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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of ossification
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Accession:GO:0030279 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
Synonyms:exact_synonym: down regulation of ossification;   downregulation of ossification;   negative regulation of bone biosynthesis;   negative regulation of bone formation
 narrow_synonym: inhibition of ossification


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negative regulation of ossification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1b activin A receptor, type 1B involved_in ISO (PMID:22155034) UniProt PMID:22155034 NCBI chr15:101,071,953...101,111,565
Ensembl chr15:101,071,948...101,111,565 		JBrowse link
G Acvr2b activin receptor IIB involved_in IDA (PMID:28659341) UniProt PMID:28659341 NCBI chr 9:119,231,081...119,271,214
Ensembl chr 9:119,231,184...119,264,061 		JBrowse link
G Adrb2 adrenergic receptor, beta 2 involved_in ISO RGD
GO_Central		 PMID:16177600 GO_REF:0000096 RGD:1598747 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 acts_upstream_of_or_within IMP (PMID:9008714) MGI PMID:9008714 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bmp3 bone morphogenetic protein 3 involved_in ISO (PMID:15269709) UniProt PMID:15269709 NCBI chr 5:99,002,274...99,031,912
Ensembl chr 5:99,002,274...99,032,255 		JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha acts_upstream_of_or_within IMP (PMID:12488435) MGI PMID:12488435 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592 		JBrowse link
G Calcr calcitonin receptor acts_upstream_of_or_within IMP (PMID:14970190) MGI PMID:14970190 NCBI chr 6:3,685,678...3,764,713
Ensembl chr 6:3,685,680...3,764,714 		JBrowse link
G Chsy1 chondroitin sulfate synthase 1 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 7:65,759,240...65,823,546
Ensembl chr 7:65,759,263...65,823,546 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 involved_in ISO RGD
GO_Central		 PMID:32231239 GO_REF:0000096 RGD:32716373 NCBI chr10:126,884,115...126,891,897
Ensembl chr10:126,884,119...126,888,875 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO
IMP		 (PMID:18505822) RGD
UniProt
GO_Central		 PMID:18505822 PMID:21773994 GO_REF:0000096 RGD:6907379 NCBI chr19:30,523,276...30,526,896
Ensembl chr19:30,523,263...30,527,065 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 involved_in ISO MGI GO_REF:0000008 NCBI chr12:109,418,411...109,429,262
Ensembl chr12:109,418,749...109,429,262 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 acts_upstream_of_or_within IMP (PMID:9662402) MGI PMID:9662402 NCBI chr10:24,513,812...24,588,057
Ensembl chr10:24,513,812...24,588,057 		JBrowse link
G Gdf10 growth differentiation factor 10 involved_in ISO (PMID:22155034) UniProt PMID:22155034 NCBI chr14:33,645,544...33,658,471
Ensembl chr14:33,645,544...33,659,940 		JBrowse link
G Gfra4 glial cell line derived neurotrophic factor family receptor alpha 4 acts_upstream_of_or_within IMP (PMID:16497798) MGI PMID:16497798 NCBI chr 2:130,881,552...130,885,008
Ensembl chr 2:130,881,552...130,885,008 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit involved_in IMP (PMID:22081627) CACAO PMID:22081627 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Kremen1 kringle containing transmembrane protein 1 involved_in IMP (PMID:18505822) UniProt PMID:18505822 NCBI chr11:5,141,551...5,212,220
Ensembl chr11:5,141,552...5,211,558 		JBrowse link
G Kremen2 kringle containing transmembrane protein 2 involved_in IMP (PMID:18505822) UniProt PMID:18505822 NCBI chr17:23,960,173...23,965,305
Ensembl chr17:23,960,171...23,964,807 		JBrowse link
G Lrp4 low density lipoprotein receptor-related protein 4 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 2:91,287,794...91,344,246
Ensembl chr 2:91,287,856...91,344,124 		JBrowse link
G Mdk midkine involved_in IMP (PMID:20200993) UniProt PMID:20200993 NCBI chr 2:91,760,149...91,762,348
Ensembl chr 2:91,760,150...91,762,642 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr13:83,652,136...83,815,197
Ensembl chr13:83,652,153...83,815,199 		JBrowse link
G Mir222 microRNA 222 ISO RGD PMID:31691506 RGD:151893486 NCBI chr  X:19,013,132...19,013,210
Ensembl chr  X:19,013,132...19,013,210 		JBrowse link
G Mkx mohawk homeobox involved_in ISO RGD
GO_Central		 PMID:27370800 GO_REF:0000096 RGD:40924660 NCBI chr18:6,934,966...7,004,779
Ensembl chr18:6,934,518...7,004,780 		JBrowse link
G Notch1 notch 1 involved_in IMP (PMID:21493891) BHF-UCL PMID:21493891 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675 		JBrowse link
G P2ry2 purinergic receptor P2Y, G-protein coupled 2 involved_in ISO RGD
GO_Central		 PMID:12210747 GO_REF:0000096 RGD:729594 NCBI chr 7:100,645,775...100,661,260
Ensembl chr 7:100,645,775...100,662,073 		JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta involved_in ISO RGD
GO_Central		 PMID:17537919 GO_REF:0000096 RGD:1642610 NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in IMP (PMID:21493891) BHF-UCL PMID:21493891 NCBI chr 5:53,713,121...53,814,787
Ensembl chr 5:53,623,494...53,814,704 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 acts_upstream_of_or_within
involved_in		 IMP
ISO		 (PMID:19254787) MGI
GO_Central		 PMID:19254787 GO_REF:0000119 NCBI chr 8:23,901,401...23,939,648
Ensembl chr 8:23,901,518...23,939,648 		JBrowse link
G Smad2 SMAD family member 2 involved_in ISO (PMID:22155034) UniProt PMID:22155034 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Smad3 SMAD family member 3 involved_in ISO (PMID:22155034) UniProt PMID:22155034 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Smad6 SMAD family member 6 involved_in IMP (PMID:10655064) BHF-UCL PMID:10655064 NCBI chr 9:63,860,358...63,929,374
Ensembl chr 9:63,860,358...63,929,341 		JBrowse link
G Smad7 SMAD family member 7 involved_in IDA (PMID:29503843) CACAO PMID:29503843 NCBI chr18:75,500,436...75,529,006
Ensembl chr18:75,500,600...75,529,006 		JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 acts_upstream_of_or_within IMP (PMID:15820682) MGI PMID:15820682 NCBI chr 5:144,813,305...144,902,657
Ensembl chr 5:144,813,305...144,902,657 		JBrowse link
G Sost sclerostin acts_upstream_of_or_within IMP (PMID:23918385) MGI PMID:23918385 NCBI chr11:101,853,284...101,857,841
Ensembl chr11:101,853,284...101,857,841 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 involved_in ISO
IMP		 (PMID:20056916) GO_Central
UniProt		 PMID:20056916 GO_REF:0000119 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within IDA (PMID:15820682) MGI PMID:15820682 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tmem53 transmembrane protein 53 involved_in IMP
ISO
ISS		 (PMID:33824347) UniProt
GO_Central		 PMID:33824347 GO_REF:0000024 GO_REF:0000119 NCBI chr 4:117,109,148...117,125,785
Ensembl chr 4:117,109,148...117,125,779 		JBrowse link
G Tph1 tryptophan hydroxylase 1 involved_in ISO
IEA		 RGD
GO_Central
Ensembl		 PMID:20139991 GO_REF:0000096 GO_REF:0000107 RGD:5686362 NCBI chr 7:46,294,065...46,321,961
Ensembl chr 7:46,294,065...46,321,961 		JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor involved_in ISO RGD
GO_Central		 PMID:32231239 GO_REF:0000096 RGD:32716373 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511 		JBrowse link
negative regulation of bone mineralization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahsg alpha-2-HS-glycoprotein involved_in ISO
IDA
IBA		 (PMID:12556469) RGD
UniProt
GO_Central		 PMID:8702833 PMID:12556469 GO_REF:0000033 GO_REF:0000096 RGD:1626074 NCBI chr16:22,710,793...22,718,193
Ensembl chr16:22,710,027...22,718,199 		JBrowse link
G Bcor BCL6 interacting corepressor involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:11,902,976...12,026,769
Ensembl chr  X:11,902,979...12,026,594 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 involved_in ISO (PMID:21403648) UniProt PMID:21403648 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 9:123,762,163...123,768,729
Ensembl chr 9:123,762,161...123,768,729 		JBrowse link
G Ccr1l1 C-C motif chemokine receptor 1 like 1 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 9:123,776,467...123,786,752
Ensembl chr 9:123,777,280...123,778,445 		JBrowse link
G Ecm1 extracellular matrix protein 1 involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr 3:95,641,459...95,646,880
Ensembl chr 3:95,641,459...95,646,881 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in IMP (PMID:22510396), (PMID:25479107), (PMID:30111653) UniProt PMID:22510396 PMID:25479107 PMID:30111653 NCBI chr10:24,513,812...24,588,057
Ensembl chr10:24,513,812...24,588,057 		JBrowse link
G Fgf23 fibroblast growth factor 23 involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 6:127,049,865...127,059,257
Ensembl chr 6:127,049,865...127,058,371 		JBrowse link
G Gata1 GATA binding protein 1 acts_upstream_of_or_within IMP (PMID:15005853) MGI PMID:15005853 NCBI chr  X:7,825,504...7,842,844
Ensembl chr  X:7,825,499...7,844,310 		JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist involved_in ISO GO_Central GO_REF:0000119 NCBI chr 2:113,579,020...113,588,993
Ensembl chr 2:113,576,509...113,588,991 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit acts_upstream_of_or_within IMP (PMID:17181398) MGI PMID:17181398 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within IMP (PMID:11790802) MGI PMID:11790802 NCBI chr19:5,790,928...5,808,564
Ensembl chr19:5,790,932...5,808,560 		JBrowse link
G Mepe matrix extracellular phosphoglycoprotein with ASARM motif (bone) acts_upstream_of_or_within IMP
IDA		 (PMID:12421822), (PMID:15843468)
(PMID:22766095)		 MGI PMID:12421822 PMID:15843468 PMID:22766095 NCBI chr 5:104,473,195...104,486,477
Ensembl chr 5:104,473,195...104,486,477 		JBrowse link
G Nfe2 nuclear factor, erythroid derived 2 acts_upstream_of_or_within IMP (PMID:15005853) MGI PMID:15005853 NCBI chr15:103,156,640...103,166,809
Ensembl chr15:103,156,639...103,166,830 		JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta involved_in IMP (PMID:17537919) UniProt PMID:17537919 NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 acts_upstream_of_or_within IMP (PMID:11371614) MGI PMID:11371614 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
G Srgn serglycin involved_in IBA
ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr10:62,329,612...62,363,224
Ensembl chr10:62,329,612...62,363,230 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 involved_in ISO
ISS		 RGD
GO_Central
BHF-UCL		 PMID:23081848 GO_REF:0000024 GO_REF:0000096 RGD:10003033 NCBI chr 7:44,952,579...44,983,495
Ensembl chr 7:44,952,056...44,983,204 		JBrowse link
negative regulation of bone mineralization involved in bone maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grem1 gremlin 1, DAN family BMP antagonist involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 2:113,579,020...113,588,993
Ensembl chr 2:113,576,509...113,588,991 		JBrowse link
G Pth parathyroid hormone involved_in ISO GO_Central GO_REF:0000096 NCBI chr 7:112,984,783...112,987,879
Ensembl chr 7:112,984,787...112,987,777 		JBrowse link
G Rflna refilin A acts_upstream_of_or_within
involved_in		 IGI
IBA		 (PMID:24436304) MGI
GO_Central		 PMID:24436304 GO_REF:0000033 NCBI chr 5:125,080,512...125,089,611
Ensembl chr 5:125,080,285...125,089,611 		JBrowse link
G Rflnb refilin B acts_upstream_of_or_within
involved_in		 IGI
IBA		 (PMID:24436304) MGI
GO_Central		 PMID:24436304 GO_REF:0000033 NCBI chr11:75,910,020...75,918,608
Ensembl chr11:75,910,020...75,918,608 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28635
    multicellular organismal process 9055
      ossification 550
        negative regulation of ossification 55
          negative regulation of bone mineralization + 21
Path 2
Term Annotations click to browse term
  biological_process 28635
    biological regulation 13440
      regulation of biological process 13004
        regulation of multicellular organismal process 3533
          regulation of ossification 154
            negative regulation of ossification 55
              negative regulation of bone mineralization + 21
paths to the root