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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of type I interferon production
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Accession:GO:0032480 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
Synonyms:exact_synonym: down regulation of type I interferon production;   downregulation of type I interferon production;   negative regulation of type I IFN production
 narrow_synonym: inhibition of type I interferon production


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negative regulation of type I interferon production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 involved_in ISO (PMID:23609450) RGD PMID:23609450 NCBI chr15:79,871,819...79,881,101
Ensembl chr15:79,871,827...79,880,529 		JBrowse link
G Atg12 autophagy related 12 involved_in ISO (PMID:17709747) RGD PMID:17709747 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418 		JBrowse link
G Atg5 autophagy related 5 involved_in IEA
ISO		 GO_REF:0000107
(PMID:17709747)		 Ensembl
RGD		 PMID:17709747 GO_REF:0000107 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Banf1 barrier to autointegration nuclear assembly factor 1 involved_in ISO
ISS		 (PMID:32792394)
GO_REF:0000024		 RGD
UniProt		 PMID:32792394 GO_REF:0000024 NCBI chr 1:202,672,170...202,674,215
Ensembl chr 1:202,671,305...202,674,188 		JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 1:182,515,335...182,520,007
Ensembl chr 1:182,515,327...182,536,633 		JBrowse link
G Cul3 cullin 3 involved_in ISO
IEA		 (PMID:36394357)
GO_REF:0000107		 RGD
Ensembl		 PMID:36394357 GO_REF:0000107 NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462 		JBrowse link
G Ddx56 DEAD-box helicase 56 involved_in ISO (PMID:31340999) RGD PMID:31340999 NCBI chr14:81,112,008...81,122,331
Ensembl chr14:81,112,012...81,122,333 		JBrowse link
G Dhx58 DEXH-box helicase 58 involved_in ISO (PMID:21525357) RGD PMID:21525357 NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525 		JBrowse link
G Gbp7 guanylate binding protein 7 involved_in ISO (PMID:33408175) RGD PMID:33408175 NCBI chr 2:231,275,521...231,297,289
Ensembl chr 2:231,275,640...231,297,278 		JBrowse link
G Gpatch3 G patch domain containing 3 involved_in ISO
IBA		 (PMID:28414768)
GO_REF:0000033		 RGD
GO_Central		 PMID:28414768 GO_REF:0000033 NCBI chr 5:145,800,107...145,809,519
Ensembl chr 5:145,800,111...145,809,250 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:22842346) RGD PMID:22842346 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Ilrun inflammation and lipid regulator with UBA-like and NBR1-like domains involved_in ISO (PMID:29802199) RGD PMID:29802199 NCBI chr20:5,809,931...5,876,197
Ensembl chr20:5,809,936...5,876,012 		JBrowse link
G Irgm immunity-related GTPase M involved_in ISS
ISO		 GO_REF:0000024
(PMID:21633090), (PMID:33510463)
(PMID:32715615), (PMID:34467632)		 UniProt
RGD		 PMID:21633090 PMID:32715615 PMID:33510463 PMID:34467632 GO_REF:0000024 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578 		JBrowse link
G Kat8 lysine acetyltransferase 8 involved_in IEA
ISO		 GO_REF:0000107
(PMID:30842237)		 Ensembl
RGD		 PMID:30842237 GO_REF:0000107 NCBI chr 1:182,524,355...182,536,638
Ensembl chr 1:182,515,327...182,536,633 		JBrowse link
G Klhl22 kelch-like family member 22 involved_in ISO (PMID:36394357) RGD PMID:36394357 NCBI chr11:83,190,891...83,231,746
Ensembl chr11:83,190,891...83,231,770 		JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:23633945) RGD PMID:23633945 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Nmi N-myc (and STAT) interactor acts_upstream_of_or_within ISO MGI:1859212 (PMID:23956435) RGD PMID:23956435 NCBI chr 3:36,415,607...36,439,716
Ensembl chr 3:36,415,607...36,439,498 		JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor involved_in ISO
IEA
ISS		 (PMID:26471729)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26471729 GO_REF:0000024 GO_REF:0000107 NCBI chr10:105,654,395...105,709,958
Ensembl chr10:105,654,812...105,709,913 		JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within ISO MGI:5441750 (PMID:23042151) RGD PMID:23042151 NCBI chr 1:202,230,034...202,242,900
Ensembl chr 1:202,232,228...202,242,857 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 involved_in ISO
IEA		 (PMID:26358190)
GO_REF:0000107		 RGD
Ensembl		 PMID:26358190 GO_REF:0000107 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Qki QKI, KH domain containing RNA binding involved_in ISO (PMID:31829086), (PMID:34428287) RGD PMID:31829086 PMID:34428287 NCBI chr 1:50,387,716...50,501,568
Ensembl chr 1:50,387,698...50,498,831 		JBrowse link
G Rbx1 ring-box 1 involved_in ISO (PMID:36394357) RGD PMID:36394357 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051 		JBrowse link
G Rnf125 ring finger protein 125 involved_in ISO (PMID:17460044), (PMID:26471729) RGD PMID:17460044 PMID:26471729 NCBI chr18:12,254,066...12,275,719
Ensembl chr18:12,253,852...12,275,983 		JBrowse link
G Siglec1 sialic acid binding Ig like lectin 1 involved_in ISO (PMID:26358190) RGD PMID:26358190 NCBI chr 3:118,287,988...118,307,125
Ensembl chr 3:118,287,988...118,306,850 		JBrowse link
G Traf3ip1 TRAF3 interacting protein 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:22079989)		 Ensembl
RGD		 PMID:22079989 GO_REF:0000107 NCBI chr 9:92,073,622...92,110,427
Ensembl chr 9:92,073,640...92,108,977 		JBrowse link
G Trim27 tripartite motif-containing 27 involved_in ISO (PMID:26358190) RGD PMID:26358190 NCBI chr17:43,538,282...43,550,633
Ensembl chr17:43,538,285...43,550,643 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in ISO (PMID:26358190) RGD PMID:26358190 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 involved_in ISO
IEA
ISS		 (PMID:26471729)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26471729 GO_REF:0000024 GO_REF:0000107 NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087 		JBrowse link
G Xaf1 XIAP associated factor 1 involved_in ISO (PMID:36394357) RGD PMID:36394357 NCBI chr10:56,917,378...56,929,791
Ensembl chr10:56,917,121...56,929,770 		JBrowse link
negative regulation of interferon-alpha production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:26492563) RGD PMID:26492563 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 involved_in ISO (PMID:24560620) RGD PMID:24560620 NCBI chr10:11,551,378...11,585,027
Ensembl chr10:11,551,356...11,584,398 		JBrowse link
G Nmi N-myc (and STAT) interactor acts_upstream_of_or_within ISO (PMID:23956435) RGD PMID:23956435 NCBI chr 3:36,415,607...36,439,716
Ensembl chr 3:36,415,607...36,439,498 		JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S involved_in ISO
IEA		 (PMID:26231120)
GO_REF:0000107		 RGD
Ensembl		 PMID:26231120 GO_REF:0000107 NCBI chr 9:1,245,408...1,307,015
Ensembl chr 9:1,245,410...1,306,947 		JBrowse link
negative regulation of interferon-beta production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg9a autophagy related 9A acts_upstream_of_or_within ISO (PMID:24670807) RGD PMID:24670807 NCBI chr 9:76,677,403...76,688,050
Ensembl chr 9:76,677,404...76,687,986 		JBrowse link
G Cactin cactin, spliceosome C complex subunit involved_in ISO (PMID:20829348) RGD PMID:20829348 NCBI chr 7:8,391,396...8,397,219
Ensembl chr 7:8,391,397...8,396,829 		JBrowse link
G Crebbp CREB binding protein involved_in ISO (PMID:11583620) RGD PMID:11583620 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Mir26b microRNA 26b acts_upstream_of ISO (PMID:26222045) RGD PMID:26222045 NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680 		JBrowse link
G Morc3 MORC family CW-type zinc finger 3 involved_in ISO (PMID:34759314) RGD PMID:34759314 NCBI chr11:33,151,906...33,194,650
Ensembl chr11:33,152,025...33,194,646 		JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 involved_in ISO (PMID:24560620) RGD PMID:24560620 NCBI chr10:11,551,378...11,585,027
Ensembl chr10:11,551,356...11,584,398 		JBrowse link
G Nlrx1 NLR family member X1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:5141085 (PMID:21703540)		 Ensembl
RGD		 PMID:21703540 GO_REF:0000107 NCBI chr 8:44,588,476...44,606,678
Ensembl chr 8:44,590,048...44,606,484 		JBrowse link
G Nmi N-myc (and STAT) interactor acts_upstream_of_or_within ISO (PMID:23956435) RGD PMID:23956435 NCBI chr 3:36,415,607...36,439,716
Ensembl chr 3:36,415,607...36,439,498 		JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:22750291)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:22750291 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:9,646,695...9,707,471
Ensembl chr 6:9,655,765...9,707,974 		JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S involved_in ISO
IEA		 (PMID:26231120)
GO_REF:0000107		 RGD
Ensembl		 PMID:26231120 GO_REF:0000107 NCBI chr 9:1,245,408...1,307,015
Ensembl chr 9:1,245,410...1,306,947 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:19158675) RGD PMID:19158675 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit involved_in ISO (PMID:22065573) RGD PMID:22065573 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit involved_in ISO (PMID:22065573) RGD PMID:22065573 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Sirpa signal-regulatory protein alpha involved_in ISO (PMID:17954568) RGD PMID:17954568 NCBI chr 3:116,819,730...116,858,099
Ensembl chr 3:116,819,726...116,858,098 		JBrowse link
G Traf3ip1 TRAF3 interacting protein 1 acts_upstream_of_or_within ISO (PMID:22079989) RGD PMID:22079989 NCBI chr 9:92,073,622...92,110,427
Ensembl chr 9:92,073,640...92,108,977 		JBrowse link
G Traip TRAF-interacting protein involved_in ISO (PMID:22945920) RGD PMID:22945920 NCBI chr 8:108,641,860...108,661,640
Ensembl chr 8:108,641,852...108,661,638 		JBrowse link
G Yy1 YY1 transcription factor involved_in ISO (PMID:16260628) RGD PMID:16260628 NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    multicellular organismal process 8906
      negative regulation of multicellular organismal process 1342
        negative regulation of cytokine production 385
          negative regulation of type I interferon production 44
            negative regulation of interferon-alpha production 4
            negative regulation of interferon-beta production 17
Path 2
Term Annotations click to browse term
  biological_process 20069
    biological regulation 13554
      regulation of biological process 13131
        regulation of cellular process 12768
          regulation of metabolic process 6743
            regulation of biosynthetic process 5507
              regulation of macromolecule biosynthetic process 5305
                regulation of gene expression 5186
                  regulation of cytokine production 906
                    negative regulation of cytokine production 385
                      negative regulation of type I interferon production 44
                        negative regulation of interferon-alpha production 4
                        negative regulation of interferon-beta production 17
paths to the root