CGAS (cyclic GMP-AMP synthase) - Rat Genome Database

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Gene: CGAS (cyclic GMP-AMP synthase) Chlorocebus sabaeus
Analyze
Symbol: CGAS
Name: cyclic GMP-AMP synthase
RGD ID: 18543387
Description: ENCODES a protein that exhibits 2',3'-cyclic GMP-AMP synthase activity (inferred); chromatin binding (inferred); DNA binding (inferred); INVOLVED IN determination of adult lifespan (ortholog); regulation of immune response (ortholog); regulation of immunoglobulin production (ortholog); ASSOCIATED WITH genetic disease (ortholog); sialuria (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Mab-21 domain containing 1; MB21D1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1171,697,446 - 1,723,626 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl171,697,775 - 1,723,472 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660587,609,831 - 7,638,092 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
CGAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1171,697,446 - 1,723,626 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl171,697,775 - 1,723,472 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660587,609,831 - 7,638,092 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CGAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38673,423,711 - 73,452,297 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl673,413,515 - 73,452,297 (-)EnsemblGRCh38hg38GRCh38
GRCh37674,133,434 - 74,162,020 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36674,191,577 - 74,218,764 (-)NCBINCBI36Build 36hg18NCBI36
Build 34674,191,313 - 74,218,720NCBI
Celera674,529,415 - 74,556,286 (-)NCBICelera
Cytogenetic Map6q13NCBI
HuRef671,333,337 - 71,360,196 (-)NCBIHuRef
CHM1_1674,301,681 - 74,328,872 (-)NCBICHM1_1
T2T-CHM13v2.0674,600,410 - 74,628,713 (-)NCBIT2T-CHM13v2.0
Cgas
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39978,337,800 - 78,350,519 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl978,337,808 - 78,350,519 (-)EnsemblGRCm39 Ensembl
GRCm38978,430,518 - 78,443,237 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl978,430,526 - 78,443,237 (-)EnsemblGRCm38mm10GRCm38
MGSCv37978,278,325 - 78,290,954 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36978,217,019 - 78,228,921 (-)NCBIMGSCv36mm8
Celera975,608,705 - 75,621,402 (-)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.65NCBI
Cgas
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8888,172,559 - 88,187,538 (-)NCBIGRCr8
mRatBN7.2879,292,282 - 79,306,998 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl879,294,511 - 79,305,496 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0885,789,515 - 85,804,008 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,789,763 - 85,803,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0885,344,976 - 85,353,236 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera879,042,110 - 79,053,035 (-)NCBICelera
Cytogenetic Map8q31NCBI
Cgas
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554938,593,104 - 8,607,297 (-)NCBIChiLan1.0ChiLan1.0
CGAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2593,404,484 - 93,435,310 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1691,329,355 - 91,359,775 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0671,252,050 - 71,279,121 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1674,542,994 - 74,567,107 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl674,544,251 - 74,566,965 (-)Ensemblpanpan1.1panPan2
CGAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11235,511,920 - 35,528,759 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1235,512,860 - 35,528,596 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1235,380,775 - 35,399,989 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01236,066,175 - 36,085,892 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1236,066,172 - 36,085,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11235,605,589 - 35,625,008 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01235,627,370 - 35,646,829 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01235,751,269 - 35,770,689 (-)NCBIUU_Cfam_GSD_1.0
Cgas
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494670,802,542 - 70,812,760 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936859797,469 - 807,036 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CGAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl192,483,327 - 92,504,307 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1192,483,253 - 92,500,376 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21103,536,112 - 103,553,221 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Cgas
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624819643,045 - 680,684 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624819587,739 - 680,618 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 29 20 41
Below cutoff 7 19

Sequence


RefSeq Acc Id: ENSCSAT00000012110   ⟹   ENSCSAP00000010160
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl171,697,775 - 1,723,472 (+)Ensembl
RefSeq Acc Id: XM_008013489   ⟹   XP_008011680
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1171,697,448 - 1,723,532 (+)NCBI
Vero_WHO_p1.0NW_0236660587,609,831 - 7,638,092 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008011680 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000010160.1
RefSeq Acc Id: XP_008011680   ⟸   XM_008013489
- UniProtKB: A0A0D9RNH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000010160   ⟸   ENSCSAT00000012110


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014020 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012110.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1410.40 UniProtKB/TrEMBL
  3.30.460.90 UniProtKB/TrEMBL
InterPro Mab-21-like_nuc_Trfase UniProtKB/TrEMBL
  Mab-21_dom UniProtKB/TrEMBL
  Mab-21_HhH/H2TH-like UniProtKB/TrEMBL
NCBI Gene CGAS ENTREZGENE
PANTHER CELL FATE DETERMINING PROTEIN MAB21-RELATED UniProtKB/TrEMBL
  CYCLIC GMP-AMP SYNTHASE UniProtKB/TrEMBL
Pfam Mab-21 UniProtKB/TrEMBL
  Mab-21_C UniProtKB/TrEMBL
SMART Mab-21 UniProtKB/TrEMBL
UniProt A0A0D9RNH1 ENTREZGENE, UniProtKB/TrEMBL