MED1 (mediator complex subunit 1) - Rat Genome Database

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Pathways
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Gene: MED1 (mediator complex subunit 1) Canis lupus familiaris
Analyze
Symbol: MED1
Name: mediator complex subunit 1
RGD ID: 12151067
Description: ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); general transcription initiation factor binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); animal organ regeneration (ortholog); brain development (ortholog); PARTICIPATES IN cortisol signaling pathway; estrogen signaling pathway; RNA polymerase II transcription pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); congestive heart failure (ortholog); dilated cardiomyopathy (ortholog); FOUND IN chromatin (ortholog); core mediator complex (ortholog); protein-DNA complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mediator of RNA polymerase II transcription subunit 1; PPAR binding protein; PPARBP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,989,257 - 23,019,350 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,989,301 - 23,019,349 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,461,097 - 22,488,309 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,782,837 - 23,810,295 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,782,848 - 23,813,191 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,554,940 - 22,582,360 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,816,047 - 22,843,443 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,941,470 - 22,968,890 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen biosynthetic process  (IEA)
angiogenesis  (IEA)
animal organ morphogenesis  (IEA,ISO)
animal organ regeneration  (IEA,ISO)
brain development  (IEA,ISO)
camera-type eye development  (IEA,ISO)
cell morphogenesis  (IEA)
cellular response to epidermal growth factor stimulus  (IEA)
cellular response to hepatocyte growth factor stimulus  (IEA,ISO)
cellular response to steroid hormone stimulus  (IEA)
cellular response to thyroid hormone stimulus  (IEA,ISO)
embryonic heart tube development  (IEA,ISO)
embryonic hemopoiesis  (IEA,ISO)
embryonic hindlimb morphogenesis  (IEA,ISO)
embryonic placenta development  (IEA,ISO)
enucleate erythrocyte development  (IEA,ISO)
epithelial cell proliferation involved in mammary gland duct elongation  (IEA,ISO)
erythrocyte development  (IEA,ISO)
fat cell differentiation  (IEA,ISO)
G0 to G1 transition  (IEA,ISO)
heart development  (IEA,ISO)
hematopoietic stem cell differentiation  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
intracellular steroid hormone receptor signaling pathway  (IEA)
keratinocyte differentiation  (IEA)
lactation  (IEA,ISO)
lens development in camera-type eye  (IEA)
liver development  (IEA,ISO)
mammary gland branching involved in pregnancy  (IEA,ISO)
mammary gland branching involved in thelarche  (IEA,ISO)
mammary gland epithelial cell proliferation  (IEA,ISO)
megakaryocyte development  (IEA)
monocyte differentiation  (IEA,ISO)
mRNA transcription by RNA polymerase II  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of keratinocyte proliferation  (IEA)
negative regulation of neuron differentiation  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
peroxisome proliferator activated receptor signaling pathway  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of erythrocyte differentiation  (IEA)
positive regulation of G0 to G1 transition  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of hepatocyte proliferation  (IEA,ISO)
positive regulation of intracellular estrogen receptor signaling pathway  (IEA,ISO)
positive regulation of keratinocyte differentiation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription initiation by RNA polymerase II  (IEA)
positive regulation of type II interferon-mediated signaling pathway  (IEA,ISO)
protein import into nucleus  (IEA,ISO)
protein ubiquitination  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of RNA biosynthetic process  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
regulation of vitamin D receptor signaling pathway  (IEA,ISO)
retinal pigment epithelium development  (IEA)
thyroid hormone generation  (IEA,ISO)
thyroid hormone mediated signaling pathway  (IEA)
ventricular trabecula myocardium morphogenesis  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MED1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,989,257 - 23,019,350 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,989,301 - 23,019,349 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,461,097 - 22,488,309 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,782,837 - 23,810,295 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,782,848 - 23,813,191 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,554,940 - 22,582,360 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,816,047 - 22,843,443 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,941,470 - 22,968,890 (+)NCBIUU_Cfam_GSD_1.0
MED1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381739,404,285 - 39,451,263 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1739,404,285 - 39,451,272 (-)EnsemblGRCh38hg38GRCh38
GRCh371737,560,538 - 37,607,516 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361734,814,064 - 34,861,053 (-)NCBINCBI36Build 36hg18NCBI36
Build 341734,816,379 - 34,861,030NCBI
Celera1734,221,470 - 34,268,494 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1733,354,022 - 33,401,237 (-)NCBIHuRef
CHM1_11737,796,744 - 37,843,728 (-)NCBICHM1_1
T2T-CHM13v2.01740,268,198 - 40,315,170 (-)NCBIT2T-CHM13v2.0
Med1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,042,980 - 98,084,121 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,042,980 - 98,084,119 (-)EnsemblGRCm39 Ensembl
GRCm381198,152,154 - 98,193,313 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,152,154 - 98,193,293 (-)EnsemblGRCm38mm10GRCm38
MGSCv371198,013,468 - 98,054,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361197,968,244 - 98,009,350 (-)NCBIMGSCv36mm8
Celera11107,807,134 - 107,848,278 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1161.75NCBI
Med1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81083,641,851 - 83,685,560 (-)NCBIGRCr8
mRatBN7.21083,145,538 - 83,189,260 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,145,568 - 83,189,299 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,091,753 - 88,133,134 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,589,837 - 87,631,219 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01082,982,482 - 83,023,863 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,101,560 - 86,145,271 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,103,600 - 86,144,880 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01085,899,172 - 85,942,182 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41086,917,525 - 86,959,080 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1081,896,663 - 81,937,929 (-)NCBICelera
Cytogenetic Map10q31NCBI
Med1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,202,744 - 14,237,797 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,204,326 - 14,237,809 (-)NCBIChiLan1.0ChiLan1.0
MED1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21925,502,545 - 25,550,519 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11727,397,326 - 27,444,674 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,836,350 - 17,883,610 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11718,050,250 - 18,096,109 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1718,050,474 - 18,095,118 (+)Ensemblpanpan1.1panPan2
Med1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560222,411,935 - 22,448,238 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649014,625,897 - 14,657,802 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649014,625,201 - 14,663,184 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,841,205 - 22,872,409 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,830,405 - 22,872,420 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,283,204 - 23,325,356 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MED1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,719,393 - 66,764,902 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,719,423 - 66,762,896 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607737,634,868 - 37,686,645 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Med1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,572,266 - 3,607,126 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,572,025 - 3,605,675 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MED1
246 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 10 5 6 8 10
Low 4 5 12 6 6 6 1 6 6 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000026068   ⟹   ENSCAFP00000024203
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl922,989,301 - 23,016,184 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000065028   ⟹   ENSCAFP00000050649
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl922,989,301 - 23,018,376 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000087248   ⟹   ENSCAFP00000061839
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl922,989,301 - 23,019,349 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845023146   ⟹   ENSCAFP00845018147
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl923,782,848 - 23,813,191 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845023217   ⟹   ENSCAFP00845018208
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl923,782,850 - 23,810,295 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845023246   ⟹   ENSCAFP00845018235
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl923,782,864 - 23,810,288 (+)Ensembl
RefSeq Acc Id: XM_038485666   ⟹   XP_038341594
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1922,554,940 - 22,582,360 (+)NCBI
RefSeq Acc Id: XM_038547436   ⟹   XP_038403364
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0922,941,470 - 22,968,890 (+)NCBI
RefSeq Acc Id: XM_038611416   ⟹   XP_038467344
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0922,816,047 - 22,843,443 (+)NCBI
RefSeq Acc Id: XM_038676615   ⟹   XP_038532543
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0923,782,837 - 23,810,295 (+)NCBI
RefSeq Acc Id: XM_858916   ⟹   XP_864009
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1922,989,257 - 23,019,350 (+)NCBI
Dog10K_Boxer_Tasha922,461,097 - 22,488,309 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_864009   ⟸   XM_858916
- UniProtKB: A0A8C0MR58 (UniProtKB/TrEMBL),   A0A8C0LED1 (UniProtKB/TrEMBL),   A0A8I3NEL7 (UniProtKB/TrEMBL),   A0A8P0SKR3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000061839   ⟸   ENSCAFT00000087248
RefSeq Acc Id: ENSCAFP00000050649   ⟸   ENSCAFT00000065028
RefSeq Acc Id: ENSCAFP00000024203   ⟸   ENSCAFT00000026068
RefSeq Acc Id: XP_038341594   ⟸   XM_038485666
RefSeq Acc Id: XP_038467344   ⟸   XM_038611416
RefSeq Acc Id: XP_038532543   ⟸   XM_038676615
- UniProtKB: A0A8C0MR58 (UniProtKB/TrEMBL),   A0A8C0LED1 (UniProtKB/TrEMBL),   A0A8I3NEL7 (UniProtKB/TrEMBL),   A0A8P0SKR3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038403364   ⟸   XM_038547436
- UniProtKB: A0A8C0LED1 (UniProtKB/TrEMBL),   A0A8C0MR58 (UniProtKB/TrEMBL),   A0A8I3NEL7 (UniProtKB/TrEMBL),   A0A8P0SKR3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845018235   ⟸   ENSCAFT00845023246
RefSeq Acc Id: ENSCAFP00845018208   ⟸   ENSCAFT00845023217
RefSeq Acc Id: ENSCAFP00845018147   ⟸   ENSCAFT00845023146
Protein Domains
Mediator complex subunit Med1

Promoters
RGD ID:13684557
Promoter ID:EPDNEW_C2624
Type:multiple initiation site
Name:MED1_1
Description:mediator complex subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1922,989,280 - 22,989,340EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016441 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030009446 UniProtKB/TrEMBL
  ENSCAFG00040002352 UniProtKB/TrEMBL
  ENSCAFG00845013007 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026068.6 UniProtKB/TrEMBL
  ENSCAFT00000065028.2 UniProtKB/TrEMBL
  ENSCAFT00000087248.2 UniProtKB/TrEMBL
  ENSCAFT00030017458.1 UniProtKB/TrEMBL
  ENSCAFT00030017584.1 UniProtKB/TrEMBL
  ENSCAFT00030017760.1 UniProtKB/TrEMBL
  ENSCAFT00030017840.1 UniProtKB/TrEMBL
  ENSCAFT00040004462.1 UniProtKB/TrEMBL
  ENSCAFT00040004494.1 UniProtKB/TrEMBL
  ENSCAFT00040004519.1 UniProtKB/TrEMBL
  ENSCAFT00040004523.1 UniProtKB/TrEMBL
  ENSCAFT00845023146.1 UniProtKB/TrEMBL
  ENSCAFT00845023217 ENTREZGENE
  ENSCAFT00845023217.1 UniProtKB/TrEMBL
  ENSCAFT00845023246.1 UniProtKB/TrEMBL
InterPro Mediator_Med1 UniProtKB/TrEMBL
KEGG Report cfa:480533 UniProtKB/TrEMBL
NCBI Gene MED1 ENTREZGENE
PANTHER MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1 UniProtKB/TrEMBL
  MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1 UniProtKB/TrEMBL
Pfam Med1 UniProtKB/TrEMBL
UniProt A0A8C0LED1 ENTREZGENE
  A0A8C0MQL9_CANLF UniProtKB/TrEMBL
  A0A8C0MR06_CANLF UniProtKB/TrEMBL
  A0A8C0MR58 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q5T5_CANLF UniProtKB/TrEMBL
  A0A8I3NEL7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NNS7_CANLF UniProtKB/TrEMBL
  A0A8I3NPA6_CANLF UniProtKB/TrEMBL
  A0A8P0P0G9_CANLF UniProtKB/TrEMBL
  A0A8P0SKR3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43117 ENTREZGENE