Acod1 (aconitate decarboxylase 1) - Rat Genome Database

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Gene: Acod1 (aconitate decarboxylase 1) Rattus norvegicus
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Symbol: Acod1
Name: aconitate decarboxylase 1
RGD ID: 1563454
Description: Predicted to enable aconitate decarboxylase activity and protein homodimerization activity. Involved in cellular response to cocaine. Predicted to be active in mitochondrion. Orthologous to human ACOD1 (aconitate decarboxylase 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cis-aconitate decarboxylase; immunoresponsive 1 homolog; immunoresponsive 1 homolog (mouse); immunoresponsive gene 1; Irg1; LOC306127; RGD1563454; similar to IMMUNE-RESPONSIVE PROTEIN 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81586,286,531 - 86,295,803 (+)NCBIGRCr8
mRatBN7.21579,871,819 - 79,881,101 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1579,871,827 - 79,880,529 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1583,850,263 - 83,858,968 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01584,973,300 - 84,982,003 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01581,900,933 - 81,909,636 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01593,612,968 - 93,622,322 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1593,612,971 - 93,622,358 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01597,100,761 - 97,110,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41587,056,688 - 87,066,471 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1579,013,093 - 79,021,717 (+)NCBICelera
Cytogenetic Map15q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Acod1Ratesophageal carcinoma  ISOACOD1 (Homo sapiens)596992333mRNA:increased expression:esophagus (human)RGD 
Acod1Rathead and neck squamous cell carcinoma  ISOACOD1 (Homo sapiens)596992333mRNA:increased expression:cranioceervical (human)RGD 
Acod1RatInvasive Breast Carcinoma  ISOACOD1 (Homo sapiens)596992333mRNA and protein:increased expression:breast cancer tumor (human)RGD 
Acod1RatNeoplasm Metastasis  ISOACOD1 (Homo sapiens)596992333mRNA:increased expression:macrophage (human)RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Acod1Ratchromosome 13q14 deletion syndrome  ISOACOD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 13q14 deletion syndromeClinVar 

1 to 20 of 54 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Acod1Rat1,2-dimethylhydrazine increases expressionISOAcod1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of ACOD1 mRNACTDPMID:22206623
Acod1Rat1-chloro-2,4-dinitrobenzene affects expressionISOAcod1 (Mus musculus)6480464Dinitrochlorobenzene affects the expression of ACOD1 mRNACTDPMID:22302311
Acod1Rat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of ACOD1 mRNACTDPMID:30723492
Acod1Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of ACOD1 mRNACTDPMID:32741896
Acod1Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of ACOD1 mRNACTDPMID:32741896
Acod1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOAcod1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of ACOD1 mRNACTDPMID:26290441
Acod1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOAcod1 (Mus musculus)64804642 more ...CTDPMID:38648751
Acod1Rat3,7-dihydropurine-6-thione increases expressionEXP 6480464Mercaptopurine results in increased expression of ACOD1 mRNACTDPMID:23358152
Acod1Ratalpha-Zearalanol decreases expressionEXP 6480464Zeranol results in decreased expression of ACOD1 mRNACTDPMID:35163327
Acod1Ratamosite asbestos decreases expressionISOAcod1 (Mus musculus)6480464Asbestos and Amosite results in decreased expression of ACOD1 mRNACTDPMID:23917077
Acod1Ratarsane decreases expressionISOAcod1 (Mus musculus)6480464Arsenic results in decreased expression of ACOD1 mRNACTDPMID:19654921
Acod1Ratarsenic atom decreases expressionISOAcod1 (Mus musculus)6480464Arsenic results in decreased expression of ACOD1 mRNACTDPMID:19654921
Acod1Ratarsenite(3-) multiple interactionsISOACOD1 (Homo sapiens)6480464arsenite promotes the reaction [G3BP1 protein binds to ACOD1 mRNA]CTDPMID:32406909
Acod1Ratbenzalkonium chloride increases expressionISOAcod1 (Mus musculus)6480464Benzalkonium Compounds results in increased expression of ACOD1 mRNACTDPMID:30171875
Acod1Ratbisphenol A affects expressionEXP 6480464bisphenol A affects the expression of ACOD1 mRNACTDPMID:25181051
Acod1Ratbisphenol A increases methylationISOAcod1 (Mus musculus)6480464bisphenol A results in increased methylation of ACOD1 promoterCTDPMID:27312807
Acod1Ratbisphenol A decreases expressionISOAcod1 (Mus musculus)6480464bisphenol A results in decreased expression of ACOD1 mRNACTDPMID:26911702
Acod1Ratcarbon nanotube increases expressionISOAcod1 (Mus musculus)6480464Nanotubes and Carbon results in increased expression of ACOD1 mRNACTDPMID:25554681
Acod1Ratcarbon nanotube affects expressionISOAcod1 (Mus musculus)6480464Nanotubes and Carbon analog affects the expression of ACOD1 mRNACTDPMID:25554681
Acod1Ratchrysene decreases expressionISOAcod1 (Mus musculus)6480464chrysene results in decreased expression of ACOD1 mRNACTDPMID:26377693

1 to 20 of 54 rows

Biological Process
1 to 20 of 31 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Acod1Ratcellular response to cocaine  IEP 596948411 RGD 
Acod1Ratcellular response to interferon-beta involved_inISOAcod1 (Mus musculus)1624291 PMID:19014335RGDPMID:19014335
Acod1Ratcellular response to interleukin-1 involved_inISOAcod1 (Mus musculus)1624291 PMID:19014335RGDPMID:19014335
Acod1Ratcellular response to lipopolysaccharide involved_inISOACOD1 (Homo sapiens)1624291 PMID:23609450 more ...RGDPMID:23609450 more ...
Acod1Ratcellular response to lipopolysaccharide involved_inIEAUniProtKB:A6NK06 and ensembl:ENSP000003666821600115GO_REF:0000107EnsemblGO_REF:0000107
Acod1Ratcellular response to lipopolysaccharide involved_inISOAcod1 (Mus musculus)1624291 PMID:23609450 and PMID:23610393RGDPMID:23609450 and PMID:23610393
Acod1Ratcellular response to molecule of bacterial origin involved_inISOAcod1 (Mus musculus)1624291 PMID:19014335RGDPMID:19014335
Acod1Ratcellular response to progesterone stimulus involved_inISOAcod1 (Mus musculus)1624291 PMID:14500577RGDPMID:14500577
Acod1Ratcellular response to tumor necrosis factor involved_inISOAcod1 (Mus musculus)1624291 PMID:19014335RGDPMID:19014335
Acod1Ratcellular response to type II interferon involved_inISOAcod1 (Mus musculus)1624291 PMID:19014335RGDPMID:19014335
Acod1Ratdefense response involved_inISOAcod1 (Mus musculus)1624291 PMID:23610393RGDPMID:23610393
Acod1Ratdefense response involved_inIEAUniProtKB:A6NK06 and ensembl:ENSP000003666821600115GO_REF:0000107EnsemblGO_REF:0000107
Acod1Ratdefense response involved_inIBAMGI:103206 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Acod1Ratdefense response involved_inISOACOD1 (Homo sapiens)1624291 PMID:23610393RGDPMID:23610393
Acod1Ratdefense response to virus involved_inISOAcod1 (Mus musculus)1624291 PMID:30635240RGDPMID:30635240
Acod1Ratembryo implantation involved_inISOAcod1 (Mus musculus)1624291 PMID:14500577RGDPMID:14500577
Acod1Ratnegative regulation of inflammatory response involved_inISOAcod1 (Mus musculus)1624291 PMID:23609450RGDPMID:23609450
Acod1Ratnegative regulation of innate immune response involved_inISOAcod1 (Mus musculus)1624291 PMID:23609450RGDPMID:23609450
Acod1Ratnegative regulation of NF-kappaB transcription factor activity involved_inISOAcod1 (Mus musculus)1624291 PMID:23609450RGDPMID:23609450
Acod1Ratnegative regulation of toll-like receptor 2 signaling pathway involved_inISOAcod1 (Mus musculus)1624291 PMID:23609450RGDPMID:23609450
1 to 20 of 31 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Acod1Ratmitochondrion located_inISOAcod1 (Mus musculus)1624291 PMID:19014335RGDPMID:19014335
Acod1Ratmitochondrion is_active_inIBAMGI:103206 and PANTHER:PTN0004242721600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  


#
Reference Title
Reference Citation
1. Suppression of HIV-TAT and cocaine-induced neurotoxicity and inflammation by cell penetrable itaconate esters. Cui BC, etal., J Neurovirol. 2024 Aug;30(4):337-352. doi: 10.1007/s13365-024-01216-9. Epub 2024 Jun 17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases. Papathanassiu AE, etal., Nat Commun. 2017 Jul 12;8:16040. doi: 10.1038/ncomms16040.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1. Zhao Y, etal., Cell Metab. 2023 Oct 3;35(10):1688-1703.e10. doi: 10.1016/j.cmet.2023.09.004.
PMID:7721348   PMID:14500577   PMID:19014335   PMID:23012479   PMID:23609450   PMID:23610393  



Acod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81586,286,531 - 86,295,803 (+)NCBIGRCr8
mRatBN7.21579,871,819 - 79,881,101 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1579,871,827 - 79,880,529 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1583,850,263 - 83,858,968 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01584,973,300 - 84,982,003 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01581,900,933 - 81,909,636 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01593,612,968 - 93,622,322 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1593,612,971 - 93,622,358 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01597,100,761 - 97,110,112 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41587,056,688 - 87,066,471 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1579,013,093 - 79,021,717 (+)NCBICelera
Cytogenetic Map15q21NCBI
ACOD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381376,948,511 - 76,958,638 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1376,948,511 - 76,958,638 (+)EnsemblGRCh38hg38GRCh38
GRCh371377,522,646 - 77,532,773 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361376,409,986 - 76,452,604 (+)NCBINCBI36Build 36hg18NCBI36
Celera1358,409,986 - 58,430,124 (+)NCBICelera
Cytogenetic Map13q22.3NCBI
HuRef1358,220,405 - 58,230,487 (+)NCBIHuRef
CHM1_11377,490,609 - 77,500,688 (+)NCBICHM1_1
T2T-CHM13v2.01376,172,176 - 76,182,288 (+)NCBIT2T-CHM13v2.0
Acod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914103,284,448 - 103,294,009 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14103,284,413 - 103,294,009 (+)EnsemblGRCm39 Ensembl
GRCm3814103,047,012 - 103,056,573 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14103,046,977 - 103,056,573 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714103,446,229 - 103,455,790 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614101,933,436 - 101,943,560 (+)NCBIMGSCv36mm8
Celera14101,673,338 - 101,682,908 (+)NCBICelera
Cytogenetic Map14E2.3NCBI
cM Map1451.67NCBI
Acod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540430,254,841 - 30,270,921 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540430,254,934 - 30,266,898 (-)NCBIChiLan1.0ChiLan1.0
ACOD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21478,518,513 - 78,527,935 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11377,114,661 - 77,124,086 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01358,166,872 - 58,176,146 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11377,148,051 - 77,219,410 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1377,211,430 - 77,222,201 (+)Ensemblpanpan1.1panPan2
ACOD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12230,545,991 - 30,557,199 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2230,547,271 - 30,555,510 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2230,408,263 - 30,418,332 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02230,859,235 - 30,869,321 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2230,859,352 - 30,867,596 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12230,526,718 - 30,536,798 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02230,565,036 - 30,575,112 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02230,634,536 - 30,644,605 (+)NCBIUU_Cfam_GSD_1.0
Acod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945128,904,519 - 128,909,335 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365114,322,198 - 4,329,686 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365114,322,198 - 4,326,562 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACOD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1149,077,492 - 49,087,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11149,077,152 - 49,088,218 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21153,715,639 - 53,729,040 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACOD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1356,037,628 - 56,048,509 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl356,042,149 - 56,047,680 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604612,246,742 - 12,256,927 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475123,478,096 - 23,483,521 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475123,478,263 - 23,488,834 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Acod1
157 total Variants


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
15 79876583 79876584 G A snv GK/FarMcwi (2019), SHR/NHsd (2021), WKY/N (2020), GK/FarMcwi (2019NG), WKY/NCrl (2019NG), SHR/OlalpcvMcwi (2019NG), European Variation Archive Release 3, European Variation Archive Release 4, European Variation Archive Release 6, HXB10/IpcvMcwi (2019), HXB2/IpcvMcwi (2019), HXB4/IpcvMcwi (2020), SHRSP/A3NCrl (2019), SHR/OlalpcvMcwi (2019), HXB17/IpcvMcwi (2021), HXB18/IpcvMcwi (2021), HXB23/IpcvMcwi (2021), SHRSP/A3NCrl (2019NG), SHR/NCrl (2021), SHR/NHsd (2021), WKY/NCrl (2019) View more Information


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
15 87062025 87062026 G A snv SHR/OlaIpcv (ICL), SHRSP/Gcrc (MDC), WKY/N (KNAW), SHR/OlaIpcv (KNAW), GK/Ox (ICL), SHR/OlaIpcv (ICL), LCR/2Mco (UMich), SHRSP/Gcrc (ICL), WKY/NCrl (ICL), WKY/Gcrc (ICL), WKY/NHsd (ICL), LCR/1Mco (UMich), HCR/2Mco (UMich), SHR/NHsd (ICL) View more Information


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
15 97105761 97105762 G A snv GK/Ox (KNAW), SHR/NCrlPrin (KNAW), SHR/NHsd (KNAW), SHR/OlaIpcv (KNAW), WKY/NHsd (KNAW), SHRSP/Gcrc (KNAW), WKY/Gcrc (KNAW), WKY/N (KNAW), WKY/NCrl (KNAW), SHR/OlaIpcvPrin (KNAW) View more Information


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
15 93617968 93617969 G A snv European Variation Archive Release 3, WKY/N (2020), European Variation Archive Release 6, WKY/N (MCW), GK/Ox (RGD), SHR/NHsd (RGD), SHRSP/Gcrc (RGD), WKY/NCrl (RGD), WKY/Gcrc (RGD), WKY/NHsd (RGD), GK/FarMcwi (2019), HXB10/IpcvMcwi (2019), HXB2/IpcvMcwi (2019), HXB4/IpcvMcwi (2020), SHRSP/A3NCrl (2019), SHR/OlalpcvMcwi (2019), WKY/NCrl (2019), European Variation Archive Release 4 View more Information

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:44
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000013182
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 24 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)155559608991365858Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)157369065795018120Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat

1 to 10 of 24 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 16 53 64 63 32 25 32 6 125 62 33 14 29 31



Ensembl Acc Id: ENSRNOT00000013182   ⟹   ENSRNOP00000013182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1579,871,827 - 79,880,529 (+)Ensembl
Rnor_6.0 Ensembl1593,612,971 - 93,622,358 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1593,613,006 - 93,616,613 (+)Ensembl
RefSeq Acc Id: NM_001107282   ⟹   NP_001100752
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81586,286,539 - 86,295,260 (+)NCBI
mRatBN7.21579,871,827 - 79,880,548 (+)NCBI
Rnor_6.01593,612,968 - 93,621,933 (+)NCBI
Rnor_5.01597,100,761 - 97,110,112 (+)NCBI
RGSC_v3.41587,056,688 - 87,066,471 (+)RGD
Celera1579,013,093 - 79,021,717 (+)RGD
Sequence:
RefSeq Acc Id: XM_006252440   ⟹   XP_006252502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81586,288,856 - 86,295,803 (+)NCBI
mRatBN7.21579,874,151 - 79,881,101 (+)NCBI
Rnor_6.01593,616,898 - 93,622,322 (+)NCBI
Rnor_5.01597,100,761 - 97,110,112 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039093396   ⟹   XP_038949324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81586,286,531 - 86,295,803 (+)NCBI
mRatBN7.21579,871,819 - 79,881,101 (+)NCBI
RefSeq Acc Id: XM_039093398   ⟹   XP_038949326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81586,288,875 - 86,295,803 (+)NCBI
mRatBN7.21579,874,162 - 79,881,101 (+)NCBI
RefSeq Acc Id: XM_039093399   ⟹   XP_038949327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81586,288,773 - 86,295,802 (+)NCBI
mRatBN7.21579,874,064 - 79,880,989 (+)NCBI
Protein RefSeqs NP_001100752 (Get FASTA)   NCBI Sequence Viewer  
  XP_006252502 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949324 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949326 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949327 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02449 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013182
  ENSRNOP00000013182.4
RefSeq Acc Id: NP_001100752   ⟸   NM_001107282
- UniProtKB: D3ZWM1 (UniProtKB/TrEMBL),   A6HU86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252502   ⟸   XM_006252440
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000013182   ⟸   ENSRNOT00000013182
RefSeq Acc Id: XP_038949324   ⟸   XM_039093396
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038949327   ⟸   XM_039093399
- Peptide Label: isoform X3
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWM1-F1-model_v2 AlphaFold D3ZWM1 1-488 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699869
Promoter ID:EPDNEW_R10390
Type:single initiation site
Name:Acod1_1
Description:aconitate decarboxylase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01593,613,008 - 93,613,068EPDNEW


1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-12699 BioCyc
BioCyc Pathway PWY-5750 [itaconate biosynthesis I] BioCyc
BioCyc Pathway Image PWY-5750 BioCyc
Ensembl Genes ENSRNOG00000009919 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013182 ENTREZGENE
  ENSRNOT00000013182.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.4100.10 UniProtKB/TrEMBL
  3.30.1330.120 UniProtKB/TrEMBL
InterPro MmgE/PrpD_sf UniProtKB/TrEMBL
  MmgE/PrpD_sf_1 UniProtKB/TrEMBL
  MmgE/PrpD_sf_2 UniProtKB/TrEMBL
  MmgE_PrpD UniProtKB/TrEMBL
  MmgE_PrpD_C UniProtKB/TrEMBL
  MmgE_PrpD_N UniProtKB/TrEMBL
KEGG Report rno:306127 UniProtKB/TrEMBL
NCBI Gene 306127 ENTREZGENE
PANTHER CIS-ACONITATE DECARBOXYLASE UniProtKB/TrEMBL
  MmgE_PrpD UniProtKB/TrEMBL
Pfam MmgE_PrpD UniProtKB/TrEMBL
  MmgE_PrpD_C UniProtKB/TrEMBL
PhenoGen Acod1 PhenoGen
RatGTEx ENSRNOG00000009919 RatGTEx
Superfamily-SCOP MmgE_PrpD UniProtKB/TrEMBL
UniProt A6HU86 ENTREZGENE, UniProtKB/TrEMBL
  D3ZWM1 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-25 Acod1  aconitate decarboxylase 1  Irg1  immunoresponsive gene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-15 Irg1  immunoresponsive gene 1  Irg1  immunoresponsive 1 homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Irg1  immunoresponsive 1 homolog (mouse)  Irg1  immunoresponsive gene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Irg1  immunoresponsive gene 1  RGD1563454_predicted  similar to IMMUNE-RESPONSIVE PROTEIN 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563454_predicted  similar to IMMUNE-RESPONSIVE PROTEIN 1 (predicted)  LOC306127  similar to IMMUNE-RESPONSIVE PROTEIN 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC306127  similar to IMMUNE-RESPONSIVE PROTEIN 1      Symbol and Name status set to provisional 70820 PROVISIONAL