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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of innate immune response
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Accession:GO:0045089 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
Synonyms:exact_synonym: up regulation of innate immune response;   upregulation of innate immune response
 narrow_synonym: stimulation of innate immune response

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positive regulation of innate immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM8 ADAM metallopeptidase domain 8 involved_in ISO (PMID:20683884) BHF-UCL PMID:20683884 NCBI chr26:53,114,184...53,129,650
Ensembl chr26:53,114,924...53,126,900 		JBrowse link
G AKIRIN2 akirin 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr13:12,146,228...12,175,198 JBrowse link
G CARD9 caspase recruitment domain family member 9 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17187069) MGI
Ensembl		 PMID:17187069 GO_REF:0000107 NCBI chr12:1,829,913...1,841,489
Ensembl chr12:1,832,989...1,837,914 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:5,704,275...5,784,077
Ensembl chr 1:5,730,853...5,784,337 		JBrowse link
G DHX9 DExH-box helicase 9 involved_in ISO (PMID:28636595) UniProt PMID:28636595 NCBI chr25:46,485,602...46,534,046
Ensembl chr25:46,485,427...46,518,406 		JBrowse link
G EREG epiregulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:22,898,998...22,924,922
Ensembl chr 7:22,901,862...22,920,678 		JBrowse link
G FPR2 formyl peptide receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:44,580,342...44,591,187
Ensembl chr 6:44,589,334...44,590,389 		JBrowse link
G HAVCR2 hepatitis A virus cellular receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:59,479,794...59,501,532
Ensembl chr23:59,475,826...59,500,836 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:19890330) UniProt PMID:19890330 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G HMGB2 high mobility group box 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:119,440,089...119,442,806
Ensembl chr 7:119,440,468...119,443,578 		JBrowse link
G IFI35 interferon induced protein 35 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:63,276,493...63,284,196
Ensembl chr16:63,273,829...63,284,283 		JBrowse link
G KAT5 lysine acetyltransferase 5 involved_in ISO (PMID:32817552) UniProt PMID:32817552 NCBI chr 1:8,528,097...8,544,512
Ensembl chr 1:8,526,788...8,544,972 		JBrowse link
G LOC103242599 galectin-9 involved_in ISO (PMID:20937702) UniProt PMID:20937702 NCBI chr16:21,421,034...21,439,583 JBrowse link
G NMI N-myc and STAT interactor involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:36,702,056...36,722,494
Ensembl chr10:36,702,068...36,715,809 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15692051) MGI
Ensembl		 PMID:15692051 GO_REF:0000107 NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499 		JBrowse link
G PLSCR1 phospholipid scramblase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:44,160,017...44,189,056
Ensembl chr15:44,160,200...44,188,195 		JBrowse link
G POLR3B RNA polymerase III subunit B involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:101,577,134...101,719,214
Ensembl chr11:101,585,900...101,713,126 		JBrowse link
G POLR3C RNA polymerase III subunit C involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:12,901,879...12,919,748
Ensembl chr20:12,901,898...12,919,783 		JBrowse link
G POLR3D RNA polymerase III subunit D involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:20,314,020...20,320,118
Ensembl chr 8:20,314,081...20,319,455 		JBrowse link
G POLR3F RNA polymerase III subunit F involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:47,527,351...47,546,932
Ensembl chr 2:47,528,587...47,547,412 		JBrowse link
G POLR3G RNA polymerase III subunit G involved_in ISO (PMID:19609254), (PMID:19631370) UniProt PMID:19609254 PMID:19631370 NCBI chr 4:84,418,692...84,459,920 JBrowse link
G RIOK3 RIO kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:57,048,500...57,078,770
Ensembl chr18:57,048,447...57,078,312 		JBrowse link
G RNF185 ring finger protein 185 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:14,050,271...14,095,819
Ensembl chr19:14,076,113...14,093,410 		JBrowse link
G SLC15A4 solute carrier family 15 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:124,170,785...124,204,358
Ensembl chr11:124,169,732...124,204,200 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 involved_in ISO (PMID:21531336) UniProt PMID:21531336 NCBI chr16:16,847,603...16,874,239
Ensembl chr16:16,845,491...16,859,554 		JBrowse link
G TASL TLR adaptor interacting with endolysosomal SLC15A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:28,953,805...28,973,055
Ensembl chr  X:28,954,266...28,955,171 		JBrowse link
G TIRAP TIR domain containing adaptor protein involved_in ISO (PMID:16301656) BHF-UCL PMID:16301656 NCBI chr 1:117,417,561...117,419,870 JBrowse link
G TLR8 toll like receptor 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:11,387,933...11,405,056
Ensembl chr  X:11,400,907...11,404,029 		JBrowse link
G TRIM56 tripartite motif containing 56 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:12,093,927...12,099,490
Ensembl chr28:12,095,421...12,097,688 		JBrowse link
G ZDHHC4 zinc finger DHHC-type palmitoyltransferase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:15,788,451...15,804,072
Ensembl chr28:15,792,215...15,804,713 		JBrowse link
activation of innate immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIM2 absent in melanoma 2 involved_in IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr20:4,759,746...4,884,460
Ensembl chr20:4,873,008...4,884,764 		JBrowse link
G CASP6 caspase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:57,592,632...57,616,094
Ensembl chr 7:57,593,342...57,607,489 		JBrowse link
G CGAS cyclic GMP-AMP synthase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr17:1,697,446...1,723,626
Ensembl chr17:1,697,775...1,723,472 		JBrowse link
G HEXIM1 HEXIM P-TEFb complex subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:61,258,910...61,264,069
Ensembl chr16:61,260,769...61,261,845 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:24971542) UniProt PMID:24971542 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:80,016,352...80,019,130
Ensembl chr24:80,016,232...80,019,120 		JBrowse link
G IFI16 interferon gamma inducible protein 16 involved_in IEA InterPro
Ensembl
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr20:4,891,816...4,933,476
Ensembl chr20:4,888,779...4,933,478 		JBrowse link
G LOC103224473 guanylate-binding protein 7 involved_in ISO (PMID:24739961) UniProt PMID:24739961 NCBI chr20:44,206,478...44,248,425 JBrowse link
G LOC103224476 guanylate-binding protein 2 involved_in ISO (PMID:24739961) UniProt PMID:24739961 NCBI chr20:44,253,290...44,280,335 JBrowse link
G LOC103227720 twinfilin-2 involved_in IEA Ensembl
UniProt		 GO_REF:0000107 GO_REF:0000117 NCBI chr22:13,581,102...13,598,830
Ensembl chr22:13,589,034...13,598,752
Ensembl chr22:13,589,034...13,598,752 		JBrowse link
G MATR3 matrin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:41,955,451...41,992,280
Ensembl chr23:41,969,459...41,994,233 		JBrowse link
G MAVS mitochondrial antiviral signaling protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:34,534,433...34,555,406
Ensembl chr 2:34,541,229...34,552,823 		JBrowse link
G MNDA myeloid cell nuclear differentiation antigen involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr20:5,079,633...5,124,967
Ensembl chr20:5,079,632...5,095,868 		JBrowse link
G NLRC4 NLR family CARD domain containing 4 involved_in ISO (PMID:16648852) UniProt PMID:16648852 NCBI chr14:75,229,262...75,273,336
Ensembl chr14:75,242,274...75,273,312 		JBrowse link
G NLRP10 NLR family pyrin domain containing 10 involved_in ISO (PMID:22672233) UniProt PMID:22672233 NCBI chr 1:56,814,157...56,835,447 JBrowse link
G NONO non-POU domain containing octamer binding involved_in ISO (PMID:28712728) UniProt PMID:28712728 NCBI chr  X:61,082,923...61,110,895 JBrowse link
G PQBP1 polyglutamine binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:46,014,664...46,020,204
Ensembl chr  X:46,015,250...46,023,988 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:43,915,226...44,119,547
Ensembl chr 8:43,914,636...44,119,541 		JBrowse link
G PSPC1 paraspeckle component 1 involved_in ISO (PMID:28712728) UniProt PMID:28712728 NCBI chr 3:1,160,227...1,232,390 JBrowse link
G PSPC1 paraspeckle component 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 3:1,179,578...1,230,034 JBrowse link
G PYCARD PYD and CARD domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:27,892,332...27,894,386
Ensembl chr 5:27,889,230...27,893,697 		JBrowse link
G PYHIN1 pyrin and HIN domain family member 1 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr20:4,967,123...5,006,172
Ensembl chr20:4,967,224...5,006,035 		JBrowse link
G SFPQ splicing factor proline and glutamine rich involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:97,698,953...97,715,762
Ensembl chr20:97,698,411...97,711,294 		JBrowse link
G SIN3A SIN3 transcription regulator family member A involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:7,971,208...8,060,888
Ensembl chr26:7,975,484...8,058,278 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr23:42,153,576...42,160,903
Ensembl chr23:42,153,026...42,160,907 		JBrowse link
G TBK1 TANK binding kinase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15661922) MGI
Ensembl		 PMID:15661922 GO_REF:0000107 NCBI chr11:60,136,162...60,182,354
Ensembl chr11:60,136,232...60,182,344 		JBrowse link
G TLR4 toll like receptor 4 acts_upstream_of_or_within ISO (PMID:15661922) MGI PMID:15661922 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G TOMM70 translocase of outer mitochondrial membrane 70 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:80,477,429...80,516,536
Ensembl chr22:80,477,872...80,516,670 		JBrowse link
G TRIM5 tripartite motif containing 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:61,040,908...61,067,815
Ensembl chr 1:61,040,928...61,069,356 		JBrowse link
G XRCC5 X-ray repair cross complementing 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:101,952,909...102,051,059
Ensembl chr10:101,953,067...102,049,964 		JBrowse link
G XRCC6 X-ray repair cross complementing 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:24,160,459...24,204,237
Ensembl chr19:24,160,483...24,206,320 		JBrowse link
G ZBP1 Z-DNA binding protein 1 involved_in ISO (PMID:32350114), (PMID:33109609)
(PMID:32200799), (PMID:32296175)		 UniProt PMID:32200799 PMID:32296175 PMID:32350114 PMID:33109609 NCBI chr 2:6,494,410...6,510,928 JBrowse link
G ZCCHC3 zinc finger CCHC-type containing 3 involved_in IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:35,422,903...35,426,145
Ensembl chr 2:35,423,430...35,424,638 		JBrowse link
G ZNFX1 zinc finger NFX1-type containing 1 involved_in ISO (PMID:31685995) UniProt PMID:31685995 NCBI chr 2:14,708,416...14,740,061 JBrowse link
CARD8 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103234962 caspase recruitment domain-containing protein 8 involved_in ISO (PMID:31525884), (PMID:33053349), (PMID:33420028), (PMID:33420033) UniProt PMID:31525884 PMID:33053349 PMID:33420028 PMID:33420033 NCBI chr 6:41,446,890...41,500,098 JBrowse link
cell surface pattern recognition receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:43,264,917...43,266,825
Ensembl chr23:43,264,336...43,266,993 		JBrowse link
G CLEC7A C-type lectin domain containing 7A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12719478) MGI
Ensembl		 PMID:12719478 GO_REF:0000107 NCBI chr11:9,989,520...10,007,442
Ensembl chr11:9,995,203...10,006,746 		JBrowse link
G FCN1 ficolin 1 involved_in ISO (PMID:21037097) UniProt PMID:21037097 NCBI chr12:3,227,790...3,236,161 JBrowse link
G FCN1 ficolin 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr12:3,231,325...3,236,174 JBrowse link
G FFAR2 free fatty acid receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:30,375,607...30,379,479
Ensembl chr 6:30,377,427...30,378,419 		JBrowse link
G LBP lipopolysaccharide binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:25,375,364...25,407,181
Ensembl chr 2:25,374,755...25,406,839 		JBrowse link
G MBL2 mannose binding lectin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:78,389,534...78,394,753
Ensembl chr 9:78,389,947...78,396,079 		JBrowse link
G SYK spleen associated tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:101,254,085...101,374,724
Ensembl chr12:101,260,061...101,349,856 		JBrowse link
G TLR2 toll like receptor 2 acts_upstream_of_or_within ISO (PMID:12719478) MGI PMID:12719478 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
cGAS/STING signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CGAS cyclic GMP-AMP synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:1,697,446...1,723,626
Ensembl chr17:1,697,775...1,723,472 		JBrowse link
G DDX41 DEAD-box helicase 41 involved_in ISO (PMID:35613581) UniProt PMID:35613581 NCBI chr23:79,522,265...79,528,628
Ensembl chr23:79,522,479...79,527,570 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:42,153,576...42,160,903
Ensembl chr23:42,153,026...42,160,907 		JBrowse link
cytoplasmic pattern recognition receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPK1 alpha kinase 1 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:60,096,755...60,233,569
Ensembl chr 7:60,202,204...60,236,743 		JBrowse link
G BECN1 beclin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:63,469,187...63,482,627
Ensembl chr16:63,469,192...63,485,322 		JBrowse link
G CGAS cyclic GMP-AMP synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:1,697,446...1,723,626
Ensembl chr17:1,697,775...1,723,472 		JBrowse link
G DHX58 DExH-box helicase 58 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr16:64,154,832...64,166,480
Ensembl chr16:64,154,984...64,166,500 		JBrowse link
G IPO5 importin 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:76,644,113...76,690,718
Ensembl chr 3:76,644,131...76,692,146 		JBrowse link
G IRF3 interferon regulatory factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:42,835,285...42,841,487
Ensembl chr 6:42,831,203...42,840,796 		JBrowse link
G IRF7 interferon regulatory factor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:430,412...433,959
Ensembl chr 1:429,310...432,925 		JBrowse link
G MAVS mitochondrial antiviral signaling protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:34,534,433...34,555,406
Ensembl chr 2:34,541,229...34,552,823 		JBrowse link
G RIGI RNA sensor RIG-I involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:47,729,040...47,800,995
Ensembl chr12:47,729,076...47,799,570 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:42,153,576...42,160,903
Ensembl chr23:42,153,026...42,160,907 		JBrowse link
G TBK1 TANK binding kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:60,136,162...60,182,354
Ensembl chr11:60,136,232...60,182,344 		JBrowse link
G TIFA TRAF interacting protein with forkhead associated domain involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:60,074,764...60,085,029
Ensembl chr 7:60,076,999...60,077,556 		JBrowse link
G TRAF3IP3 TRAF3 interacting protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:19,671,531...19,699,737
Ensembl chr25:19,671,693...19,695,356 		JBrowse link
G TRAF6 TNF receptor associated factor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:28,726,357...28,752,389
Ensembl chr 1:28,734,380...28,747,092 		JBrowse link
G TRIM25 tripartite motif containing 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:36,496,829...36,522,427
Ensembl chr16:36,496,772...36,524,148 		JBrowse link
G YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:1,031,840...1,086,950
Ensembl chr16:1,035,250...1,087,013 		JBrowse link
endolysosomal toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WASHC4 WASH complex subunit 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:33749590) MGI
Ensembl		 PMID:33749590 GO_REF:0000107 NCBI chr11:100,333,806...100,395,930
Ensembl chr11:100,333,912...100,398,713 		JBrowse link
inflammasome-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ELP6 elongator acetyltransferase complex subunit 6 acts_upstream_of_or_within ISO (PMID:30097576) MGI PMID:30097576 NCBI chr22:8,899,078...8,929,072 JBrowse link
innate immune response-activating signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TLR4 toll like receptor 4 ISO RGD PMID:19226379 RGD:2312509 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
MDA-5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFIH1 interferon induced with helicase C domain 1 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:47,676,799...47,732,310
Ensembl chr10:47,676,920...47,732,264 		JBrowse link
G OAS3 2'-5'-oligoadenylate synthetase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:108,192,595...108,210,332
Ensembl chr11:108,192,509...108,213,333 		JBrowse link
MyD88-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LRRFIP2 LRR binding FLII interacting protein 2 acts_upstream_of_or_within ISO (PMID:19265123) MGI PMID:19265123 NCBI chr15:2,231,423...2,362,394
Ensembl chr15:2,231,525...2,361,544 		JBrowse link
MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD180 CD180 molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 4:63,361,277...63,377,492
Ensembl chr 4:63,359,844...63,377,459 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:14660645) UniProt PMID:14660645 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:83,003,266...83,017,397
Ensembl chr10:83,003,717...83,017,363 		JBrowse link
G LOC103227720 twinfilin-2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:13,581,102...13,598,830
Ensembl chr22:13,589,034...13,598,752
Ensembl chr22:13,589,034...13,598,752 		JBrowse link
G LOC103238722 60 kDa heat shock protein, mitochondrial-like involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:66,923,204...66,925,397 JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14764662)
(PMID:12719478)
(PMID:12872135)		 Ensembl
MGI
InterPro		 PMID:12719478 PMID:12872135 PMID:14764662 GO_REF:0000002 GO_REF:0000107 NCBI chr15:1,276,804...1,281,811
Ensembl chr15:1,276,798...1,281,166 		JBrowse link
G REG3G regenerating family member 3 gamma involved_in ISO (PMID:17635956) UniProt PMID:17635956 NCBI chr14:28,213,731...28,217,299 JBrowse link
G TLR2 toll like receptor 2 acts_upstream_of_or_within ISO (PMID:12719478) MGI PMID:12719478 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
G TLR4 toll like receptor 4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G TLR6 toll like receptor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:11,439,288...11,461,580
Ensembl chr27:11,459,181...11,461,571 		JBrowse link
G TNIP1 TNFAIP3 interacting protein 1 involved_in ISO (PMID:22011580) UniProt PMID:22011580 NCBI chr23:53,586,243...53,643,599
Ensembl chr23:53,587,008...53,621,489 		JBrowse link
MyD88-independent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LRRFIP2 LRR binding FLII interacting protein 2 acts_upstream_of_or_within ISO (PMID:19265123) MGI PMID:19265123 NCBI chr15:2,231,423...2,362,394
Ensembl chr15:2,231,525...2,361,544 		JBrowse link
G TICAM1 toll like receptor adaptor molecule 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12872135)
(PMID:12855817)		 MGI
Ensembl		 PMID:12855817 PMID:12872135 GO_REF:0000107 NCBI chr 6:4,526,719...4,543,251
Ensembl chr 6:4,527,033...4,529,168 		JBrowse link
G TNIP3 TNFAIP3 interacting protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:68,416,674...68,519,097
Ensembl chr 7:68,422,328...68,454,143 		JBrowse link
negative regulation of AIM2 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFI16 interferon gamma inducible protein 16 involved_in ISO (PMID:30104205) UniProt PMID:30104205 NCBI chr20:4,891,816...4,933,476
Ensembl chr20:4,888,779...4,933,478 		JBrowse link
G PYDC5 pyrin domain containing 5 involved_in ISO (PMID:24531343) UniProt PMID:24531343
G TRIM11 tripartite motif containing 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:1,322,817...1,336,535
Ensembl chr25:1,323,528...1,335,504 		JBrowse link
negative regulation of cGAS/STING signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AARS2 alanyl-tRNA synthetase 2, mitochondrial involved_in ISO (PMID:39322678) UniProt PMID:39322678 NCBI chr17:27,855,688...27,869,427
Ensembl chr17:27,855,713...27,870,409 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:82,704,087...82,730,711
Ensembl chr24:82,704,068...82,727,698 		JBrowse link
G AURKB aurora kinase B involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:7,571,255...7,583,034
Ensembl chr16:7,570,538...7,582,959 		JBrowse link
G BANF1 barrier to autointegration nuclear assembly factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:8,254,186...8,255,571
Ensembl chr 1:8,253,884...8,255,572 		JBrowse link
G CGAS cyclic GMP-AMP synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:1,697,446...1,723,626
Ensembl chr17:1,697,775...1,723,472 		JBrowse link
G IRGM immunity related GTPase M involved_in ISO (PMID:32715615) UniProt PMID:32715615 NCBI chr23:53,449,576...53,451,373 JBrowse link
G LOC119622651 barrier-to-autointegration factor involved_in IEA Ensembl GO_REF:0000107
G LYPLAL1 lysophospholipase like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:10,370,715...10,408,807
Ensembl chr25:10,370,814...10,408,767 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 involved_in ISO (PMID:35460603) UniProt PMID:35460603 NCBI chr25:3,350,798...3,405,040 JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr25:3,350,821...3,388,826 JBrowse link
G PCBP2 poly(rC) binding protein 2 involved_in ISO (PMID:35322803) UniProt PMID:35322803 NCBI chr11:49,548,615...49,580,962 JBrowse link
G PPP6C protein phosphatase 6 catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:12,964,706...13,007,339
Ensembl chr12:12,964,842...13,007,351 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:43,915,226...44,119,547
Ensembl chr 8:43,914,636...44,119,541 		JBrowse link
G SMPDL3A sphingomyelin phosphodiesterase acid like 3A involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:50,996,472...51,017,056
Ensembl chr13:50,996,674...51,016,108 		JBrowse link
G SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:1,685,741...1,691,542
Ensembl chr 5:1,686,095...1,691,489 		JBrowse link
G TREX1 three prime repair exonuclease 1 involved_in ISO (PMID:33476576) UniProt PMID:33476576 NCBI chr22:9,869,502...9,871,659 JBrowse link
G ZDHHC18 zinc finger DHHC-type palmitoyltransferase 18 involved_in ISO (PMID:35438208) UniProt PMID:35438208 NCBI chr20:105,907,293...105,941,233 JBrowse link
G ZDHHC18 zinc finger DHHC-type palmitoyltransferase 18 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr20:105,909,557...105,940,971 JBrowse link
negative regulation of cytoplasmic pattern recognition receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITCH itchy E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:38,671,170...38,808,621
Ensembl chr 2:38,701,396...38,805,005 		JBrowse link
G TARBP2 TARBP2 subunit of RISC loading complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:49,601,634...49,607,097
Ensembl chr11:49,602,113...49,606,816 		JBrowse link
G TAX1BP1 Tax1 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:30,539,867...30,629,372
Ensembl chr21:30,540,791...30,629,345 		JBrowse link
G TSPAN6 tetraspanin 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:88,940,666...88,948,459
Ensembl chr  X:88,942,300...88,948,069 		JBrowse link
negative regulation of MDA-5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QBP complement C1q binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:4,843,202...4,850,639
Ensembl chr16:4,843,438...4,850,600 		JBrowse link
G DHX58 DExH-box helicase 58 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:64,154,832...64,166,480
Ensembl chr16:64,154,984...64,166,500 		JBrowse link
G RIOK3 RIO kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:57,048,500...57,078,770
Ensembl chr18:57,048,447...57,078,312 		JBrowse link
G TKFC triokinase and FMN cyclase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:12,495,058...12,508,693
Ensembl chr 1:12,495,477...12,507,927 		JBrowse link
negative regulation of MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD300A CD300a molecule involved_in ISO (PMID:22043923) UniProt PMID:22043923
G CD300LF CD300 molecule like family member f involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:46,944,701...46,963,559
Ensembl chr16:46,944,921...46,962,770 		JBrowse link
G LOC103243088 CMRF35-like molecule 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:47,153,766...47,173,780
Ensembl chr16:47,154,437...47,170,038 		JBrowse link
negative regulation of MyD88-independent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SARM1 sterile alpha and TIR motif containing 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr16:22,137,990...22,163,431
Ensembl chr16:22,138,588...22,162,893 		JBrowse link
negative regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD17A abhydrolase domain containing 17A, depalmitoylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:1,678,836...1,687,370
Ensembl chr 6:1,676,438...1,687,353 		JBrowse link
G CPTP ceramide-1-phosphate transfer protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:130,124,705...130,128,745
Ensembl chr20:130,125,790...130,126,711 		JBrowse link
G CSNK1A1 casein kinase 1 alpha 1 involved_in ISO (PMID:34615873) UniProt PMID:34615873 NCBI chr23:52,111,500...52,169,043
Ensembl chr23:52,114,053...52,168,998 		JBrowse link
G FBXL2 F-box and leucine rich repeat protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:77,769,424...77,895,994
Ensembl chr15:77,769,748...77,878,340 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:114,447,348...114,452,693
Ensembl chr 1:114,446,544...114,451,562 		JBrowse link
G IRGM immunity related GTPase M involved_in ISO (PMID:30612879) UniProt PMID:30612879 NCBI chr23:53,449,576...53,451,373 JBrowse link
G LAMP2 lysosomal associated membrane protein 2 involved_in ISO (PMID:36586411) UniProt PMID:36586411
G LOC103234962 caspase recruitment domain-containing protein 8 involved_in ISO (PMID:24517500) UniProt PMID:24517500 NCBI chr 6:41,446,890...41,500,098 JBrowse link
G MEFV MEFV innate immunity regulator, pyrin involved_in ISO (PMID:26347139) UniProt PMID:26347139 NCBI chr 5:2,971,323...2,991,501 JBrowse link
G MEFV MEFV innate immunity regulator, pyrin involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 5:2,971,419...2,981,911 JBrowse link
G NLRC3 NLR family CARD domain containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:3,241,552...3,262,763
Ensembl chr 5:3,242,242...3,262,261 		JBrowse link
G PYDC1 pyrin domain containing 1 NOT|involved_in ISO (PMID:24871464) UniProt PMID:24871464
G PYDC2 pyrin domain containing 2 involved_in ISO (PMID:17339483), (PMID:24871464) UniProt PMID:17339483 PMID:24871464 NCBI chr15:85,595,175...85,675,489 JBrowse link
G PYDC2 pyrin domain containing 2 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr15:85,626,825...85,627,115 JBrowse link
G SIRT2 sirtuin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23502856) Ensembl
MGI		 PMID:23502856 GO_REF:0000107 NCBI chr 6:33,493,106...33,518,793
Ensembl chr 6:33,493,079...33,518,647 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:32514138)
(PMID:29887864)		 ARUK-UCL
Ensembl		 PMID:29887864 PMID:32514138 GO_REF:0000107 NCBI chr17:30,965,091...30,999,073
Ensembl chr17:30,994,357...30,999,087 		JBrowse link
G TRIM22 tripartite motif containing 22 involved_in ISO (PMID:21048113) UniProt PMID:21048113 NCBI chr 1:61,018,252...61,036,690
Ensembl chr 1:61,019,464...61,036,548 		JBrowse link
G ZDHHC12 zinc finger DHHC-type palmitoyltransferase 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:9,419,784...9,423,091
Ensembl chr12:9,419,852...9,422,774 		JBrowse link
negative regulation of non-canonical inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:61,351,047...61,393,541
Ensembl chr  X:61,351,054...61,394,305 		JBrowse link
negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFAIP3 TNF alpha induced protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:35,537,103...35,553,396
Ensembl chr13:35,537,102...35,549,197 		JBrowse link
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERBIN erbb2 interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:62,123,012...62,267,832
Ensembl chr 4:62,182,705...62,268,617 		JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:19,792,807...19,855,784
Ensembl chr20:19,793,083...19,855,827 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:35,537,103...35,553,396
Ensembl chr13:35,537,102...35,549,197 		JBrowse link
G ZNRF4 zinc and ring finger 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:5,127,332...5,129,463
Ensembl chr 6:5,127,865...5,129,154 		JBrowse link
negative regulation of RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QBP complement C1q binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:4,843,202...4,850,639
Ensembl chr16:4,843,438...4,850,600 		JBrowse link
G DHX58 DExH-box helicase 58 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr16:64,154,832...64,166,480
Ensembl chr16:64,154,984...64,166,500 		JBrowse link
G GPATCH3 G-patch domain containing 3 involved_in ISO (PMID:28414768) UniProt PMID:28414768 NCBI chr20:105,853,831...105,873,276 JBrowse link
G GPATCH3 G-patch domain containing 3 involved_in IEA InterPro
Ensembl
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 Ensembl chr20:105,867,845...105,872,764 JBrowse link
G NLRX1 NLR family member X1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21703540) Ensembl
MGI		 PMID:21703540 GO_REF:0000107 NCBI chr 1:110,541,777...110,559,846
Ensembl chr 1:110,545,190...110,560,149 		JBrowse link
G NPLOC4 NPL4 homolog, ubiquitin recognition factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:73,499,737...73,570,753
Ensembl chr16:73,502,123...73,570,710 		JBrowse link
G RNF125 ring finger protein 125 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:48,665,694...48,712,371
Ensembl chr18:48,666,554...48,711,604 		JBrowse link
G SEC14L1 SEC14 like lipid binding 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr16:44,490,927...44,565,922
Ensembl chr16:44,489,852...44,565,853 		JBrowse link
G UFD1 ubiquitin recognition factor in ER associated degradation 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:6,275,834...6,305,940
Ensembl chr19:6,275,844...6,308,035 		JBrowse link
negative regulation of toll-like receptor 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOD1 aconitate decarboxylase 1 involved_in ISO (PMID:23609450) UniProt PMID:23609450 NCBI chr 3:56,037,628...56,048,509
Ensembl chr 3:56,042,149...56,047,680 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:51,919,656...52,057,376
Ensembl chr 8:51,919,808...52,057,959 		JBrowse link
G MFHAS1 multifunctional ROCO family signaling regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:10,158,951...10,268,286
Ensembl chr 8:10,159,421...10,268,323 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15220916) MGI
Ensembl		 PMID:15220916 GO_REF:0000107 NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499 		JBrowse link
G TLR6 toll like receptor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:11,439,288...11,461,580
Ensembl chr27:11,459,181...11,461,571 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:31134514) ARUK-UCL PMID:31134514 NCBI chr17:30,965,091...30,999,073
Ensembl chr17:30,994,357...30,999,087 		JBrowse link
negative regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:71,095,446...71,109,832
Ensembl chr 4:71,095,500...71,110,005 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:35,537,103...35,553,396
Ensembl chr13:35,537,102...35,549,197 		JBrowse link
G UBQLN1 ubiquilin 1 involved_in ISO (PMID:21695056) CACAO PMID:21695056 NCBI chr12:94,462,867...94,512,313
Ensembl chr12:94,461,972...94,511,747 		JBrowse link
negative regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOD1 aconitate decarboxylase 1 involved_in ISO (PMID:23609450) UniProt PMID:23609450 NCBI chr 3:56,037,628...56,048,509
Ensembl chr 3:56,042,149...56,047,680 		JBrowse link
G BPIFB1 BPI fold containing family B member 1 involved_in ISO (PMID:21900486) UniProt PMID:21900486 NCBI chr 2:37,612,111...37,638,397 JBrowse link
G BPIFB1 BPI fold containing family B member 1 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 Ensembl chr 2:37,615,068...37,633,307 JBrowse link
G DAB2IP DAB2 interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:17,802,030...18,017,648
Ensembl chr12:17,801,831...17,830,890 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:51,919,656...52,057,376
Ensembl chr 8:51,919,808...52,057,959 		JBrowse link
G MFHAS1 multifunctional ROCO family signaling regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:10,158,951...10,268,286
Ensembl chr 8:10,159,421...10,268,323 		JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:66,078,990...66,086,927
Ensembl chr16:66,079,089...66,090,685 		JBrowse link
G RAB7B RAB7B, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:23,341,090...23,367,414
Ensembl chr25:23,341,490...23,367,398 		JBrowse link
G SQSTM1 sequestosome 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:81,536,271...81,571,061
Ensembl chr23:81,558,082...81,574,830 		JBrowse link
G TAX1BP1 Tax1 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:30,539,867...30,629,372
Ensembl chr21:30,540,791...30,629,345 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in ISO (PMID:19412184) UniProt PMID:19412184 NCBI chr23:18,831,361...18,855,476
Ensembl chr23:18,833,262...18,833,969 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:31134514)
(PMID:29407460)		 ARUK-UCL PMID:29407460 PMID:31134514 NCBI chr17:30,965,091...30,999,073
Ensembl chr17:30,994,357...30,999,087 		JBrowse link
G TRIM32 tripartite motif containing 32 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:22,893,689...22,906,913
Ensembl chr12:22,894,886...22,896,847 		JBrowse link
negative regulation of toll-like receptor 5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFAIP3 TNF alpha induced protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:35,537,103...35,553,396
Ensembl chr13:35,537,102...35,549,197 		JBrowse link
negative regulation of toll-like receptor 7 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LILRA4 leukocyte immunoglobulin like receptor A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:47,023,469...47,038,665
Ensembl chr 6:47,023,620...47,037,336 		JBrowse link
negative regulation of toll-like receptor 9 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GRAMD4 GRAM domain containing 4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr19:29,068,166...29,175,646
Ensembl chr19:29,070,023...29,172,977 		JBrowse link
G LILRA4 leukocyte immunoglobulin like receptor A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:47,023,469...47,038,665
Ensembl chr 6:47,023,620...47,037,336 		JBrowse link
G PPT1 palmitoyl-protein thioesterase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:92,809,373...92,833,048
Ensembl chr20:92,809,552...92,833,244 		JBrowse link
G PTPRS protein tyrosine phosphatase receptor type S involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:4,880,942...5,019,654
Ensembl chr 6:4,882,223...4,964,919 		JBrowse link
G RAB7B RAB7B, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:23,341,090...23,367,414
Ensembl chr25:23,341,490...23,367,398 		JBrowse link
negative regulation of toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB2 arrestin beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:4,191,040...4,202,382
Ensembl chr16:4,191,172...4,202,385 		JBrowse link
G CACTIN cactin, spliceosome C complex subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:3,369,445...3,386,684
Ensembl chr 6:3,369,279...3,383,226 		JBrowse link
G GPR108 G protein-coupled receptor 108 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:6,299,294...6,306,957
Ensembl chr 6:6,299,548...6,306,564 		JBrowse link
G GPS2 G protein pathway suppressor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:6,690,831...6,694,245
Ensembl chr16:6,686,667...6,693,804 		JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:61,868,817...61,920,896
Ensembl chr11:61,869,173...61,920,406 		JBrowse link
G IRF4 interferon regulatory factor 4 acts_upstream_of_or_within ISO (PMID:16236719) MGI PMID:16236719 NCBI chr17:71,739,920...71,758,811 JBrowse link
G IRF4 interferon regulatory factor 4 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr17:71,751,770...71,757,496 JBrowse link
G LGR4 leucine rich repeat containing G protein-coupled receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:37,632,748...37,741,100
Ensembl chr 1:37,632,710...37,741,330 		JBrowse link
G LRRC14 leucine rich repeat containing 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:138,732,276...138,736,348
Ensembl chr 8:138,734,046...138,735,804 		JBrowse link
G NFKBIL1 NFKB inhibitor like 1 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr17:40,428,001...40,440,386
Ensembl chr17:40,428,222...40,439,433 		JBrowse link
G NLRP6 NLR family pyrin domain containing 6 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:22763455) MGI
Ensembl		 PMID:22763455 GO_REF:0000107 NCBI chr 1:92,213...99,919 JBrowse link
G OTUD4 OTU deubiquitinase 4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:91,709,184...91,756,437
Ensembl chr 7:91,708,767...91,756,793 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 involved_in ISO (PMID:20584979) UniProt PMID:20584979
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (PMID:20728433) UniProt PMID:20728433 NCBI chr 9:89,750,792...89,875,309 JBrowse link
G RNF115 ring finger protein 115 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:12,919,988...13,001,736
Ensembl chr20:12,920,232...13,001,135 		JBrowse link
G SMPDL3B sphingomyelin phosphodiesterase acid like 3B involved_in ISO (PMID:26095358) UniProt PMID:26095358 NCBI chr20:104,852,055...104,872,123 JBrowse link
G TRIM22 tripartite motif containing 22 involved_in ISO (PMID:18345001) UniProt PMID:18345001 NCBI chr 1:61,018,252...61,036,690
Ensembl chr 1:61,019,464...61,036,548 		JBrowse link
G TYRO3 TYRO3 protein tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:41,429,667...41,449,130
Ensembl chr26:41,429,556...41,449,175 		JBrowse link
G YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:1,031,840...1,086,950
Ensembl chr16:1,035,250...1,087,013 		JBrowse link
NLRP1 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NLRP1 NLR family pyrin domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:4,930,643...4,983,378 JBrowse link
NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAT1 alpha tubulin acetyltransferase 1 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:23502856) Ensembl
MGI		 PMID:23502856 GO_REF:0000107 NCBI chr17:41,807,405...41,830,670
Ensembl chr17:41,807,291...41,830,000 		JBrowse link
G GKN2 gastrokine 2 acts_upstream_of_or_within ISO (PMID:32226647) MGI PMID:32226647 NCBI chr14:38,171,433...38,179,689
Ensembl chr14:38,172,306...38,179,457 		JBrowse link
G KCNJ8 potassium inwardly rectifying channel subfamily J member 8 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:28928055) Ensembl
MGI		 PMID:28928055 GO_REF:0000107 NCBI chr11:21,624,963...21,634,940
Ensembl chr11:21,624,970...21,634,042 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 acts_upstream_of_or_within
involved_in		 ISO (PMID:22753929)
(PMID:17483456), (PMID:23582325), (PMID:25686105), (PMID:27043286), (PMID:27432880), (PMID:28465465), (PMID:28656979), (PMID:28943315), (PMID:30487600), (PMID:31189953), (PMID:33231615), (PMID:34554188), (PMID:34615873), (PMID:35114687), (PMID:35254907), (PMID:35559676), (PMID:36442502), (PMID:39173637)
(PMID:23582325), (PMID:26173909), (PMID:27043286), (PMID:28465465), (PMID:28656979), (PMID:28716882), (PMID:28943315), (PMID:30487600), (PMID:34615873), (PMID:34861190)		 MGI
UniProt		 PMID:17483456 PMID:22753929 PMID:23582325 PMID:25686105 PMID:26173909 More... NCBI chr25:84,431,436...84,463,387
Ensembl chr25:84,434,527...84,463,249 		JBrowse link
G PYCARD PYD and CARD domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:27,892,332...27,894,386
Ensembl chr 5:27,889,230...27,893,697 		JBrowse link
G SIRT2 sirtuin 2 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:23502856) Ensembl
MGI		 PMID:23502856 GO_REF:0000107 NCBI chr 6:33,493,106...33,518,793
Ensembl chr 6:33,493,079...33,518,647 		JBrowse link
NLRP6 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NLRP6 NLR family pyrin domain containing 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:92,213...99,919 JBrowse link
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RNF34 ring finger protein 34 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:116,777,294...116,800,816
Ensembl chr11:116,777,419...116,800,035 		JBrowse link
nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFKBIA NFKB inhibitor alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chr24:12,211,619...12,216,185
Ensembl chr24:12,210,281...12,214,854 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:27,907,628...27,957,621
Ensembl chr21:27,926,710...27,957,619 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11894098) Ensembl
MGI		 PMID:11894098 GO_REF:0000107 NCBI chr 8:84,843,391...84,881,087
Ensembl chr 8:84,843,471...84,881,303 		JBrowse link
G TLR4 toll like receptor 4 acts_upstream_of ISO (PMID:18261938) MGI PMID:18261938 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G XIAP X-linked inhibitor of apoptosis involved_in ISO (PMID:29452636) UniProt PMID:29452636
nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INAVA innate immunity activator involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:28,488,990...28,513,997
Ensembl chr25:28,488,901...28,509,704 		JBrowse link
G IRGM immunity related GTPase M involved_in ISO (PMID:25891078) UniProt PMID:25891078 NCBI chr23:53,449,576...53,451,373 JBrowse link
G LACC1 laccase domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:21,995,405...22,008,310
Ensembl chr 3:21,997,133...22,006,418 		JBrowse link
G NFKBIA NFKB inhibitor alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18261938) Ensembl
MGI		 PMID:18261938 GO_REF:0000107 NCBI chr24:12,211,619...12,216,185
Ensembl chr24:12,210,281...12,214,854 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12527755)
(PMID:23892723)		 MGI
Ensembl		 PMID:12527755 PMID:23892723 GO_REF:0000107 NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499 		JBrowse link
G OTULIN OTU deubiquitinase with linear linkage specificity involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:14,358,556...14,395,539
Ensembl chr 4:14,358,538...14,389,987 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12527755) MGI
Ensembl		 PMID:12527755 GO_REF:0000107 NCBI chr 1:8,576,059...8,585,561
Ensembl chr 1:8,576,542...8,586,516 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11894098) Ensembl
MGI		 PMID:11894098 GO_REF:0000107 NCBI chr 8:84,843,391...84,881,087
Ensembl chr 8:84,843,471...84,881,303 		JBrowse link
G TLR4 toll like receptor 4 acts_upstream_of ISO (PMID:18261938) MGI PMID:18261938 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G XIAP X-linked inhibitor of apoptosis involved_in ISO (PMID:19667203), (PMID:22607974), (PMID:29452636) UniProt PMID:19667203 PMID:22607974 PMID:29452636
pattern recognition receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CGAS cyclic GMP-AMP synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:1,697,446...1,723,626
Ensembl chr17:1,697,775...1,723,472 		JBrowse link
G CLEC4E C-type lectin domain family 4 member E involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:8,315,888...8,322,240
Ensembl chr11:8,316,049...8,321,274 		JBrowse link
G INAVA innate immunity activator involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:28,488,990...28,513,997
Ensembl chr25:28,488,901...28,509,704 		JBrowse link
G LACC1 laccase domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:21,995,405...22,008,310
Ensembl chr 3:21,997,133...22,006,418 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:27,907,628...27,957,621
Ensembl chr21:27,926,710...27,957,619 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499 		JBrowse link
G RNF144A ring finger protein 144A involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:100,646,376...100,765,860
Ensembl chr14:100,644,270...100,743,634 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:42,153,576...42,160,903
Ensembl chr23:42,153,026...42,160,907 		JBrowse link
positive regulation of AIM2 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103224476 guanylate-binding protein 2 involved_in ISO (PMID:25774715), (PMID:25774716) UniProt PMID:25774715 PMID:25774716 NCBI chr20:44,253,290...44,280,335 JBrowse link
positive regulation of antifungal innate immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLA2G5 phospholipase A2 group V involved_in ISO (PMID:19342668) UniProt PMID:19342668 NCBI chr20:112,465,341...112,487,082
Ensembl chr20:112,464,033...112,487,089 		JBrowse link
G SPI1 Spi-1 proto-oncogene involved_in ISO (PMID:30911105) ARUK-UCL PMID:30911105 NCBI chr 1:17,935,037...17,961,638
Ensembl chr 1:17,935,922...17,961,717 		JBrowse link
G TRIM62 tripartite motif containing 62 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:99,697,568...99,731,660
Ensembl chr20:99,698,497...99,731,379 		JBrowse link
positive regulation of cGAS/STING signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BTK Bruton tyrosine kinase involved_in ISO (PMID:25704810) UniProt PMID:25704810 NCBI chr  X:89,690,569...89,727,420 JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 involved_in ISO (PMID:37832545) UniProt PMID:37832545 NCBI chr13:15,284,927...15,360,539
Ensembl chr13:15,284,923...15,360,832 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:89,188,171...89,232,081
Ensembl chr 2:89,188,733...89,209,281 		JBrowse link
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 involved_in ISO (PMID:37832545) UniProt PMID:37832545 NCBI chr19:21,971,362...22,004,289 JBrowse link
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr19:21,988,922...22,002,627 JBrowse link
G ZDHHC9 zinc finger DHHC-type palmitoyltransferase 9 involved_in ISO (PMID:37802025) UniProt PMID:37802025 NCBI chr  X:105,082,531...105,120,802 JBrowse link
G ZDHHC9 zinc finger DHHC-type palmitoyltransferase 9 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr  X:105,090,824...105,120,787 JBrowse link
positive regulation of MDA-5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKRD17 ankyrin repeat domain 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:21,536,241...21,719,320
Ensembl chr 7:21,535,409...21,683,246 		JBrowse link
G DDX60 DExD/H-box helicase 60 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:114,474,678...114,578,749
Ensembl chr 7:114,474,680...114,578,563 		JBrowse link
G DHX58 DExH-box helicase 58 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:64,154,832...64,166,480
Ensembl chr16:64,154,984...64,166,500 		JBrowse link
positive regulation of natural killer cell cytokine production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD160 CD160 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:13,009,168...13,029,766
Ensembl chr20:13,012,460...13,020,466 		JBrowse link
G CD226 CD226 molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24658051) InterPro
MGI
Ensembl		 PMID:24658051 GO_REF:0000002 GO_REF:0000107 NCBI chr18:9,790,483...9,900,376
Ensembl chr18:9,811,168...9,901,830 		JBrowse link
G CLNK cytokine dependent hematopoietic cell linker involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:39,333,435...39,574,050
Ensembl chr27:39,481,226...39,573,795 		JBrowse link
G IL21 interleukin 21 acts_upstream_of_or_within ISO (PMID:14764669) MGI PMID:14764669 NCBI chr 7:69,859,793...69,872,237
Ensembl chr 7:69,863,535...69,872,025 		JBrowse link
G LOC103221837 popy class I histocompatibility antigen, alpha chain E involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:41,940,842...42,692,045
Ensembl chr17:41,941,869...41,946,176 		JBrowse link
G LOC103221863 mamu class I histocompatibility antigen, alpha chain F involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:42,899,211...42,903,274 JBrowse link
G LOC103240146 UL-16 binding protein 5 involved_in ISO (PMID:18544572) UniProt PMID:18544572 NCBI chr13:21,701,503...21,708,851 JBrowse link
G LOC119618283 patr class I histocompatibility antigen, alpha chain E involved_in IEA Ensembl GO_REF:0000107
G RAET1G retinoic acid early transcript 1G involved_in IEA Ensembl GO_REF:0000107 Ensembl chr13:21,702,133...21,715,835 JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP1G1 adaptor related protein complex 1 subunit gamma 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:54,850,831...54,944,915
Ensembl chr 5:54,850,694...54,944,900 		JBrowse link
G CD160 CD160 molecule involved_in ISO (PMID:19109136) UniProt PMID:19109136 NCBI chr20:13,009,168...13,029,766
Ensembl chr20:13,012,460...13,020,466 		JBrowse link
G KLRC2 killer cell lectin like receptor C2 involved_in ISO (PMID:21825173) UniProt PMID:21825173 NCBI chr11:10,266,581...10,277,175 JBrowse link
G LAMP1 lysosomal associated membrane protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:91,295,758...91,319,881
Ensembl chr 3:91,295,681...91,321,333 		JBrowse link
G LOC103221863 mamu class I histocompatibility antigen, alpha chain F involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:42,899,211...42,903,274 JBrowse link
positive regulation of natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP1G1 adaptor related protein complex 1 subunit gamma 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:54,850,831...54,944,915
Ensembl chr 5:54,850,694...54,944,900 		JBrowse link
G CADM1 cell adhesion molecule 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:106,539,262...106,876,397
Ensembl chr 1:106,539,136...106,606,637 		JBrowse link
G CD160 CD160 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:13,009,168...13,029,766
Ensembl chr20:13,012,460...13,020,466 		JBrowse link
G CD226 CD226 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:9,790,483...9,900,376
Ensembl chr18:9,811,168...9,901,830 		JBrowse link
G CRTAM cytotoxic and regulatory T cell molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:114,233,767...114,265,780
Ensembl chr 1:114,234,357...114,265,994 		JBrowse link
G IL12A interleukin 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:30,887,048...30,896,577
Ensembl chr15:30,887,897...30,894,550 		JBrowse link
G IL18RAP interleukin 18 receptor accessory protein acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15843532) MGI
Ensembl		 PMID:15843532 GO_REF:0000107 NCBI chr14:6,081,539...6,114,412
Ensembl chr14:6,085,262...6,114,028 		JBrowse link
G IL21 interleukin 21 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14764669) Ensembl
TreeGrafter
MGI		 PMID:14764669 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:69,859,793...69,872,237
Ensembl chr 7:69,863,535...69,872,025 		JBrowse link
G KLRC1 killer cell lectin like receptor C1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:10,286,280...10,294,853
Ensembl chr11:10,286,787...10,293,585 		JBrowse link
G KLRC2 killer cell lectin like receptor C2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:10,266,581...10,277,175 JBrowse link
G KLRD1 killer cell lectin like receptor D1 involved_in ISO (PMID:9754572) UniProt PMID:9754572 NCBI chr11:10,181,681...10,192,544 JBrowse link
G KLRF2 killer cell lectin like receptor F2 acts_upstream_of_or_within ISO (PMID:10229823), (PMID:10229828) MGI PMID:10229823 PMID:10229828 NCBI chr11:9,765,192...9,781,662
Ensembl chr11:9,766,837...9,781,420 		JBrowse link
G KLRK1 killer cell lectin like receptor K1 involved_in IEA InterPro
Ensembl
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr11:10,207,066...10,223,922
Ensembl chr11:10,207,211...10,223,899 		JBrowse link
G LAG3 lymphocyte activating 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:8602528) MGI
Ensembl		 PMID:8602528 GO_REF:0000107 NCBI chr11:6,809,381...6,815,390
Ensembl chr11:6,809,584...6,815,325 		JBrowse link
G LAMP1 lysosomal associated membrane protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:91,295,758...91,319,881
Ensembl chr 3:91,295,681...91,321,333 		JBrowse link
G LOC103221837 popy class I histocompatibility antigen, alpha chain E involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:41,940,842...42,692,045
Ensembl chr17:41,941,869...41,946,176 		JBrowse link
G LOC103234825 PVR cell adhesion molecule involved_in ISO (PMID:16304049) BHF-UCL PMID:16304049 NCBI chr 6:38,127,864...38,141,612 JBrowse link
G LOC103243413 signal transducer and activator of transcription 5B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9841920) MGI
Ensembl		 PMID:9841920 GO_REF:0000107 NCBI chr16:63,997,486...64,070,392
Ensembl chr16:63,997,441...64,070,445 		JBrowse link
G LOC119618283 patr class I histocompatibility antigen, alpha chain E involved_in IEA Ensembl GO_REF:0000107
G NCR3 natural cytotoxicity triggering receptor 3 involved_in ISO (PMID:16304049) BHF-UCL PMID:16304049
G NECTIN2 nectin cell adhesion molecule 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:38,320,791...38,361,419
Ensembl chr 6:38,320,933...38,361,742 		JBrowse link
G RAET1E retinoic acid early transcript 1E involved_in ISO (PMID:18544572) UniProt PMID:18544572 NCBI chr13:21,728,551...21,755,588 JBrowse link
G RAET1E retinoic acid early transcript 1E involved_in IEA Ensembl GO_REF:0000107 Ensembl chr13:21,738,263...21,740,910 JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 involved_in ISO (PMID:19933860) UniProt PMID:19933860 NCBI chr26:44,405,007...44,483,291 JBrowse link
G RASGRP1 RAS guanyl releasing protein 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr26:44,451,634...44,486,570 JBrowse link
G SH2D1A SH2 domain containing 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19648922)
(PMID:16127454)		 Ensembl
MGI		 PMID:16127454 PMID:19648922 GO_REF:0000107
G SH2D1B SH2 domain containing 1B acts_upstream_of_or_within ISO (PMID:20962259)
(PMID:19648922)		 MGI PMID:19648922 PMID:20962259 NCBI chr20:1,667,247...1,684,951
Ensembl chr20:1,668,588...1,682,949 		JBrowse link
G SLAMF6 SLAM family member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:3,426,868...3,465,553
Ensembl chr20:3,453,370...3,463,901 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO (PMID:9841920) MGI PMID:9841920 NCBI chr16:63,959,265...63,986,627
Ensembl chr16:63,960,515...63,985,026 		JBrowse link
G VAV1 vav guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO (PMID:20962259) MGI PMID:20962259 NCBI chr 6:6,337,255...6,415,851 JBrowse link
G VAV1 vav guanine nucleotide exchange factor 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 6:6,337,599...6,404,449 JBrowse link
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD226 CD226 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:9,790,483...9,900,376
Ensembl chr18:9,811,168...9,901,830 		JBrowse link
G CRTAM cytotoxic and regulatory T cell molecule involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:114,233,767...114,265,780
Ensembl chr 1:114,234,357...114,265,994 		JBrowse link
G IL12A interleukin 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:30,887,048...30,896,577
Ensembl chr15:30,887,897...30,894,550 		JBrowse link
G IL12B interleukin 12B involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:61,714,293...61,731,835 JBrowse link
G LOC103234825 PVR cell adhesion molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:38,127,864...38,141,612 JBrowse link
G NECTIN2 nectin cell adhesion molecule 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:38,320,791...38,361,419
Ensembl chr 6:38,320,933...38,361,742 		JBrowse link
positive regulation of natural killer cell mediated immune response to tumor cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD160 CD160 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:13,009,168...13,029,766
Ensembl chr20:13,012,460...13,020,466 		JBrowse link
positive regulation of natural killer cell mediated immunity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPP4 dipeptidyl peptidase 4 ISO RGD PMID:19327106 RGD:41408336 NCBI chr10:47,396,605...47,481,478
Ensembl chr10:47,394,093...47,480,893 		JBrowse link
G LOC103221837 popy class I histocompatibility antigen, alpha chain E involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:41,940,842...42,692,045
Ensembl chr17:41,941,869...41,946,176 		JBrowse link
G LOC119618283 patr class I histocompatibility antigen, alpha chain E involved_in IEA Ensembl GO_REF:0000107
G RASGRP4 RAS guanyl releasing protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:33,055,161...33,073,153
Ensembl chr 6:33,055,499...33,072,413 		JBrowse link
positive regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAT1 alpha tubulin acetyltransferase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23502856) Ensembl
MGI		 PMID:23502856 GO_REF:0000107 NCBI chr17:41,807,405...41,830,670
Ensembl chr17:41,807,291...41,830,000 		JBrowse link
G BRCC3 BRCA1/BRCA2-containing complex subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:129,358,759...129,406,293
Ensembl chr  X:129,358,862...129,403,352 		JBrowse link
G BTK Bruton tyrosine kinase involved_in ISO (PMID:34554188) UniProt PMID:34554188 NCBI chr  X:89,690,569...89,727,420 JBrowse link
G BTK Bruton tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 Ensembl chr  X:89,690,671...89,711,218 JBrowse link
G CD36 CD36 molecule (CD36 blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:68,214,875...68,309,336
Ensembl chr21:68,216,201...68,268,669 		JBrowse link
G DDX3X DEAD-box helicase 3 X-linked involved_in ISO (PMID:31511697) UniProt PMID:31511697 NCBI chr  X:38,513,251...38,539,982
Ensembl chr  Y:689,380...706,092 		JBrowse link
G DHX33 DEAH-box helicase 33 involved_in ISO (PMID:23871209) UniProt PMID:23871209 NCBI chr16:4,855,374...4,879,892 JBrowse link
G DHX33 DEAH-box helicase 33 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:4,855,652...4,879,902 JBrowse link
G KCNK6 potassium two pore domain channel subfamily K member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:32,959,275...32,977,601
Ensembl chr 6:32,962,535...32,973,196 		JBrowse link
G LATS1 large tumor suppressor kinase 1 involved_in ISO (PMID:39173637) UniProt PMID:39173637 NCBI chr13:21,901,153...21,966,227
Ensembl chr13:21,919,280...21,967,117 		JBrowse link
G LATS2 large tumor suppressor kinase 2 involved_in ISO (PMID:39173637) UniProt PMID:39173637 NCBI chr 3:124,520...215,426 JBrowse link
G LOC103248367 caspase-4 involved_in ISO (PMID:26173909) UniProt PMID:26173909 NCBI chr 1:96,315,781...96,342,057
Ensembl chr 1:96,315,569...96,342,016 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:43,356,603...43,489,066
Ensembl chr 9:43,356,308...43,393,425 		JBrowse link
G MARK4 microtubule affinity regulating kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:38,710,593...38,761,548
Ensembl chr 6:38,710,467...38,760,561 		JBrowse link
G MAVS mitochondrial antiviral signaling protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:34,534,433...34,555,406
Ensembl chr 2:34,541,229...34,552,823 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:1,276,804...1,281,811
Ensembl chr15:1,276,798...1,281,166 		JBrowse link
G NEK7 NIMA related kinase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:31,111,332...31,257,445
Ensembl chr25:31,110,616...31,257,374 		JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in ISO (PMID:29958799) UniProt PMID:29958799 NCBI chr11:116,505,975...116,560,151
Ensembl chr11:116,529,346...116,563,059 		JBrowse link
G PLCG2 phospholipase C gamma 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:32514138) ARUK-UCL
Ensembl		 PMID:32514138 GO_REF:0000107 NCBI chr 5:67,209,268...67,394,865
Ensembl chr 5:67,215,459...67,398,990 		JBrowse link
G PPP2CA protein phosphatase 2 catalytic subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:36,999,110...37,028,916
Ensembl chr23:36,997,078...37,029,280 		JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:19,792,807...19,855,784
Ensembl chr20:19,793,083...19,855,827 		JBrowse link
G STMP1 short transmembrane mitochondrial protein 1 involved_in ISO (PMID:31836654) UniProt PMID:31836654 NCBI chr21:104,340,369...104,352,965 JBrowse link
G TLR4 toll like receptor 4 involved_in ISO (PMID:23812099) UniProt PMID:23812099 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G TLR6 toll like receptor 6 involved_in ISO (PMID:23812099) UniProt PMID:23812099 NCBI chr27:11,439,288...11,461,580
Ensembl chr27:11,459,181...11,461,571 		JBrowse link
G USP50 ubiquitin specific peptidase 50 acts_upstream_of_or_within ISO (PMID:28094437) MGI PMID:28094437 NCBI chr26:32,785,817...32,830,148 JBrowse link
G USP50 ubiquitin specific peptidase 50 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr26:32,786,271...32,792,010 JBrowse link
G ZDHHC1 zinc finger DHHC-type containing 1 involved_in ISO (PMID:39173637) UniProt PMID:39173637 NCBI chr 5:60,040,264...60,062,531
Ensembl chr 5:60,040,266...60,062,548 		JBrowse link
G ZDHHC5 zinc finger DHHC-type palmitoyltransferase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:15,526,735...15,560,562
Ensembl chr 1:15,525,169...15,555,405 		JBrowse link
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC15A4 solute carrier family 15 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:124,170,785...124,204,358
Ensembl chr11:124,169,732...124,204,200 		JBrowse link
G SLC46A2 solute carrier family 46 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:26,631,295...26,646,112
Ensembl chr12:26,633,493...26,646,038 		JBrowse link
G TLR4 toll like receptor 4 acts_upstream_of_or_within ISO (PMID:18261938) MGI PMID:18261938 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103221743 heat shock 70 kDa protein 1A involved_in ISO (PMID:24790089) UniProt PMID:24790089 NCBI chr17:40,191,695...40,194,459
Ensembl chr17:40,203,936...40,205,858 		JBrowse link
G LOC103221745 heat shock 70 kDa protein 1A involved_in ISO (PMID:24790089) UniProt PMID:24790089 NCBI chr17:40,203,647...40,206,028
Ensembl chr17:40,203,936...40,205,858 		JBrowse link
G NAGK N-acetylglucosamine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:36,086,624...36,098,465
Ensembl chr14:36,082,137...36,096,914 		JBrowse link
G PELI3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within ISO (PMID:23892723) MGI PMID:23892723 NCBI chr 1:7,800,430...7,811,226
Ensembl chr 1:7,799,182...7,811,208 		JBrowse link
G SLC15A3 solute carrier family 15 member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:12,896,612...12,910,740
Ensembl chr 1:12,895,982...12,912,214 		JBrowse link
G SLC15A4 solute carrier family 15 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:124,170,785...124,204,358
Ensembl chr11:124,169,732...124,204,200 		JBrowse link
G TLR4 toll like receptor 4 acts_upstream_of_or_within ISO (PMID:18261938) MGI PMID:18261938 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
positive regulation of pattern recognition receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZDHHC5 zinc finger DHHC-type palmitoyltransferase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:15,526,735...15,560,562
Ensembl chr 1:15,525,169...15,555,405 		JBrowse link
positive regulation of respiratory burst involved in inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LBP lipopolysaccharide binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:25,375,364...25,407,181
Ensembl chr 2:25,374,755...25,406,839 		JBrowse link
G RPS19 ribosomal protein S19 involved_in ISO (PMID:15750715) UniProt PMID:15750715 NCBI chr 6:36,067,959...36,085,581 JBrowse link
positive regulation of response to type II interferon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPX hemopexin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18641331) Ensembl
MGI		 PMID:18641331 GO_REF:0000107 NCBI chr 1:58,385,860...58,396,269
Ensembl chr 1:58,386,190...58,396,298 		JBrowse link
positive regulation of RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKRD17 ankyrin repeat domain 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:21,536,241...21,719,320
Ensembl chr 7:21,535,409...21,683,246 		JBrowse link
G DDX60 DExD/H-box helicase 60 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:114,474,678...114,578,749
Ensembl chr 7:114,474,680...114,578,563 		JBrowse link
G DHX58 DExH-box helicase 58 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:64,154,832...64,166,480
Ensembl chr16:64,154,984...64,166,500 		JBrowse link
G OASL 2'-5'-oligoadenylate synthetase like involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:116,376,806...116,396,239
Ensembl chr11:116,376,217...116,395,945 		JBrowse link
G PUM1 pumilio RNA binding family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:101,773,819...101,910,433
Ensembl chr20:101,773,960...101,910,519 		JBrowse link
G PUM2 pumilio RNA binding family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:87,368,288...87,473,282
Ensembl chr14:87,391,219...87,474,676 		JBrowse link
G TRIM15 tripartite motif containing 15 involved_in ISO (PMID:23077300) UniProt PMID:23077300 NCBI chr17:42,334,910...42,345,895 JBrowse link
G TRIM15 tripartite motif containing 15 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr17:42,335,630...42,343,745 JBrowse link
G USP15 ubiquitin specific peptidase 15 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:58,154,905...58,300,431
Ensembl chr11:58,154,919...58,300,522 		JBrowse link
G ZC3HAV1 zinc finger CCCH-type containing, antiviral 1 involved_in ISO (PMID:21102435) UniProt PMID:21102435 NCBI chr21:107,770,270...107,808,575 JBrowse link
G ZCCHC3 zinc finger CCHC-type containing 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:35,422,903...35,426,145
Ensembl chr 2:35,423,430...35,424,638 		JBrowse link
positive regulation of toll-like receptor 13 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103222345 trem-like transcript 4 protein involved_in ISO (PMID:25848864) UniProt PMID:25848864 NCBI chr17:30,907,797...30,923,226
Ensembl chr17:30,915,052...30,923,486 		JBrowse link
positive regulation of toll-like receptor 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:71,095,446...71,109,832
Ensembl chr 4:71,095,500...71,110,005 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:16267105) UniProt PMID:16267105 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G LOC103233451 cytochrome b-245 light chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:74,023,134...74,030,793
Ensembl chr 5:74,023,082...74,030,750 		JBrowse link
G MFHAS1 multifunctional ROCO family signaling regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:10,158,951...10,268,286
Ensembl chr 8:10,159,421...10,268,323 		JBrowse link
G PJA2 praja ring finger ubiquitin ligase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:12,753,505...12,825,279
Ensembl chr23:12,753,513...12,796,482 		JBrowse link
G TIRAP TIR domain containing adaptor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:117,417,561...117,419,870 JBrowse link
G TLR1 toll like receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:11,482,307...11,490,847
Ensembl chr27:11,488,294...11,490,654 		JBrowse link
positive regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV1 caveolin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:85,222,724...85,258,562
Ensembl chr21:85,222,879...85,258,627 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:71,095,446...71,109,832
Ensembl chr 4:71,095,500...71,110,005 		JBrowse link
G FLOT1 flotillin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:41,714,354...41,725,820
Ensembl chr17:41,714,402...41,725,397 		JBrowse link
G PELI1 pellino E3 ubiquitin protein ligase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19734906) Ensembl
MGI		 PMID:19734906 GO_REF:0000107 NCBI chr14:42,864,857...42,930,315
Ensembl chr14:42,864,897...42,930,394 		JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:19,792,807...19,855,784
Ensembl chr20:19,793,083...19,855,827 		JBrowse link
G TIRAP TIR domain containing adaptor protein involved_in ISO (PMID:17322885) BHF-UCL PMID:17322885 NCBI chr 1:117,417,561...117,419,870 JBrowse link
G TRIM3 tripartite motif containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:58,353,338...58,378,959
Ensembl chr 1:58,354,117...58,379,100 		JBrowse link
G WDFY1 WD repeat and FYVE domain containing 1 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:109,815,043...109,889,120
Ensembl chr10:109,818,422...109,889,023 		JBrowse link
positive regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:43,264,917...43,266,825
Ensembl chr23:43,264,336...43,266,993 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:71,095,446...71,109,832
Ensembl chr 4:71,095,500...71,110,005 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:16267105) UniProt PMID:16267105 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G IFI35 interferon induced protein 35 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:63,276,493...63,284,196
Ensembl chr16:63,273,829...63,284,283 		JBrowse link
G LBP lipopolysaccharide binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:25,375,364...25,407,181
Ensembl chr 2:25,374,755...25,406,839 		JBrowse link
G LTF lactotransferrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:7,867,332...7,896,403
Ensembl chr22:7,867,286...7,894,521 		JBrowse link
G NINJ1 ninjurin 1 involved_in ISO (PMID:25860173) UniProt PMID:25860173 NCBI chr12:103,509,950...103,523,158
Ensembl chr12:103,510,454...103,523,084 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:18,041,495...18,061,196
Ensembl chr 1:18,041,830...18,051,501 		JBrowse link
G PELI1 pellino E3 ubiquitin protein ligase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19734906) Ensembl
MGI		 PMID:19734906 GO_REF:0000107 NCBI chr14:42,864,857...42,930,315
Ensembl chr14:42,864,897...42,930,394 		JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:19,792,807...19,855,784
Ensembl chr20:19,793,083...19,855,827 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:18,831,361...18,855,476
Ensembl chr23:18,833,262...18,833,969 		JBrowse link
G TIRAP TIR domain containing adaptor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:117,417,561...117,419,870 JBrowse link
G WDFY1 WD repeat and FYVE domain containing 1 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:109,815,043...109,889,120
Ensembl chr10:109,818,422...109,889,023 		JBrowse link
G ZNRF1 zinc and ring finger 1 involved_in ISO (PMID:28593998) UniProt PMID:28593998 NCBI chr 5:60,568,582...60,590,699 JBrowse link
G ZNRF1 zinc and ring finger 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 5:52,702,740...52,703,165 JBrowse link
positive regulation of toll-like receptor 7 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDX3X DEAD-box helicase 3 X-linked involved_in ISO (PMID:30341167) UniProt PMID:30341167 NCBI chr  X:38,513,251...38,539,982
Ensembl chr  Y:689,380...706,092 		JBrowse link
G DDX3X DEAD-box helicase 3 X-linked involved_in IEA Ensembl GO_REF:0000107 Ensembl chr  X:38,512,983...38,525,055 JBrowse link
G LOC103222345 trem-like transcript 4 protein involved_in ISO (PMID:25848864) UniProt PMID:25848864 NCBI chr17:30,907,797...30,923,226
Ensembl chr17:30,915,052...30,923,486 		JBrowse link
G LOC119623506 trem-like transcript 4 protein involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118
G PTPN22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:19,792,807...19,855,784
Ensembl chr20:19,793,083...19,855,827 		JBrowse link
G RSAD2 radical S-adenosyl methionine domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:100,778,801...100,804,205
Ensembl chr14:100,778,302...100,798,044 		JBrowse link
G SLC15A4 solute carrier family 15 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:124,170,785...124,204,358
Ensembl chr11:124,169,732...124,204,200 		JBrowse link
G TASL TLR adaptor interacting with endolysosomal SLC15A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:28,953,805...28,973,055
Ensembl chr  X:28,954,266...28,955,171 		JBrowse link
positive regulation of toll-like receptor 8 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDX3X DEAD-box helicase 3 X-linked involved_in ISO (PMID:30341167) UniProt PMID:30341167 NCBI chr  X:38,513,251...38,539,982
Ensembl chr  Y:689,380...706,092 		JBrowse link
G DDX3X DEAD-box helicase 3 X-linked involved_in IEA Ensembl GO_REF:0000107 Ensembl chr  X:38,512,983...38,525,055 JBrowse link
G SLC15A4 solute carrier family 15 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:124,170,785...124,204,358
Ensembl chr11:124,169,732...124,204,200 		JBrowse link
G TASL TLR adaptor interacting with endolysosomal SLC15A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:28,953,805...28,973,055
Ensembl chr  X:28,954,266...28,955,171 		JBrowse link
positive regulation of toll-like receptor 9 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103222345 trem-like transcript 4 protein involved_in ISO (PMID:25848864) UniProt PMID:25848864 NCBI chr17:30,907,797...30,923,226
Ensembl chr17:30,915,052...30,923,486 		JBrowse link
G LOC103227720 twinfilin-2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:13,581,102...13,598,830
Ensembl chr22:13,589,034...13,598,752
Ensembl chr22:13,589,034...13,598,752 		JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:19,792,807...19,855,784
Ensembl chr20:19,793,083...19,855,827 		JBrowse link
G RSAD2 radical S-adenosyl methionine domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:100,778,801...100,804,205
Ensembl chr14:100,778,302...100,798,044 		JBrowse link
G RTN4 reticulon 4 involved_in ISO (PMID:25917084) UniProt PMID:25917084 NCBI chr14:51,876,697...51,955,788 JBrowse link
G SLC15A4 solute carrier family 15 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:124,170,785...124,204,358
Ensembl chr11:124,169,732...124,204,200 		JBrowse link
G ZDHHC3 zinc finger DHHC-type palmitoyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:6,391,980...6,452,079
Ensembl chr22:6,403,431...6,452,037 		JBrowse link
positive regulation of toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GDI1 GDP dissociation inhibitor 1 involved_in IEA Ensembl GO_REF:0000107
G LRCH4 leucine rich repeats and calponin homology domain containing 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:12,627,666...12,639,312
Ensembl chr28:12,627,712...12,638,228 		JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (PMID:20728433) UniProt PMID:20728433 NCBI chr 9:89,750,792...89,875,309 JBrowse link
positive regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FADD Fas associated via death domain involved_in ISO (PMID:21109225) UniProt PMID:21109225 NCBI chr 1:4,358,314...4,361,863 JBrowse link
G IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:22,865,720...22,892,346
Ensembl chr25:22,865,734...22,891,920 		JBrowse link
G IRF3 interferon regulatory factor 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17618271) MGI
Ensembl		 PMID:17618271 GO_REF:0000107 NCBI chr 6:42,835,285...42,841,487
Ensembl chr 6:42,831,203...42,840,796 		JBrowse link
G IRF7 interferon regulatory factor 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17618271) Ensembl
MGI		 PMID:17618271 GO_REF:0000107 NCBI chr 1:430,412...433,959
Ensembl chr 1:429,310...432,925 		JBrowse link
G LOC103232103 protein LSM14 homolog A-like involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:56,502,326...56,504,163 JBrowse link
G LSM14A LSM14A mRNA processing body assembly factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22745163) Ensembl
MGI		 PMID:22745163 GO_REF:0000107 NCBI chr 6:29,211,582...29,266,793
Ensembl chr 6:29,211,785...29,266,981 		JBrowse link
G MAVS mitochondrial antiviral signaling protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:34,534,433...34,555,406
Ensembl chr 2:34,541,229...34,552,823 		JBrowse link
G MMP12 matrix metallopeptidase 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:94,243,061...94,261,035
Ensembl chr 1:94,243,875...94,259,591 		JBrowse link
G NLRC5 NLR family CARD domain containing 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:42,942,875...43,035,043
Ensembl chr 5:42,974,300...43,035,351 		JBrowse link
G RBM47 RNA binding motif protein 47 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:9,683,026...9,888,245
Ensembl chr27:9,873,138...9,888,239 		JBrowse link
G RNF185 ring finger protein 185 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:14,050,271...14,095,819
Ensembl chr19:14,076,113...14,093,410 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:42,153,576...42,160,903
Ensembl chr23:42,153,026...42,160,907 		JBrowse link
G TBK1 TANK binding kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:60,136,162...60,182,354
Ensembl chr11:60,136,232...60,182,344 		JBrowse link
G TRIM41 tripartite motif containing 41 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:82,786,967...82,798,993
Ensembl chr23:82,787,021...82,798,588 		JBrowse link
G TRIM42 tripartite motif containing 42 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:49,859,731...49,883,086
Ensembl chr15:49,869,281...49,882,176 		JBrowse link
G TRIM56 tripartite motif containing 56 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr28:12,093,927...12,099,490
Ensembl chr28:12,095,421...12,097,688 		JBrowse link
G TRIM6 tripartite motif containing 6 involved_in ISO (PMID:24882218) UniProt PMID:24882218 NCBI chr 1:61,136,690...61,147,911 JBrowse link
G UBE2K ubiquitin conjugating enzyme E2 K involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:10,535,091...10,618,659
Ensembl chr27:10,539,402...10,618,573 		JBrowse link
G USP27X ubiquitin specific peptidase 27 X-linked involved_in ISO (PMID:31534008) UniProt PMID:31534008 NCBI chr  X:46,718,329...46,728,205 JBrowse link
G USP27X ubiquitin specific peptidase 27 X-linked involved_in IEA Ensembl GO_REF:0000107 Ensembl chr  X:46,726,133...46,727,449 JBrowse link
G USP29 ubiquitin specific peptidase 29 involved_in ISO (PMID:32457395) UniProt PMID:32457395 NCBI chr 6:49,539,006...49,557,565
Ensembl chr 6:49,554,341...49,557,079 		JBrowse link
G WNT5A Wnt family member 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:16,809,454...16,836,815
Ensembl chr22:16,809,451...16,825,048 		JBrowse link
G ZBP1 Z-DNA binding protein 1 acts_upstream_of_or_within ISO (PMID:17618271) MGI PMID:17618271 NCBI chr 2:6,494,410...6,510,928 JBrowse link
positive regulation of type II interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPX hemopexin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18641331) Ensembl
MGI		 PMID:18641331 GO_REF:0000107 NCBI chr 1:58,385,860...58,396,269
Ensembl chr 1:58,386,190...58,396,298 		JBrowse link
G IRGM immunity related GTPase M involved_in ISO (PMID:16888103) UniProt PMID:16888103 NCBI chr23:53,449,576...53,451,373 JBrowse link
G MED1 mediator complex subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18339625) Ensembl
MGI		 PMID:18339625 GO_REF:0000107 NCBI chr16:66,719,393...66,764,902
Ensembl chr16:66,719,423...66,762,896 		JBrowse link
G NLRC5 NLR family CARD domain containing 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:42,942,875...43,035,043
Ensembl chr 5:42,974,300...43,035,351 		JBrowse link
G PARP9 poly(ADP-ribose) polymerase family member 9 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr22:58,297,526...58,336,243
Ensembl chr22:58,298,046...58,337,124 		JBrowse link
G TXK TXK tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:2,120,429...2,186,950
Ensembl chr27:2,140,685...2,190,398 		JBrowse link
regulation of MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IRF1 interferon regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:35,309,058...35,317,765
Ensembl chr23:35,307,772...35,316,763 		JBrowse link
G IRF7 interferon regulatory factor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:430,412...433,959
Ensembl chr 1:429,310...432,925 		JBrowse link
regulation of MyD88-independent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IRF7 interferon regulatory factor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:430,412...433,959
Ensembl chr 1:429,310...432,925 		JBrowse link
regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:70,246,081...70,290,851
Ensembl chr14:70,247,168...70,296,463 		JBrowse link
G KCNK13 potassium two pore domain channel subfamily K member 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:67,782,523...67,912,950
Ensembl chr24:67,781,977...67,913,195 		JBrowse link
regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC15A2 solute carrier family 15 member 2 involved_in ISO (PMID:29784761) UniProt PMID:29784761 NCBI chr22:58,916,389...58,966,725
Ensembl chr22:58,913,676...58,966,906 		JBrowse link
G SLC15A4 solute carrier family 15 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:124,170,785...124,204,358
Ensembl chr11:124,169,732...124,204,200 		JBrowse link
regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PELI3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within ISO (PMID:23892723) MGI PMID:23892723 NCBI chr 1:7,800,430...7,811,226
Ensembl chr 1:7,799,182...7,811,208 		JBrowse link
regulation of RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOP53 NOP53 ribosome biogenesis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:41,058,199...41,070,220
Ensembl chr 6:41,057,906...41,071,202 		JBrowse link
regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLOT2 flotillin 2 NOT|involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chr16:22,639,403...22,658,311
Ensembl chr16:22,639,381...22,658,194 		JBrowse link
G HCFC2 host cell factor C2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:28970238) MGI
Ensembl		 PMID:28970238 GO_REF:0000107 NCBI chr11:99,264,638...99,303,923
Ensembl chr11:99,264,674...99,303,732 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:26,344,480...26,367,448
Ensembl chr 2:26,343,450...26,367,776 		JBrowse link
regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:18,546,694...18,591,239
Ensembl chr22:18,546,751...18,589,552 		JBrowse link
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:100,400,093...100,469,234
Ensembl chr11:100,400,084...100,462,507 		JBrowse link
G FLOT1 flotillin 1 NOT|involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chr17:41,714,354...41,725,820
Ensembl chr17:41,714,402...41,725,397 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:64,321,296...64,406,188
Ensembl chr 4:64,321,078...64,406,519 		JBrowse link
regulation of toll-like receptor 6 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:31134514) ARUK-UCL PMID:31134514 NCBI chr17:30,965,091...30,999,073
Ensembl chr17:30,994,357...30,999,087 		JBrowse link
regulation of toll-like receptor 9 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FCRL3 Fc receptor like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:6,201,252...6,223,913
Ensembl chr20:6,202,200...6,224,479 		JBrowse link
regulation of toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein involved_in ISO (PMID:20037584) ARUK-UCL PMID:20037584 NCBI chr 2:66,037,224...66,320,860
Ensembl chr 2:66,037,261...66,321,306 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:68,214,875...68,309,336
Ensembl chr21:68,216,201...68,268,669 		JBrowse link
G ESR1 estrogen receptor 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:22659029) MGI
Ensembl		 PMID:22659029 GO_REF:0000107 NCBI chr13:79,153,418...79,554,552
Ensembl chr13:79,270,265...79,554,549 		JBrowse link
G GFI1 growth factor independent 1 transcriptional repressor involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:40,771,238...40,786,008
Ensembl chr20:40,776,816...40,783,717 		JBrowse link
G MFHAS1 multifunctional ROCO family signaling regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:10,158,951...10,268,286
Ensembl chr 8:10,159,421...10,268,323 		JBrowse link
G TASL TLR adaptor interacting with endolysosomal SLC15A4 involved_in IEA InterPro GO_REF:0000002 NCBI chr  X:28,953,805...28,973,055
Ensembl chr  X:28,954,266...28,955,171 		JBrowse link
RIG-I signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLPB ClpB family mitochondrial disaggregase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:63,520,305...63,667,237
Ensembl chr 1:63,515,814...63,667,105 		JBrowse link
G LOC103232103 protein LSM14 homolog A-like involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:56,502,326...56,504,163 JBrowse link
G LOC103232243 prohibitin-2-like involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:67,716,566...67,718,426 JBrowse link
G LSM14A LSM14A mRNA processing body assembly factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22745163) Ensembl
MGI		 PMID:22745163 GO_REF:0000107 NCBI chr 6:29,211,582...29,266,793
Ensembl chr 6:29,211,785...29,266,981 		JBrowse link
G MAVS mitochondrial antiviral signaling protein acts_upstream_of_or_within ISO (PMID:22745163) MGI PMID:22745163 NCBI chr 2:34,534,433...34,555,406
Ensembl chr 2:34,541,229...34,552,823 		JBrowse link
G OAS3 2'-5'-oligoadenylate synthetase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:108,192,595...108,210,332
Ensembl chr11:108,192,509...108,213,333 		JBrowse link
G PHB1 prohibitin 1 involved_in ISO (PMID:31522117) UniProt PMID:31522117 NCBI chr16:69,805,968...69,816,792
Ensembl chr16:69,806,923...69,816,754 		JBrowse link
G PHB2 prohibitin 2 involved_in ISO (PMID:31522117) UniProt PMID:31522117 NCBI chr11:6,998,517...7,004,437 JBrowse link
G RIGI RNA sensor RIG-I involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:47,729,040...47,800,995
Ensembl chr12:47,729,076...47,799,570 		JBrowse link
G RNF135 ring finger protein 135 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:25,677,632...25,700,769
Ensembl chr16:25,678,197...25,700,061 		JBrowse link
G TRIM25 tripartite motif containing 25 NOT|involved_in ISO (PMID:31006531) UniProt PMID:31006531 NCBI chr16:36,496,829...36,522,427
Ensembl chr16:36,496,772...36,524,148 		JBrowse link
stimulatory C-type lectin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLEC6A C-type lectin domain containing 6A involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:8,227,590...8,250,857
Ensembl chr11:8,228,381...8,253,159 		JBrowse link
G CLEC7A C-type lectin domain containing 7A involved_in ISO (PMID:19136564) ARUK-UCL PMID:19136564 NCBI chr11:9,989,520...10,007,442
Ensembl chr11:9,995,203...10,006,746 		JBrowse link
G KLRC1 killer cell lectin like receptor C1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:10,286,280...10,294,853
Ensembl chr11:10,286,787...10,293,585 		JBrowse link
G KLRC2 killer cell lectin like receptor C2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:10,266,581...10,277,175 JBrowse link
G KLRD1 killer cell lectin like receptor D1 involved_in ISO (PMID:9655483) UniProt PMID:9655483 NCBI chr11:10,181,681...10,192,544 JBrowse link
G KLRK1 killer cell lectin like receptor K1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:10,207,066...10,223,922
Ensembl chr11:10,207,211...10,223,899 		JBrowse link
G PLCG2 phospholipase C gamma 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:67,209,268...67,394,865
Ensembl chr 5:67,215,459...67,398,990 		JBrowse link
G SYK spleen associated tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:101,254,085...101,374,724
Ensembl chr12:101,260,061...101,349,856 		JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:30,816,675...30,820,816
Ensembl chr 6:30,816,678...30,820,597 		JBrowse link
stimulatory killer cell immunoglobulin-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:30,816,675...30,820,816
Ensembl chr 6:30,816,678...30,820,597 		JBrowse link
susceptibility to natural killer cell mediated cytotoxicity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CADM1 cell adhesion molecule 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:106,539,262...106,876,397
Ensembl chr 1:106,539,136...106,606,637 		JBrowse link
G LOC103234825 PVR cell adhesion molecule involved_in ISO (PMID:12913096) BHF-UCL PMID:12913096 NCBI chr 6:38,127,864...38,141,612 JBrowse link
G LOC103240141 UL16-binding protein 1 acts_upstream_of_or_within ISO (PMID:12645935) MGI PMID:12645935 NCBI chr13:21,625,381...21,638,933
Ensembl chr13:21,629,092...21,636,623 		JBrowse link
G NECTIN2 nectin cell adhesion molecule 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:38,320,791...38,361,419
Ensembl chr 6:38,320,933...38,361,742 		JBrowse link
TIRAP-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TIRAP TIR domain containing adaptor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:117,417,561...117,419,870 JBrowse link
toll-like receptor 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMGB1 high mobility group box 1 involved_in ISO (PMID:14660645) UniProt PMID:14660645 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10549626) Ensembl
MGI		 PMID:10549626 GO_REF:0000107 NCBI chr  X:128,433,462...128,443,126
Ensembl chr  X:128,433,465...128,443,043 		JBrowse link
G LOC103242599 galectin-9 NOT|involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chr16:21,421,034...21,439,583 JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:15220916) MGI
Ensembl		 PMID:15220916 GO_REF:0000107 NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499 		JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (PMID:22187460) UniProt PMID:22187460 NCBI chr 9:89,750,792...89,875,309 JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 9:89,783,883...89,875,226 JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11894098) MGI
Ensembl		 PMID:11894098 GO_REF:0000107 NCBI chr 8:84,843,391...84,881,087
Ensembl chr 8:84,843,471...84,881,303 		JBrowse link
G TLR2 toll like receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
G TNIP2 TNFAIP3 interacting protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr27:46,001,814...46,017,676
Ensembl chr27:46,001,872...46,018,494 		JBrowse link
toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD86 CD86 molecule involved_in ISO (PMID:25158758) UniProt PMID:25158758 NCBI chr22:58,741,534...58,805,417
Ensembl chr22:58,741,525...58,805,366 		JBrowse link
G COLEC12 collectin subfamily member 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:59,701,131...59,884,445
Ensembl chr18:59,699,348...59,884,461 		JBrowse link
G HAVCR2 hepatitis A virus cellular receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:59,479,794...59,501,532
Ensembl chr23:59,475,826...59,500,836 		JBrowse link
G LOC103242599 galectin-9 involved_in ISO PMID:25158758 UniProt PMID:25158758 RGD:10054077 NCBI chr16:21,421,034...21,439,583 JBrowse link
G OAS1 2'-5'-oligoadenylate synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:108,163,203...108,176,191
Ensembl chr11:108,163,299...108,176,193 		JBrowse link
G RFTN1 raftlin, lipid raft linker 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:21266579) MGI
Ensembl		 PMID:21266579 GO_REF:0000107 NCBI chr15:61,159,573...61,290,342
Ensembl chr15:61,159,930...61,289,965 		JBrowse link
G RNF170 ring finger protein 170 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:31076723) MGI
Ensembl		 PMID:31076723 GO_REF:0000107 NCBI chr 8:40,852,995...40,896,800
Ensembl chr 8:40,850,552...40,896,887 		JBrowse link
G SCARA3 scavenger receptor class A member 3 NOT|involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chr 8:25,741,988...25,779,224
Ensembl chr 8:25,742,127...25,782,247 		JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in ISO (PMID:28098138) UniProt PMID:28098138 NCBI chr16:4,616,325...4,643,791 JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:4,617,279...4,628,308 JBrowse link
G TICAM1 toll like receptor adaptor molecule 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:4,526,719...4,543,251
Ensembl chr 6:4,527,033...4,529,168 		JBrowse link
G TLR3 toll like receptor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:131,991,068...132,014,366
Ensembl chr 7:131,991,029...132,016,232 		JBrowse link
G TNF tumor necrosis factor involved_in ISO PMID:25158758 UniProt PMID:25158758 RGD:10054077
G TNIP2 TNFAIP3 interacting protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr27:46,001,814...46,017,676
Ensembl chr27:46,001,872...46,018,494 		JBrowse link
G UNC93B1 unc-93 homolog B1, TLR signaling regulator involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:6,537,198...6,549,457
Ensembl chr 1:6,537,273...6,549,450 		JBrowse link
toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr23:43,264,917...43,266,825
Ensembl chr23:43,264,336...43,266,993 		JBrowse link
G CD180 CD180 molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 4:63,361,277...63,377,492
Ensembl chr 4:63,359,844...63,377,459 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:93,219,374...93,263,077
Ensembl chr 9:93,219,383...93,262,700 		JBrowse link
G ECSIT ECSIT signaling integrator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:10,430,333...10,440,047
Ensembl chr 6:10,430,446...10,439,830 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:14660645) UniProt PMID:14660645 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 acts_upstream_of_or_within ISO (PMID:10549626) MGI PMID:10549626 NCBI chr  X:128,433,462...128,443,126
Ensembl chr  X:128,433,465...128,443,043 		JBrowse link
G IRAK2 interleukin 1 receptor associated kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:46,204,600...46,279,863
Ensembl chr22:46,204,893...46,278,260 		JBrowse link
G IRF3 interferon regulatory factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:42,835,285...42,841,487
Ensembl chr 6:42,831,203...42,840,796 		JBrowse link
G LOC103242599 galectin-9 NOT|involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chr16:21,421,034...21,439,583 JBrowse link
G LY96 lymphocyte antigen 96 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:69,591,885...69,629,939
Ensembl chr 8:69,591,941...69,630,274 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:51,919,656...52,057,376
Ensembl chr 8:51,919,808...52,057,959 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:15,284,927...15,360,539
Ensembl chr13:15,284,923...15,360,832 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr15:1,276,804...1,281,811
Ensembl chr15:1,276,798...1,281,166 		JBrowse link
G NAGLU N-acetyl-alpha-glucosaminidase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29624734) Ensembl
MGI		 PMID:29624734 GO_REF:0000107 NCBI chr16:63,735,411...63,744,365 JBrowse link
G NFKBIA NFKB inhibitor alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18261938) Ensembl
TreeGrafter
MGI		 PMID:18261938 GO_REF:0000107 GO_REF:0000118 NCBI chr24:12,211,619...12,216,185
Ensembl chr24:12,210,281...12,214,854 		JBrowse link
G NMI N-myc and STAT interactor involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:36,702,056...36,722,494
Ensembl chr10:36,702,068...36,715,809 		JBrowse link
G OAS1 2'-5'-oligoadenylate synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:108,163,203...108,176,191
Ensembl chr11:108,163,299...108,176,193 		JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (PMID:22187458), (PMID:22187460) UniProt PMID:22187458 PMID:22187460 NCBI chr 9:89,750,792...89,875,309 JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 9:89,783,883...89,875,226 JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:8,576,059...8,585,561
Ensembl chr 1:8,576,542...8,586,516 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11894098) Ensembl
MGI		 PMID:11894098 GO_REF:0000107 NCBI chr 8:84,843,391...84,881,087
Ensembl chr 8:84,843,471...84,881,303 		JBrowse link
G S100A14 S100 calcium binding protein A14 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:10,188,016...10,190,973
Ensembl chr20:10,188,866...10,190,979 		JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in ISO (PMID:28098138) UniProt PMID:28098138 NCBI chr16:4,616,325...4,643,791 JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:4,617,279...4,628,308 JBrowse link
G TBK1 TANK binding kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:60,136,162...60,182,354
Ensembl chr11:60,136,232...60,182,344 		JBrowse link
G TICAM1 toll like receptor adaptor molecule 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:4,526,719...4,543,251
Ensembl chr 6:4,527,033...4,529,168 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:18,831,361...18,855,476
Ensembl chr23:18,833,262...18,833,969 		JBrowse link
G TIRAP TIR domain containing adaptor protein involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:117,417,561...117,419,870 JBrowse link
G TLR4 toll like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25549946) Ensembl
TreeGrafter
MGI		 PMID:25549946 GO_REF:0000107 GO_REF:0000118 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G TMEM126A transmembrane protein 126A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25549946) Ensembl
MGI		 PMID:25549946 GO_REF:0000107 NCBI chr 1:76,888,688...76,897,883
Ensembl chr 1:76,888,734...76,897,841 		JBrowse link
G TNIP3 TNFAIP3 interacting protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:68,416,674...68,519,097
Ensembl chr 7:68,422,328...68,454,143 		JBrowse link
G TRAF3 TNF receptor associated factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:80,735,234...80,872,104
Ensembl chr24:80,789,699...80,866,480 		JBrowse link
G TRAF6 TNF receptor associated factor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:28,726,357...28,752,389
Ensembl chr 1:28,734,380...28,747,092 		JBrowse link
G TRIL TLR4 interactor with leucine rich repeats involved_in ISO (PMID:19710467) UniProt PMID:19710467 NCBI chr21:29,416,135...29,421,192 JBrowse link
toll-like receptor 5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYD88 MYD88 innate immune signal transduction adaptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:1,276,804...1,281,811
Ensembl chr15:1,276,798...1,281,166 		JBrowse link
G TIRAP TIR domain containing adaptor protein NOT|involved_in ISO (PMID:12447442) BHF-UCL PMID:12447442 NCBI chr 1:117,417,561...117,419,870 JBrowse link
G TLR5 toll like receptor 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:6,418,895...6,440,433
Ensembl chr25:6,437,638...6,440,211 		JBrowse link
toll-like receptor 7 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAVCR2 hepatitis A virus cellular receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:59,479,794...59,501,532
Ensembl chr23:59,475,826...59,500,836 		JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (PMID:22187458) UniProt PMID:22187458 NCBI chr 9:89,750,792...89,875,309 JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 9:89,783,883...89,875,226 JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in ISO (PMID:28098138) UniProt PMID:28098138 NCBI chr16:4,616,325...4,643,791 JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:4,617,279...4,628,308 JBrowse link
G TLR7 toll like receptor 7 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:11,348,520...11,372,132 JBrowse link
G UNC93B1 unc-93 homolog B1, TLR signaling regulator involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:6,537,198...6,549,457
Ensembl chr 1:6,537,273...6,549,450 		JBrowse link
toll-like receptor 8 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYD88 MYD88 innate immune signal transduction adaptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:1,276,804...1,281,811
Ensembl chr15:1,276,798...1,281,166 		JBrowse link
G TLR7 toll like receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:11,348,520...11,372,132 JBrowse link
G TLR8 toll like receptor 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:11,387,933...11,405,056
Ensembl chr  X:11,400,907...11,404,029 		JBrowse link
toll-like receptor 9 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EPG5 ectopic P-granules 5 autophagy tethering factor acts_upstream_of_positive_effect
involved_in		 ISO
IEA		 (PMID:29130391) UniProt
Ensembl		 PMID:29130391 GO_REF:0000107 NCBI chr18:34,946,778...35,065,449
Ensembl chr18:34,946,796...35,060,595 		JBrowse link
G HAVCR2 hepatitis A virus cellular receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:59,479,794...59,501,532
Ensembl chr23:59,475,826...59,500,836 		JBrowse link
G LOC103227720 twinfilin-2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:13,581,102...13,598,830
Ensembl chr22:13,589,034...13,598,752
Ensembl chr22:13,589,034...13,598,752 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:95,792,428...95,877,989
Ensembl chr11:95,792,996...95,878,293 		JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (PMID:22187458), (PMID:22187460) UniProt PMID:22187458 PMID:22187460 NCBI chr 9:89,750,792...89,875,309 JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 9:89,783,883...89,875,226 JBrowse link
G TNIP2 TNFAIP3 interacting protein 2 involved_in ISO (PMID:16633345) UniProt PMID:16633345 NCBI chr27:46,001,814...46,017,676
Ensembl chr27:46,001,872...46,018,494 		JBrowse link
G UNC93B1 unc-93 homolog B1, TLR signaling regulator involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:6,537,198...6,549,457
Ensembl chr 1:6,537,273...6,549,450 		JBrowse link
toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP3B1 adaptor related protein complex 3 subunit beta 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:20847273) MGI
Ensembl		 PMID:20847273 GO_REF:0000107 NCBI chr 4:72,225,658...72,524,971
Ensembl chr 4:72,225,599...72,524,933 		JBrowse link
G BCL10 BCL10 immune signaling adaptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:48,073,489...48,084,635
Ensembl chr20:48,073,800...48,085,136 		JBrowse link
G CD86 CD86 molecule acts_upstream_of_or_within ISO (PMID:19734906) MGI PMID:19734906 NCBI chr22:58,741,534...58,805,417
Ensembl chr22:58,741,525...58,805,366 		JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:30990796) Ensembl
MGI		 PMID:30990796 GO_REF:0000107 NCBI chr 1:8,356,263...8,365,606
Ensembl chr 1:8,356,836...8,364,918 		JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 ISO RGD PMID:27832756 RGD:34888235 NCBI chr11:61,868,817...61,920,896
Ensembl chr11:61,869,173...61,920,406 		JBrowse link
G LOC103227720 twinfilin-2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr22:13,581,102...13,598,830
Ensembl chr22:13,589,034...13,598,752
Ensembl chr22:13,589,034...13,598,752 		JBrowse link
G LY96 lymphocyte antigen 96 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:69,591,885...69,629,939
Ensembl chr 8:69,591,941...69,630,274 		JBrowse link
G MAPKAPK2 MAPK activated protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:22,632,180...22,681,250
Ensembl chr25:22,629,729...22,681,373 		JBrowse link
G MAPKAPK3 MAPK activated protein kinase 3 involved_in ISO (PMID:17906627) UniProt PMID:17906627 NCBI chr22:11,998,774...12,036,477 JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:79,044,624...79,077,736
Ensembl chr22:79,044,619...79,055,776 		JBrowse link
G PLCG2 phospholipase C gamma 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:67,209,268...67,394,865
Ensembl chr 5:67,215,459...67,398,990 		JBrowse link
G RPS6KA3 ribosomal protein S6 kinase A3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:18,614,664...18,730,591
Ensembl chr  X:18,620,159...18,730,581 		JBrowse link
G TICAM1 toll like receptor adaptor molecule 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:4,526,719...4,543,251
Ensembl chr 6:4,527,033...4,529,168 		JBrowse link
G TIFAB TIFA inhibitor acts_upstream_of_negative_effect ISO (PMID:26458771) MGI PMID:26458771 NCBI chr23:38,228,904...38,232,892 JBrowse link
G TIFAB TIFA inhibitor involved_in IEA Ensembl GO_REF:0000107 Ensembl chr23:38,229,485...38,232,210 JBrowse link
G TLR1 toll like receptor 1 involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl
InterPro		 PMID:16973131 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1643119 NCBI chr27:11,482,307...11,490,847
Ensembl chr27:11,488,294...11,490,654 		JBrowse link
G TLR10 toll like receptor 10 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr27:11,486,273...11,515,841
Ensembl chr27:11,512,239...11,514,671 		JBrowse link
G TLR2 toll like receptor 2 involved_in ISO
IEA		 RGD
Ensembl
TreeGrafter
UniProt
InterPro		 PMID:16973131 PMID:18353287 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1643119 RGD:5684896 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
G TLR3 toll like receptor 3 involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:16973131 GO_REF:0000107 GO_REF:0000118 RGD:1643119 NCBI chr 7:131,991,068...132,014,366
Ensembl chr 7:131,991,029...132,016,232 		JBrowse link
G TLR4 toll like receptor 4 involved_in ISO
IEA		 RGD
Ensembl
InterPro		 PMID:16973131 GO_REF:0000002 GO_REF:0000107 RGD:1643119 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G TLR5 toll like receptor 5 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr25:6,418,895...6,440,433
Ensembl chr25:6,437,638...6,440,211 		JBrowse link
G TLR6 toll like receptor 6 involved_in ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:16973131 PMID:18353287 GO_REF:0000002 GO_REF:0000118 RGD:1643119 RGD:5684896 NCBI chr27:11,439,288...11,461,580
Ensembl chr27:11,459,181...11,461,571 		JBrowse link
G TLR7 toll like receptor 7 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:11,348,520...11,372,132 JBrowse link
G TLR8 toll like receptor 8 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:11,387,933...11,405,056
Ensembl chr  X:11,400,907...11,404,029 		JBrowse link
G TRAF3 TNF receptor associated factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:80,735,234...80,872,104
Ensembl chr24:80,789,699...80,866,480 		JBrowse link
G UNC93B1 unc-93 homolog B1, TLR signaling regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16415873) InterPro
Ensembl
MGI		 PMID:16415873 GO_REF:0000002 GO_REF:0000107 NCBI chr 1:6,537,198...6,549,457
Ensembl chr 1:6,537,273...6,549,450 		JBrowse link
toll-like receptor TLR1:TLR2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in ISO (PMID:28098138) UniProt PMID:28098138 NCBI chr16:4,616,325...4,643,791 JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:4,617,279...4,628,308 JBrowse link
toll-like receptor TLR6:TLR2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYD88 MYD88 innate immune signal transduction adaptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:1,276,804...1,281,811
Ensembl chr15:1,276,798...1,281,166 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:8,576,059...8,585,561
Ensembl chr 1:8,576,542...8,586,516 		JBrowse link
G TLR2 toll like receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
G TLR6 toll like receptor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:11,439,288...11,461,580
Ensembl chr27:11,459,181...11,461,571 		JBrowse link
TRAM-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKCE protein kinase C epsilon involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:61,022,903...61,570,390
Ensembl chr14:61,026,017...61,242,343 		JBrowse link
G RAB11FIP2 RAB11 family interacting protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:110,805,236...110,846,691
Ensembl chr 9:110,805,022...110,846,830 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:18,831,361...18,855,476
Ensembl chr23:18,833,262...18,833,969 		JBrowse link
TRIF-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD274 CD274 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:74,038,844...74,060,662
Ensembl chr12:74,041,767...74,056,806 		JBrowse link
G CD300LF CD300 molecule like family member f involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:46,944,701...46,963,559
Ensembl chr16:46,944,921...46,962,770 		JBrowse link
G IRF3 interferon regulatory factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:42,835,285...42,841,487
Ensembl chr 6:42,831,203...42,840,796 		JBrowse link
G TICAM1 toll like receptor adaptor molecule 1 involved_in IEA InterPro
Ensembl
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:4,526,719...4,543,251
Ensembl chr 6:4,527,033...4,529,168 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr23:18,831,361...18,855,476
Ensembl chr23:18,833,262...18,833,969 		JBrowse link
G TLR4 toll like receptor 4 involved_in ISO (PMID:20037584) ARUK-UCL PMID:20037584 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G TLR6 toll like receptor 6 involved_in ISO (PMID:20037584) ARUK-UCL PMID:20037584 NCBI chr27:11,439,288...11,461,580
Ensembl chr27:11,459,181...11,461,571 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17042
    response to stimulus 8791
      response to biotic stimulus 1678
        positive regulation of response to biotic stimulus 435
          positive regulation of innate immune response 394
            activation of innate immune response + 319
            positive regulation of age-related resistance 0
            positive regulation of antifungal innate immune response 3
            positive regulation of complement activation, alternative pathway 0
            positive regulation of complement activation, lectin pathway 0
            positive regulation of innate immunity memory response 0
            positive regulation of melanization defense response 0
            positive regulation of natural killer cell mediated immunity + 39
            positive regulation of pattern recognition receptor signaling pathway + 85
            positive regulation of plant-type hypersensitive response 0
            positive regulation of respiratory burst involved in inflammatory response 2
            positive regulation of response to type II interferon + 6
            positive regulation of type I interferon-mediated signaling pathway 23
Path 2
Term Annotations click to browse term
  biological_process 17042
    response to stimulus 8791
      response to external stimulus 2541
        response to external biotic stimulus 1628
          response to other organism 1625
            defense response to other organism 1158
              defense response to symbiont 1042
                innate immune response 856
                  regulation of innate immune response 472
                    positive regulation of innate immune response 394
                      activation of innate immune response + 319
                      positive regulation of age-related resistance 0
                      positive regulation of antifungal innate immune response 3
                      positive regulation of complement activation, alternative pathway 0
                      positive regulation of complement activation, lectin pathway 0
                      positive regulation of innate immunity memory response 0
                      positive regulation of melanization defense response 0
                      positive regulation of natural killer cell mediated immunity + 39
                      positive regulation of pattern recognition receptor signaling pathway + 85
                      positive regulation of plant-type hypersensitive response 0
                      positive regulation of respiratory burst involved in inflammatory response 2
                      positive regulation of response to type II interferon + 6
                      positive regulation of type I interferon-mediated signaling pathway 23
paths to the root