NAGLU (N-acetyl-alpha-glucosaminidase) - Rat Genome Database

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Pathways
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Gene: NAGLU (N-acetyl-alpha-glucosaminidase) Chlorocebus sabaeus
Analyze
Symbol: NAGLU
Name: N-acetyl-alpha-glucosaminidase
RGD ID: 18554349
Description: ENCODES a protein that exhibits alpha-N-acetylglucosaminidase activity (inferred); INVOLVED IN adult behavior (ortholog); amyloid precursor protein metabolic process (ortholog); aorta development (ortholog); ASSOCIATED WITH Brain Hypoxia-Ischemia (ortholog); Charcot-Marie-Tooth disease axonal type 2V (ortholog); genetic disease (ortholog); FOUND IN lysosomal lumen (ortholog); vacuole (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-N-acetylglucosaminidase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,735,411 - 63,744,365 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607734,531,080 - 34,540,643 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult behavior  (IEA,ISO)
amyloid precursor protein metabolic process  (IEA,ISO)
aorta development  (IEA,ISO)
aorta morphogenesis  (IEA,ISO)
astrocyte activation  (IEA,ISO)
astrocyte differentiation  (IEA,ISO)
autophagy  (IEA,ISO)
cardiac muscle cell development  (IEA,ISO)
cell surface receptor signaling pathway via STAT  (IEA,ISO)
cellular lipid catabolic process  (IEA,ISO)
cellular response to organic cyclic compound  (IEA,ISO)
cellular response to organic substance  (IEA,ISO)
cellular response to oxidative stress  (IEA,ISO)
cerebellar Purkinje cell layer development  (IEA,ISO)
collagen metabolic process  (IEA,ISO)
cone retinal bipolar cell differentiation  (IEA,ISO)
cytoplasm organization  (IEA,ISO)
determination of adult lifespan  (IEA,ISO)
endothelium development  (IEA,ISO)
exploration behavior  (IEA,ISO)
ganglioside metabolic process  (IEA,ISO)
gene expression  (IEA,ISO)
glycoprotein metabolic process  (IEA,ISO)
glycosaminoglycan metabolic process  (IEA,ISO)
Golgi organization  (IEA,ISO)
hair follicle morphogenesis  (IEA,ISO)
heart development  (IEA,ISO)
heart valve development  (IEA,ISO)
heparan sulfate proteoglycan catabolic process  (IEA)
heparan sulfate proteoglycan metabolic process  (IEA,ISO)
heparin metabolic process  (IEA,ISO)
hormone metabolic process  (IEA,ISO)
inflammatory response  (IEA,ISO)
inner ear receptor cell development  (IEA,ISO)
left ventricular cardiac muscle tissue morphogenesis  (IEA,ISO)
limb development  (IEA,ISO)
liver development  (IEA,ISO)
locomotor rhythm  (IEA,ISO)
locomotory behavior  (IEA,ISO)
lysosome organization  (IEA,ISO)
maintenance of blood-brain barrier  (IEA,ISO)
microglia differentiation  (IEA,ISO)
microglial cell activation  (IEA,ISO)
middle ear morphogenesis  (IEA,ISO)
mitral valve morphogenesis  (IEA,ISO)
motor behavior  (IEA,ISO)
multicellular organismal-level iron ion homeostasis  (IEA,ISO)
nerve development  (IEA,ISO)
neurogenesis  (IEA,ISO)
neuroinflammatory response  (IEA,ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA,ISO)
protein metabolic process  (IEA,ISO)
protein processing  (IEA,ISO)
proteoglycan metabolic process  (IEA,ISO)
response to disaccharide  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to wounding  (IEA,ISO)
retina development in camera-type eye  (IEA,ISO)
retinal rod cell development  (IEA,ISO)
rod bipolar cell differentiation  (IEA,ISO)
sequestering of iron ion  (IEA,ISO)
superoxide metabolic process  (IEA,ISO)
toll-like receptor 4 signaling pathway  (IEA,ISO)
vacuole organization  (IEA,ISO)
vasculature development  (IEA,ISO)
vesicle tethering  (IEA,ISO)

Cellular Component
extracellular exosome  (IEA)
lysosomal lumen  (IEA,ISO)
vacuole  (IEA,ISO)

Molecular Function

References

Genomics

Comparative Map Data
NAGLU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,735,411 - 63,744,365 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607734,531,080 - 34,540,643 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NAGLU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,536,241 - 42,544,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,536,241 - 42,544,449 (+)EnsemblGRCh38hg38GRCh38
GRCh371740,688,259 - 40,696,467 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,941,477 - 37,949,993 (+)NCBINCBI36Build 36hg18NCBI36
Build 341737,941,476 - 37,949,992NCBI
Celera1737,343,885 - 37,352,401 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,452,897 - 36,461,477 (+)NCBIHuRef
CHM1_11740,923,793 - 40,932,309 (+)NCBICHM1_1
T2T-CHM13v2.01743,393,428 - 43,401,636 (+)NCBIT2T-CHM13v2.0
Naglu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,960,918 - 100,968,483 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,960,838 - 100,968,498 (+)EnsemblGRCm39 Ensembl
GRCm3811101,070,090 - 101,077,672 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,070,012 - 101,077,672 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711100,931,408 - 100,938,986 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,886,215 - 100,893,742 (+)NCBIMGSCv36mm8
Celera11112,366,211 - 112,373,780 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.15NCBI
Naglu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,501,864 - 86,509,333 (+)NCBIGRCr8
mRatBN7.21086,001,545 - 86,009,049 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,001,566 - 86,008,972 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01088,979,363 - 88,986,879 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,979,383 - 88,986,867 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,777,870 - 88,785,375 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,085,836 - 90,093,926 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1084,719,246 - 84,726,764 (+)NCBICelera
Cytogenetic Map10q31NCBI
Naglu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,445,338 - 16,450,062 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,445,338 - 16,449,243 (+)NCBIChiLan1.0ChiLan1.0
NAGLU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,440,123 - 22,448,164 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,330,125 - 24,338,167 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,772,054 - 14,780,398 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,996,420 - 15,004,124 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,996,420 - 15,004,242 (-)Ensemblpanpan1.1panPan2
NAGLU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,407,296 - 20,414,094 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,407,281 - 20,414,056 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,869,143 - 19,875,907 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,126,245 - 21,133,008 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,126,249 - 21,133,008 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,912,074 - 19,918,837 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,177,305 - 20,184,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,281,366 - 20,288,130 (-)NCBIUU_Cfam_GSD_1.0
Naglu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,762,972 - 19,769,861 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,304,586 - 17,314,521 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,305,033 - 17,312,167 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Naglu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,553,037 - 1,558,197 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,553,582 - 1,558,110 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_008012630   ⟹   XP_008010821
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11663,735,411 - 63,744,365 (-)NCBI
Vero_WHO_p1.0NW_02366607734,531,080 - 34,539,956 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037993162   ⟹   XP_037849090
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607734,531,080 - 34,540,643 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008010821 (Get FASTA)   NCBI Sequence Viewer  
  XP_037849090 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000014816.1
Reference Protein Sequences
RefSeq Acc Id: XP_008010821   ⟸   XM_008012630
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037849090   ⟸   XM_037993162
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S1S7 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003229 UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001258.1 UniProtKB/TrEMBL
Gene3D-CATH Glycosidases UniProtKB/TrEMBL
  N-acetyl-b-d-glucoasminidase UniProtKB/TrEMBL
InterPro Glycoside_hydrolase_SF UniProtKB/TrEMBL
  NAGLU UniProtKB/TrEMBL
  NAGLU_C UniProtKB/TrEMBL
  NAGLU_tim-barrel UniProtKB/TrEMBL
NCBI Gene NAGLU ENTREZGENE
PANTHER ALPHA-N-ACETYLGLUCOSAMINIDASE UniProtKB/TrEMBL
  ALPHA-N-ACETYLGLUCOSAMINIDASE UniProtKB/TrEMBL
Pfam NAGLU UniProtKB/TrEMBL
  NAGLU_C UniProtKB/TrEMBL
Superfamily-SCOP (Trans)glycosidases UniProtKB/TrEMBL
UniProt A0A0D9S1S7 ENTREZGENE, UniProtKB/TrEMBL