RGD Reference Report - AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus. - Rat Genome Database

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AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus.

Authors: Coope, A  Milanski, M  Araujo, EP  Tambascia, M  Saad, MJ  Geloneze, B  Velloso, LA 
Citation: Coope A, etal., FEBS Lett. 2008 Apr 30;582(10):1471-6. Epub 2008 Apr 3.
RGD ID: 2317907
Pubmed: PMID:18394428   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2008.03.037   (Journal Full-text)

Adiponectin exerts an insulin-sensitizing effect, improving insulin action in peripheral tissues and restraining insulin resistance. Here, we explore the hypothesis that adiponectin can reproduce some of the actions of insulin/leptin in the hypothalamus. The presence of AdipoR1 and AdipoR2 was mapped to the arcuate and lateral hypothalamic nuclei. Icv adiponectin reduced food intake, which was accompanied by activation/engagement of IRS1/2, ERK, Akt, FOXO1, JAK2 and STAT3. All these actions were dependent on AdipoR1, since inhibition of this receptor, and not of AdipoR2, completely reversed the effects described above. Thus, adiponectin acts in the hypothalamus, activating elements of the canonical insulin and leptin signaling pathways and promoting reduction of food intake.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Adipor1  (adiponectin receptor 1)


Additional Information