IRF4 (interferon regulatory factor 4) - Rat Genome Database

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Gene: IRF4 (interferon regulatory factor 4) Chlorocebus sabaeus
Analyze
Symbol: IRF4
Name: interferon regulatory factor 4
RGD ID: 18397681
Description: ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN chromatin remodeling (ortholog); defense response to protozoan (ortholog); myeloid dendritic cell differentiation (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); adult T-cell leukemia/lymphoma (ortholog); anaplastic large cell lymphoma (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); nucleosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11771,739,920 - 71,758,811 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666044315,955 - 334,864 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 23 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IRF4Green Monkeyacute lymphoblastic leukemia  ISOIRF4 (Homo sapiens)9068941DNA:SNP:intron:rs12203592 (human)RGDPMID:19897031 and REF_RGD_ID:11526162
IRF4Green Monkeyanaplastic large cell lymphoma  ISOIRF4 (Homo sapiens)9068941DNA:translocationRGDPMID:18987657 and REF_RGD_ID:11526155
IRF4Green MonkeyB-Cell Chronic Lymphocytic Leukemia disease_progressionISOIRF4 (Homo sapiens)9068941 RGDPMID:12079517 more ...
IRF4Green MonkeyB-lymphoblastic leukemia/lymphoma  ISOIrf4 (Mus musculus)9068941 RGDPMID:20585039 more ...
IRF4Green MonkeyCardiomegaly  ISOIrf4 (Mus musculus)9068941 RGDPMID:23589561 and REF_RGD_ID:11530060
IRF4Green Monkeychronic lymphocytic leukemia  ISOIRF4 (Homo sapiens)9068941DNA:SNPs:3' utr:multipleRGDPMID:20123861 and REF_RGD_ID:11530031
IRF4Green Monkeychronic lymphocytic leukemia  ISOIRF4 (Homo sapiens)9068941DNA:missense mutation:exon:p.L116R (human)RGDPMID:21791429 and REF_RGD_ID:11526158
IRF4Green Monkeychronic lymphocytic leukemia  ISOIRF4 (Homo sapiens)9068941DNA:SNP: :rs872071 (human)RGDPMID:20731705 and REF_RGD_ID:11530029
IRF4Green Monkeychronic lymphocytic leukemia disease_progressionISOIRF4 (Homo sapiens)9068941 RGDPMID:20090783 and REF_RGD_ID:11530021
IRF4Green Monkeychronic lymphocytic leukemia  ISOIrf4 (Mus musculus)9068941 RGDPMID:23926303 and REF_RGD_ID:11530026
IRF4Green Monkeychronic lymphocytic leukemia disease_progressionISOIrf4 (Mus musculus)9068941 RGDPMID:23897826 and REF_RGD_ID:11526156
IRF4Green MonkeyCOVID-19  ISOIRF4 (Homo sapiens)9068941mRNA:decreased expression:antibody secreting B cells (human)RGDPMID:32377375 and REF_RGD_ID:32716422
IRF4Green Monkeydiffuse large B-cell lymphoma disease_progressionISOIRF4 (Homo sapiens)9068941 RGDPMID:15701085 and REF_RGD_ID:11530023
IRF4Green Monkeydilated cardiomyopathy  ISOIRF4 (Homo sapiens)9068941protein:decreased expression:heartRGDPMID:23589561 and REF_RGD_ID:11530060
IRF4Green Monkeyfollicular lymphoma severityISOIRF4 (Homo sapiens)9068941 RGDPMID:17296585 and REF_RGD_ID:11530032
IRF4Green Monkeyleukemia disease_progressionISOIRF4 (Homo sapiens)9068941 RGDPMID:23977280 and REF_RGD_ID:11526157
IRF4Green Monkeylymphoplasmacytic lymphoma  ISOIRF4 (Homo sapiens)9068941 RGDPMID:23355206 and REF_RGD_ID:11530052
IRF4Green Monkeymiddle cerebral artery infarction  ISOIrf4 (Rattus norvegicus)9068941 RGDPMID:25652434 and REF_RGD_ID:11530061
IRF4Green Monkeymultiple myeloma  ISOIRF4 (Homo sapiens)9068941DNA:translocationRGDPMID:10557056 and REF_RGD_ID:11526161
IRF4Green Monkeymultiple myeloma treatmentISOIRF4 (Homo sapiens)9068941 RGDPMID:21707574 and REF_RGD_ID:11530055
1 to 20 of 23 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IRF4Green MonkeyImmunodeficiency 131  ISOIRF4 (Homo sapiens)8554872ClinVar Annotator: match by term: IMMUNODEFICIENCY 131ClinVarPMID:28492532 more ...
IRF4Green MonkeySkin/Hair/Eye Pigmentation, Variation In, 1  ISOIRF4 (Homo sapiens)8554872ClinVar Annotator: match by term: SKIN/HAIR/EYE PIGMENTATION 1 and BLUE/NONBLUE EYESClinVarPMID:25741868
IRF4Green MonkeySkin/Hair/Eye Pigmentation, Variation In, 8  ISOIRF4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18483556 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IRF4Green Monkeyadult T-cell leukemia/lymphoma  ISOIRF4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:26437031
IRF4Green MonkeyB-Cell Chronic Lymphocytic Leukemia  ISOIRF4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18758461
IRF4Green MonkeyGastrointestinal Hemorrhage  ISOIRF4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:38164749
IRF4Green MonkeyLung Neoplasms  ISOIRF4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:35915169
IRF4Green Monkeymultiple myeloma  ISOIRF4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18568025
IRF4Green Monkeyprimary cutaneous T-cell non-Hodgkin lymphoma  ISOIRF4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:26192916
IRF4Green Monkeyulcerative colitis  ISOIRF4 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:38164749
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IRF4Green MonkeyImmunodeficiency 131  ISOIRF4 (Homo sapiens)7240710 OMIM 
IRF4Green MonkeySkin/Hair/Eye Pigmentation, Variation In, 8  ISOIRF4 (Homo sapiens)7240710 OMIM 


Biological Process
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IRF4Green Monkeychromatin remodeling acts_upstream_of_or_withinISOIrf4 (Mus musculus)9068941 PMID:16428437MGIPMID:16428437
IRF4Green Monkeydefense response to protozoan involved_inISOIrf4 (Mus musculus)9068941 PMID:22992524UniProtPMID:22992524
IRF4Green Monkeymyeloid dendritic cell differentiation involved_inISOIrf4 (Mus musculus)9068941 PMID:22992524UniProtPMID:22992524
IRF4Green Monkeymyeloid dendritic cell differentiation acts_upstream_of_or_withinISOMGI:23879419068941 PMID:15184678MGIPMID:15184678
IRF4Green Monkeynegative regulation of toll-like receptor signaling pathway acts_upstream_of_or_withinISOMGI:23879419068941 PMID:16236719MGIPMID:16236719
IRF4Green Monkeypositive regulation of cold-induced thermogenesis involved_inISOIrf4 (Mus musculus)9068941 PMID:24995979YuBioLabPMID:24995979
IRF4Green Monkeypositive regulation of DNA-templated transcription involved_inISOIrf4 (Mus musculus)9068941 PMID:30413670ARUK-UCLPMID:30413670
IRF4Green Monkeypositive regulation of DNA-templated transcription involved_inISOUniProtKB:P174339068941 PMID:28338898ARUK-UCLPMID:28338898
IRF4Green Monkeypositive regulation of DNA-templated transcription involved_inISOIRF4 (Homo sapiens)9068941 PMID:12374808UniProtPMID:12374808
IRF4Green Monkeypositive regulation of interleukin-10 production involved_inISOIRF4 (Homo sapiens)9068941 PMID:12374808UniProtPMID:12374808
IRF4Green Monkeypositive regulation of interleukin-13 production involved_inISOIRF4 (Homo sapiens)9068941 PMID:12374808UniProtPMID:12374808
IRF4Green Monkeypositive regulation of interleukin-2 production involved_inISOIRF4 (Homo sapiens)9068941 PMID:12374808UniProtPMID:12374808
IRF4Green Monkeypositive regulation of interleukin-4 production involved_inISOIRF4 (Homo sapiens)9068941 PMID:12374808UniProtPMID:12374808
IRF4Green Monkeypositive regulation of transcription by RNA polymerase II involved_inISOIRF4 (Homo sapiens)9068941 PMID:12374808NTNU_SBPMID:12374808
IRF4Green Monkeypositive regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOIrf4 (Mus musculus)9068941 PMID:16428437MGIPMID:16428437
IRF4Green MonkeyT-helper 17 cell lineage commitment involved_inISOIrf4 (Mus musculus)9068941 PMID:22983707UniProtPMID:22983707
1 to 16 of 16 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IRF4Green Monkeycytosol located_inISOIRF4 (Homo sapiens)9068941 HPAGO_REF:0000052
IRF4Green Monkeynucleoplasm located_inISOIRF4 (Homo sapiens)9068941 HPAGO_REF:0000052
IRF4Green Monkeynucleosome part_ofISOIrf4 (Mus musculus)9068941 PMID:16428437MGIPMID:16428437

Molecular Function
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IRF4Green Monkeycis-regulatory region sequence-specific DNA binding enablesISOIrf4 (Mus musculus)9068941 PMID:30413670ARUK-UCLPMID:30413670
IRF4Green MonkeyDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOIRF4 (Homo sapiens)9068941 PMID:12374808NTNU_SBPMID:12374808
IRF4Green MonkeyDNA-binding transcription factor activity enablesISOIrf4 (Mus musculus)9068941 PMID:22983707 more ...UniProtPMID:22983707 more ...
IRF4Green Monkeyprotein binding enablesISOUniProtKB:O352849068941 PMID:22983707 more ...UniProtPMID:22983707 more ...
IRF4Green Monkeyprotein binding enablesISOPR:P223669068941 PMID:16236719MGIPMID:16236719
IRF4Green Monkeyprotein binding enablesISOUniProtKB:O703439068941 PMID:24995979IntActPMID:24995979
IRF4Green Monkeyprotein binding enablesISOUniProtKB:Q8R4B89068941 PMID:26098997UniProtPMID:26098997
IRF4Green Monkeyprotein binding enablesISOUniProtKB:Q7Z6J9 and UniProtKB:Q8TF659068941 PMID:32296183IntActPMID:32296183
IRF4Green Monkeyprotein binding enablesISOUniProtKB:O95163 more ...9068941 PMID:21903422IntActPMID:21903422
IRF4Green Monkeyprotein binding enablesISOUniProtKB:P179479068941 PMID:33951726UniProtPMID:33951726
IRF4Green Monkeyprotein binding enablesISOUniProtKB:O35284 more ...9068941 PMID:22992523UniProtPMID:22992523
IRF4Green MonkeyRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesISOIRF4 (Homo sapiens)9068941 PMID:12374808NTNU_SBPMID:12374808
IRF4Green Monkeysequence-specific DNA binding enablesISOIrf4 (Mus musculus)9068941 PMID:22983707 more ...UniProtPMID:22983707 more ...
IRF4Green Monkeysequence-specific double-stranded DNA binding enablesISOIRF4 (Homo sapiens)9068941 PMID:28473536ARUK-UCLPMID:28473536
IRF4Green Monkeytranscription coactivator activity enablesISOIrf4 (Mus musculus)9068941 PMID:30413670ARUK-UCLPMID:30413670
1 to 15 of 15 rows

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
IRF4Green Monkeyinterleukin-4 signaling pathway  ISOIRF4 (Homo sapiens)9068941 PIDPID:200022
PMID:22301074   PMID:30032202  



IRF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11771,739,920 - 71,758,811 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666044315,955 - 334,864 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
IRF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386391,752 - 411,443 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6391,739 - 411,443 (+)EnsemblGRCh38hg38GRCh38
GRCh376391,752 - 411,443 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366336,760 - 356,193 (+)NCBINCBI36Build 36hg18NCBI36
Build 346336,759 - 356,193NCBI
Celera61,620,599 - 1,639,926 (+)NCBICelera
Cytogenetic Map6p25.3NCBI
HuRef6264,308 - 284,078 (+)NCBIHuRef
CHM1_16393,650 - 413,301 (+)NCBICHM1_1
T2T-CHM13v2.06250,136 - 269,771 (+)NCBIT2T-CHM13v2.0
Irf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391330,933,191 - 30,950,965 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1330,933,209 - 30,950,959 (+)EnsemblGRCm39 Ensembl
GRCm381330,749,233 - 30,766,981 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1330,749,226 - 30,766,976 (+)EnsemblGRCm38mm10GRCm38
MGSCv371330,841,127 - 30,858,796 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361330,756,723 - 30,774,392 (+)NCBIMGSCv36mm8
Celera1330,963,334 - 30,981,003 (+)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.28NCBI
Irf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81733,930,460 - 33,948,842 (-)NCBIGRCr8
mRatBN7.21733,721,800 - 33,742,570 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1733,721,811 - 33,740,070 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1733,560,168 - 33,578,389 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01735,164,039 - 35,182,262 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01733,555,976 - 33,574,191 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01734,886,746 - 34,905,191 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1734,886,739 - 34,905,117 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01738,499,069 - 38,517,524 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41740,170,409 - 40,189,976 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11740,176,635 - 40,190,951 (-)NCBI
Celera1733,262,619 - 33,280,861 (-)NCBICelera
Cytogenetic Map17p12NCBI
Irf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546512,497,462 - 12,513,106 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546512,497,534 - 12,512,529 (-)NCBIChiLan1.0ChiLan1.0
IRF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2515,006,113 - 15,026,173 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1610,998,041 - 11,017,502 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06206,282 - 226,487 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16341,637 - 360,492 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6342,718 - 356,654 (+)Ensemblpanpan1.1panPan2
IRF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.135760,367 - 782,314 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl35767,011 - 781,339 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha35777,727 - 796,599 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.035714,152 - 737,540 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl35714,202 - 738,113 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.135700,365 - 719,274 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.035718,232 - 734,827 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0352,054,228 - 2,070,812 (+)NCBIUU_Cfam_GSD_1.0
Irf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494625,039,805 - 25,055,378 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366331,564,637 - 1,580,859 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366331,565,293 - 1,580,859 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7133,371 - 149,609 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17133,358 - 149,609 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Irf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475623,918,323 - 23,931,501 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475623,917,111 - 23,931,482 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in IRF4
450 total Variants






RefSeq Acc Id: XM_007973883   ⟹   XP_007972074
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11771,739,920 - 71,758,811 (-)NCBI
Vero_WHO_p1.0NW_023666044315,955 - 334,864 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007973885   ⟹   XP_007972076
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11771,739,920 - 71,758,811 (-)NCBI
Vero_WHO_p1.0NW_023666044315,955 - 334,864 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038005694   ⟹   XP_037861622
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666044315,955 - 334,864 (+)NCBI
Protein RefSeqs XP_007972074 (Get FASTA)   NCBI Sequence Viewer  
  XP_007972076 (Get FASTA)   NCBI Sequence Viewer  
  XP_037861622 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_007972076   ⟸   XM_007973885
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007972074   ⟸   XM_007973883
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037861622   ⟸   XM_038005694
- Peptide Label: isoform X3



Database
Acc Id
Source(s)
NCBI Gene IRF4 ENTREZGENE