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Gene: TBP (TATA-box binding protein) Homo sapiens
Symbol: TBP
Name: TATA-box binding protein
RGD ID: 68980
Description: Exhibits several functions, including RNA polymerase II core promoter sequence-specific DNA binding activity; general transcription initiation factor activity; and transcription factor binding activity. Involved in RNA polymerase II preinitiation complex assembly and transcription by RNA polymerase III. Localizes to nuclear lumen and transcription preinitiation complex. Implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Biomarker of Alzheimer's disease; Huntington's disease; and sleep apnea.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GTF2D; GTF2D1; HDL4; MGC117320; MGC126054; MGC126055; SCA17; TATA sequence-binding protein; TATA-box binding protein N-terminal domain; TATA-box factor; TATA-box-binding protein; TFIID; transcription initiation factor TFIID TBP subunit
Mus musculus (house mouse) : Tbp (TATA box binding protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tbp (TATA box binding protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tbp (TATA-box binding protein)
Pan paniscus (bonobo/pygmy chimpanzee) : TBP (TATA-box binding protein)
Canis lupus familiaris (dog) : TBP (TATA-box binding protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tbp (TATA-box binding protein)
Sus scrofa (pig) : TBP (TATA-box binding protein)
Chlorocebus sabaeus (African green monkey) : TBP (TATA-box binding protein)
Heterocephalus glaber (naked mole-rat) : Tbp (TATA-box binding protein)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   BW323_H   BMD3_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl6170,554,302 - 170,572,870 (+)EnsemblGRCh38hg38GRCh38
GRCh386170,554,369 - 170,572,859 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376170,863,384 - 170,881,958 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366170,705,396 - 170,723,872 (+)NCBINCBI36hg18NCBI36
Build 346170,781,102 - 170,799,578NCBI
Celera6171,658,683 - 171,677,210 (+)NCBI
Cytogenetic Map6q27NCBI
HuRef6168,368,477 - 168,387,004 (+)NCBIHuRef
CHM1_16171,124,696 - 171,144,174 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TBP
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68980
Created: 2001-11-06
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.