,798...62,691,685
Ensembl chr18:60,419,832...60,421,719
G
Mc4rm1Hubr
melanocortin 4 receptor; ENU induced mutation 1, Hubr
IMP
RGD
PMID:24400148
RGD:13825242
G
Tmem67
transmembrane protein 67
IAGP
RGD
PMID:30705305
RGD:14995942
NCBI chr 5:30,333,793...30,386,702
Ensembl chr 5:25,536,458...25,589,334
G
Tmem67wpk
transmembrane protein 67; wpk mutant
IAGP
RGD
PMID:30705305
RGD:14995942
G
Htr7
5-hydroxytryptamine receptor 7
IMP
RGD
PMID:31125292
RGD:14696718
NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
G
Htr7em1Msu
5-hydroxytryptamine receptor 7; CRISPR/Cas9 induced mutant 1, Msu
IMP
RGD
PMID:31125292
RGD:14696718
G
Mc4r
melanocortin 4 receptor
IMP
RGD
PMID:24400148
RGD:13825242
NCBI chr18:62,689,798...62,691,685
Ensembl chr18:60,419,832...60,421,719
G
Mc4rm1Hubr
melanocortin 4 receptor; ENU induced mutation 1, Hubr
IMP
RGD
PMID:24400148
RGD:13825242
G
Rarres2
retinoic acid receptor responder 2
sexual_dimorphism
IMP IAGP
compared to female knockout compared to wild-type
RGD
PMID:29906243 PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340 , RGD:38596340
NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:77,522,535...77,525,556
G
Rarres2em1Msu
retinoic acid receptor responder 2; CRISPR/Cas9 induced mutant 1, Msu
sexual_dimorphism
IMP IAGP
compared to female knockout compared to wild-type
RGD
PMID:29906243 PMID:29906243 PMID:29906243
RGD:38596340 , RGD:38596340 , RGD:38596340
G
Shc1
SHC adaptor protein 1
IMP
RGD
PMID:27270176
RGD:12792230
NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:174,837,930...174,849,536
G
Shc1em1Mcwi
SHC adaptor protein 1; ZFN induced mutant 1, Medical College of Wisconsin
IMP
RGD
PMID:27270176
RGD:12792230
G
Shc1em4Mcwi
SHC adaptor protein 1; ZFN induced mutant 4, Medical College of Wisconsin
IMP
RGD
PMID:27270176
RGD:12792230
G
Sod3
superoxide dismutase 3
IMP
XCO:0000145;DNA:missense mutation:cds:p.E124D
RGD
PMID:24322611
RGD:38548929
NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990
G
Sod3m1Mcwi
superoxide dismutase 3; mutation 1, Medical College of Wisconsin
IMP
XCO:0000145
RGD
PMID:24322611
RGD:38548929
G
Gper1
G protein-coupled estrogen receptor 1
IMP
compared to wild type SS rat
RGD
PMID:30354811
RGD:39939000
NCBI chr12:20,331,073...20,336,527
Ensembl chr12:15,217,442...15,221,889
G
Gper1em1Bj
G protein-coupled estrogen receptor 1; CRISPR/Cas 9 induced mutant 1, Bj
IMP
compared to wild type SS rat
RGD
PMID:30354811
RGD:39939000
G
Hmox1
heme oxygenase 1
IDA
RGD
PMID:15057912
RGD:1580452
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
G
Plekha7
pleckstrin homology domain containing A7
IMP
compared to wild type
RGD
PMID:25136115
RGD:11079199
NCBI chr 1:179,798,856...179,982,155
Ensembl chr 1:170,365,135...170,547,775
G
Plekha7em4Mcwi
pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin
IMP
compared to wild type
RGD
PMID:25136115
RGD:11079199
G
Sod3
superoxide dismutase 3
IMP
compared to SS/JrHsdMcwi;DNA:missense mutation:CDS:p.E124D
RGD
PMID:24322611
RGD:38548929
NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990
G
Sod3m1Mcwi
superoxide dismutase 3; mutation 1, Medical College of Wisconsin
IMP
compared to SS/JrHsdMcwi;DNA:missense mutation:CDS:p.E124D
RGD
PMID:24322611
RGD:38548929
G
Ccdc39
coiled-coil domain 39 molecular ruler complex subunit
IMP
RGD
PMID:31771992
RGD:150521527
NCBI chr 2:118,593,881...118,631,584
Ensembl chr 2:116,665,261...116,703,350
G
Ccdc39em1Jgn
coiled-coil domain containing 39; CRISPR/Cas9 induced mutant 1, Jgn
IMP
RGD
PMID:31771992
RGD:150521527
G
Ccdc85c
coiled-coil domain containing 85C
IMP
RGD
PMID:31341137
RGD:150520163
NCBI chr 6:132,877,851...132,948,744
Ensembl chr 6:127,113,442...127,184,371
G
Ccdc85cem1Kyo
coiled-coil domain containing 85C; TALEN induced mutant1,Kyo
IMP
RGD
PMID:31341137
RGD:150520163
G
Apoe
apolipoprotein E
IMP
RGD
PMID:28808185
RGD:13703132
NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932
G
Epha2
Eph receptor A2
IDA
RGD
PMID:16359662
RGD:1580975
NCBI chr 5:158,888,629...158,917,100
Ensembl chr 5:153,605,644...153,634,117
G
Kdr
kinase insert domain receptor
IDA
inhibition reduces portal-systemic collateral vessel formation
RGD
PMID:14988842
RGD:2292014
NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018
G
Kcnq1
potassium voltage-gated channel subfamily Q member 1
IAGP
DNA:deletion:exon (rat)
RGD
PMID:16368876
RGD:1581602
NCBI chr 1:207,721,134...208,054,073
Ensembl chr 1:198,291,766...198,624,669
G
Kcnq1dfk
potassium voltage-gated channel subfamily Q member 1;deafness Kyoto
IAGP
RGD
PMID:16368876
RGD:1581602
G
Nppb
natriuretic peptide B
IMP
RGD
PMID:26063669
RGD:12910116
NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168
G
Nppbem2Mcwi
natriuretic peptide B; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:26063669
RGD:12910116
G
Ahr
aryl hydrocarbon receptor
ameliorates
IMP
compared to wild type littermates
RGD
PMID:33836606
RGD:401940192
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
G
Ahrem1Iexas
aryl hydrocarbon receptor; CRISPR/Cas9 induced mutant1, Iexas
ameliorates
IMP
compared to wild type littermates
RGD
PMID:33836606
RGD:401940192
G
Lepr
leptin receptor
treatment
IAGP
RGD
PMID:33568522
RGD:401965412
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
G
Apc
APC regulator of WNT signaling pathway
sexual_dimorphism
IMP
compared to females
RGD
PMID:17360473
RGD:1601201
NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696
G
ApcPirc
APC, WNT signaling pathway regulator; polyposis in the rat colon
sexual_dimorphism
IMP
compared to females
RGD
PMID:17360473
RGD:1601201
G
Alms1
ALMS1, centrosome and basal body associated protein
exacerbates
IMP
compared to wild type
RGD
PMID:30385718
RGD:151361229
NCBI chr 4:119,683,085...119,783,471
Ensembl chr 4:118,125,607...118,226,005
G
Alms1em1Mcwi
Alstrom syndrome 1 homolog (human); zinc finger nuclease induced mutant 1, Medical College of Wisconsin
exacerbates
IMP
compared to wild type
RGD
PMID:30385718
RGD:151361229
G
Astn1
astrotactin 1
IMP
RGD
PMID:24714719
RGD:12792227
NCBI chr13:73,070,754...73,388,902
Ensembl chr13:70,537,703...70,855,440
G
Brinp2
BMP/retinoic acid inducible neural specific 2
IMP
RGD
PMID:24714719
RGD:12792227
NCBI chr13:72,964,498...73,065,312
Ensembl chr13:70,431,010...70,531,810
G
Btg2
BTG anti-proliferation factor 2
IAGP
RGD
PMID:23817491
RGD:12802368
NCBI chr13:48,083,931...48,087,690
Ensembl chr13:45,531,925...45,535,628
G
Cd247
Cd247 molecule
severity
IMP
RGD
PMID:24343121
RGD:13442481
NCBI chr13:80,576,264...80,651,422
Ensembl chr13:78,043,307...78,122,263
G
Cd247em1Mcwi
Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
severity
IMP
RGD
PMID:24343121
RGD:13442481
G
Chi3l1
chitinase 3 like 1
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:48,193,839...48,201,822
Ensembl chr13:45,641,802...45,649,787
G
Chit1
chitinase 1
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:48,117,886...48,165,645
Ensembl chr13:45,593,845...45,613,592
G
Cop1
COP1, E3 ubiquitin ligase
IMP
RGD
PMID:24714719
RGD:12792227
NCBI chr13:73,954,058...74,095,283
Ensembl chr13:71,429,961...71,538,890
G
Etnk2
ethanolamine kinase 2
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:47,362,964...47,381,100
Ensembl chr13:44,811,015...44,829,037
G
Fmod
fibromodulin
IAGP
RGD
PMID:23817491
RGD:12802368
NCBI chr13:48,045,567...48,056,184
Ensembl chr13:45,493,517...45,504,133
G
Gpr37l1
G protein-coupled receptor 37-like 1
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:49,150,355...49,157,204
Ensembl chr13:46,598,578...46,605,421
G
Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
IMP
RGD
PMID:26077568
RGD:13800514
NCBI chr19:50,307,569...50,312,812
Ensembl chr19:33,397,656...33,402,899
G
Hsd11b2em1Jmul
hydroxysteroid 11-beta dehydrogenase 2; ZFN induced mutant1, Jmul
IMP
RGD
PMID:26077568
RGD:13800514
G
Ipo9
importin 9
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:49,362,244...49,414,477
Ensembl chr13:46,813,171...46,862,673
G
Kcnj1
potassium inwardly-rectifying channel, subfamily J, member 1
IMP
RGD
PMID:23753405
RGD:13782272
NCBI chr 8:39,014,822...39,066,716
Ensembl chr 8:30,753,617...30,813,796
G
Kcnj1em1Kasu
potassium voltage-gated channel subfamily J member 1; ZFN induced mutant 1,Kasu
IMP
RGD
PMID:23753405
RGD:13782272
G
Lgr6
leucine-rich repeat-containing G protein-coupled receptor 6
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:48,976,193...49,095,870
Ensembl chr13:46,424,383...46,543,945
G
Mgat5
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
IAGP
RGD
PMID:21257920
RGD:12798539
NCBI chr13:41,228,327...41,516,462
Ensembl chr13:38,676,119...38,959,513
G
Mybph
myosin binding protein H
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:48,205,162...48,212,928
Ensembl chr13:45,653,234...45,660,893
G
Ncf2
neutrophil cytosolic factor 2
ameliorates
IMP
compared to wild-type littermates
RGD
PMID:22326221
RGD:9587793
NCBI chr13:67,505,492...67,536,015
Ensembl chr13:64,955,503...64,986,277
G
Ncf2em1Mcwi
neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1,Mcwi
ameliorates
IMP
compared to wild-type littermates
RGD
PMID:22326221
RGD:9587793
G
Nckap5
NCK-associated protein 5
IAGP
RGD
PMID:21257920
RGD:12798539
NCBI chr13:39,922,576...40,835,849
Ensembl chr13:37,370,792...38,283,268
G
Nox4
NADPH oxidase 4
severity
IMP
RGD
PMID:26644237
RGD:11085830
NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406
G
Optc
opticin
IAGP
RGD
PMID:23817491
RGD:12802368
NCBI chr13:47,906,145...47,920,334
Ensembl chr13:45,355,148...45,365,237
G
Pappa2
pappalysin 2
IMP
RGD
PMID:24714719
RGD:12792227
NCBI chr13:73,407,385...73,683,699
Ensembl chr13:70,876,794...71,147,779
G
Plekha6
pleckstrin homology domain containing A6
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:47,166,899...47,307,003
Ensembl chr13:44,615,011...44,754,673
G
Plekha7
pleckstrin homology domain containing A7
ameliorates
IMP
compared to wild type
RGD
PMID:25136115
RGD:11079199
NCBI chr 1:179,798,856...179,982,155
Ensembl chr 1:170,365,135...170,547,775
G
Plekha7em4Mcwi
pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin
ameliorates
IMP
compared to wild type
RGD
PMID:25136115
RGD:11079199
G
Prelp
proline and arginine rich end leucine rich repeat protein
IAGP
RGD
PMID:23817491
RGD:12802368
NCBI chr13:47,920,480...47,943,547
Ensembl chr13:45,370,533...45,380,270
G
Psme2-ps1
proteasome activator subunit 2, pseudogene 1
IAGP
RGD
PMID:21257920
RGD:12798539
NCBI chr13:40,742,081...40,742,929
G
Ptprv
protein tyrosine phosphatase, receptor type, V
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:49,099,922...49,120,247
Ensembl chr13:46,548,128...46,568,329
G
Ren
renin
IAGP
RGD
PMID:23817491
RGD:12802368
NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489
G
Resp18
regulated endocrine-specific protein 18
IMP
RGD
PMID:29570433
RGD:14348960
NCBI chr 9:84,213,844...84,220,186
Ensembl chr 9:76,764,590...76,778,722
G
Resp18em2Mcwi
regulated endocrine-specific protein 18; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:29570433
RGD:14348960
G
Rnpep
arginyl aminopeptidase
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:49,251,259...49,271,440
Ensembl chr13:46,699,463...46,717,998
G
Sox13
SRY-box transcription factor 13
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:47,383,145...47,427,572
Ensembl chr13:44,831,085...44,875,762
G
Syt2
synaptotagmin 2
IAGP
RGD
PMID:23460292
RGD:12802369
NCBI chr13:48,639,634...48,749,814
Ensembl chr13:46,185,282...46,193,859
G
Tmem163
transmembrane protein 163
IAGP
RGD
PMID:21257920
RGD:12798539
NCBI chr13:41,520,595...41,693,938
Ensembl chr13:38,968,101...39,141,452
G
Tnr
tenascin R
IMP
RGD
PMID:24714719
RGD:12792227
NCBI chr13:74,285,141...74,706,174
Ensembl chr13:72,091,585...72,167,641
G
Tuba1c-ps1
tubulin, alpha 1C, pseudogene 1
IAGP
RGD
PMID:21257920
RGD:12798539
NCBI chr13:41,060,047...41,061,387
Ensembl chr13:38,507,401...38,508,943 Ensembl chr13:38,507,401...38,508,943
G
Rffl
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
IAGP
as compared to SS/Jr
RGD
PMID:21357277
RGD:13442502
NCBI chr10:68,238,273...68,301,225
Ensembl chr10:67,740,712...67,824,434
G
Ccdc39
coiled-coil domain 39 molecular ruler complex subunit
IMP
RGD
PMID:31771992
RGD:150521527
NCBI chr 2:118,593,881...118,631,584
Ensembl chr 2:116,665,261...116,703,350
G
Ccdc39em1Jgn
coiled-coil domain containing 39; CRISPR/Cas9 induced mutant 1, Jgn
IMP
RGD
PMID:31771992
RGD:150521527
G
Lamp2
lysosomal-associated membrane protein 2
IMP
in hemizygote mutant male (LAMP2y/-)
RGD
PMID:29720683
RGD:13703117
NCBI chr X:122,038,734...122,087,745
Ensembl chr X:117,057,606...117,260,522
G
Lamp2em1
lysosomal-associated membrane protein 2; TALEN induced mutant1
IMP
in hemizygote mutant male (LAMP2y/-)
RGD
PMID:29720683
RGD:13703117
G
Myh7b
myosin heavy chain 7B
IMP
RGD
PMID:32207065
RGD:126925946
NCBI chr 3:164,537,211...164,582,441
Ensembl chr 3:144,098,190...144,122,084
G
Myh7bem1Blar
myosin heavy chain 7B; CRISPR/Cas9 induced mutant 1, Blar
IMP
RGD
PMID:32207065
RGD:126925946
G
Gla
galactosidase, alpha
onset
IMP
compared to Wild type
RGD
PMID:29979634
RGD:401976416
NCBI chr X:102,062,497...102,073,915
Ensembl chr X:97,768,996...97,780,664
G
Glaem2Mcwi
galactosidase, alpha; CRISPR/Cas9 system induced mutant 2, Medical College of Wisconsin
onset
IMP
compared to Wild type
RGD
PMID:29979634
RGD:401976416
G
Adora2b
adenosine A2B receptor
IMP
RGD
PMID:26385692
RGD:11533328
NCBI chr10:47,439,712...47,456,092
Ensembl chr10:46,940,384...46,956,772
G
Adora2bem2Mcwi
adenosine A2B receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:26385692
RGD:11533328
G
Lamp2
lysosomal-associated membrane protein 2
IMP
in hemizygote mutant male (LAMP2y/-)
RGD
PMID:29720683
RGD:13703117
NCBI chr X:122,038,734...122,087,745
Ensembl chr X:117,057,606...117,260,522
G
Lamp2em1
lysosomal-associated membrane protein 2; TALEN induced mutant1
IMP
in hemizygote mutant male (LAMP2y/-)
RGD
PMID:29720683
RGD:13703117
G
Adamts16
ADAM metallopeptidase with thrombospondin type 1 motif, 16
IMP
As compared to SS parents
RGD
PMID:23185005
RGD:9685162
NCBI chr 1:34,258,899...34,388,952
Ensembl chr 1:32,430,436...32,560,494
G
Adamts16em1Bj
ADAM metallopeptidase with thrombospondin type 1 motif, 16; ZFN mutant1,Bj
IMP
As compared to SS parents
RGD
PMID:23185005
RGD:9685162
G
Ttn
titin
IAGP
RGD
PMID:27869827
RGD:11565821
NCBI chr 3:82,059,648...82,332,130
Ensembl chr 3:61,652,439...61,924,741
G
Ttnem2Sage
Titin; zinc finger nuclease induced mutant 2,Sigma Advanced Genetic Engineering Labs
IAGP
RGD
PMID:27869827
RGD:11565821
G
Bmpr2
bone morphogenetic protein receptor type 2
IMP
RGD
PMID:25593290
RGD:38500244
NCBI chr 9:68,685,942...68,801,353
Ensembl chr 9:61,190,566...61,301,809
G
Bmpr2em1Ang
bone morphogenetic protein receptor type 2; ZFN induced mutant 1, Ang
IMP
RGD
PMID:25593290
RGD:38500244
G
Pld2
phospholipase D2
IDA
angiotensin II induced
RGD
PMID:16113073
RGD:1642674
NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,256,359...55,272,808
G
Prkcz
protein kinase C, zeta
IDA
angiotensin II induced
RGD
PMID:16113073
RGD:1642674
NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:165,819,466...165,930,367
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