SLC46A2 (solute carrier family 46 member 2) - Rat Genome Database

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Pathways
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Gene: SLC46A2 (solute carrier family 46 member 2) Chlorocebus sabaeus
Analyze
Symbol: SLC46A2
Name: solute carrier family 46 member 2
RGD ID: 18645738
Description: ENCODES a protein that exhibits cyclic-GMP-AMP transmembrane transporter activity (ortholog); INVOLVED IN cyclic-GMP-AMP transmembrane import across plasma membrane (ortholog); negative regulation of T cell apoptotic process (ortholog); positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: thymic stromal cotransporter homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11226,631,295 - 26,646,112 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1226,633,493 - 26,646,038 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603516,145,372 - 16,158,151 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC46A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11226,631,295 - 26,646,112 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1226,633,493 - 26,646,038 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603516,145,372 - 16,158,151 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SLC46A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389112,878,920 - 112,890,876 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9112,878,920 - 112,890,876 (-)EnsemblGRCh38hg38GRCh38
GRCh379115,641,200 - 115,653,156 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369114,681,021 - 114,692,866 (-)NCBINCBI36Build 36hg18NCBI36
Build 349112,720,755 - 112,732,600NCBI
Celera986,314,093 - 86,326,088 (+)NCBICelera
Cytogenetic Map9q32NCBI
HuRef985,239,036 - 85,251,012 (-)NCBIHuRef
CHM1_19115,788,488 - 115,800,474 (-)NCBICHM1_1
T2T-CHM13v2.09125,050,362 - 125,072,489 (-)NCBIT2T-CHM13v2.0
Slc46a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39459,905,899 - 59,915,056 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl459,905,126 - 59,915,056 (-)EnsemblGRCm39 Ensembl
GRCm38459,905,899 - 59,915,056 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl459,905,126 - 59,915,056 (-)EnsemblGRCm38mm10GRCm38
MGSCv37459,918,771 - 59,927,928 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36459,999,180 - 60,009,110 (-)NCBIMGSCv36mm8
Celera459,822,589 - 59,831,770 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map432.81NCBI
Slc46a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8579,594,003 - 79,603,074 (-)NCBIGRCr8
mRatBN7.2574,800,226 - 74,808,128 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl574,800,226 - 74,808,128 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx576,700,364 - 76,708,304 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0578,521,999 - 78,529,935 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0578,494,162 - 78,502,102 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0577,165,463 - 77,174,177 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl577,165,598 - 77,173,502 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0581,300,022 - 81,307,920 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4578,044,714 - 78,052,612 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1578,043,262 - 78,057,672 (-)NCBI
Celera573,609,789 - 73,617,699 (-)NCBICelera
Cytogenetic Map5q24NCBI
Slc46a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541914,547,103 - 14,557,531 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541914,547,393 - 14,557,447 (+)NCBIChiLan1.0ChiLan1.0
SLC46A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21126,549,345 - 26,561,525 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1926,551,704 - 26,563,884 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0984,001,056 - 84,013,231 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19112,154,001 - 112,165,906 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9112,154,001 - 112,165,906 (-)Ensemblpanpan1.1panPan2
SLC46A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11167,297,596 - 67,305,893 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1167,297,597 - 67,305,893 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1165,704,288 - 65,712,588 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01168,423,487 - 68,431,777 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1168,423,488 - 68,431,777 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11166,939,761 - 66,948,049 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01166,962,952 - 66,971,235 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01167,707,572 - 67,715,860 (-)NCBIUU_Cfam_GSD_1.0
Slc46a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947182,586,765 - 182,596,316 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936559670,231 - 679,766 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936559670,239 - 674,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC46A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1253,559,546 - 253,570,113 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11253,559,545 - 253,571,015 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21284,368,646 - 284,379,213 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Slc46a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476022,124,321 - 22,134,906 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476022,124,321 - 22,134,601 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 1
Low 19 1
Below cutoff 33 52

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000010453   ⟹   ENSCSAP00000008550
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1226,633,493 - 26,646,038 (+)Ensembl
RefSeq Acc Id: XM_007968390   ⟹   XP_007966581
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11226,631,297 - 26,646,112 (+)NCBI
Vero_WHO_p1.0NW_02366603516,145,372 - 16,158,151 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007966581 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000008550
  ENSCSAP00000008550.1
Reference Protein Sequences
RefSeq Acc Id: XP_007966581   ⟸   XM_007968390
- UniProtKB: A0A0D9RIW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000008550   ⟸   ENSCSAT00000010453


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000012363 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000010453.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro MFS UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
  Tet-R_TetA/multi-R_MdtG UniProtKB/TrEMBL
KEGG Report csab:103219003 UniProtKB/TrEMBL
NCBI Gene SLC46A2 ENTREZGENE
PANTHER THYMIC STROMAL COTRANSPORTER HOMOLOG UniProtKB/TrEMBL
  ZGC:174356 UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
PRINTS TCRTETA UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/TrEMBL
UniProt A0A0D9RIW1 ENTREZGENE, UniProtKB/TrEMBL