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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of insulin receptor signaling pathway
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Accession:GO:0046628 term browser browse the term
Definition:Any process that increases the frequency, rate or extent of insulin receptor signaling.
Synonyms:exact_synonym: positive regulation of insulin receptor signalling pathway;   up regulation of insulin receptor signaling pathway;   upregulation of insulin receptor signaling pathway
 narrow_synonym: activation of insulin receptor signaling pathway;   stimulation of insulin receptor signaling pathway



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positive regulation of insulin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor1 adiponectin receptor 1 IMP RGD PMID:18394428 RGD:2317907 NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241
JBrowse link
G Agt angiotensinogen IDA RGD PMID:24184594 RGD:11039409 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G C1qtnf12 C1q and TNF related 12 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:5317500|PMID:22275362)
RGD PMID:22275362 PMID:21873635 MGI:5317500, RGD:13792537 NCBI chr 5:166,551,628...166,556,003
Ensembl chr 5:166,551,628...166,556,003
JBrowse link
G Erfe erythroferrone involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:91,956,971...91,964,846
Ensembl chr 9:91,956,977...91,964,846
JBrowse link
G Gkap1 G kinase anchoring protein 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:6201784|PMID:25586176)
UniProt
RGD
PMID:25586176 GO_REF:0000024 MGI:6201784 NCBI chr17:6,383,963...6,423,684
Ensembl chr17:6,383,963...6,423,679
JBrowse link
G Gnai2 G protein subunit alpha i2 IMP RGD PMID:11500506 RGD:13508599 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Igf2 insulin-like growth factor 2 involved_in ISO
IBA
(PMID:11500939)
PMID:21873635
(MGI:4438697|PMID:20032056)
RGD PMID:11500939 PMID:20032056 PMID:21873635 MGI:4438697, RGD:13792537 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Ins2 insulin 2 involved_in ISO (PMID:14615391), (PMID:15792832), (PMID:7688386)
(PMID:7513704)
RGD PMID:7513704 PMID:7688386 PMID:14615391 PMID:15792832 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Irs1 insulin receptor substrate 1 involved_in ISO
IMP
IEA
(PMID:7493946)
PMID:18285345
GO_REF:0000107
RGD
Ensembl
PMID:7493946 PMID:18285345 GO_REF:0000107, RGD:8553881 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Lep leptin IDA RGD PMID:20977462 RGD:5128575 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate IMP RGD PMID:19252893 RGD:9685323 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012
JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:25034891 RGD:13204821 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 involved_in ISO
IEA
(MGI:3640632|PMID:16446356)
GO_REF:0000107
RGD
Ensembl
PMID:16446356 GO_REF:0000107 MGI:3640632 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 acts_upstream_of_or_within ISO (MGI:5576396|PMID:24931609) RGD PMID:24931609 MGI:5576396 NCBI chr13:43,345,091...43,374,316
Ensembl chr13:43,345,115...43,370,229
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase IMP RGD PMID:24085037 RGD:13208948 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Osbpl8 oxysterol binding protein-like 8 involved_in
acts_upstream_of_or_within
ISO (MGI:5644010|PMID:23812417)
(MGI:5289772|PMID:21441927)
RGD PMID:21441927 PMID:23812417 MGI:5289772 MGI:5644010 NCBI chr 7:46,596,944...46,749,888
Ensembl chr 7:46,596,983...46,749,888
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 IMP RGD PMID:25199455 RGD:11533947 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383
JBrowse link
G Prkcz protein kinase C, zeta involved_in IMP PMID:9374484 UniProt PMID:9374484 RGD:8553908 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 involved_in ISO (PMID:7493946) RGD PMID:7493946 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G Serpina12 serpin family A member 12 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5568548 (MGI:5563627|PMID:22837305)
Ensembl
RGD
PMID:22837305 GO_REF:0000107 MGI:5563627 NCBI chr 6:122,952,552...122,967,271
Ensembl chr 6:122,952,552...122,967,271
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:21241768) RGD PMID:21241768 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Snx5 sorting nexin 5 involved_in ISO (PMID:25825816) RGD PMID:25825816 NCBI chr 3:131,621,709...131,641,205
Ensembl chr 3:131,621,880...131,641,192
JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3690172|PMID:11001060)
UniProt
RGD
PMID:11001060 GO_REF:0000024 MGI:3690172 NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169
JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:27322061)
(MGI:5811185|PMID:27322061)
RGD PMID:27322061 MGI:5811185 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IDA RGD PMID:14985360 RGD:1581139 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:6120228|PMID:29420538) RGD PMID:29420538 MGI:6120228 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236
JBrowse link
insulin receptor recycling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsd cathepsin D involved_in ISO
IEA
(MGI:5812606|PMID:27703010)
GO_REF:0000107
RGD
Ensembl
PMID:27703010 GO_REF:0000107 MGI:5812606 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ide insulin degrading enzyme involved_in ISO (MGI:5812606|PMID:27703010) RGD PMID:27703010 MGI:5812606 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO
IEA
MGI:2384135 (MGI:3769646|PMID:17068137)
GO_REF:0000107
RGD
Ensembl
PMID:17068137 GO_REF:0000107 MGI:3769646 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO (MGI:3528540|PMID:15632081) RGD PMID:15632081 MGI:3528540 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:27322061)
(MGI:5811185|PMID:27322061)
RGD PMID:27322061 MGI:5811185 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    cellular process 18675
      signal transduction 7133
        positive regulation of signal transduction 1680
          positive regulation of insulin receptor signaling pathway 30
            insulin receptor recycling 5
            positive regulation of insulin receptor signaling pathway by insulin receptor internalization 0
Path 2
Term Annotations click to browse term
  biological_process 20091
    response to stimulus 10574
      response to chemical 6090
        response to organic substance 3641
          response to organonitrogen compound 1534
            response to peptide 747
              response to peptide hormone 645
                response to insulin 386
                  cellular response to insulin stimulus 285
                    insulin receptor signaling pathway 151
                      regulation of insulin receptor signaling pathway 92
                        positive regulation of insulin receptor signaling pathway 30
                          insulin receptor recycling 5
                          positive regulation of insulin receptor signaling pathway by insulin receptor internalization 0
paths to the root