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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:insulin receptor signaling pathway
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Accession:GO:0008286 term browser browse the term
Definition:The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
Synonyms:exact_synonym: insulin receptor signalling pathway
 narrow_synonym: daf-2 receptor signaling pathway
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa


show annotations for term's descendants           Sort by:
insulin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193 		JBrowse link
G AKT2 AKT serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21148297) Ensembl
MGI		 PMID:21148297 GO_REF:0000107 NCBI chr 1:113,359,038...113,407,119
Ensembl chr 1:113,359,575...113,407,131 		JBrowse link
G ANKRD26 ankyrin repeat domain containing 26 acts_upstream_of ISO (PMID:21842266) MGI PMID:21842266 NCBI chr 2:6,230,466...6,402,360 JBrowse link
G APC APC regulator of WNT signaling pathway involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:252,052...380,506
Ensembl chr 3:253,081...322,993 		JBrowse link
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:33,123,577...33,166,831
Ensembl chr20:33,130,723...33,166,792 		JBrowse link
G BCAR1 BCAR1 scaffold protein, Cas family member involved_in ISO PMID:9627109 UniProt PMID:9627109 RGD:8553632 NCBI chr 5:75,463,906...75,499,557
Ensembl chr 5:75,463,926...75,512,476 		JBrowse link
G BCAR3 BCAR3 adaptor protein, NSP family member involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:55,276,300...55,525,246
Ensembl chr 6:55,347,955...55,525,246 		JBrowse link
G C2CD5 C2 calcium dependent domain containing 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:24,697,036...24,798,138
Ensembl chr27:24,697,016...24,797,543 		JBrowse link
G CAV2 caveolin 2 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr14:55,437,622...55,445,481
Ensembl chr14:55,437,622...55,445,469 		JBrowse link
G COL6A1 collagen type VI alpha 1 chain involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19114551) Ensembl
MGI		 PMID:19114551 GO_REF:0000107 NCBI chr31:39,301,718...39,319,895
Ensembl chr31:39,301,748...39,448,062 		JBrowse link
G CSRP3 cysteine and glycine rich protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29634311) Ensembl
MGI		 PMID:29634311 GO_REF:0000107 NCBI chr21:41,300,277...41,318,788
Ensembl chr21:41,300,425...41,318,738 		JBrowse link
G DNAI1 dynein axonemal intermediate chain 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:51,080,080...51,205,381
Ensembl chr11:51,106,370...51,237,467 		JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 acts_upstream_of_or_within ISO (PMID:7629182) MGI PMID:7629182 NCBI chr16:27,389,850...27,410,154
Ensembl chr16:27,390,181...27,410,110 		JBrowse link
G EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8939971) Ensembl
MGI		 PMID:8939971 GO_REF:0000107 NCBI chr 4:21,339,037...21,364,224
Ensembl chr 4:21,339,045...21,358,072 		JBrowse link
G FER FER tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:2,863,804...3,295,999
Ensembl chr 3:2,867,726...3,295,999 		JBrowse link
G FOXC2 forkhead box C2 involved_in ISO (PMID:16456100) UniProt PMID:16456100 NCBI chr 5:66,234,336...66,296,007
Ensembl chr 5:66,294,176...66,295,693 		JBrowse link
G FOXC2 forkhead box C2 involved_in IEA Ensembl GO_REF:0000107
G FOXO1 forkhead box O1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12488434)
(PMID:29867121)		 TreeGrafter
MGI		 PMID:12488434 PMID:29867121 GO_REF:0000118 NCBI chr25:603,433...706,961
Ensembl chr25:603,543...702,825 		JBrowse link
G FOXO4 forkhead box O4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:55,469,738...55,477,699
Ensembl chr  X:55,469,382...55,477,699 		JBrowse link
G GPLD1 glycosylphosphatidylinositol specific phospholipase D1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr35:22,495,001...22,556,264
Ensembl chr35:22,495,073...22,554,105 		JBrowse link
G GPR21 G protein-coupled receptor 21 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:22653059) Ensembl
MGI		 PMID:22653059 GO_REF:0000107 NCBI chr 9:59,760,384...59,764,309 JBrowse link
G GRB10 growth factor receptor bound protein 10 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr18:1,890,689...2,014,836
Ensembl chr18:1,890,792...2,014,839 		JBrowse link
G GRB14 growth factor receptor bound protein 14 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:9748281 GO_REF:0000118 RGD:61620 NCBI chr36:9,711,885...9,843,266
Ensembl chr36:9,712,142...9,721,769 		JBrowse link
G GRB2 growth factor receptor bound protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:5,108,128...5,182,091
Ensembl chr 9:5,117,164...5,180,296 		JBrowse link
G GSK3A glycogen synthase kinase 3 alpha involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:112,129,116...112,138,714
Ensembl chr 1:112,103,825...112,138,559 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr33:23,458,369...23,659,878
Ensembl chr33:23,463,767...23,659,666 		JBrowse link
G HMGA1 high mobility group AT-hook 1 acts_upstream_of_or_within ISO (PMID:22355763)
(PMID:15924147)
(PMID:29867121)		 MGI PMID:15924147 PMID:22355763 PMID:29867121 NCBI chr12:3,528,818...3,538,533
Ensembl chr12:3,533,102...3,538,533 		JBrowse link
G HRAS HRas proto-oncogene, GTPase involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:25,642,844...25,644,717
Ensembl chr18:25,642,844...25,644,717 		JBrowse link
G IGF1R insulin like growth factor 1 receptor involved_in IEA GOC GO_REF:0000108 NCBI chr 3:41,795,337...42,096,255
Ensembl chr 3:41,794,623...42,090,387 		JBrowse link
G IGF2 insulin like growth factor 2 involved_in ISO (MGI:4438697|PMID:20032056) BHF-UCL PMID:20032056 MGI:4438697 NCBI chr18:46,294,036...46,311,982
Ensembl chr18:46,294,019...46,311,982 		JBrowse link
G IGFBP1 insulin like growth factor binding protein 1 ISO RGD PMID:11784721 RGD:729306 NCBI chr16:1,037,169...1,040,996
Ensembl chr16:1,037,162...1,167,094 		JBrowse link
G INS insulin involved_in
acts_upstream_of_or_within		 ISO (PMID:7782332)
(PMID:12805218)
(PMID:20056832)
(PMID:15792832), (PMID:20455999)
(PMID:14615391)		 BHF-UCL
MGI
UniProt		 PMID:7782332 PMID:12805218 PMID:14615391 PMID:15792832 PMID:20056832 More... NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
G INSR insulin receptor involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:12488434) RGD
GOC
MGI
Ensembl		 PMID:12488434 PMID:12850498 PMID:12891559 PMID:15520221 PMID:26300412 More... GO_REF:0000107 GO_REF:0000108 RGD:11529553 RGD:1299201 RGD:14700925 RGD:1580595 RGD:2306052 NCBI chr20:52,017,261...52,136,061
Ensembl chr20:52,021,887...52,136,046 		JBrowse link
G INSRR insulin receptor related receptor involved_in IEA GOC GO_REF:0000108 NCBI chr 7:41,161,036...41,176,739
Ensembl chr 7:41,161,333...41,175,940 		JBrowse link
G IRS1 insulin receptor substrate 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15249583)
(PMID:9813005)		 InterPro
MGI
TreeGrafter
Ensembl		 PMID:9813005 PMID:15249583 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr25:39,624,554...39,687,991 JBrowse link
G IRS1 insulin receptor substrate 1 involved_in IEA InterPro GO_REF:0000002 Ensembl chr25:39,684,250...39,687,971 JBrowse link
G IRS2 insulin receptor substrate 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9813005)
(PMID:12488434)		 RGD
MGI
TreeGrafter
Ensembl
InterPro		 PMID:9813005 PMID:12488434 PMID:12891559 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:1299201 NCBI chr22:58,197,016...58,229,026
Ensembl chr22:58,223,387...58,227,535 		JBrowse link
G IRS4 insulin receptor substrate 4 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr  X:82,275,642...82,292,398
Ensembl chr  X:82,276,187...82,292,375 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:22,261,753...22,296,704
Ensembl chr27:22,257,941...22,293,369 		JBrowse link
G LOC100856339 phosphatidylinositol 3-kinase regulatory subunit gamma involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7542745) Ensembl
MGI
TreeGrafter		 PMID:7542745 GO_REF:0000107 GO_REF:0000118 NCBI chr15:14,222,059...14,357,200
Ensembl chr15:14,235,824...14,353,832 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 involved_in ISO (PMID:20889126) MGI PMID:20889126 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G MTCL2 microtubule crosslinking factor 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr24:25,525,564...25,602,158
Ensembl chr24:25,531,865...25,600,727 		JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase NOT|involved_in ISO (PMID:17983582) BHF-UCL PMID:17983582 NCBI chr18:14,110,045...14,211,268
Ensembl chr18:13,993,022...14,208,657 		JBrowse link
G NCOA5 nuclear receptor coactivator 5 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:24332041) Ensembl
MGI		 PMID:24332041 GO_REF:0000107 NCBI chr24:33,323,645...33,352,836
Ensembl chr24:33,322,650...33,352,809 		JBrowse link
G NDEL1 nudE neurodevelopment protein 1 like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:33,187,614...33,244,483
Ensembl chr 5:33,204,452...33,266,052 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 ISO RGD PMID:11781314 RGD:625467 NCBI chr18:42,333,173...42,346,152
Ensembl chr18:42,333,202...42,341,236 		JBrowse link
G PDK2 pyruvate dehydrogenase kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:26,099,457...26,116,094
Ensembl chr 9:26,100,343...26,115,423 		JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:20,825,861...20,839,290
Ensembl chr14:20,827,831...20,839,256 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:38,426,464...38,506,520
Ensembl chr 6:38,431,600...38,499,295 		JBrowse link
G PHIP pleckstrin homology domain interacting protein acts_upstream_of_or_within ISO (PMID:11018022) MGI PMID:11018022 NCBI chr12:39,899,738...40,015,795
Ensembl chr12:39,904,603...40,032,194 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha involved_in ISO (PMID:20197055) MGI PMID:20197055 NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:15161606 GO_REF:0000107 GO_REF:0000118 RGD:1625251 NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970 		JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:44,826,037...44,838,449
Ensembl chr20:44,826,339...44,836,558 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15632081) Ensembl
MGI		 PMID:15632081 GO_REF:0000107 NCBI chr24:36,936,469...37,010,929
Ensembl chr24:36,936,298...37,003,720 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15632081) Ensembl
MGI		 PMID:15632081 GO_REF:0000107 NCBI chr 7:78,160,564...78,252,382
Ensembl chr 7:78,160,589...78,252,719 		JBrowse link
G PTPRA protein tyrosine phosphatase receptor type A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14733908) Ensembl
MGI		 PMID:14733908 GO_REF:0000107 NCBI chr24:18,224,355...18,395,650
Ensembl chr24:18,224,801...18,296,350 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:5,892,839...5,972,672
Ensembl chr20:5,892,834...5,972,090 		JBrowse link
G RARRES2 retinoic acid receptor responder 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:14,671,345...14,675,000
Ensembl chr16:14,671,130...14,674,926 		JBrowse link
G RHOQ ras homolog family member Q involved_in ISO (PMID:11309621) BHF-UCL PMID:11309621 NCBI chr10:48,766,623...48,807,198
Ensembl chr10:48,768,191...48,804,129 		JBrowse link
G SH2B2 SH2B adaptor protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10196204) Ensembl
MGI		 PMID:10196204 GO_REF:0000107 NCBI chr 6:7,795,756...7,820,010
Ensembl chr 6:7,795,373...7,819,843 		JBrowse link
G SHC1 SHC adaptor protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:42,501,829...42,509,613
Ensembl chr 7:42,500,185...42,508,276 		JBrowse link
G SIK2 salt inducible kinase 2 acts_upstream_of_or_within ISO (PMID:12624099) MGI PMID:12624099 NCBI chr 5:21,354,127...21,479,891
Ensembl chr 5:21,358,902...21,479,841 		JBrowse link
G SLC2A8 solute carrier family 2 member 8 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10860996) Ensembl
MGI		 PMID:10860996 GO_REF:0000107 NCBI chr 9:55,921,635...55,928,753
Ensembl chr 9:55,921,635...55,928,753 		JBrowse link
G SLC39A14 solute carrier family 39 member 14 acts_upstream_of
involved_in		 ISO
IEA		 (MGI:5812606|PMID:27703010) UniProt
Ensembl		 PMID:27703010 GO_REF:0000107 MGI:5812606 NCBI chr25:34,854,371...34,901,030
Ensembl chr25:34,846,653...34,869,695 		JBrowse link
G SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17074803) Ensembl
MGI		 PMID:17074803 GO_REF:0000107 NCBI chr20:41,165,593...41,337,237
Ensembl chr20:41,165,522...41,335,917 		JBrowse link
G SOCS7 suppressor of cytokine signaling 7 acts_upstream_of_or_within ISO (PMID:16127460) MGI PMID:16127460 NCBI chr 9:23,775,349...23,809,325
Ensembl chr 9:23,776,827...23,803,994 		JBrowse link
G SORBS1 sorbin and SH3 domain containing 1 involved_in ISO (MGI:1201213|PMID:9447983) UniProt PMID:9447983 MGI:1201213 NCBI chr28:8,834,530...9,063,739
Ensembl chr28:8,837,338...9,063,777 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:31,007,940...31,181,569
Ensembl chr17:31,009,257...31,142,063 		JBrowse link
G SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:26,636,849...26,698,837
Ensembl chr 8:26,637,895...26,717,781 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17074803) Ensembl
MGI		 PMID:17074803 GO_REF:0000107 NCBI chr 5:41,663,809...41,686,764
Ensembl chr 5:41,663,773...41,686,776 		JBrowse link
G STXBP4 syntaxin binding protein 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10394363) Ensembl
MGI
TreeGrafter		 PMID:10394363 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:30,079,797...30,293,750
Ensembl chr 9:30,092,289...30,236,135 		JBrowse link
G TMEM87A transmembrane protein 87A acts_upstream_of_or_within ISO (PMID:9507006) MGI PMID:9507006 NCBI chr30:9,215,585...9,253,712
Ensembl chr30:9,216,702...9,253,700 		JBrowse link
G ZNF106 zinc finger protein 106 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr30:9,389,184...9,452,891
Ensembl chr30:9,392,761...9,452,850 		JBrowse link
insulin receptor recycling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTSD cathepsin D involved_in ISO (PMID:27703010) MGI PMID:27703010 NCBI chr18:46,010,440...46,019,457
Ensembl chr18:46,010,440...46,019,457 		JBrowse link
G IDE insulin degrading enzyme involved_in ISO (PMID:27703010) MGI PMID:27703010 NCBI chr28:6,844,480...6,967,713
Ensembl chr28:6,844,055...6,967,713 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:36,936,469...37,010,929
Ensembl chr24:36,936,298...37,003,720 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:78,160,564...78,252,382
Ensembl chr 7:78,160,589...78,252,719 		JBrowse link
G SORL1 sortilin related receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:12,493,750...12,650,530
Ensembl chr 5:12,431,377...12,650,784 		JBrowse link
negative regulation of insulin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHSG alpha 2-HS glycoprotein ISO RGD PMID:2766355 RGD:632173 NCBI chr34:19,221,034...19,228,866
Ensembl chr34:19,221,107...19,228,716 		JBrowse link
G ANKRD26 ankyrin repeat domain containing 26 acts_upstream_of_or_within ISO (PMID:21842266) MGI PMID:21842266 NCBI chr 2:6,230,466...6,402,360 JBrowse link
G BLVRB biliverdin reductase B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:113,244,484...113,258,170
Ensembl chr 1:113,244,503...113,258,073 		JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO (PMID:17849011), (PMID:7830796) BHF-UCL PMID:7830796 PMID:17849011 NCBI chr 1:251,985...322,081
Ensembl chr 1:252,103...322,718 		JBrowse link
G GPR21 G protein-coupled receptor 21 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22653059) Ensembl
MGI		 PMID:22653059 GO_REF:0000107 NCBI chr 9:59,760,384...59,764,309 JBrowse link
G GRB10 growth factor receptor bound protein 10 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr18:1,890,689...2,014,836
Ensembl chr18:1,890,792...2,014,839 		JBrowse link
G GRB14 growth factor receptor bound protein 14 involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:9748281 PMID:18657188 GO_REF:0000107 GO_REF:0000118 RGD:2307023 RGD:61620 NCBI chr36:9,711,885...9,843,266
Ensembl chr36:9,712,142...9,721,769 		JBrowse link
G GSK3A glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:112,129,116...112,138,714
Ensembl chr 1:112,103,825...112,138,559 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta involved_in ISO PMID:8524413 BHF-UCL PMID:8524413 RGD:8554844 NCBI chr33:23,458,369...23,659,878
Ensembl chr33:23,463,767...23,659,666 		JBrowse link
G IL1B interleukin 1 beta involved_in ISO (MGI:3828398|PMID:16865359) BHF-UCL PMID:16865359 MGI:3828398 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G INPP5K inositol polyphosphate-5-phosphatase K involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:45,660,445...45,680,407
Ensembl chr 9:45,660,446...45,680,363 		JBrowse link
G INPPL1 inositol polyphosphate phosphatase like 1 ISO RGD PMID:11692174 RGD:2312443 NCBI chr21:25,900,308...25,914,527
Ensembl chr21:25,900,900...25,915,577 		JBrowse link
G IRS1 insulin receptor substrate 1 involved_in ISO PMID:15069075 BHF-UCL PMID:15069075 RGD:8554248 NCBI chr25:39,624,554...39,687,991 JBrowse link
G KANK1 KN motif and ankyrin repeat domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:89,446,340...89,618,716
Ensembl chr 1:89,480,399...89,618,143 		JBrowse link
G LEP leptin involved_in ISO (PMID:14677856) CACAO PMID:14677856 NCBI chr14:8,115,396...8,130,946
Ensembl chr14:8,116,122...8,131,395 		JBrowse link
G LONP1 lon peptidase 1, mitochondrial acts_upstream_of_or_within ISO (PMID:9813005) MGI PMID:9813005 NCBI chr20:54,312,678...54,334,142
Ensembl chr20:54,312,678...54,334,141 		JBrowse link
G MIR143 microRNA mir-143 acts_upstream_of_or_within ISO (PMID:21441927) MGI PMID:21441927 NCBI chr 4:59,534,535...59,534,589
Ensembl chr 4:59,534,535...59,534,594 		JBrowse link
G MIR15B microRNA mir-15b involved_in ISO (PMID:26179126) ARUK-UCL PMID:26179126 NCBI chr34:26,460,663...26,460,722
Ensembl chr34:26,460,645...26,460,741 		JBrowse link
G MIR195 microRNA mir-195 involved_in ISO (PMID:25240198) ARUK-UCL PMID:25240198 NCBI chr 5:32,045,450...32,045,510
Ensembl chr 5:32,045,450...32,045,510 		JBrowse link
G MSTN myostatin involved_in ISO (MGI:3604221|PMID:16182246) CACAO PMID:16182246 MGI:3604221 NCBI chr37:729,172...734,255
Ensembl chr37:729,172...734,362 		JBrowse link
G NCK1 NCK adaptor protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:33,297,660...33,374,025
Ensembl chr23:33,297,756...33,372,534 		JBrowse link
G NCL nucleolin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9813005) Ensembl
MGI		 PMID:9813005 GO_REF:0000107 NCBI chr25:43,330,524...43,384,909
Ensembl chr25:43,330,799...43,384,258 		JBrowse link
G NCOA5 nuclear receptor coactivator 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24332041) Ensembl
MGI		 PMID:24332041 GO_REF:0000107 NCBI chr24:33,323,645...33,352,836
Ensembl chr24:33,322,650...33,352,809 		JBrowse link
G NUCB2 nucleobindin 2 ISO RGD PMID:22486620 RGD:9831186 NCBI chr21:39,868,756...39,918,724
Ensembl chr21:39,874,781...39,918,689 		JBrowse link
G PID1 phosphotyrosine interaction domain containing 1 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr25:41,424,307...41,649,736
Ensembl chr25:41,425,811...41,652,672 		JBrowse link
G PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:10,464,019...10,642,365
Ensembl chr 2:10,463,010...10,640,327 		JBrowse link
G PIP4K2B phosphatidylinositol-5-phosphate 4-kinase type 2 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:23,445,350...23,473,195
Ensembl chr 9:23,445,482...23,470,184 		JBrowse link
G PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:1,670,076...1,680,975
Ensembl chr10:1,672,380...1,680,840 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 ISO RGD PMID:20501641 RGD:6484547 NCBI chr 4:68,579,061...68,614,548
Ensembl chr 4:68,579,037...68,611,841 		JBrowse link
G PRKCA protein kinase C alpha acts_upstream_of_or_within ISO (PMID:11923480) MGI PMID:11923480 NCBI chr 9:13,638,106...13,879,571
Ensembl chr 9:13,644,010...13,967,630 		JBrowse link
G PRKCB protein kinase C beta involved_in ISO PMID:11714718 UniProt PMID:11714718 RGD:8553365 NCBI chr 6:21,742,970...22,064,360
Ensembl chr 6:21,742,973...22,065,185 		JBrowse link
G PRKCD protein kinase C delta involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:36,723,491...36,751,982
Ensembl chr20:36,723,809...36,752,191 		JBrowse link
G PRKCQ protein kinase C theta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:29,319,123...29,505,338
Ensembl chr 2:29,318,870...29,505,337 		JBrowse link
G PRKCZ protein kinase C zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:78,160,564...78,252,382
Ensembl chr 7:78,160,589...78,252,719 		JBrowse link
G PTPRE protein tyrosine phosphatase receptor type E involved_in ISO PMID:15738637
(MGI:3772995|PMID:18006633)		 UniProt PMID:15738637 PMID:18006633 MGI:3772995 RGD:8553759 NCBI chr28:36,761,314...36,904,902
Ensembl chr28:36,746,822...36,902,325 		JBrowse link
G PTPRF protein tyrosine phosphatase receptor type F ISO RGD PMID:8557682 RGD:1642757 NCBI chr15:16,590,908...16,666,673
Ensembl chr15:16,591,308...16,666,673 		JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:41,586,262...41,635,386
Ensembl chr18:41,586,112...41,635,308 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO RGD PMID:18073321 RGD:2298860 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15249583) Ensembl
MGI		 PMID:15249583 GO_REF:0000107 NCBI chr 9:34,387,084...34,590,603
Ensembl chr 9:34,387,091...34,425,292 		JBrowse link
G RPS6KB2 ribosomal protein S6 kinase B2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15249583) Ensembl
MGI		 PMID:15249583 GO_REF:0000107 NCBI chr18:50,034,318...50,039,892
Ensembl chr18:50,034,364...50,040,250 		JBrowse link
G SLC27A4 solute carrier family 27 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:55,164,106...55,177,567
Ensembl chr 9:55,164,817...55,177,511 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 acts_upstream_of_or_within ISO (PMID:15169905) MGI PMID:15169905 NCBI chr 6:31,511,003...31,511,995
Ensembl chr 6:31,509,268...31,511,557 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15169905) Ensembl
MGI		 PMID:15169905 GO_REF:0000107 NCBI chr 9:2,859,267...2,859,944 JBrowse link
G TNS2 tensin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:2,096,287...2,112,626
Ensembl chr27:2,096,616...2,113,619 		JBrowse link
G TRIM72 tripartite motif containing 72 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23965929) Ensembl
MGI		 PMID:23965929 GO_REF:0000107 NCBI chr 6:17,031,175...17,053,399
Ensembl chr 6:17,031,913...17,039,556 		JBrowse link
G TSC2 TSC complex subunit 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:38,865,509...38,898,977
Ensembl chr 6:38,865,507...38,898,960 		JBrowse link
G ZNF592 zinc finger protein 592 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9813005) Ensembl
MGI		 PMID:9813005 GO_REF:0000107 NCBI chr 3:53,980,438...54,056,011
Ensembl chr 3:53,990,434...54,114,486 		JBrowse link
positive regulation of insulin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOR1 adiponectin receptor 1 ISO RGD PMID:18394428 RGD:2317907 NCBI chr 7:240,035...254,287
Ensembl chr 7:240,065...282,845 		JBrowse link
G AGT angiotensinogen ISO RGD PMID:24184594 RGD:11039409 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G C1QTNF12 C1q and TNF related 12 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22275362) TreeGrafter
MGI		 PMID:22275362 GO_REF:0000118 NCBI chr 5:56,433,555...56,438,419
Ensembl chr 5:56,433,552...56,438,339 		JBrowse link
G GKAP1 G kinase anchoring protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:75,662,369...75,732,663
Ensembl chr 1:75,674,901...75,732,661 		JBrowse link
G GNAI2 G protein subunit alpha i2 ISO RGD PMID:11500506 RGD:13508599 NCBI chr20:39,075,085...39,094,697
Ensembl chr20:39,075,085...39,094,697 		JBrowse link
G IGF2 insulin like growth factor 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr18:46,294,036...46,311,982
Ensembl chr18:46,294,019...46,311,982 		JBrowse link
G INS insulin involved_in ISO (PMID:7688386)
(PMID:7513704)		 BHF-UCL PMID:7513704 PMID:7688386 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
G IRS1 insulin receptor substrate 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:39,624,554...39,687,991 JBrowse link
G LEP leptin ISO RGD PMID:20977462 RGD:5128575 NCBI chr14:8,115,396...8,130,946
Ensembl chr14:8,116,122...8,131,395 		JBrowse link
G MARCKS myristoylated alanine rich protein kinase C substrate ISO RGD PMID:19252893 RGD:9685323 NCBI chr12:69,980,003...69,987,150
Ensembl chr12:69,980,433...69,984,848 		JBrowse link
G MFN2 mitofusin 2 ISO RGD PMID:25034891 RGD:13204821 NCBI chr 2:84,284,719...84,310,715
Ensembl chr 2:84,284,719...84,308,225 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:39,497,313...39,608,120
Ensembl chr15:39,536,290...39,608,116 		JBrowse link
G NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24931609) Ensembl
MGI		 PMID:24931609 GO_REF:0000107 NCBI chr38:2,157,109...2,188,543
Ensembl chr38:2,160,233...2,170,560 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase ISO RGD PMID:24085037 RGD:13208948 NCBI chr23:52,068,123...52,154,410
Ensembl chr23:52,068,118...52,151,593 		JBrowse link
G OSBPL8 oxysterol binding protein like 8 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21441927) Ensembl
MGI		 PMID:21441927 GO_REF:0000107 NCBI chr15:19,339,385...19,441,583
Ensembl chr15:19,142,987...19,637,708 		JBrowse link
G PAK1 p21 (RAC1) activated kinase 1 ISO RGD PMID:25199455 RGD:11533947 NCBI chr21:21,341,530...21,409,535
Ensembl chr21:21,265,484...21,408,416 		JBrowse link
G PRKCZ protein kinase C zeta involved_in ISO PMID:9374484 UniProt PMID:9374484 RGD:8553908 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:9,989,218...10,072,245
Ensembl chr26:9,989,425...10,067,481 		JBrowse link
G SERPINA12 serpin family A member 12 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22837305) Ensembl
MGI		 PMID:22837305 GO_REF:0000107 NCBI chr 8:63,497,542...63,511,701
Ensembl chr 8:63,497,849...63,512,171 		JBrowse link
G SIRT1 sirtuin 1 involved_in ISO (PMID:21241768) UniProt PMID:21241768 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279 		JBrowse link
G SNX5 sorting nexin 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:5,085,140...5,110,942
Ensembl chr24:5,084,986...5,110,283 		JBrowse link
G SORBS1 sorbin and SH3 domain containing 1 involved_in ISO (MGI:3690172|PMID:11001060) UniProt PMID:11001060 MGI:3690172 NCBI chr28:8,834,530...9,063,739
Ensembl chr28:8,837,338...9,063,777 		JBrowse link
G SORL1 sortilin related receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:12,493,750...12,650,530
Ensembl chr 5:12,431,377...12,650,784 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:14985360 RGD:1581139 NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077 		JBrowse link
G TSC2 TSC complex subunit 2 acts_upstream_of_or_within ISO (PMID:15249583) MGI PMID:15249583 NCBI chr 6:38,865,509...38,898,977
Ensembl chr 6:38,865,507...38,898,960 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:42,468,376...42,482,219
Ensembl chr 7:42,468,247...42,483,436 		JBrowse link
regulation of insulin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FFAR3 free fatty acid receptor 3 involved_in ISO (MGI:5574424|PMID:24748202) UniProt PMID:24748202 MGI:5574424 NCBI chr 1:117,251,604...117,257,048 JBrowse link
G FFAR3 involved_in IEA Ensembl GO_REF:0000107
G FUT7 fucosyltransferase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:48,604,879...48,609,292
Ensembl chr 9:48,606,435...48,609,303 		JBrowse link
G MIR494 microRNA mir-494 acts_upstream_of_or_within ISO (PMID:24349514) MGI PMID:24349514 NCBI chr 8:69,261,385...69,261,465
Ensembl chr 8:69,261,385...69,261,465 		JBrowse link
G MZB1 marginal zone B and B1 cell specific protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:34,710,487...34,712,660
Ensembl chr 2:34,706,007...34,712,626 		JBrowse link
G NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:2,157,109...2,188,543
Ensembl chr38:2,160,233...2,170,560 		JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:55,821,227...55,857,597
Ensembl chr  X:55,821,234...55,855,502 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 ISO RGD PMID:12941932 RGD:1625241 NCBI chr24:36,936,469...37,010,929
Ensembl chr24:36,936,298...37,003,720 		JBrowse link
G RARRES2 retinoic acid receptor responder 2 involved_in ISO (MGI:5520045|PMID:18242188) UniProt PMID:18242188 MGI:5520045 NCBI chr16:14,671,345...14,675,000
Ensembl chr16:14,671,130...14,674,926 		JBrowse link
G SESN3 sestrin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:5,827,957...5,899,540
Ensembl chr21:5,777,780...5,892,805 		JBrowse link
G SIK2 salt inducible kinase 2 involved_in ISO (MGI:2662666|PMID:12624099) UniProt PMID:12624099 MGI:2662666 NCBI chr 5:21,354,127...21,479,891
Ensembl chr 5:21,358,902...21,479,841 		JBrowse link
G TSC2 TSC complex subunit 2 acts_upstream_of_or_within ISO (PMID:12403809) MGI PMID:12403809 NCBI chr 6:38,865,509...38,898,977
Ensembl chr 6:38,865,507...38,898,960 		JBrowse link
G VWA2 von Willebrand factor A domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:25,089,499...25,136,879
Ensembl chr28:25,089,499...25,136,893 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17925
    cellular process 16910
      signal transduction 6317
        cell surface receptor signaling pathway 2807
          enzyme-linked receptor protein signaling pathway 1041
            cell surface receptor protein tyrosine kinase signaling pathway 654
              insulin receptor signaling pathway 142
                negative regulation of insulin receptor signaling pathway + 48
                positive regulation of insulin receptor signaling pathway + 30
                regulation of insulin receptor signaling pathway + 83
Path 2
Term Annotations click to browse term
  biological_process 17925
    response to stimulus 9451
      cellular response to stimulus 7883
        cellular response to chemical stimulus 2645
          cellular response to nitrogen compound 847
            cellular response to organonitrogen compound 772
              cellular response to peptide hormone stimulus 426
                cellular response to insulin stimulus 273
                  insulin receptor signaling pathway 142
                    negative regulation of insulin receptor signaling pathway + 48
                    positive regulation of insulin receptor signaling pathway + 30
                    regulation of insulin receptor signaling pathway + 83
paths to the root