Gbp7 (guanylate binding protein 7) - Rat Genome Database

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Gene: Gbp7 (guanylate binding protein 7) Rattus norvegicus
Analyze
Symbol: Gbp7
Name: guanylate binding protein 7
RGD ID: 1583235
Description: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of cytokine production; and regulation of signal transduction. Predicted to act upstream of or within adhesion of symbiont to host and defense response to other organism. Predicted to be located in cytoplasmic vesicle. Orthologous to human GBP7 (guanylate binding protein 7); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: guanylate-binding protein 4; LOC685067; similar to guanylate binding protein family, member 6; uncharacterized protein LOC685067
RGD Orthologs
Human
Mouse
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82233,948,774 - 233,970,532 (+)NCBIGRCr8
mRatBN7.22231,275,521 - 231,297,289 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2231,275,640 - 231,297,278 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02248,215,324 - 248,241,278 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2248,219,428 - 248,239,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02266,744,474 - 266,769,717 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42240,470,367 - 240,486,428 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2223,324,085 - 223,344,943 (+)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
GTP binding  (IBA,ISO)
GTPase activity  (IBA,ISO)
protein binding  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Gbp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82233,948,774 - 233,970,532 (+)NCBIGRCr8
mRatBN7.22231,275,521 - 231,297,289 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2231,275,640 - 231,297,278 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02248,215,324 - 248,241,278 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2248,219,428 - 248,239,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02266,744,474 - 266,769,717 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42240,470,367 - 240,486,428 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2223,324,085 - 223,344,943 (+)NCBICelera
Cytogenetic Map2q44NCBI
GBP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38189,131,742 - 89,176,003 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl189,131,742 - 89,176,009 (-)EnsemblGRCh38hg38GRCh38
GRCh37189,597,425 - 89,641,686 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36189,370,022 - 89,414,311 (-)NCBINCBI36Build 36hg18NCBI36
Celera187,843,240 - 87,887,538 (-)NCBICelera
Cytogenetic Map1p22.2NCBI
HuRef187,714,649 - 87,758,948 (-)NCBIHuRef
CHM1_1189,712,487 - 89,756,786 (-)NCBICHM1_1
T2T-CHM13v2.0188,975,111 - 89,019,382 (-)NCBIT2T-CHM13v2.0
Gbp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393142,236,097 - 142,255,912 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3142,236,103 - 142,255,910 (+)EnsemblGRCm39 Ensembl
GRCm383142,530,336 - 142,550,151 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3142,530,342 - 142,550,149 (+)EnsemblGRCm38mm10GRCm38
MGSCv373142,193,302 - 142,213,047 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363142,467,728 - 142,484,907 (+)NCBIMGSCv36mm8
Celera3148,953,085 - 148,972,729 (+)NCBICelera
Cytogenetic Map3H1NCBI
cM Map366.69NCBI
GBP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21137,799,420 - 137,843,619 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11136,955,167 - 136,999,366 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,841,867 - 91,886,638 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1190,593,577 - 90,637,789 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl190,590,242 - 90,660,565 (-)Ensemblpanpan1.1panPan2
LOC100155195
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.14127,356,794 - 127,376,858 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24139,582,091 - 139,601,987 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103224473
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12044,206,478 - 44,248,425 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603373,658,619 - 73,700,319 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gbp7
152 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:69
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000037181
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2217139753236660713Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2221136523241305619Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000037181   ⟹   ENSRNOP00000032768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2231,275,640 - 231,297,278 (+)Ensembl
Rnor_6.0 Ensembl2248,219,428 - 248,239,899 (+)Ensembl
RefSeq Acc Id: NM_001409108   ⟹   NP_001396037
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82233,948,889 - 233,970,532 (+)NCBI
mRatBN7.22231,275,640 - 231,297,284 (+)NCBI
RefSeq Acc Id: XM_039103864   ⟹   XP_038959792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82233,948,774 - 233,970,532 (+)NCBI
mRatBN7.22231,275,521 - 231,297,289 (+)NCBI
RefSeq Acc Id: XM_039103865   ⟹   XP_038959793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82233,949,001 - 233,970,532 (+)NCBI
mRatBN7.22231,275,786 - 231,297,289 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001396037 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959792 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959793 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL82350 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032768.6
Ensembl Acc Id: ENSRNOP00000032768   ⟸   ENSRNOT00000037181
RefSeq Acc Id: XP_038959792   ⟸   XM_039103864
- Peptide Label: isoform X1
- UniProtKB: D3ZV82 (UniProtKB/TrEMBL),   A6HW64 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959793   ⟸   XM_039103865
- Peptide Label: isoform X1
- UniProtKB: D3ZV82 (UniProtKB/TrEMBL),   A6HW64 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396037   ⟸   NM_001409108
- UniProtKB: D3ZV82 (UniProtKB/TrEMBL),   A6HW64 (UniProtKB/TrEMBL)
Protein Domains
GB1/RHD3-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZV82-F1-model_v2 AlphaFold D3ZV82 1-626 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583235 AgrOrtholog
BioCyc Gene G2FUF-50998 BioCyc
Ensembl Genes ENSRNOG00000029191 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037181.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  Guanylate-binding protein, C-terminal domain UniProtKB/TrEMBL
InterPro G_GB1_RHD3_dom UniProtKB/TrEMBL
  GBP_C UniProtKB/TrEMBL
  Guanylate-bd/ATL_C UniProtKB/TrEMBL
  Guanylate-bd_C_sf UniProtKB/TrEMBL
  Guanylate-bd_N UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 685067 ENTREZGENE
PANTHER GUANYLATE BINDING PROTEIN UniProtKB/TrEMBL
  GUANYLATE-BINDING PROTEIN 7 UniProtKB/TrEMBL
Pfam GBP UniProtKB/TrEMBL
  GBP_C UniProtKB/TrEMBL
PhenoGen Gbp7 PhenoGen
PROSITE G_GB1_RHD3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029191 RatGTEx
Superfamily-SCOP SSF48340 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A6HW64 ENTREZGENE, UniProtKB/TrEMBL
  D3ZV82 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-26 Gbp7  guanylate binding protein 7  LOC685067  similar to guanylate binding protein family, member 6  Name and Symbol changed 629549 APPROVED
2008-01-09 LOC685067  similar to guanylate binding protein family, member 6  LOC687510  similar to guanylate binding protein 4-like  Data merged from RGD:1584255 1643240 APPROVED
2006-11-19 LOC685067  similar to guanylate binding protein family, member 6      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687510  similar to guanylate binding protein 4-like      Symbol and Name status set to provisional 70820 PROVISIONAL