SYK (spleen associated tyrosine kinase) - Rat Genome Database

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Pathways
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Gene: SYK (spleen associated tyrosine kinase) Chlorocebus sabaeus
Analyze
Symbol: SYK
Name: spleen associated tyrosine kinase
RGD ID: 18609752
Description: ENCODES a protein that exhibits protein domain specific binding (ortholog); protein kinase activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN B cell differentiation (ortholog); B cell receptor signaling pathway (ortholog); beta selection (ortholog); PARTICIPATES IN eicosanoid signaling pathway; FasL mediated signaling pathway; Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH anti-basement membrane glomerulonephritis (ortholog); arthritis (ortholog); colitis (ortholog); FOUND IN B cell receptor complex (inferred); cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein kinase SYK
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112101,254,085 - 101,374,724 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12101,260,061 - 101,349,856 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603889,575,971 - 89,671,205 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
B cell differentiation  (IEA,ISO)
B cell receptor signaling pathway  (IEA,ISO)
beta selection  (IEA,ISO)
blood vessel morphogenesis  (IEA)
calcium-mediated signaling  (IEA,ISO)
cell activation  (IEA)
cell surface receptor signaling pathway  (IEA,ISO)
cellular response to lectin  (IEA)
cellular response to lipid  (IEA)
cellular response to low-density lipoprotein particle stimulus  (IEA)
cellular response to molecule of fungal origin  (IEA)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA,ISO)
defense response to bacterium  (IEA)
enzyme-linked receptor protein signaling pathway  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
gamma-delta T cell differentiation  (IEA,ISO)
immune system process  (IEA)
innate immune response  (IEA)
integrin-mediated signaling pathway  (IEA)
interleukin-3-mediated signaling pathway  (IEA)
intracellular signal transduction  (IEA,ISO)
leukocyte activation involved in immune response  (IEA)
leukocyte cell-cell adhesion  (IEA)
leukotriene biosynthetic process  (IEA,ISO)
lymph vessel development  (IEA)
macrophage activation involved in immune response  (IEA)
mast cell degranulation  (IEA,ISO)
neutrophil activation involved in immune response  (IEA)
neutrophil chemotaxis  (IEA)
positive regulation of alpha-beta T cell differentiation  (IEA,ISO)
positive regulation of alpha-beta T cell proliferation  (IEA,ISO)
positive regulation of B cell differentiation  (IEA,ISO)
positive regulation of bone resorption  (IEA)
positive regulation of calcium-mediated signaling  (IEA,ISO)
positive regulation of cell adhesion mediated by integrin  (IEA)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of cytokine production  (IEA,ISO)
positive regulation of gamma-delta T cell differentiation  (IEA,ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (IEA,ISO)
positive regulation of immune system process  (IEA)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-12 production  (IEA)
positive regulation of interleukin-3 production  (IEA,ISO)
positive regulation of interleukin-4 production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of killing of cells of another organism  (IEA)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of mast cell cytokine production  (IEA,ISO)
positive regulation of mast cell degranulation  (IEA,ISO)
positive regulation of monocyte chemotactic protein-1 production  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of protein-containing complex assembly  (IEA)
positive regulation of receptor internalization  (IEA)
positive regulation of superoxide anion generation  (IEA)
positive regulation of TORC1 signaling  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of type I interferon production  (IEA)
protein autophosphorylation  (ISO)
protein import into nucleus  (IEA,ISO)
receptor internalization  (IEA)
regulation of arachidonic acid secretion  (IEA)
regulation of ERK1 and ERK2 cascade  (IEA)
regulation of immune response  (IEA,ISO)
regulation of neutrophil degranulation  (IEA)
regulation of phagocytosis  (IEA)
regulation of platelet activation  (IEA)
regulation of platelet aggregation  (IEA)
regulation of superoxide anion generation  (IEA)
regulation of tumor necrosis factor-mediated signaling pathway  (IEA)
serotonin secretion  (IEA,ISO)
serotonin secretion by platelet  (IEA)
stimulatory C-type lectin receptor signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SYK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112101,254,085 - 101,374,724 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12101,260,061 - 101,349,856 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603889,575,971 - 89,671,205 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SYK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38990,801,600 - 90,898,549 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl990,801,787 - 90,898,549 (+)EnsemblGRCh38hg38GRCh38
GRCh37993,563,882 - 93,660,831 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36992,603,891 - 92,698,305 (+)NCBINCBI36Build 36hg18NCBI36
Build 34990,643,624 - 90,738,036NCBI
Celera963,998,674 - 64,095,487 (+)NCBICelera
Cytogenetic Map9q22.2NCBI
HuRef963,244,666 - 63,341,118 (+)NCBIHuRef
CHM1_1993,710,484 - 93,807,287 (+)NCBICHM1_1
T2T-CHM13v2.09102,966,952 - 103,064,392 (+)NCBIT2T-CHM13v2.0
Syk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391352,736,670 - 52,802,828 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1352,737,209 - 52,802,828 (+)EnsemblGRCm39 Ensembl
GRCm381352,582,610 - 52,648,792 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1352,583,173 - 52,648,792 (+)EnsemblGRCm38mm10GRCm38
MGSCv371352,692,251 - 52,744,161 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361352,609,314 - 52,661,224 (+)NCBIMGSCv36mm8
Celera1353,673,505 - 53,725,528 (+)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1327.41NCBI
Syk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81712,756,493 - 12,830,927 (-)NCBIGRCr8
mRatBN7.21712,604,615 - 12,678,437 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1712,604,619 - 12,661,410 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1712,538,728 - 12,595,465 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01714,142,936 - 14,199,625 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01712,459,903 - 12,516,603 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01712,614,311 - 12,669,568 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1712,614,311 - 12,669,573 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01714,703,903 - 14,759,160 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41718,440,672 - 18,498,001 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11718,440,671 - 18,498,006 (-)NCBI
Celera1712,367,624 - 12,424,213 (-)NCBICelera
RH 3.4 Map17126.2RGD
Cytogenetic Map17p14NCBI
Syk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555151,328,630 - 1,380,581 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555151,328,793 - 1,400,206 (-)NCBIChiLan1.0ChiLan1.0
SYK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21148,594,158 - 48,691,283 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1948,596,546 - 48,693,675 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0961,859,767 - 61,956,619 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1989,959,599 - 90,056,101 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl989,959,599 - 90,056,101 (+)Ensemblpanpan1.1panPan2
SYK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1195,903,501 - 95,955,577 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl195,903,566 - 95,955,583 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha196,356,719 - 96,440,184 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0196,507,029 - 96,590,534 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl196,506,228 - 96,590,524 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1196,134,620 - 96,217,990 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0195,855,025 - 95,938,496 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0196,615,264 - 96,698,710 (-)NCBIUU_Cfam_GSD_1.0
Syk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494412,408,886 - 12,455,229 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367801,553,605 - 1,598,158 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367801,553,605 - 1,601,036 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl142,056,670 - 2,161,171 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1142,103,706 - 2,160,886 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2142,866,432 - 2,869,706 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Syk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248681,653,997 - 1,701,391 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248681,654,079 - 1,738,648 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 20
Low 36 60
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000005323   ⟹   ENSCSAP00000003544
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl12101,260,061 - 101,349,856 (+)Ensembl
RefSeq Acc Id: XM_007969717   ⟹   XP_007967908
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.112101,254,086 - 101,349,439 (+)NCBI
Vero_WHO_p1.0NW_02366603889,575,971 - 89,671,205 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007969718   ⟹   XP_007967909
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.112101,278,213 - 101,349,439 (+)NCBI
Vero_WHO_p1.0NW_02366603889,600,084 - 89,671,205 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007969719   ⟹   XP_007967910
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.112101,254,197 - 101,349,439 (+)NCBI
Vero_WHO_p1.0NW_02366603889,576,295 - 89,671,205 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007969722   ⟹   XP_007967913
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.112101,254,085 - 101,349,439 (+)NCBI
Vero_WHO_p1.0NW_02366603889,575,971 - 89,671,205 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007967908 (Get FASTA)   NCBI Sequence Viewer  
  XP_007967909 (Get FASTA)   NCBI Sequence Viewer  
  XP_007967910 (Get FASTA)   NCBI Sequence Viewer  
  XP_007967913 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000003544
  ENSCSAP00000003544.1
Reference Protein Sequences
RefSeq Acc Id: XP_007967913   ⟸   XM_007969722
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007967908   ⟸   XM_007969717
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4K5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007967910   ⟸   XM_007969719
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4K5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007967909   ⟸   XM_007969718
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4K5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000003544   ⟸   ENSCSAT00000005323


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000007280 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000005323.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Kinase_SYK/ZAP-70_inter-SH2_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SYK/ZAP-70_N_SH2 UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_SYK/ZAP70 UniProtKB/TrEMBL
KEGG Report csab:103219736 UniProtKB/TrEMBL
NCBI Gene SYK ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE SYK UniProtKB/TrEMBL
Pfam Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PIRSF TyrPK_SYK UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9R4K5 ENTREZGENE, UniProtKB/TrEMBL