CHUK (component of inhibitor of nuclear factor kappa B kinase complex) - Rat Genome Database

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Gene: CHUK (component of inhibitor of nuclear factor kappa B kinase complex) Chlorocebus sabaeus
Analyze
Symbol: CHUK
Name: component of inhibitor of nuclear factor kappa B kinase complex
RGD ID: 18685807
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN defense response to virus (ortholog); integrin-mediated signaling pathway (ortholog); lactation (ortholog); PARTICIPATES IN adenosine signaling pathway; FasL mediated signaling pathway; interleukin-1 signaling pathway; ASSOCIATED WITH asthma (ortholog); autistic disorder (ortholog); bacterial pneumonia (ortholog); FOUND IN CD40 receptor complex (ortholog); cytoplasmic side of plasma membrane (ortholog); IkappaB kinase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: conserved helix-loop-helix ubiquitous kinase; inhibitor of nuclear factor kappa-B kinase subunit alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1993,219,374 - 93,263,077 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl993,219,383 - 93,262,700 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604854,220,658 - 54,264,717 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202   PMID:33181435  


Genomics

Comparative Map Data
CHUK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1993,219,374 - 93,263,077 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl993,219,383 - 93,262,700 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604854,220,658 - 54,264,717 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CHUK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810100,186,319 - 100,229,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10100,188,300 - 100,229,596 (-)EnsemblGRCh38hg38GRCh38
GRCh3710101,948,057 - 101,989,353 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,938,114 - 101,979,334 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410101,938,114 - 101,979,366NCBI
Celera1095,686,067 - 95,727,300 (-)NCBICelera
Cytogenetic Map10q24.31NCBI
HuRef1095,577,055 - 95,618,304 (-)NCBIHuRef
CHM1_110102,232,811 - 102,274,037 (-)NCBICHM1_1
T2T-CHM13v2.010101,070,354 - 101,113,853 (-)NCBIT2T-CHM13v2.0
Chuk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,061,773 - 44,095,940 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1944,061,774 - 44,095,919 (-)EnsemblGRCm39 Ensembl
GRCm381944,073,334 - 44,107,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,073,335 - 44,107,480 (-)EnsemblGRCm38mm10GRCm38
MGSCv371944,147,824 - 44,181,967 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361944,126,647 - 44,160,756 (-)NCBIMGSCv36mm8
Celera1944,858,810 - 44,892,945 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.71NCBI
Chuk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,908,748 - 252,944,273 (-)NCBIGRCr8
mRatBN7.21242,959,539 - 242,995,066 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,959,760 - 242,995,065 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1251,109,858 - 251,145,433 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,806,623 - 257,842,185 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,460,007 - 250,495,589 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,848,829 - 263,884,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,848,884 - 263,885,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,293,821 - 271,329,346 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,122,845 - 249,158,369 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11249,381,683 - 249,416,016 (+)NCBI
Celera1238,777,027 - 238,812,551 (-)NCBICelera
Cytogenetic Map1q54NCBI
Chuk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555076,067,203 - 6,102,001 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555076,066,026 - 6,102,066 (-)NCBIChiLan1.0ChiLan1.0
CHUK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28112,077,682 - 112,118,610 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110112,083,001 - 112,123,929 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01096,794,228 - 96,835,449 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110100,276,290 - 100,317,082 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10100,280,490 - 100,316,918 (-)Ensemblpanpan1.1panPan2
CHUK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12812,964,670 - 13,001,557 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2812,965,479 - 13,001,512 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2813,147,837 - 13,184,707 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02813,433,260 - 13,470,158 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,433,260 - 13,470,130 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12812,980,085 - 13,016,958 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02813,017,918 - 13,055,038 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02813,152,231 - 13,189,348 (-)NCBIUU_Cfam_GSD_1.0
Chuk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721333,995,060 - 34,039,500 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493663633,673 - 79,194 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493663633,933 - 78,990 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHUK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14111,315,141 - 111,351,868 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114111,316,178 - 111,351,669 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,757,214 - 120,854,090 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Chuk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473712,022,419 - 12,052,131 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473712,022,081 - 12,052,128 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 5 57
Low 15 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000003698   ⟹   ENSCSAP00000001972
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl993,219,383 - 93,262,700 (-)Ensembl
RefSeq Acc Id: XM_007963830   ⟹   XP_007962021
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1993,219,374 - 93,263,071 (-)NCBI
Vero_WHO_p1.0NW_02366604854,220,658 - 54,264,632 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007963831   ⟹   XP_007962022
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1993,223,511 - 93,263,077 (-)NCBI
Vero_WHO_p1.0NW_02366604854,224,868 - 54,264,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007963832   ⟹   XP_007962023
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1993,220,108 - 93,263,074 (-)NCBI
Vero_WHO_p1.0NW_02366604854,220,658 - 54,264,609 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038009435   ⟹   XP_037865363
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604854,220,658 - 54,264,644 (-)NCBI
RefSeq Acc Id: XM_038009436   ⟹   XP_037865364
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604854,221,433 - 54,264,706 (-)NCBI
RefSeq Acc Id: XR_005244200
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604854,223,157 - 54,264,717 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_007962021   ⟸   XM_007963830
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R033 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007962023   ⟸   XM_007963832
- Peptide Label: isoform X5
RefSeq Acc Id: XP_007962022   ⟸   XM_007963831
- Peptide Label: isoform X4
RefSeq Acc Id: ENSCSAP00000001972   ⟸   ENSCSAT00000003698
RefSeq Acc Id: XP_037865363   ⟸   XM_038009435
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037865364   ⟸   XM_038009436
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000005664 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000003698.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.250 UniProtKB/TrEMBL
  6.10.250.2110 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro IKBKB_SDD UniProtKB/TrEMBL
  IKBKB_SDD_sf UniProtKB/TrEMBL
  IKKbetaNEMObind UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report csab:103216382 UniProtKB/TrEMBL
NCBI Gene CHUK ENTREZGENE
PANTHER IKB KINASE UniProtKB/TrEMBL
  INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam IKBKB_SDD UniProtKB/TrEMBL
  IKKbetaNEMObind UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART IKKbetaNEMObind UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9R033 ENTREZGENE, UniProtKB/TrEMBL