MMP12 (matrix metallopeptidase 12) - Rat Genome Database

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Gene: MMP12 (matrix metallopeptidase 12) Chlorocebus sabaeus
Analyze
Symbol: MMP12
Name: matrix metallopeptidase 12
RGD ID: 18740470
Description: ENCODES a protein that exhibits calcium ion binding (inferred); collagen binding (inferred); core promoter sequence-specific DNA binding (inferred); INVOLVED IN bronchiole development (ortholog); lung alveolus development (ortholog); positive regulation of epithelial cell proliferation (ortholog); ASSOCIATED WITH Alport syndrome (ortholog); anti-basement membrane glomerulonephritis (ortholog); arteriosclerosis (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: macrophage metalloelastase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,243,061 - 94,261,035 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,243,875 - 94,259,591 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604331,622,735 - 31,635,226 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MMP12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,243,061 - 94,261,035 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,243,875 - 94,259,591 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604331,622,735 - 31,635,226 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MMP12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,862,736 - 102,874,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,862,736 - 102,874,982 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,733,467 - 102,745,712 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,238,674 - 102,250,922 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411102,238,685 - 102,250,889NCBI
Celera1199,895,056 - 99,907,358 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,661,485 - 98,673,788 (-)NCBIHuRef
CHM1_111102,616,439 - 102,628,740 (-)NCBICHM1_1
T2T-CHM13v2.011102,866,505 - 102,878,751 (-)NCBIT2T-CHM13v2.0
Mmp12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,344,397 - 7,360,461 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,344,381 - 7,369,499 (+)EnsemblGRCm39 Ensembl
GRCm3897,344,397 - 7,360,461 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,344,381 - 7,369,499 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,347,374 - 7,360,461 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,347,406 - 7,360,461 (+)NCBIMGSCv36mm8
Celera94,747,651 - 4,760,738 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Mmp12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8812,866,652 - 12,876,554 (+)NCBIGRCr8
mRatBN7.284,581,785 - 4,591,687 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,581,785 - 4,599,611 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,541,507 - 8,551,408 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.086,839,275 - 6,849,176 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.084,841,439 - 4,851,341 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,594,717 - 5,616,494 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,606,592 - 5,616,493 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,610,392 - 5,620,294 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,249,938 - 4,259,675 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,249,937 - 4,259,675 (+)NCBI
Celera86,141,589 - 6,151,491 (+)NCBICelera
Cytogenetic Map8q11NCBI
Mmp12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554126,045,100 - 6,057,262 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554126,045,146 - 6,057,112 (-)NCBIChiLan1.0ChiLan1.0
MMP12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,662,554 - 103,674,969 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,750,772 - 104,763,148 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,809,644 - 97,822,063 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111101,294,469 - 101,306,762 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,294,475 - 101,306,762 (-)Ensemblpanpan1.1panPan2
MMP12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1528,918,626 - 28,933,404 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl528,918,594 - 28,933,309 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha528,867,153 - 28,881,802 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0528,944,813 - 28,984,612 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl528,969,618 - 28,984,462 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,004,848 - 29,019,524 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0528,884,303 - 28,898,943 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,059,239 - 29,073,925 (+)NCBIUU_Cfam_GSD_1.0
Mmp12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494786,418,317 - 86,430,234 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,106,285 - 5,117,843 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365515,107,567 - 5,117,843 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,473,093 - 33,483,679 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,473,625 - 33,483,630 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2937,421,192 - 37,431,173 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Mmp12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248786,035 - 17,445 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248786,017 - 17,368 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 13 19
Below cutoff 14 7 33

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008020669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000001217   ⟹   ENSCSAP00000014855
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl194,243,875 - 94,259,591 (-)Ensembl
RefSeq Acc Id: XM_008020669   ⟹   XP_008018860
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1194,243,061 - 94,261,035 (-)NCBI
Vero_WHO_p1.0NW_02366604331,622,735 - 31,635,226 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008018860 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000014855.1
Reference Protein Sequences
RefSeq Acc Id: XP_008018860   ⟸   XM_008020669
- UniProtKB: A0A0D9S1W6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000014855   ⟸   ENSCSAT00000001217


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003188 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001217.1 UniProtKB/TrEMBL
Gene3D-CATH 2.110.10.10 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro Hemopexin-like_dom UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/TrEMBL
  M10A_MMP UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/TrEMBL
  Pept_M10A UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/TrEMBL
KEGG Report csab:103248345 UniProtKB/TrEMBL
NCBI Gene MMP12 ENTREZGENE
PANTHER MACROPHAGE METALLOELASTASE UniProtKB/TrEMBL
  MATRIX METALLOPROTEINASE UniProtKB/TrEMBL
Pfam Hemopexin UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/TrEMBL
PIRSF Peptidase_M10A_matrix UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/TrEMBL
  HEMOPEXIN UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/TrEMBL
SMART SM00120 UniProtKB/TrEMBL
  ZnMc UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF47090 UniProtKB/TrEMBL
  SSF50923 UniProtKB/TrEMBL
UniProt A0A0D9S1W6 ENTREZGENE, UniProtKB/TrEMBL