Mkx (mohawk homeobox) - Rat Genome Database

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Gene: Mkx (mohawk homeobox) Mus musculus
Analyze
Symbol: Mkx
Name: mohawk homeobox
RGD ID: 1313807
MGI Page MGI
Description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including collagen fibril organization; regulation of gene expression; and tendon development. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb; limb bud; and sensory organ. Orthologous to human MKX (mohawk homeobox).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9430023B20Rik; homeobox protein Mohawk; Ir; iroquois homeobox protein-like 1; Irxl1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,934,966 - 7,004,779 (-)NCBIGRCm39mm39
GRCm39 Ensembl186,934,518 - 7,004,780 (-)Ensembl
GRCm38186,934,966 - 7,004,779 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,934,518 - 7,004,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv37186,934,964 - 7,004,777 (-)NCBIGRCm37mm9NCBIm37
MGSCv36186,934,998 - 7,004,754 (-)NCBImm8
Celera186,980,394 - 7,049,750 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map184.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11544199   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16408284   PMID:16426902   PMID:16824806   PMID:18287559   PMID:19235719  
PMID:20059953   PMID:20412781   PMID:20498044   PMID:20696843   PMID:21173153   PMID:21254332   PMID:21267068   PMID:21873635   PMID:22923612   PMID:22988430   PMID:23653374   PMID:24166359  
PMID:24952961   PMID:25332192   PMID:26884464   PMID:27527664   PMID:27993989   PMID:28327634   PMID:29618652   PMID:30458056   PMID:32325033   PMID:33497014   PMID:34816492  


Genomics

Comparative Map Data
Mkx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,934,966 - 7,004,779 (-)NCBIGRCm39mm39
GRCm39 Ensembl186,934,518 - 7,004,780 (-)Ensembl
GRCm38186,934,966 - 7,004,779 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,934,518 - 7,004,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv37186,934,964 - 7,004,777 (-)NCBIGRCm37mm9NCBIm37
MGSCv36186,934,998 - 7,004,754 (-)NCBImm8
Celera186,980,394 - 7,049,750 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map184.53NCBI
MKX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381027,672,874 - 27,745,819 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1027,672,874 - 27,746,060 (-)EnsemblGRCh38hg38GRCh38
GRCh371027,961,803 - 28,034,748 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361028,001,809 - 28,074,753 (-)NCBINCBI36hg18NCBI36
Build 341028,001,811 - 28,074,753NCBI
Celera1027,725,254 - 27,798,252 (-)NCBI
Cytogenetic Map10p12.1NCBI
HuRef1027,678,080 - 27,751,075 (-)NCBIHuRef
CHM1_11027,961,725 - 28,034,733 (-)NCBICHM1_1
T2T-CHM13v2.01027,703,607 - 27,776,565 (-)NCBI
Mkx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21755,077,073 - 55,156,877 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1755,077,540 - 55,156,124 (-)Ensembl
Rnor_6.01760,537,615 - 60,553,284 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1760,537,935 - 60,549,750 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01762,321,329 - 62,332,471 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41763,631,540 - 63,710,138 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11763,642,477 - 63,722,172 (-)NCBI
Celera1756,416,753 - 56,495,058 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
Mkx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554621,564,191 - 1,631,951 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554621,564,739 - 1,631,613 (-)NCBIChiLan1.0ChiLan1.0
MKX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11028,181,483 - 28,254,311 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1028,181,483 - 28,254,311 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01027,820,454 - 27,893,373 (-)NCBIMhudiblu_PPA_v0panPan3
LOC487079
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.125,898,155 - 5,964,577 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha24,371,377 - 4,437,081 (-)NCBI
ROS_Cfam_1.024,651,755 - 4,720,172 (+)NCBI
UNSW_CanFamBas_1.0216,010,859 - 16,077,012 (+)NCBI
Mkx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093447,469,239 - 7,533,485 (-)NCBI
SpeTri2.0NW_0049366132,019,815 - 2,083,724 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MKX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1039,096,782 - 39,172,199 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11039,096,778 - 39,173,384 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21053,679,406 - 53,744,157 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MKX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1927,228,061 - 27,305,852 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605133,247,101 - 33,322,551 (-)NCBIVero_WHO_p1.0
Mkx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248056,061,635 - 6,121,926 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248056,060,131 - 6,122,305 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
BB094774  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38186,935,100 - 6,935,193UniSTSGRCm38
MGSCv37186,935,098 - 6,935,191UniSTSGRCm37
Celera186,980,528 - 6,980,621UniSTS
Cytogenetic Map18A1UniSTS
cM Map183.0UniSTS
Whitehead/MRC_RH1831.31UniSTS
Mkx  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18A1UniSTS
cM Map183.0UniSTS
cM Map183.0UniSTS
UniSTS:224641  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38186,944,464 - 6,944,578UniSTSGRCm38
MGSCv37186,944,462 - 6,944,576UniSTSGRCm37
Celera186,989,893 - 6,990,007UniSTS
Cytogenetic Map18A1UniSTS
cM Map183.0UniSTS
Mkx  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18A1UniSTS
cM Map183.0UniSTS
Mkx  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18A1UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142127Rafaril_mRafar interacting locus (mouse)Not determined18123108555Mouse
14928307Manh83_mmandible shape 83 (mouse)18126902168Mouse
11354953Mom21_mmodifier of Min 21 (mouse)18128893823Mouse
12801462Intim3_mintima modifier 3 (mouse)18131720756Mouse
12801458Intmrm3_mintima/media ratio modifier 3 (mouse)18131720756Mouse
13207585Mwmlpt3_mMorris water maze latency to platform, training, 3 (mouse)18133547739Mouse
13207589Mwmlpa3_mMorris water maze latency to platform, all, 3 (mouse)18133547739Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
4142250Idd21.3_minsulin dependent diabetes susceptibility 21.3 (mouse)Not determined18610840421646477Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:679
Count of miRNA genes:473
Interacting mature miRNAs:529
Transcripts:ENSMUST00000079788, ENSMUST00000176608, ENSMUST00000176757
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000079788   ⟹   ENSMUSP00000078718
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl186,934,518 - 7,004,780 (-)Ensembl
GRCm38.p6 Ensembl186,934,518 - 7,004,780 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176608   ⟹   ENSMUSP00000157351
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl187,000,636 - 7,003,782 (-)Ensembl
GRCm38.p6 Ensembl187,000,636 - 7,003,782 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176757
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl187,002,304 - 7,004,726 (-)Ensembl
GRCm38.p6 Ensembl187,002,304 - 7,004,726 (-)Ensembl
RefSeq Acc Id: ENSMUST00000188926
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl186,936,952 - 6,992,988 (-)Ensembl
GRCm38.p6 Ensembl186,936,952 - 6,992,988 (-)Ensembl
RefSeq Acc Id: NM_177595   ⟹   NP_808263
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39186,934,966 - 7,004,779 (-)NCBI
GRCm38186,934,966 - 7,004,779 (-)ENTREZGENE
MGSCv37186,934,964 - 7,004,777 (-)RGD
Celera186,980,394 - 7,049,750 (-)RGD
cM Map18 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_808263 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI37729 (Get FASTA)   NCBI Sequence Viewer  
  BAC28793 (Get FASTA)   NCBI Sequence Viewer  
  EDL23027 (Get FASTA)   NCBI Sequence Viewer  
  Q8BIA3 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_808263   ⟸   NM_177595
- UniProtKB: Q8BIA3 (UniProtKB/Swiss-Prot),   B2RQ30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000078718   ⟸   ENSMUST00000079788
RefSeq Acc Id: ENSMUSP00000157351   ⟸   ENSMUST00000176608
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BIA3-F1-model_v2 AlphaFold Q8BIA3 1-353 view protein structure

Promoters
RGD ID:6847506
Promoter ID:MM_ACW:24079
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:MKX.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36187,003,696 - 7,004,196 (-)MPROMDB
RGD ID:6829375
Promoter ID:MM_KWN:24530
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3
Transcripts:NM_177595
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36187,004,521 - 7,005,021 (-)MPROMDB
RGD ID:13677058
Promoter ID:EPDNEW_M22678
Type:multiple initiation site
Name:Mkx_1
Description:Mus musculus mohawk homeobox , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38187,004,726 - 7,004,786EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2687286 AgrOrtholog
Ensembl Genes ENSMUSG00000061013 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000078718 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000157351 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000079788 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000176608 UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_KN_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:210719 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2687286 ENTREZGENE
NCBI Gene 210719 ENTREZGENE
Pfam Homeobox_KN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mkx PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3Q4EH75_MOUSE UniProtKB/TrEMBL
  B2RQ30 ENTREZGENE, UniProtKB/TrEMBL
  MKX_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE