PARP9 (poly(ADP-ribose) polymerase family member 9) - Rat Genome Database

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Gene: PARP9 (poly(ADP-ribose) polymerase family member 9) Chlorocebus sabaeus
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Symbol: PARP9
Name: poly(ADP-ribose) polymerase family member 9
RGD ID: 18476636
Description: ENCODES a protein that exhibits NAD+ ADP-ribosyltransferase activity (ortholog); NAD+ binding (ortholog); INVOLVED IN DNA damage checkpoint signaling (inferred); double-strand break repair (inferred); negative regulation of gene expression (inferred); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH alkaptonuria (ortholog); familial hypocalciuric hypercalcemia (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: poly [ADP-ribose] polymerase 9
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12258,297,526 - 58,336,243 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2258,298,046 - 58,337,124 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041108,011,893 - 108,049,617 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PARP9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12258,297,526 - 58,336,243 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2258,298,046 - 58,337,124 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041108,011,893 - 108,049,617 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PARP9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383122,527,924 - 122,564,784 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3122,527,924 - 122,564,577 (-)EnsemblGRCh38hg38GRCh38
GRCh373122,246,771 - 122,283,631 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363123,729,461 - 123,766,114 (-)NCBINCBI36Build 36hg18NCBI36
Build 343123,729,462 - 123,766,114NCBI
Celera3120,656,569 - 120,693,333 (-)NCBICelera
Cytogenetic Map3q21.1NCBI
HuRef3119,620,038 - 119,656,801 (-)NCBIHuRef
CHM1_13122,210,449 - 122,247,205 (-)NCBICHM1_1
T2T-CHM13v2.03125,247,222 - 125,284,030 (-)NCBIT2T-CHM13v2.0
Parp9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391635,759,360 - 35,792,975 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1635,758,840 - 35,792,975 (+)EnsemblGRCm39 Ensembl
GRCm381635,938,470 - 35,972,621 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1635,938,470 - 35,972,605 (+)EnsemblGRCm38mm10GRCm38
MGSCv371635,938,556 - 35,972,691 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361635,858,217 - 35,892,352 (+)NCBIMGSCv36mm8
Celera1636,418,713 - 36,452,749 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1625.43NCBI
Parp9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,286,282 - 78,320,409 (-)NCBIGRCr8
mRatBN7.21164,780,977 - 64,814,995 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,780,981 - 64,815,455 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1173,606,279 - 73,638,748 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01166,268,543 - 66,301,015 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01165,299,789 - 65,332,261 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,724,071 - 67,758,027 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,724,076 - 67,756,799 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,812,294 - 70,846,215 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41166,615,587 - 66,648,294 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11166,673,175 - 66,702,103 (-)NCBI
Celera1164,246,917 - 64,279,634 (-)NCBICelera
Cytogenetic Map11q22NCBI
Parp9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542721,770,577 - 21,804,717 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542721,770,158 - 21,806,091 (-)NCBIChiLan1.0ChiLan1.0
PARP9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22120,472,642 - 120,509,741 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13120,477,421 - 120,514,085 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03119,617,722 - 119,655,039 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13126,522,859 - 126,559,609 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3126,522,859 - 126,559,647 (-)Ensemblpanpan1.1panPan2
PARP9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13325,643,439 - 25,676,979 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3325,643,883 - 25,677,462 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3325,667,797 - 25,701,331 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03325,878,555 - 25,912,166 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3325,878,555 - 25,912,539 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13325,675,496 - 25,709,331 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03325,718,998 - 25,752,634 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03326,276,577 - 26,310,190 (-)NCBIUU_Cfam_GSD_1.0
Parp9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602128,677,266 - 128,715,188 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365368,806,818 - 8,840,746 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365368,806,824 - 8,845,099 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARP9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13137,966,562 - 138,000,846 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113137,960,987 - 138,000,862 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213147,581,288 - 147,621,200 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Parp9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624912827,547 - 859,199 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624912827,112 - 968,501 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 19 21
Low 1 39
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000005448   ⟹   ENSCSAP00000003669
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2258,298,046 - 58,337,124 (+)Ensembl
RefSeq Acc Id: XM_007985601   ⟹   XP_007983792
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12258,298,566 - 58,336,243 (+)NCBI
Vero_WHO_p1.0NW_023666041108,011,893 - 108,048,941 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007985602   ⟹   XP_007983793
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12258,297,526 - 58,336,243 (+)NCBI
Vero_WHO_p1.0NW_023666041108,011,893 - 108,049,617 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007985603   ⟹   XP_007983794
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12258,298,512 - 58,336,243 (+)NCBI
Vero_WHO_p1.0NW_023666041108,011,893 - 108,048,939 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038003406   ⟹   XP_037859334
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666041108,011,893 - 108,048,941 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007983792 (Get FASTA)   NCBI Sequence Viewer  
  XP_007983793 (Get FASTA)   NCBI Sequence Viewer  
  XP_007983794 (Get FASTA)   NCBI Sequence Viewer  
  XP_037859334 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000003669.1
RefSeq Acc Id: XP_007983793   ⟸   XM_007985602
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4Y0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007983794   ⟸   XM_007985603
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4Y0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007983792   ⟸   XM_007985601
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4Y0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000003669   ⟸   ENSCSAT00000005448
RefSeq Acc Id: XP_037859334   ⟸   XM_038003406
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R4Y0 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000007401 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000005448.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.220.10 UniProtKB/TrEMBL
  3.90.228.10 UniProtKB/TrEMBL
InterPro Macro_dom UniProtKB/TrEMBL
  Macro_dom-like UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_cat_dom UniProtKB/TrEMBL
KEGG Report csab:103228181 UniProtKB/TrEMBL
NCBI Gene PARP9 ENTREZGENE
PANTHER PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN UniProtKB/TrEMBL
  PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP9 UniProtKB/TrEMBL
Pfam Macro UniProtKB/TrEMBL
PROSITE MACRO UniProtKB/TrEMBL
  PARP_CATALYTIC UniProtKB/TrEMBL
SMART A1pp UniProtKB/TrEMBL
Superfamily-SCOP ADP-ribosylation UniProtKB/TrEMBL
  SSF52949 UniProtKB/TrEMBL
UniProt A0A0D9R4Y0 ENTREZGENE, UniProtKB/TrEMBL