LOC103234962 (caspase recruitment domain-containing protein 8) - Rat Genome Database

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Gene: LOC103234962 (caspase recruitment domain-containing protein 8) Chlorocebus sabaeus
Analyze
Symbol: LOC103234962
Name: caspase recruitment domain-containing protein 8
RGD ID: 18411630
Description: ENCODES a protein that exhibits CARD domain binding (ortholog); cysteine-type endopeptidase activator activity (ortholog); endopeptidase activity (ortholog); INVOLVED IN antiviral innate immune response (ortholog); CARD8 inflammasome complex assembly (ortholog); defense response to virus (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; ASSOCIATED WITH gout (ortholog); inflammatory bowel disease 30 (ortholog); Occupational Diseases (ortholog); FOUND IN canonical inflammasome complex (ortholog); CARD8 inflammasome complex (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CARD8; caspase recruitment domain family member 8
RGD Orthologs
Human
Bonobo
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,446,890 - 41,500,098 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607321,233,430 - 21,247,488 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC103234962
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,446,890 - 41,500,098 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607321,233,430 - 21,247,488 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CARD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,203,148 - 48,255,946 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,180,770 - 48,255,946 (-)EnsemblGRCh38hg38GRCh38
GRCh371948,706,405 - 48,759,203 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,403,325 - 53,444,737 (-)NCBINCBI36Build 36hg18NCBI36
Build 341953,403,324 - 53,444,734NCBI
Celera1945,576,569 - 45,624,446 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,093,304 - 45,141,176 (-)NCBIHuRef
CHM1_11948,713,493 - 48,761,345 (-)NCBICHM1_1
T2T-CHM13v2.01951,197,212 - 51,250,053 (-)NCBIT2T-CHM13v2.0
CARD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22054,308,114 - 54,360,131 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,234,309 - 56,286,412 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,204,735 - 45,256,481 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11953,798,913 - 53,850,328 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1953,798,967 - 53,850,328 (-)Ensemblpanpan1.1panPan2
LOC491519
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,994,215 - 108,025,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,507,437 - 107,519,633 (+)NCBIDog10K_Boxer_Tasha


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


RefSeq Acc Id: XM_037991340   ⟹   XP_037847268
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607321,233,430 - 21,247,488 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037847268 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000015147.1
RefSeq Acc Id: XP_037847268   ⟸   XM_037991340


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000002891 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000000918.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  FIIND_dom UniProtKB/TrEMBL
  NLRP_Inflammasome UniProtKB/TrEMBL
KEGG Report csab:103234962 UniProtKB/TrEMBL
NCBI Gene CARD8 ENTREZGENE
PANTHER CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 8 UniProtKB/TrEMBL
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  FIIND UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  FIIND UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
UniProt A0A0D9S2Q8_CHLSB UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-08 LOC103234962  caspase recruitment domain-containing protein 8  CARD8  caspase recruitment domain family member 8  Symbol and/or name change 5135510 APPROVED