MED1 (mediator complex subunit 1) - Rat Genome Database

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Gene: MED1 (mediator complex subunit 1) Chlorocebus sabaeus
Analyze
Symbol: MED1
Name: mediator complex subunit 1
RGD ID: 18542676
Description: ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); general transcription initiation factor binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); animal organ regeneration (ortholog); brain development (ortholog); PARTICIPATES IN cortisol signaling pathway; estrogen signaling pathway; RNA polymerase II transcription pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); congestive heart failure (ortholog); dilated cardiomyopathy (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog); protein-DNA complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mediator of RNA polymerase II transcription subunit 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,719,393 - 66,764,902 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,719,423 - 66,762,896 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607737,634,868 - 37,686,645 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen biosynthetic process  (IEA)
angiogenesis  (IEA)
animal organ morphogenesis  (IEA,ISO)
animal organ regeneration  (IEA,ISO)
brain development  (IEA,ISO)
camera-type eye development  (IEA,ISO)
cell morphogenesis  (IEA)
cellular response to epidermal growth factor stimulus  (IEA)
cellular response to hepatocyte growth factor stimulus  (IEA,ISO)
cellular response to steroid hormone stimulus  (IEA)
cellular response to thyroid hormone stimulus  (IEA,ISO)
embryonic heart tube development  (IEA,ISO)
embryonic hemopoiesis  (IEA,ISO)
embryonic hindlimb morphogenesis  (IEA,ISO)
embryonic placenta development  (IEA,ISO)
enucleate erythrocyte development  (IEA,ISO)
epithelial cell proliferation involved in mammary gland duct elongation  (IEA,ISO)
erythrocyte development  (IEA,ISO)
fat cell differentiation  (IEA,ISO)
G0 to G1 transition  (IEA,ISO)
heart development  (IEA,ISO)
hematopoietic stem cell differentiation  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
keratinocyte differentiation  (IEA)
lactation  (IEA,ISO)
lens development in camera-type eye  (IEA)
liver development  (IEA,ISO)
mammary gland branching involved in pregnancy  (IEA,ISO)
mammary gland branching involved in thelarche  (IEA,ISO)
mammary gland epithelial cell proliferation  (IEA,ISO)
megakaryocyte development  (IEA)
monocyte differentiation  (IEA,ISO)
mRNA transcription by RNA polymerase II  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of keratinocyte proliferation  (IEA)
negative regulation of neuron differentiation  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
nuclear receptor-mediated steroid hormone signaling pathway  (IEA)
peroxisome proliferator activated receptor signaling pathway  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of erythrocyte differentiation  (IEA)
positive regulation of G0 to G1 transition  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of hepatocyte proliferation  (IEA,ISO)
positive regulation of intracellular estrogen receptor signaling pathway  (IEA,ISO)
positive regulation of keratinocyte differentiation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription initiation by RNA polymerase II  (IEA)
positive regulation of type II interferon-mediated signaling pathway  (IEA,ISO)
protein import into nucleus  (IEA,ISO)
protein ubiquitination  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of RNA biosynthetic process  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
regulation of vitamin D receptor signaling pathway  (IEA,ISO)
retinal pigment epithelium development  (IEA)
thyroid hormone generation  (IEA,ISO)
thyroid hormone receptor signaling pathway  (IEA)
ventricular trabecula myocardium morphogenesis  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MED1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,719,393 - 66,764,902 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,719,423 - 66,762,896 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607737,634,868 - 37,686,645 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MED1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381739,404,285 - 39,451,263 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1739,404,285 - 39,451,272 (-)EnsemblGRCh38hg38GRCh38
GRCh371737,560,538 - 37,607,516 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361734,814,064 - 34,861,053 (-)NCBINCBI36Build 36hg18NCBI36
Build 341734,816,379 - 34,861,030NCBI
Celera1734,221,470 - 34,268,494 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1733,354,022 - 33,401,237 (-)NCBIHuRef
CHM1_11737,796,744 - 37,843,728 (-)NCBICHM1_1
T2T-CHM13v2.01740,268,198 - 40,315,170 (-)NCBIT2T-CHM13v2.0
Med1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,042,980 - 98,084,121 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,042,980 - 98,084,119 (-)EnsemblGRCm39 Ensembl
GRCm381198,152,154 - 98,193,313 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,152,154 - 98,193,293 (-)EnsemblGRCm38mm10GRCm38
MGSCv371198,013,468 - 98,054,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361197,968,244 - 98,009,350 (-)NCBIMGSCv36mm8
Celera11107,807,134 - 107,848,278 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1161.75NCBI
Med1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81083,641,851 - 83,685,560 (-)NCBIGRCr8
mRatBN7.21083,145,538 - 83,189,260 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,145,568 - 83,189,299 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,091,753 - 88,133,134 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,589,837 - 87,631,219 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01082,982,482 - 83,023,863 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,101,560 - 86,145,271 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,103,600 - 86,144,880 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01085,899,172 - 85,942,182 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41086,917,525 - 86,959,080 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1081,896,663 - 81,937,929 (-)NCBICelera
Cytogenetic Map10q31NCBI
Med1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,202,744 - 14,237,797 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,204,326 - 14,237,809 (-)NCBIChiLan1.0ChiLan1.0
MED1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21925,502,545 - 25,550,519 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11727,397,326 - 27,444,674 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,836,350 - 17,883,610 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11718,050,250 - 18,096,109 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1718,050,474 - 18,095,118 (+)Ensemblpanpan1.1panPan2
MED1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,989,257 - 23,019,350 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,989,301 - 23,019,349 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,461,097 - 22,488,309 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,782,837 - 23,810,295 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,782,848 - 23,813,191 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,554,940 - 22,582,360 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,816,047 - 22,843,443 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,941,470 - 22,968,890 (+)NCBIUU_Cfam_GSD_1.0
Med1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560222,411,935 - 22,448,238 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649014,625,897 - 14,657,802 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649014,625,201 - 14,663,184 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,841,205 - 22,872,409 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,830,405 - 22,872,420 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,283,204 - 23,325,356 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Med1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,572,266 - 3,607,126 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,572,025 - 3,605,675 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000000701   ⟹   ENSCSAP00000015361
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1666,719,423 - 66,762,896 (+)Ensembl
RefSeq Acc Id: XM_037993117   ⟹   XP_037849045
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607737,634,868 - 37,686,645 (+)NCBI
RefSeq Acc Id: XM_037993118   ⟹   XP_037849046
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607737,634,868 - 37,686,645 (+)NCBI
RefSeq Acc Id: XM_037993119   ⟹   XP_037849047
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607737,634,870 - 37,686,645 (+)NCBI
RefSeq Acc Id: XM_037993120   ⟹   XP_037849048
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607737,644,070 - 37,686,645 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037849045 (Get FASTA)   NCBI Sequence Viewer  
  XP_037849046 (Get FASTA)   NCBI Sequence Viewer  
  XP_037849047 (Get FASTA)   NCBI Sequence Viewer  
  XP_037849048 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000015361.1
Ensembl Acc Id: ENSCSAP00000015361   ⟸   ENSCSAT00000000701
RefSeq Acc Id: XP_037849045   ⟸   XM_037993117
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S3C2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037849046   ⟸   XM_037993118
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S3C2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037849047   ⟸   XM_037993119
- Peptide Label: isoform X3
- UniProtKB: A0A0D9S3C2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037849048   ⟸   XM_037993120
- Peptide Label: isoform X3
- UniProtKB: A0A0D9S3C2 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000002689 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000000701.1 UniProtKB/TrEMBL
InterPro Mediator_complex_subunit_1 UniProtKB/TrEMBL
  Mediator_Med1 UniProtKB/TrEMBL
NCBI Gene MED1 ENTREZGENE
PANTHER MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1 UniProtKB/TrEMBL
  MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1 UniProtKB/TrEMBL
Pfam Med1 UniProtKB/TrEMBL
UniProt A0A0D9S3C2 ENTREZGENE, UniProtKB/TrEMBL