RGD Reference Report - The Mediator complex and transcription regulation. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

The Mediator complex and transcription regulation.

Authors: Poss, ZC  Ebmeier, CC  Taatjes, DJ 
Citation: Poss ZC, etal., Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):575-608. doi: 10.3109/10409238.2013.840259. Epub 2013 Oct 3.
RGD ID: 9681732
Pubmed: PMID:24088064   (View Abstract at PubMed)
PMCID: PMC3852498   (View Article at PubMed Central)
DOI: DOI:10.3109/10409238.2013.840259   (Journal Full-text)

The Mediator complex is a multi-subunit assembly that appears to be required for regulating expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and most non-coding RNA genes. Mediator and pol II function within the pre-initiation complex (PIC), which consists of Mediator, pol II, TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH and is approximately 4.0 MDa in size. Mediator serves as a central scaffold within the PIC and helps regulate pol II activity in ways that remain poorly understood. Mediator is also generally targeted by sequence-specific, DNA-binding transcription factors (TFs) that work to control gene expression programs in response to developmental or environmental cues. At a basic level, Mediator functions by relaying signals from TFs directly to the pol II enzyme, thereby facilitating TF-dependent regulation of gene expression. Thus, Mediator is essential for converting biological inputs (communicated by TFs) to physiological responses (via changes in gene expression). In this review, we summarize an expansive body of research on the Mediator complex, with an emphasis on yeast and mammalian complexes. We focus on the basics that underlie Mediator function, such as its structure and subunit composition, and describe its broad regulatory influence on gene expression, ranging from chromatin architecture to transcription initiation and elongation, to mRNA processing. We also describe factors that influence Mediator structure and activity, including TFs, non-coding RNAs and the CDK8 module.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCNCHumanRNA polymerase II transcription pathway   TAS  RGD 
CDK19HumanRNA polymerase II transcription pathway   TAS  RGD 
CDK8HumanRNA polymerase II transcription pathway   TAS  RGD 
CcncRatRNA polymerase II transcription pathway   ISOCCNC (Homo sapiens) RGD 
CcncMouseRNA polymerase II transcription pathway   ISOCCNC (Homo sapiens) RGD 
Cdk19RatRNA polymerase II transcription pathway   ISOCDK19 (Homo sapiens) RGD 
Cdk19MouseRNA polymerase II transcription pathway   ISOCDK19 (Homo sapiens) RGD 
Cdk8RatRNA polymerase II transcription pathway   ISOCDK8 (Homo sapiens) RGD 
Cdk8MouseRNA polymerase II transcription pathway   ISOCDK8 (Homo sapiens) RGD 
MED1HumanRNA polymerase II transcription pathway   TAS  RGD 
MED10HumanRNA polymerase II transcription pathway   TAS  RGD 
MED11HumanRNA polymerase II transcription pathway   TAS  RGD 
MED12HumanRNA polymerase II transcription pathway   TAS  RGD 
MED12LHumanRNA polymerase II transcription pathway   TAS  RGD 
MED13HumanRNA polymerase II transcription pathway   TAS  RGD 
MED13LHumanRNA polymerase II transcription pathway   TAS  RGD 
MED14HumanRNA polymerase II transcription pathway   TAS  RGD 
MED15HumanRNA polymerase II transcription pathway   TAS  RGD 
MED16HumanRNA polymerase II transcription pathway   TAS  RGD 
MED17HumanRNA polymerase II transcription pathway   TAS  RGD 
MED18HumanRNA polymerase II transcription pathway   TAS  RGD 
MED19HumanRNA polymerase II transcription pathway   TAS  RGD 
MED20HumanRNA polymerase II transcription pathway   TAS  RGD 
MED21HumanRNA polymerase II transcription pathway   TAS  RGD 
MED22HumanRNA polymerase II transcription pathway   TAS  RGD 
MED23HumanRNA polymerase II transcription pathway   TAS  RGD 
MED24HumanRNA polymerase II transcription pathway   TAS  RGD 
MED25HumanRNA polymerase II transcription pathway   TAS  RGD 
MED26HumanRNA polymerase II transcription pathway   TAS  RGD 
MED27HumanRNA polymerase II transcription pathway   TAS  RGD 
MED28HumanRNA polymerase II transcription pathway   TAS  RGD 
MED29HumanRNA polymerase II transcription pathway   TAS  RGD 
MED30HumanRNA polymerase II transcription pathway   TAS  RGD 
MED31HumanRNA polymerase II transcription pathway   TAS  RGD 
MED4HumanRNA polymerase II transcription pathway   TAS  RGD 
MED6HumanRNA polymerase II transcription pathway   TAS  RGD 
MED7HumanRNA polymerase II transcription pathway   TAS  RGD 
MED8HumanRNA polymerase II transcription pathway   TAS  RGD 
MED9HumanRNA polymerase II transcription pathway   TAS  RGD 
Med1RatRNA polymerase II transcription pathway   ISOMED1 (Homo sapiens) RGD 
Med1MouseRNA polymerase II transcription pathway   ISOMED1 (Homo sapiens) RGD 
Med10RatRNA polymerase II transcription pathway   ISOMED10 (Homo sapiens) RGD 
Med10MouseRNA polymerase II transcription pathway   ISOMED10 (Homo sapiens) RGD 
Med11RatRNA polymerase II transcription pathway   ISOMED11 (Homo sapiens) RGD 
Med11MouseRNA polymerase II transcription pathway   ISOMED11 (Homo sapiens) RGD 
Med12MouseRNA polymerase II transcription pathway   ISOMED12 (Homo sapiens) RGD 
Med12RatRNA polymerase II transcription pathway   ISOMED12 (Homo sapiens) RGD 
Med12lMouseRNA polymerase II transcription pathway   ISOMED12L (Homo sapiens) RGD 
Med12lRatRNA polymerase II transcription pathway   ISOMED12L (Homo sapiens) RGD 
Med13RatRNA polymerase II transcription pathway   ISOMED13 (Homo sapiens) RGD 
Med13MouseRNA polymerase II transcription pathway   ISOMED13 (Homo sapiens) RGD 
Med13lRatRNA polymerase II transcription pathway   ISOMED13L (Homo sapiens) RGD 
Med13lMouseRNA polymerase II transcription pathway   ISOMED13L (Homo sapiens) RGD 
Med14RatRNA polymerase II transcription pathway   ISOMED14 (Homo sapiens) RGD 
Med14MouseRNA polymerase II transcription pathway   ISOMED14 (Homo sapiens) RGD 
Med15RatRNA polymerase II transcription pathway   ISOMED15 (Homo sapiens) RGD 
Med15MouseRNA polymerase II transcription pathway   ISOMED15 (Homo sapiens) RGD 
Med16RatRNA polymerase II transcription pathway   ISOMED16 (Homo sapiens) RGD 
Med16MouseRNA polymerase II transcription pathway   ISOMED16 (Homo sapiens) RGD 
Med17RatRNA polymerase II transcription pathway   ISOMED17 (Homo sapiens) RGD 
Med17MouseRNA polymerase II transcription pathway   ISOMED17 (Homo sapiens) RGD 
Med18RatRNA polymerase II transcription pathway   ISOMED18 (Homo sapiens) RGD 
Med18MouseRNA polymerase II transcription pathway   ISOMED18 (Homo sapiens) RGD 
Med19RatRNA polymerase II transcription pathway   ISOMED19 (Homo sapiens) RGD 
Med19MouseRNA polymerase II transcription pathway   ISOMED19 (Homo sapiens) RGD 
Med20RatRNA polymerase II transcription pathway   ISOMED20 (Homo sapiens) RGD 
Med20MouseRNA polymerase II transcription pathway   ISOMED20 (Homo sapiens) RGD 
Med21RatRNA polymerase II transcription pathway   ISOMED21 (Homo sapiens) RGD 
Med21MouseRNA polymerase II transcription pathway   ISOMED21 (Homo sapiens) RGD 
Med22MouseRNA polymerase II transcription pathway   ISOMED22 (Homo sapiens) RGD 
Med23RatRNA polymerase II transcription pathway   ISOMED23 (Homo sapiens) RGD 
Med23MouseRNA polymerase II transcription pathway   ISOMED23 (Homo sapiens) RGD 
Med24RatRNA polymerase II transcription pathway   ISOMED24 (Homo sapiens) RGD 
Med24MouseRNA polymerase II transcription pathway   ISOMED24 (Homo sapiens) RGD 
Med25RatRNA polymerase II transcription pathway   ISOMED25 (Homo sapiens) RGD 
Med25MouseRNA polymerase II transcription pathway   ISOMED25 (Homo sapiens) RGD 
Med26RatRNA polymerase II transcription pathway   ISOMED26 (Homo sapiens) RGD 
Med26MouseRNA polymerase II transcription pathway   ISOMED26 (Homo sapiens) RGD 
Med27RatRNA polymerase II transcription pathway   ISOMED27 (Homo sapiens) RGD 
Med27MouseRNA polymerase II transcription pathway   ISOMED27 (Homo sapiens) RGD 
Med28RatRNA polymerase II transcription pathway   ISOMED28 (Homo sapiens) RGD 
Med28MouseRNA polymerase II transcription pathway   ISOMED28 (Homo sapiens) RGD 
Med29RatRNA polymerase II transcription pathway   ISOMED29 (Homo sapiens) RGD 
Med29MouseRNA polymerase II transcription pathway   ISOMED29 (Homo sapiens) RGD 
Med30RatRNA polymerase II transcription pathway   ISOMED30 (Homo sapiens) RGD 
Med30MouseRNA polymerase II transcription pathway   ISOMED30 (Homo sapiens) RGD 
Med31RatRNA polymerase II transcription pathway   ISOMED31 (Homo sapiens) RGD 
Med31MouseRNA polymerase II transcription pathway   ISOMED31 (Homo sapiens) RGD 
Med4RatRNA polymerase II transcription pathway   ISOMED4 (Homo sapiens) RGD 
Med4MouseRNA polymerase II transcription pathway   ISOMED4 (Homo sapiens) RGD 
Med6RatRNA polymerase II transcription pathway   ISOMED6 (Homo sapiens) RGD 
Med6MouseRNA polymerase II transcription pathway   ISOMED6 (Homo sapiens) RGD 
Med7MouseRNA polymerase II transcription pathway   ISOMED7 (Homo sapiens) RGD 
Med7RatRNA polymerase II transcription pathway   ISOMED7 (Homo sapiens) RGD 
Med8MouseRNA polymerase II transcription pathway   ISOMED8 (Homo sapiens) RGD 
Med9MouseRNA polymerase II transcription pathway   ISOMED9 (Homo sapiens) RGD 
Med9RatRNA polymerase II transcription pathway   ISOMED9 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Ccnc  (cyclin C)
Cdk19  (cyclin-dependent kinase 19)
Cdk8  (cyclin-dependent kinase 8)
Med1  (mediator complex subunit 1)
Med10  (mediator complex subunit 10)
Med11  (mediator complex subunit 11)
Med12  (mediator complex subunit 12)
Med12l  (mediator complex subunit 12L)
Med13  (mediator complex subunit 13)
Med13l  (mediator complex subunit 13L)
Med14  (mediator complex subunit 14)
Med15  (mediator complex subunit 15)
Med16  (mediator complex subunit 16)
Med17  (mediator complex subunit 17)
Med18  (mediator complex subunit 18)
Med19  (mediator complex subunit 19)
Med20  (mediator complex subunit 20)
Med21  (mediator complex subunit 21)
Med23  (mediator complex subunit 23)
Med24  (mediator complex subunit 24)
Med25  (mediator complex subunit 25)
Med26  (mediator complex subunit 26)
Med27  (mediator complex subunit 27)
Med28  (mediator complex subunit 28)
Med29  (mediator complex subunit 29)
Med30  (mediator complex subunit 30)
Med31  (mediator complex subunit 31)
Med4  (mediator complex subunit 4)
Med6  (mediator complex subunit 6)
Med7  (mediator complex subunit 7)
Med9  (mediator complex subunit 9)

Genes (Mus musculus)
Ccnc  (cyclin C)
Cdk19  (cyclin dependent kinase 19)
Cdk8  (cyclin dependent kinase 8)
Med1  (mediator complex subunit 1)
Med10  (mediator complex subunit 10)
Med11  (mediator complex subunit 11)
Med12  (mediator complex subunit 12)
Med12l  (mediator complex subunit 12-like)
Med13  (mediator complex subunit 13)
Med13l  (mediator complex subunit 13-like)
Med14  (mediator complex subunit 14)
Med15  (mediator complex subunit 15)
Med16  (mediator complex subunit 16)
Med17  (mediator complex subunit 17)
Med18  (mediator complex subunit 18)
Med19  (mediator complex subunit 19)
Med20  (mediator complex subunit 20)
Med21  (mediator complex subunit 21)
Med22  (mediator complex subunit 22)
Med23  (mediator complex subunit 23)
Med24  (mediator complex subunit 24)
Med25  (mediator complex subunit 25)
Med26  (mediator complex subunit 26)
Med27  (mediator complex subunit 27)
Med28  (mediator complex subunit 28)
Med29  (mediator complex subunit 29)
Med30  (mediator complex subunit 30)
Med31  (mediator complex subunit 31)
Med4  (mediator complex subunit 4)
Med6  (mediator complex subunit 6)
Med7  (mediator complex subunit 7)
Med8  (mediator complex subunit 8)
Med9  (mediator complex subunit 9)

Genes (Homo sapiens)
CCNC  (cyclin C)
CDK19  (cyclin dependent kinase 19)
CDK8  (cyclin dependent kinase 8)
MED1  (mediator complex subunit 1)
MED10  (mediator complex subunit 10)
MED11  (mediator complex subunit 11)
MED12  (mediator complex subunit 12)
MED12L  (mediator complex subunit 12L)
MED13  (mediator complex subunit 13)
MED13L  (mediator complex subunit 13L)
MED14  (mediator complex subunit 14)
MED15  (mediator complex subunit 15)
MED16  (mediator complex subunit 16)
MED17  (mediator complex subunit 17)
MED18  (mediator complex subunit 18)
MED19  (mediator complex subunit 19)
MED20  (mediator complex subunit 20)
MED21  (mediator complex subunit 21)
MED22  (mediator complex subunit 22)
MED23  (mediator complex subunit 23)
MED24  (mediator complex subunit 24)
MED25  (mediator complex subunit 25)
MED26  (mediator complex subunit 26)
MED27  (mediator complex subunit 27)
MED28  (mediator complex subunit 28)
MED29  (mediator complex subunit 29)
MED30  (mediator complex subunit 30)
MED31  (mediator complex subunit 31)
MED4  (mediator complex subunit 4)
MED6  (mediator complex subunit 6)
MED7  (mediator complex subunit 7)
MED8  (mediator complex subunit 8)
MED9  (mediator complex subunit 9)


Additional Information