RGD Reference Report - Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats. - Rat Genome Database

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Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats.

Authors: Hirata, AE  Alvarez-Rojas, F  Carvalheira, JB  Carvalho, CR  Dolnikoff, MS  Abdalla Saad, MJ 
Citation: Hirata AE, etal., Life Sci. 2003 Aug 1;73(11):1369-81.
RGD ID: 1580595
Pubmed: (View Article at PubMed) PMID:12850498

PTP1B has been shown to be a negative regulator of the insulin signal transduction in insulin resistant states. Herein we investigated IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of 10 and 28-week-old MSG-insulin resistant rats which represent different stages of insulin resistance. Our results demonstrated that the increase in PTP1B expression and/or association with IR in MSG animals may contribute to the impaired insulin signaling mainly in liver and muscle. Although, adipose tissue of 10-week-old MSG rats showed higher PTP1B expression and IR/PTP1B interaction, they were not sufficient to impair all insulin signaling since IRS-2 phosphorylation and association with PI3-kinase and Akt serine phosphorylation were increased, which may contribute for the increased adiposity of these animals. In 28-week-old-MSG rats there was an increase in IR/PTP1B interaction and reduced insulin signaling in liver, muscle and adipocytes, and a more pronounced insulin resistance.

Annotation

Gene Ontology Annotations    

Biological Process

Molecular Pathway Annotations    
Objects Annotated

Genes (Rattus norvegicus)
Insr  (insulin receptor)
Irs1  (insulin receptor substrate 1)
Irs2  (insulin receptor substrate 2)
Ptpn1  (protein tyrosine phosphatase, non-receptor type 1)

Genes (Mus musculus)
Insr  (insulin receptor)
Irs1  (insulin receptor substrate 1)
Irs2  (insulin receptor substrate 2)
Ptpn1  (protein tyrosine phosphatase, non-receptor type 1)

Genes (Homo sapiens)
INSR  (insulin receptor)
IRS1  (insulin receptor substrate 1)
IRS2  (insulin receptor substrate 2)
PTPN1  (protein tyrosine phosphatase non-receptor type 1)


Additional Information