Acod1 (aconitate decarboxylase 1)

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Gene: Acod1 (aconitate decarboxylase 1) Rattus norvegicus

Analyze

Symbol:

Acod1

Name:

aconitate decarboxylase 1

RGD ID:

1563454

Description:

Predicted to enable aconitate decarboxylase activity and protein homodimerization activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and regulation of defense response. Predicted to act upstream of or within response to lipopolysaccharide. Predicted to be active in mitochondrion. Orthologous to human ACOD1 (aconitate decarboxylase 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cis-aconitate decarboxylase; immunoresponsive 1 homolog; immunoresponsive 1 homolog (mouse); immunoresponsive gene 1; Irg1; LOC306127; RGD1563454; similar to IMMUNE-RESPONSIVE PROTEIN 1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ACOD1 (aconitate decarboxylase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Acod1 (aconitate decarboxylase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Acod1 (aconitate decarboxylase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ACOD1 (aconitate decarboxylase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ACOD1 (aconitate decarboxylase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Acod1 (aconitate decarboxylase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ACOD1 (aconitate decarboxylase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ACOD1 (aconitate decarboxylase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Acod1 (aconitate decarboxylase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Acod1 (aconitate decarboxylase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ACOD1 (aconitate decarboxylase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PDH1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector)
Danio rerio (zebrafish):	acod1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	acod1lb	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	acod1la	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	79,871,819 - 79,881,101 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	79,871,827 - 79,880,529 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	83,850,263 - 83,858,968 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	84,973,300 - 84,982,003 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	81,900,933 - 81,909,636 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	93,612,968 - 93,622,322 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	93,612,971 - 93,622,358 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	97,100,761 - 97,110,112 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	87,056,688 - 87,066,471 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	15	79,013,093 - 79,021,717 (+)	NCBI		Celera
Cytogenetic Map	15	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 13q14 deletion syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,7-dihydropurine-6-thione (EXP)

amosite asbestos (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzalkonium chloride (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

chrysene (ISO)

copper atom (EXP)

copper(0) (EXP)

cyclophosphamide (ISO)

hydrazine (ISO)

lipopolysaccharide (ISO)

mercaptopurine (EXP)

methyl salicylate (ISO)

paracetamol (ISO)

pioglitazone (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

purine-6-thiol (EXP)

quartz (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

succimer (ISO)

testosterone (EXP)

thioacetamide (EXP)

titanium dioxide (EXP,ISO)

trichloroethene (EXP)

trimellitic anhydride (ISO)

XL147 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to interferon-beta (ISO)

cellular response to interleukin-1 (ISO)

cellular response to lipopolysaccharide (ISO)

cellular response to molecule of bacterial origin (ISO)

cellular response to progesterone stimulus (ISO)

cellular response to tumor necrosis factor (ISO)

cellular response to type II interferon (ISO)

defense response (IBA,ISO)

defense response to virus (ISO)

embryo implantation (ISO)

negative regulation of inflammatory response (ISO)

negative regulation of innate immune response (ISO)

negative regulation of toll-like receptor 2 signaling pathway (ISO)

negative regulation of toll-like receptor 4 signaling pathway (ISO)

negative regulation of type I interferon production (ISO)

positive regulation of antimicrobial humoral response (ISO)

positive regulation of reactive oxygen species metabolic process (ISO)

response to bacterium (ISO)

response to lipopolysaccharide (ISO)

tolerance induction to lipopolysaccharide (ISO)

Cellular Component

mitochondrion (IBA,ISO)

Molecular Function

aconitate decarboxylase activity (IBA,ISO)

protein homodimerization activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7721348	PMID:14500577	PMID:19014335	PMID:23012479	PMID:23609450	PMID:23610393

Genomics

Comparative Map Data

Acod1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	15	79,871,819 - 79,881,101 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	79,871,827 - 79,880,529 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	83,850,263 - 83,858,968 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	84,973,300 - 84,982,003 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	81,900,933 - 81,909,636 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	93,612,968 - 93,622,322 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	93,612,971 - 93,622,358 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	97,100,761 - 97,110,112 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	87,056,688 - 87,066,471 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	15	79,013,093 - 79,021,717 (+)	NCBI		Celera
Cytogenetic Map	15	q21	NCBI

ACOD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	76,948,511 - 76,958,638 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	76,948,511 - 76,958,638 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	77,522,646 - 77,532,773 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	76,409,986 - 76,452,604 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	13	58,409,986 - 58,430,124 (+)	NCBI		Celera
Cytogenetic Map	13	q22.3	NCBI
HuRef	13	58,220,405 - 58,230,487 (+)	NCBI		HuRef
CHM1_1	13	77,490,609 - 77,500,688 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	13	76,172,176 - 76,182,288 (+)	NCBI		T2T-CHM13v2.0

Acod1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	103,284,448 - 103,294,009 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	103,284,413 - 103,294,009 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	103,047,012 - 103,056,573 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	103,046,977 - 103,056,573 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	103,446,229 - 103,455,790 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	101,933,436 - 101,943,560 (+)	NCBI		MGSCv36	mm8
Celera	14	101,673,338 - 101,682,908 (+)	NCBI		Celera
Cytogenetic Map	14	E2.3	NCBI
cM Map	14	51.67	NCBI

Acod1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955404	30,254,841 - 30,270,921 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955404	30,254,934 - 30,266,898 (-)	NCBI	ChiLan1.0	ChiLan1.0

ACOD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	13	77,114,661 - 77,124,086 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	58,166,872 - 58,176,146 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	77,148,051 - 77,219,410 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	77,211,430 - 77,222,201 (+)	Ensembl	panpan1.1		panPan2

ACOD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	30,545,991 - 30,557,199 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	30,547,271 - 30,555,510 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	30,408,263 - 30,418,332 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	30,859,235 - 30,869,321 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	30,859,352 - 30,867,596 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	30,526,718 - 30,536,798 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	30,565,036 - 30,575,112 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	30,634,536 - 30,644,605 (+)	NCBI		UU_Cfam_GSD_1.0

Acod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	128,904,519 - 128,909,335 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936511	4,322,198 - 4,329,686 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936511	4,322,198 - 4,326,562 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACOD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	49,077,492 - 49,087,104 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	49,077,152 - 49,088,218 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	53,715,639 - 53,729,040 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACOD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	56,037,628 - 56,048,509 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	56,042,149 - 56,047,680 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666046	12,246,742 - 12,256,927 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Acod1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624751	23,478,096 - 23,483,521 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624751	23,478,263 - 23,488,834 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Acod1
155 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	47
Count of miRNA genes:	44
Interacting mature miRNAs:	46
Transcripts:	ENSRNOT00000013182
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	28030665	82262678	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	28030665	82262678	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	28030665	82262678	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
1300144	Rf23	Renal function QTL 23	3.61		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	15	40631268	98288169	Rat
1576315	Schws6	Schwannoma susceptibility QTL 6		0.0069	nervous system integrity trait (VT:0010566)	post-insult time of death (CMO:0002005)	15	53806152	98806152	Rat
61477	Aia4	Adjuvant induced arthritis QTL 4	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	15	55596089	91365858	Rat
631516	Gluco31	Glucose level QTL 31	7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	55596089	95018120	Rat
631655	Bp126	Blood pressure QTL 126	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	58156477	101769107	Rat
731177	Uae26	Urinary albumin excretion QTL 26	2.4	0.025	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	15	67588667	101769107	Rat
2300326	Plaw1	Placental weight QTL 1	15	0.005	placenta mass (VT:0004257)	placenta wet weight (CMO:0002088)	15	68327165	100062518	Rat
1331724	Bp223	Blood pressure QTL 223	3.53715		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	73690518	95018228	Rat
1641889	Colcr6	Colorectal carcinoma resistance QTL 6	2.9	0.0126	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	15	73690518	99794247	Rat
70182	BpQTLcluster12	Blood pressure QTL cluster 12	3.53		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	15	73690657	95018120	Rat
2317055	Aia10	Adjuvant induced arthritis QTL 10	3.41		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	15	75788062	101769107	Rat
1549844	Bss7	Bone structure and strength QTL 7	6.4		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	15	75788062	101769107	Rat
1581555	Eae19	Experimental allergic encephalomyelitis QTL 19	4.7		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	15	76306099	90088744	Rat
70155	Gcs1	Gastric cancer susceptibility QTL1	3.8		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	15	76306099	101769107	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium												1
Low	3	9	26	10	18	10	7	8	9	10	9	10	7
Below cutoff		1	6	6	1	6	1	2	10		4		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006252440	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093396	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093397	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093398	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093399	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000013182 ⟹ ENSRNOP00000013182

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	79,871,827 - 79,880,529 (+)	Ensembl
Rnor_6.0 Ensembl	15	93,612,971 - 93,622,358 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093478

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	15	93,613,006 - 93,616,613 (+)	Ensembl

RefSeq Acc Id:

NM_001107282 ⟹ NP_001100752

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	79,871,827 - 79,880,548 (+)	NCBI
Rnor_6.0	15	93,612,968 - 93,621,933 (+)	NCBI
Rnor_5.0	15	97,100,761 - 97,110,112 (+)	NCBI
RGSC_v3.4	15	87,056,688 - 87,066,471 (+)	RGD
Celera	15	79,013,093 - 79,021,717 (+)	RGD

Sequence:

show sequence

GATGACTGTGTATAAAGGCACCTGGTCACTCAAGGCACACAGCCAGCAACTGCTCCTACCATTC
ACTCCTGAGCCAGAGGTACCTTCCAAAGCATCATGATGCTCAAGTCTGTCACAGAGAGCTTTGC
CAGTATGATTCACGGCTTGAGAGTGGGCCACCTGACAGATGGCGTCATTCAGAGGAGCAAGAGG
ATGATCCTGGACTCTCTGGGCGTTGGTTTCCTGGGAACAGGCACGGAAGTGTTCCATAACGTCA
CCCAATATAGTAAAATCTACAGTTCCAACACCTCCAGCACTGTTTGGGGTCGACCAGACTTCAG
GCTCCCTCCCACATATGCTGCTTTTGTTAACGGTGTTGCTATTCACTCCATGGATTTTGATGAC
ACGTGGCACCCTGCCACCCACCCTTCCGGGGCTGTCCTACCTGTGCTCACAGCTTTATCGGAAG
CCCTGCCCCAGACGCCAAAGTTTTCTGGCCTCGACCTGCTGCTGGCGTTCAGCGTTGGTATTGA
AGTACAAGGACGATTGTTGCACTTCTCCAAGGAGGCCAAGGACATACCAAAGAGGTTCCATCCT
CCCTCTGTGGTGGGGACTCTGGGAAGTGCTGCTGCCACATCCAAGTTTTTGGGGCTCAGCTTAA
CAAAGTGCCGTGAGGCCTTGGCTATTGCTGTTTCCCATGCCGGGGCGCCCATAGCAAACGCTGC
CACTCAGACTAAGCCCCTTCATATCGGCAATGCAGCCAAGCATGGGATGGAAGCCACATTTCTG
GCAATGCTGGGCCTCCAAGGAAACAAACAGATCTTGGACCTGGGGTCAGGGTTTGGCGCCTTCT
ATGCCAACTACTCCCCCAAAGACCTTCCAAGCCTGGATTCTCACATCTGGCTCCTAGACCAGCA
GGATGTGGCCTTTAAGAGCTTCCCGGCACATCTGGCTACCCACTGGGTGGCAGACGCAGCCGCA
GCTGTGAGAAAGCACCTCGTGACTTCAGAAAGAGCCCTGCTTCCTGCTGACCACATCGAGAGAA
TCGTGCTCAGGATCCCTGATGTCCAGTACGTAAACAGGCCCTTCCCGGACTCAGAGCATGAAGC
CCGTCATTCCTTCCAGTATGTGGCCTGTGCCACGCTGCTCGATGGTAGCGTCACTGTCCCATCC
TTCTATAGCCAGAAGGTCAACAGGCCTCAGGTGAAAGAGTTGCTCAAGAAGGTGGAGTTGGAAC
ATCCTCCCGACAACCTGCCAAGCTTCAACACGCTCTACTGTGAAATAAGCATCACTCTAAAGGA
TGGAACCACTTTCACCGAGCGCTCTGACACCTTCTATGGTCACTGGAGGAAACCACTGAGCCAG
GAGGATCTGCACAAGAAGTTCCGTGCCAATGCCTCAAAGATTCTAGGCGAGGACACAGTAGAAA
GCCTTATAACGGTAGTAGAAAAACTAGAAGACCTAGAAGACTGCGCCATGCTAACCAGACTTCT
GAAAGGACCCTCTGTCCAAGAGGAGGCTTCCAAACTATCCAGCATATTCTCATTCCATCACACA
AGTTTGCCCAAGTTTACCAATATCTAAACAATGTTGCAATGGAATAGATACAACGTTTTAGTTT
ACTGCTCCATATGCTCAGCCATGAATACAGCAAGGTGGAGAGTCCAGAAACAAGAGATAAGTGT
ATTTAGAAGGAGTCTTGTCCTATAAGTTTGGTAGAACCAGTCCTACCACCTTCAAACAACGCAG
GATCTGATGTGTATTCACAAGGGTAAAGTCTAAGTCACCTGTTGCCTGCTTATAATCTTTTCTG
AGGAATTATTTATTAGCTCCGGGAACTTCATAGATGTAGAGGAATGTGCATGTGGCTGGCTGCA
GAGGGAGCGATCTTGGTCTACCCACCACTTATCCAGAGAGGGTGGGTACTGCCCAACCCTCCTC
TCTGCAATGGCTGGTTTGAGGGAGTGGCAGGCACCTTGTCTTCTTCCACATATAGCCTTGAATC
CTTCTGCTTCCGCTTCTCTCCTGCAGATATAAGACAATCTGAGCTGCAGCAGGGAAGGCTTAAG
ACCCATAGTTTCACTCTTTCTATGAGATAGTCTGTTAACCTCAAAAATTATTTTGAGAAAATTT
GAGAACTTGGAGACAATAAAAAAGAAAGGGG

hide sequence

RefSeq Acc Id:

XM_006252440 ⟹ XP_006252502

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	79,874,151 - 79,881,101 (+)	NCBI
Rnor_6.0	15	93,616,898 - 93,622,322 (+)	NCBI
Rnor_5.0	15	97,100,761 - 97,110,112 (+)	NCBI

Sequence:

show sequence

GAAGAGAGATGGGGGAGAGCATGTTGGGATTCAAGAGTCATAATAACTTGTTTGTGGGGACATC
CTCTCAGACTAATGGAAGTAAAGCCACAGCATATCCTTCAGGTAATATAAAACCCATTAGCCAC
ATTGGATAGGCATAAAAATCTATGTTTAAATCATTTTCTGATTGTTACTAATGTTTCACATATG
GAAAAAATAAATGGCTTAGATGAAAAAGGACAAAACCTTAGGACATAAAATAATCATTTTAAGA
TACAGCTTAGTAGGTAATGTAGGTTCGAGAGCTCTTTGCTGTTATTGCAACTTTGATAAAACTT
TTAAATTACTTCGTAACCGATACACAGAAAATATTTGACCCAAAATATAATAAACGATATTAAA
TTTTTAGTATGTCTTGTTTCAAAGTAAAGGAAGAAGGAAAGTACAGCCTTGCCAGGGAAAGTAT
AGATCTTCCCAGGAGCTCTGGTCTCAGCATCCTCTAGAAAATCACTAGCTACTCTCCAGGGCCC
CGCTGTGAGGAGACAGAGGAGCCAAGGACAACTGTTGACCCAGCATGAGATTCACTCCATGGAT
TTTGATGACACGTGGCACCCTGCCACCCACCCTTCCGGGGCTGTCCTACCTGTGCTCACAGCTT
TATCGGAAGCCCTGCCCCAGACGCCAAAGTTTTCTGGCCTCGACCTGCTGCTGGCGTTCAGCGT
TGGTATTGAAGTACAAGGACGATTGTTGCACTTCTCCAAGGAGGCCAAGGACATACCAAAGAGG
TTCCATCCTCCCTCTGTGGTGGGGACTCTGGGAAGTGCTGCTGCCACATCCAAGTTTTTGGGGC
TCAGCTTAACAAAGTGCCGTGAGGCCTTGGCTATTGCTGTTTCCCATGCCGGGGCGCCCATAGC
AAACGCTGCCACTCAGACTAAGCCCCTTCATATCGGCAATGCAGCCAAGCATGGGATGGAAGCC
ACATTTCTGGCAATGCTGGGCCTCCAAGGAAACAAACAGATCTTGGACCTGGGGTCAGGGTTTG
GCGCCTTCTATGCCAACTACTCCCCCAAAGACCTTCCAAGCCTGGATTCTCACATCTGGCTCCT
AGACCAGCAGGATGTGGCCTTTAAGAGCTTCCCGGCACATCTGGCTACCCACTGGGTGGCAGAC
GCAGCCGCAGCTGTGAGAAAGCACCTCGTGACTTCAGAAAGAGCCCTGCTTCCTGCTGACCACA
TCGAGAGAATCGTGCTCAGGATCCCTGATGTCCAGTACGTAAACAGGCCCTTCCCGGACTCAGA
GCATGAAGCCCGTCATTCCTTCCAGTATGTGGCCTGTGCCACGCTGCTCGATGGTAGCGTCACT
GTCCCATCCTTCTATAGCCAGAAGGTCAACAGGCCTCAGGTGAAAGAGTTGCTCAAGAAGGTGG
AGTTGGAACATCCTCCCGACAACCTGCCAAGCTTCAACACGCTCTACTGTGAAATAAGCATCAC
TCTAAAGGATGGAACCACTTTCACCGAGCGCTCTGACACCTTCTATGGTCACTGGAGGAAACCA
CTGAGCCAGGAGGATCTGCACAAGAAGTTCCGTGCCAATGCCTCAAAGATTCTAGGCGAGGACA
CAGTAGAAAGCCTTATAACGGTAGTAGAAAAACTAGAAGACCTAGAAGACTGCGCCATGCTAAC
CAGACTTCTGAAAGGACCCTCTGTCCAAGAGGAGGCTTCCAAACTATCCAGCATATTCTCATTC
CATCACACAAGTTTGCCCAAGTTTACCAATATCTAAACAATGTTGCAATGGAATAGATACAACG
TTTTAGTTTACTGCTCCATATGCTCAGCCATGAATACAGCAAGGTGGAGAGTCCAGAAACAAGA
GATAAGTGTATTTAGAAGGAGTCTTGTCCTATAAGTTTGGTAGAACCAGTCCTACCACCTTCAA
ACAACGCAGGATCTGATGTGTATTCACAAGGGTAAAGTCTAAGTCACCTGTTGCCTGCTTATAA
TCTTTTCTGAGGAATTATTTATTAGCTCCGGGAACTTCATAGATGTAGAGGAATGTGCATGTGG
CTGGCTGCAGAGGGAGCGATCTTGGTCTACCCACCACTTATCCAGAGAGGGTGGGTACTGCCCA
ACCCTCCTCTCTGCAATGGCTGGTTTGAGGGAGTGGCAGGCACCTTGTCTTCTTCCACATATAG
CCTTGAATCCTTCTGCTTCCGCTTCTCTCCTGCAGATATAAGACAATCTGAGCTGCAGCAGGGA
AGGCTTAAGACCCATAGTTTCACTCTTTCTATGAGATAGTCTGTTAACCTCAAAAATTATTTTG
AGAAAATTTGAGAACTTGGAGACAATAAAAAAGAAAGGGGGAACATTGCAAATGTGTGGGTAAT
GAAGATATTAACCACCAAGTACACAGATATCACATTAGCAACTGTGCTGAAATATCTTCTGAAT
TCCTGCCATTCTCAAGAACAGAACAGGCTCTTAGTTCCAGATATTGCCTTGCAAGCGTTCACAG
AGAAGTACGTTGAGTAACCATTTGAGAACTCCAGCAGAGTGAGTTAGTTCTCAGTTCATAGGGG
TAAAATGTAATTAGAAAAGTGATCATCTGGGCTGGAGAGACAGCTCAGTGGTTAAGAGCACTGA
CTGCTCTTTCCAGAGGTCCTGAGTTCAAATCCCAGCCATCACGTGATGGCTCATAGCCATGTGT
AATGGGGTCTGATGCCCTCTTCTGGTGTGTCTGAAGACAGCTATG

hide sequence

RefSeq Acc Id:

XM_039093396 ⟹ XP_038949324

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	79,871,819 - 79,881,101 (+)	NCBI

RefSeq Acc Id:

XM_039093397 ⟹ XP_038949325

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	79,871,865 - 79,881,101 (+)	NCBI

RefSeq Acc Id:

XM_039093398 ⟹ XP_038949326

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	79,874,162 - 79,881,101 (+)	NCBI

RefSeq Acc Id:

XM_039093399 ⟹ XP_038949327

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	15	79,874,064 - 79,880,989 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100752	(Get FASTA)	NCBI Sequence Viewer
	XP_006252502	(Get FASTA)	NCBI Sequence Viewer
	XP_038949324	(Get FASTA)	NCBI Sequence Viewer
	XP_038949325	(Get FASTA)	NCBI Sequence Viewer
	XP_038949326	(Get FASTA)	NCBI Sequence Viewer
	XP_038949327	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM02449	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001100752 ⟸ NM_001107282

- UniProtKB:

D3ZWM1 (UniProtKB/TrEMBL), A6HU86 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MMLKSVTESFASMIHGLRVGHLTDGVIQRSKRMILDSLGVGFLGTGTEVFHNVTQYSKIYSSNT
SSTVWGRPDFRLPPTYAAFVNGVAIHSMDFDDTWHPATHPSGAVLPVLTALSEALPQTPKFSGL
DLLLAFSVGIEVQGRLLHFSKEAKDIPKRFHPPSVVGTLGSAAATSKFLGLSLTKCREALAIAV
SHAGAPIANAATQTKPLHIGNAAKHGMEATFLAMLGLQGNKQILDLGSGFGAFYANYSPKDLPS
LDSHIWLLDQQDVAFKSFPAHLATHWVADAAAAVRKHLVTSERALLPADHIERIVLRIPDVQYV
NRPFPDSEHEARHSFQYVACATLLDGSVTVPSFYSQKVNRPQVKELLKKVELEHPPDNLPSFNT
LYCEISITLKDGTTFTERSDTFYGHWRKPLSQEDLHKKFRANASKILGEDTVESLITVVEKLED
LEDCAMLTRLLKGPSVQEEASKLSSIFSFHHTSLPKFTNI

hide sequence

RefSeq Acc Id:

XP_006252502 ⟸ XM_006252440

- Peptide Label:

isoform X2

- Sequence:

show sequence

MDFDDTWHPATHPSGAVLPVLTALSEALPQTPKFSGLDLLLAFSVGIEVQGRLLHFSKEAKDIP
KRFHPPSVVGTLGSAAATSKFLGLSLTKCREALAIAVSHAGAPIANAATQTKPLHIGNAAKHGM
EATFLAMLGLQGNKQILDLGSGFGAFYANYSPKDLPSLDSHIWLLDQQDVAFKSFPAHLATHWV
ADAAAAVRKHLVTSERALLPADHIERIVLRIPDVQYVNRPFPDSEHEARHSFQYVACATLLDGS
VTVPSFYSQKVNRPQVKELLKKVELEHPPDNLPSFNTLYCEISITLKDGTTFTERSDTFYGHWR
KPLSQEDLHKKFRANASKILGEDTVESLITVVEKLEDLEDCAMLTRLLKGPSVQEEASKLSSIF
SFHHTSLPKFTNI

hide sequence

RefSeq Acc Id:

ENSRNOP00000013182 ⟸ ENSRNOT00000013182

RefSeq Acc Id:	XP_038949324 ⟸ XM_039093396
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038949325 ⟸ XM_039093397
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038949327 ⟸ XM_039093399
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038949326 ⟸ XM_039093398
- Peptide Label:	isoform X2

Protein Domains

MmgE/PrpD C-terminal MmgE/PrpD N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZWM1-F1-model_v2	AlphaFold	D3ZWM1	1-488	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563454	AgrOrtholog
BioCyc Gene	G2FUF-12699	BioCyc
BioCyc Pathway	PWY-5750 [itaconate biosynthesis I]	BioCyc
Ensembl Genes	ENSRNOG00000009919	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000013182	ENTREZGENE
	ENSRNOP00000013182.4	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000013182	ENTREZGENE
	ENSRNOT00000013182.7	UniProtKB/TrEMBL
Gene3D-CATH	1.10.4100.10	UniProtKB/TrEMBL
	3.30.1330.120	UniProtKB/TrEMBL
InterPro	MmgE/PrpD_sf	UniProtKB/TrEMBL
	MmgE/PrpD_sf_1	UniProtKB/TrEMBL
	MmgE/PrpD_sf_2	UniProtKB/TrEMBL
	MmgE_PrpD	UniProtKB/TrEMBL
	MmgE_PrpD_C	UniProtKB/TrEMBL
	MmgE_PrpD_N	UniProtKB/TrEMBL
KEGG Report	rno:306127	UniProtKB/TrEMBL
NCBI Gene	306127	ENTREZGENE
PANTHER	CIS-ACONITATE DECARBOXYLASE	UniProtKB/TrEMBL
	MmgE_PrpD	UniProtKB/TrEMBL
Pfam	MmgE_PrpD	UniProtKB/TrEMBL
	MmgE_PrpD_C	UniProtKB/TrEMBL
PhenoGen	Acod1	PhenoGen
Superfamily-SCOP	MmgE_PrpD	UniProtKB/TrEMBL
UniProt	A6HU86	ENTREZGENE, UniProtKB/TrEMBL
	D3ZWM1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-25	Acod1	aconitate decarboxylase 1	Irg1	immunoresponsive gene 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-01-15	Irg1	immunoresponsive gene 1	Irg1	immunoresponsive 1 homolog (mouse)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-26	Irg1	immunoresponsive 1 homolog (mouse)	Irg1	immunoresponsive gene 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Irg1	immunoresponsive gene 1	RGD1563454_predicted	similar to IMMUNE-RESPONSIVE PROTEIN 1 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1563454_predicted	similar to IMMUNE-RESPONSIVE PROTEIN 1 (predicted)	LOC306127	similar to IMMUNE-RESPONSIVE PROTEIN 1	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC306127	similar to IMMUNE-RESPONSIVE PROTEIN 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar