Mkx (mohawk homeobox) - Rat Genome Database

Name: Mkx
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Mkx (mohawk homeobox) Mus musculus

Analyze

Symbol:

Mkx

Name:

mohawk homeobox

RGD ID:

1313807

MGI Page

MGI

Description:

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including collagen fibril organization; regulation of gene expression; and tendon development. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb; limb bud; and sensory organ. Orthologous to human MKX (mohawk homeobox).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

9430023B20Rik; homeobox protein Mohawk; Ir; iroquois homeobox protein-like 1; Irxl1

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MKX (mohawk homeobox)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Mkx (mohawk homeobox)	HGNC	Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Mkx (mohawk homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MKX (mohawk homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC487079 (homeobox protein Mohawk)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mkx (mohawk homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MKX (mohawk homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MKX (mohawk homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mkx (mohawk homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Mkx (mohawk homeobox)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	MKX (mohawk homeobox)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	mkxa (mohawk homeobox a)	Alliance	DIOPT (TreeFam\|ZFIN)
Danio rerio (zebrafish):	mkxb (mohawk homeobox b)	Alliance	DIOPT (ZFIN)
Drosophila melanogaster (fruit fly):	CG11617	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	6,934,966 - 7,004,779 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	18	6,934,518 - 7,004,780 (-)	Ensembl
GRCm38	18	6,934,966 - 7,004,779 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	6,934,518 - 7,004,780 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	6,934,964 - 7,004,777 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	18	6,934,998 - 7,004,754 (-)	NCBI			mm8
Celera	18	6,980,394 - 7,049,750 (-)	NCBI		Celera
Cytogenetic Map	18	A1	NCBI
cM Map	18	4.53	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Heterotopic Ossification (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

aflatoxin B1 (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

bisphenol F (EXP)

cadmium dichloride (ISO)

choline (EXP)

chromium(6+) (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

dimethylarsinic acid (EXP)

folic acid (EXP)

genistein (EXP)

gentamycin (ISO)

irinotecan (ISO)

L-methionine (EXP)

methylarsonic acid (EXP)

N,N-diethyl-m-toluamide (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

octadecanoic acid (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

permethrin (ISO)

potassium chromate (ISO)

silver atom (EXP)

silver(0) (EXP)

sodium arsenate (EXP)

sodium arsenite (EXP,ISO)

tetrachloromethane (ISO)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell development (IBA)

cellular response to mechanical stimulus (ISO)

collagen fibril organization (IMP)

intratendonous ossification (ISO)

muscle organ development (IBA,IEP)

negative regulation of chondrocyte differentiation (ISO)

negative regulation of fat cell differentiation (ISO)

negative regulation of myoblast differentiation (IDA)

negative regulation of ossification (ISO)

negative regulation of transcription by RNA polymerase II (IDA,IMP)

positive regulation of collagen biosynthetic process (IMP)

positive regulation of gene expression (IMP)

positive regulation of transcription by RNA polymerase II (IMP)

regulation of gene expression (IMP)

regulation of transcription by RNA polymerase II (IBA)

regulation of transcription, DNA-templated (IEA)

tendon cell differentiation (IMP,ISO)

tendon formation (IMP)

tendon sheath development (IMP)

Cellular Component

nucleus (IBA)

transcription regulator complex (IC)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IDA,IMP)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IDA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IDA,IMP)

protein binding (IPI)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IDA)

RNA polymerase II-specific DNA-binding transcription factor binding (IPI)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal tendon morphology (IAGP)

abnormal tendon sheath morphology (IAGP)

wavy tail (IAGP)

References

References - curated


1.	Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3.	MGD data from the GO Consortium
4.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5.	RGD automated import pipeline
6.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	RGD automated import pipeline for gene-chemical interactions
8.	Suzuki H, etal., Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7840-5. doi: 10.1073/pnas.1522054113. Epub 2016 Jul 1.

Additional References at PubMed

PMID:10349636	PMID:11042159	PMID:11076861	PMID:11544199	PMID:12477932	PMID:16141072	PMID:16141073	PMID:16408284	PMID:16426902	PMID:16824806	PMID:18287559	PMID:19235719
PMID:20059953	PMID:20412781	PMID:20498044	PMID:20696843	PMID:21173153	PMID:21254332	PMID:21267068	PMID:21873635	PMID:22923612	PMID:22988430	PMID:23653374	PMID:24166359
PMID:24952961	PMID:25332192	PMID:26884464	PMID:27527664	PMID:27993989	PMID:28327634	PMID:29618652	PMID:30458056	PMID:32325033	PMID:33497014	PMID:34816492

Genomics

Comparative Map Data

Mkx
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	6,934,966 - 7,004,779 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	18	6,934,518 - 7,004,780 (-)	Ensembl
GRCm38	18	6,934,966 - 7,004,779 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	6,934,518 - 7,004,780 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	6,934,964 - 7,004,777 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	18	6,934,998 - 7,004,754 (-)	NCBI			mm8
Celera	18	6,980,394 - 7,049,750 (-)	NCBI		Celera
Cytogenetic Map	18	A1	NCBI
cM Map	18	4.53	NCBI

MKX
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	27,672,874 - 27,745,819 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	10	27,672,874 - 27,746,060 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	27,961,803 - 28,034,748 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	28,001,809 - 28,074,753 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	10	28,001,811 - 28,074,753	NCBI
Celera	10	27,725,254 - 27,798,252 (-)	NCBI
Cytogenetic Map	10	p12.1	NCBI
HuRef	10	27,678,080 - 27,751,075 (-)	NCBI		HuRef
CHM1_1	10	27,961,725 - 28,034,733 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	27,703,607 - 27,776,565 (-)	NCBI

Mkx
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	17	55,077,073 - 55,156,877 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	17	55,077,540 - 55,156,124 (-)	Ensembl
Rnor_6.0	17	60,537,615 - 60,553,284 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	60,537,935 - 60,549,750 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	62,321,329 - 62,332,471 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	63,631,540 - 63,710,138 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	17	63,642,477 - 63,722,172 (-)	NCBI
Celera	17	56,416,753 - 56,495,058 (-)	NCBI		Celera
Cytogenetic Map	17	q12.1	NCBI

Mkx
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955462	1,564,191 - 1,631,951 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955462	1,564,739 - 1,631,613 (-)	NCBI	ChiLan1.0	ChiLan1.0

MKX
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	10	28,181,483 - 28,254,311 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	28,181,483 - 28,254,311 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	10	27,820,454 - 27,893,373 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

LOC487079
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	5,898,155 - 5,964,577 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	4,371,377 - 4,437,081 (-)	NCBI
ROS_Cfam_1.0	2	4,651,755 - 4,720,172 (+)	NCBI
UNSW_CanFamBas_1.0	2	16,010,859 - 16,077,012 (+)	NCBI

Mkx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	7,469,239 - 7,533,485 (-)	NCBI
SpeTri2.0	NW_004936613	2,019,815 - 2,083,724 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MKX
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	39,096,782 - 39,172,199 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	39,096,778 - 39,173,384 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	53,679,406 - 53,744,157 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MKX
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	27,228,061 - 27,305,852 (-)	NCBI	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666051	33,247,101 - 33,322,551 (-)	NCBI	Vero_WHO_p1.0

Mkx
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624805	6,061,635 - 6,121,926 (-)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624805	6,060,131 - 6,122,305 (-)	NCBI	HetGla_female_1.0		hetGla2

Position Markers

BB094774

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	18	6,935,100 - 6,935,193	UniSTS	GRCm38
MGSCv37	18	6,935,098 - 6,935,191	UniSTS	GRCm37
Celera	18	6,980,528 - 6,980,621	UniSTS
Cytogenetic Map	18	A1	UniSTS
cM Map	18	3.0	UniSTS
Whitehead/MRC_RH	18	31.31	UniSTS

Mkx

Mouse Assembly	Chr	Position (strand)	Source
Cytogenetic Map	18	A1	UniSTS
cM Map	18	3.0	UniSTS
cM Map	18	3.0	UniSTS

UniSTS:224641

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	18	6,944,464 - 6,944,578	UniSTS	GRCm38
MGSCv37	18	6,944,462 - 6,944,576	UniSTS	GRCm37
Celera	18	6,989,893 - 6,990,007	UniSTS
Cytogenetic Map	18	A1	UniSTS
cM Map	18	3.0	UniSTS

Mkx

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	18	A1	UniSTS
cM Map	18	3.0	UniSTS

Mkx

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	18	A1	UniSTS

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4142127	Rafaril_m	Rafar interacting locus (mouse)			Not determined		18	1	23108555	Mouse
14928307	Manh83_m	mandible shape 83 (mouse)					18	1	26902168	Mouse
11354953	Mom21_m	modifier of Min 21 (mouse)					18	1	28893823	Mouse
12801462	Intim3_m	intima modifier 3 (mouse)					18	1	31720756	Mouse
12801458	Intmrm3_m	intima/media ratio modifier 3 (mouse)					18	1	31720756	Mouse
13207585	Mwmlpt3_m	Morris water maze latency to platform, training, 3 (mouse)					18	1	33547739	Mouse
13207589	Mwmlpa3_m	Morris water maze latency to platform, all, 3 (mouse)					18	1	33547739	Mouse
27226723	Tibw9_m	tibia width 9, proximal, 16 week (mouse)					18	3200000	60933072	Mouse
1558849	W3q15_m	weight 3 weeks QTL 15 (mouse)			Not determined		18	5041119	61272643	Mouse
4142250	Idd21.3_m	insulin dependent diabetes susceptibility 21.3 (mouse)			Not determined		18	6108404	21646477	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	679
Count of miRNA genes:	473
Interacting mature miRNAs:	529
Transcripts:	ENSMUST00000079788, ENSMUST00000176608, ENSMUST00000176757
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_177595	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC148004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK034675	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BB856607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC137728	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY644476	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CD544112	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466592	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000079788 ⟹ ENSMUSP00000078718

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	18	6,934,518 - 7,004,780 (-)	Ensembl
GRCm38.p6 Ensembl	18	6,934,518 - 7,004,780 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000176608 ⟹ ENSMUSP00000157351

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	18	7,000,636 - 7,003,782 (-)	Ensembl
GRCm38.p6 Ensembl	18	7,000,636 - 7,003,782 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000176757

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	18	7,002,304 - 7,004,726 (-)	Ensembl
GRCm38.p6 Ensembl	18	7,002,304 - 7,004,726 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000188926

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	18	6,936,952 - 6,992,988 (-)	Ensembl
GRCm38.p6 Ensembl	18	6,936,952 - 6,992,988 (-)	Ensembl

RefSeq Acc Id:

NM_177595 ⟹ NP_808263

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	18	6,934,966 - 7,004,779 (-)	NCBI
GRCm38	18	6,934,966 - 7,004,779 (-)	ENTREZGENE
MGSCv37	18	6,934,964 - 7,004,777 (-)	RGD
Celera	18	6,980,394 - 7,049,750 (-)	RGD
cM Map	18		ENTREZGENE

Sequence:

show sequence

GGGCCGCGCGCATCAGTCTGGGTAAATAAAGCAGAGACGACTCCGGTGGCCCCGGTGAACGCGT
CGGAGCCTGAGCCGAGAACATGCGGTGGGGATGGGAGTGTGCCTAGTCCAGAGACAGGAGTGTC
AGCCGCTGGCTGCCGATTCCGCGGCCACAGAACCCGAGCCCTGCTGCGGAGCTCCTGGTGGACT
CCGAGGCTCTGCCGCAAGGCCGCGCGTCCCTGCCAGCCCCCAATCATGAACACCATCGTCTTCA
ACAAGCTCGGGGGAGCCGTGCTTTTTGAAGACCGAGGCACTCCAGATCGGGAACGTGGCAGCCG
GACGTTCAGTGGTTTCCTGGACAATCCACACACAGGGCCGGAGGTGGGCATACCAGACGGCCCG
CCCCTCAAGGACAACCTCAGCCTGAGACACCGGAGGACAGGGGCCCGGCAGAATGGAGGGAAGG
TAAGGCATAAGCGACAGGCCCTGCAAGACATGGCGCGTCCTCTTAAGCAGTGGCTTTACAAGCA
CCGTGACAACCCGTACCCTACGAAGACTGAGAAGATACTCTTGGCCCTAGGCTCGCAGATGACG
CTAGTGCAGGTGTCAAATTGGTTCGCTAATGCTAGACGTCGGCTGAAGAACACTGTCCGGCAGC
CAGATTTAAGTTGGGCCTTAAGAATAAAGTTATACAACAAGTATGTTCAGGGCAACGCTGAACG
GCTGAGTGTGAGCAGCGATGGCGACTCCTGCTCTGAAGATGGAGAAAATCCCCCAAGAAATCAC
ATGAACGAAGAAGGCTACAGCACCCCCGCCCACCACACTGTGATTAAAGGGGAAAGCTCAGCGA
TAAAAGCTGGCGGCAGACCGGAGTCGAGGGCTGCCGAGGATTATGTGTCACCGCCCAAGTATAA
GAGCAGCTTGTTGAACCGTTACCTTAACGACTCCTTGAGACATGTCATGGCCACCAGCACTGCC
ATGATGGGGAAAACAAGGCGAAGGAACCATTCGGGGTCTTTTAGCTCCAACGAATTTGAAGAAG
AGTTGGTGTCTCCATCATCATCAGAAACTGAAGGCACCTTTGTCTATCGCACAGACACCCCGGA
CATCGGATCTACTAAGGGTGACAGTGCTGCTAACAGAAGGGGACCAAGCAAAGATGACACATAC
TGGAAGGAGATCAATGCAGCCATGGCCTTAACAAACCTTGCCCAAGGAAAAGATGAAGTGCAGG
GGACGACCACCAGTTGCATCATCCAGAAGTCTTCCCACATAGCAGAAGTAAAGACAGTCAAGCT
GCCACTGGTGCAGCGCTTCTAGAGTGGCCAGGAAGTGCTGAGCTGTCAGTGGGTTGTTTGTTTG
TTTGTGTTTGTTTTTACCTAAATCCTCATCCTAAGAGCCAAAGCAGAGGTGAAGAGGACTCCCT
TAAAACTCCTGAGTTCAACTATCGTAAATATATCAGTTGCTTCTATAAAAAGACATATAAGTTA
TAAAAACTCATTTTAATCAAAAATATTAACTTATTTTTATGTTACTGAAACTATGCATAAAGTA
TCTGCATTACCATTACAGTAAGTGCCTTGCTCCCTGAGGTAAGCCCCAACGTGGGCACAGTGAA
GAGCTGTGCCTCAAACCATCAATGCCAACACTTGCTAGACTGCATCATTCCCACTGGTCCAGGA
CAGAAGCCAATCGCCGAAAGCCCATGAAACAATTTCATTCATTCACATGTTCAAACTTGGAAAT
CTGTTCAGCCCAGATGAGGTGATCTTTTCTTTCTTTTTTCTTTCCTTTTCTTTTTCTTTTTCTC
TTTCTTTTTCTTTCCTCTTTCTTTTTTTTTTTTCTTTTCCTTAACTTCCGGTGTGATGGTGAGA
ATTTTATGTGTGGGTTTTGTTTGCATATCAGTTAGTGCATCCAAAATGAAAGGTGCTGCAGGAC
CACATGATGCATACACTTAAGAAGAGATGCTTTCAAACTACTTTAATATTGTAATGCAGTCAAG
GATTGTTTTCCCAAGCACTGCTGGAAAGTATCCCAATGCCCTTTACAACTAATTGGGATTTTTT
TTCCCTGAAGCTTTAAAAAGAGTCTTATTATATAAATCTTTGAAATTTTTTCCTGTGTAAAGCT
AAACCTAAAGTTTAGTTTTAAATCATAATCTTGTTTGCATTAGAGCTCAGGGTTCCTGTGTGAT
GGAAGCCGCTTTCATGTGGAGTGAGTAAAAGCTTTTTATTTGGTTCATTTCAAATCCCAATTCA
GATGGACAATTTGTATTGCAATGAGAACAAGACAACGAAGAAAAAATCTGTGTGTGTATATACA
TATACATGCAGAAAAATTGATTTCTTAAAAATTTAAAATGTACGGGTAGCAAAATATGTTCATG
TAGCATAGACTGTTTAGTCTCTGATTTTTGCCAGATAGGACATTCAAATAGAAATTAAGTGAAG
TCTTGCATTAAAAGAAAGAAAGTCTTGTTTCTAAATGTCACTACCACAGAGTGAGAGCAATCGC
TATCAAGAAAGAAAAGTCTTTTCCATCAAGCATTAACATCCTCCCCTGCCTGGGAAGACTGCAA
ACCAGAGGAATGTGGAGATGCCCAGTAGAAAAGGAAATCTGGAGATGGCCTATAAAACAGAGCA
AACGTTCAACAGCAAAGTAAAAAAGACTAGGCTATCGGGGGAATTTTTTTCTGGTTATGTAATG
TATTTTCTAATTGTTTTAGGCTGGAAAGCATTTTTGCAAGTGTGAATGACATCTGGTTTCACAG
CACATGCTGACGTTTTTTTCTTTATTTTACAAAATGCTTTTAATGCCAAAGTTAATCTGGTTGC
TGAGCAGACATGACGGCCTTGATGGCCCTCGTAGGACACTTTCTCCTGTATCATAGCATAGTGG
GGTGGGGGTTATCTAGTGTAATGAAGATAATTTGATATGAAAATATTTTGTACGTATATTTTTA
CTTTGTTTTCTCAAGTGCTGTTGGCAGTTGCAGTTGCCCTAGGTGAGATGTGTCAGTGCTGACT
GTATGAATGGATGAAGTATTGGGTTCTTCTCGTGCAGCCAGCCAAGTGGGGATCACTACAAGAC
AAGCCTGCCCAGATGTGCATGAGGCAGTGAGAAGCAAGAACGAATACTTCACTCTTTCTCATAC
TATTATAAGTTATTCTGGTATTAAATATTTTAATAAAAGTGTTCTTGTTTTAACATATTGTGAT
T

hide sequence

Protein Sequences


Protein RefSeqs	NP_808263	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI37729	(Get FASTA)	NCBI Sequence Viewer
	BAC28793	(Get FASTA)	NCBI Sequence Viewer
	EDL23027	(Get FASTA)	NCBI Sequence Viewer
	Q8BIA3	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_808263 ⟸ NM_177595

- UniProtKB:

Q8BIA3 (UniProtKB/Swiss-Prot), B2RQ30 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNTIVFNKLGGAVLFEDRGTPDRERGSRTFSGFLDNPHTGPEVGIPDGPPLKDNLSLRHRRTGA
RQNGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNWFANARRRL
KNTVRQPDLSWALRIKLYNKYVQGNAERLSVSSDGDSCSEDGENPPRNHMNEEGYSTPAHHTVI
KGESSAIKAGGRPESRAAEDYVSPPKYKSSLLNRYLNDSLRHVMATSTAMMGKTRRRNHSGSFS
SNEFEEELVSPSSSETEGTFVYRTDTPDIGSTKGDSAANRRGPSKDDTYWKEINAAMALTNLAQ
GKDEVQGTTTSCIIQKSSHIAEVKTVKLPLVQRF

hide sequence

RefSeq Acc Id:

ENSMUSP00000078718 ⟸ ENSMUST00000079788

RefSeq Acc Id:

ENSMUSP00000157351 ⟸ ENSMUST00000176608

Protein Domains

Homeobox

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8BIA3-F1-model_v2	AlphaFold	Q8BIA3	1-353	view protein structure

Promoters

RGD ID:

6847506

Promoter ID:

MM_ACW:24079

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Brain

Transcripts:

MKX.DSEP07

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	18	7,003,696 - 7,004,196 (-)	MPROMDB

RGD ID:

6829375

Promoter ID:

MM_KWN:24530

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day2, 3T3L1_Day3

Transcripts:

NM_177595

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	18	7,004,521 - 7,005,021 (-)	MPROMDB

RGD ID:

13677058

Promoter ID:

EPDNEW_M22678

Type:

multiple initiation site

Name:

Mkx_1

Description:

Mus musculus mohawk homeobox , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	18	7,004,726 - 7,004,786	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2687286	AgrOrtholog
Ensembl Genes	ENSMUSG00000061013	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000078718	ENTREZGENE, UniProtKB/TrEMBL
	ENSMUSP00000157351	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000079788	ENTREZGENE, UniProtKB/TrEMBL
	ENSMUST00000176608	UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_KN_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:210719	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:2687286	ENTREZGENE
NCBI Gene	210719	ENTREZGENE
Pfam	Homeobox_KN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mkx	PhenoGen
PROSITE	HOMEOBOX_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	HOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A3Q4EH75_MOUSE	UniProtKB/TrEMBL
	B2RQ30	ENTREZGENE, UniProtKB/TrEMBL
	MKX_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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