F2RL1 (F2R like trypsin receptor 1) - Rat Genome Database

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Gene: F2RL1 (F2R like trypsin receptor 1) Chlorocebus sabaeus
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Symbol: F2RL1
Name: F2R like trypsin receptor 1
RGD ID: 18670982
Description: ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); G-protein alpha-subunit binding (inferred); G-protein beta-subunit binding (inferred); INVOLVED IN positive regulation of glomerular filtration (ortholog); positive regulation of GTPase activity (ortholog); positive regulation of vasoconstriction (ortholog); PARTICIPATES IN protease mediated signaling via protease-activated receptor 2; ASSOCIATED WITH asthma (ortholog); chronic obstructive pulmonary disease (ortholog); Experimental Arthritis (ortholog); FOUND IN early endosome (inferred); membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proteinase-activated receptor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1471,095,446 - 71,109,832 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl471,095,500 - 71,110,005 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604919,926,695 - 19,941,181 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood coagulation  (IEA)
cell-cell junction maintenance  (IEA)
defense response to virus  (IEA)
establishment of endothelial barrier  (IEA)
G protein-coupled receptor signaling pathway  (IEA)
leukocyte migration  (IEA)
leukocyte proliferation  (IEA)
mature conventional dendritic cell differentiation  (IEA)
negative regulation of chemokine production  (IEA)
negative regulation of insulin secretion  (IEA)
negative regulation of JNK cascade  (IEA)
negative regulation of toll-like receptor 3 signaling pathway  (IEA)
negative regulation of tumor necrosis factor-mediated signaling pathway  (IEA)
neutrophil activation  (IEA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IEA)
positive regulation of actin filament depolymerization  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of chemokine production  (IEA)
positive regulation of chemotaxis  (IEA)
positive regulation of cytokine production involved in immune response  (IEA)
positive regulation of cytosolic calcium ion concentration  (IEA)
positive regulation of eosinophil degranulation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of glomerular filtration  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of JNK cascade  (IEA)
positive regulation of leukocyte chemotaxis  (IEA)
positive regulation of neutrophil mediated killing of gram-negative bacterium  (IEA)
positive regulation of phagocytosis, engulfment  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of positive chemotaxis  (IEA)
positive regulation of pseudopodium assembly  (IEA)
positive regulation of renin secretion into blood stream  (IEA)
positive regulation of Rho protein signal transduction  (IEA)
positive regulation of superoxide anion generation  (IEA)
positive regulation of toll-like receptor 2 signaling pathway  (IEA)
positive regulation of toll-like receptor 3 signaling pathway  (IEA)
positive regulation of toll-like receptor 4 signaling pathway  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of type II interferon production  (IEA)
positive regulation of vasoconstriction  (ISO)
potassium channel activating, G protein-coupled receptor signaling pathway  (IEA)
regulation of biological quality  (IEA)
regulation of blood coagulation  (IEA)
regulation of canonical NF-kappaB signal transduction  (IEA)
regulation of chemokine (C-X-C motif) ligand 2 production  (IEA)
regulation of JNK cascade  (IEA)
T cell activation involved in immune response  (IEA)
thrombin-activated receptor signaling pathway  (IEA)
vasodilation  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
F2RL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1471,095,446 - 71,109,832 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl471,095,500 - 71,110,005 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604919,926,695 - 19,941,181 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F2RL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38576,819,030 - 76,835,315 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl576,818,933 - 76,835,315 (+)EnsemblGRCh38hg38GRCh38
GRCh37576,114,855 - 76,131,140 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,150,610 - 76,166,896 (+)NCBINCBI36Build 36hg18NCBI36
Build 34576,150,609 - 76,166,895NCBI
Celera572,008,729 - 72,025,166 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef571,322,693 - 71,339,004 (+)NCBIHuRef
CHM1_1575,547,934 - 75,564,299 (+)NCBICHM1_1
T2T-CHM13v2.0577,300,842 - 77,317,122 (+)NCBIT2T-CHM13v2.0
F2rl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,648,226 - 95,661,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,648,240 - 95,661,735 (-)EnsemblGRCm39 Ensembl
GRCm381395,511,718 - 95,525,240 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,511,732 - 95,525,227 (-)EnsemblGRCm38mm10GRCm38
MGSCv371396,281,673 - 96,295,195 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361396,612,431 - 96,634,965 (-)NCBIMGSCv36mm8
Celera1399,130,515 - 99,143,639 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1349.53NCBI
F2rl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,507,003 - 28,519,954 (-)NCBIGRCr8
mRatBN7.2226,772,274 - 26,785,226 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,772,278 - 26,785,226 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx233,810,431 - 33,823,386 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0231,910,649 - 31,923,604 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0226,726,513 - 26,739,491 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0225,222,324 - 25,235,275 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl225,222,328 - 25,235,275 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0244,378,262 - 44,391,213 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,886,177 - 25,899,128 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,808,013 - 25,819,410 (-)NCBI
Celera222,836,384 - 22,849,335 (-)NCBICelera
Cytogenetic Map2q12NCBI
F2rl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542524,050,901 - 24,054,039 (-)NCBIChiLan1.0ChiLan1.0
F2RL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2438,466,053 - 38,482,458 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1536,619,680 - 36,636,075 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl539,006,331 - 39,024,265 (-)Ensemblpanpan1.1panPan2
F2RL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,801,119 - 29,810,006 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,800,211 - 29,810,180 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,040,276 - 31,049,162 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0329,720,255 - 29,729,156 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,719,346 - 29,729,322 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,656,957 - 29,665,844 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,637,871 - 29,646,815 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0330,007,024 - 30,015,914 (-)NCBIUU_Cfam_GSD_1.0
F2rl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213190,705,232 - 190,716,606 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936549141,512 - 153,602 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936549142,281 - 153,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F2RL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,732,189 - 85,750,858 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1285,732,082 - 85,747,552 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,348,813 - 87,364,248 (+)NCBISscrofa10.2Sscrofa10.2susScr3
F2rl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248691,326,605 - 1,337,195 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000013438   ⟹   ENSCSAP00000011438
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl471,095,500 - 71,110,005 (+)Ensembl
RefSeq Acc Id: XM_007975893   ⟹   XP_007974084
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1471,095,446 - 71,109,832 (+)NCBI
Vero_WHO_p1.0NW_02366604919,926,695 - 19,941,181 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007974084 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000011438
  ENSCSAP00000011438.1
RefSeq Acc Id: XP_007974084   ⟸   XM_007975893
- UniProtKB: A0A0D9RS49 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000011438   ⟸   ENSCSAT00000013438


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015342 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013438.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Pro_rcpt_2 UniProtKB/TrEMBL
  Protea_act_rcpt UniProtKB/TrEMBL
KEGG Report csab:103223368 UniProtKB/TrEMBL
NCBI Gene F2RL1 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PROTEINASE-ACTIVATED RECEPTOR 2 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  PROTEASEAR UniProtKB/TrEMBL
  PROTEASEAR2 UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A0D9RS49 ENTREZGENE, UniProtKB/TrEMBL