PTPRJ (protein tyrosine phosphatase receptor type J) - Rat Genome Database

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Gene: PTPRJ (protein tyrosine phosphatase receptor type J) Canis lupus familiaris
Analyze
Symbol: PTPRJ
Name: protein tyrosine phosphatase receptor type J
RGD ID: 12277864
Description: ENCODES a protein that exhibits beta-catenin binding (inferred); cadherin binding (inferred); delta-catenin binding (inferred); INVOLVED IN heart development (ortholog); obsolete calcium-mediated signaling using intracellular calcium source (ortholog); oligodendrocyte differentiation (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; platelet-derived growth factor signaling pathway; somatostatin signaling pathway; ASSOCIATED WITH colon carcinoma (ortholog); colorectal cancer (ortholog); Colorectal Neoplasms (ortholog); FOUND IN cell surface (inferred); cell-cell junction (inferred); immunological synapse (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: receptor-type tyrosine-protein phosphatase eta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11841,586,262 - 41,635,386 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1841,586,112 - 41,635,308 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,315,308 - 40,366,352 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,238,579 - 42,289,675 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,238,586 - 42,285,426 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11841,727,516 - 41,778,615 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,280,105 - 41,331,461 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,009,997 - 42,061,288 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell differentiation  (IEA)
blood coagulation  (IEA)
glucose homeostasis  (IEA)
heart development  (IEA,ISO)
negative regulation of cell growth  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of epidermal growth factor receptor signaling pathway  (IEA)
negative regulation of insulin receptor signaling pathway  (IEA)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
negative regulation of platelet-derived growth factor receptor signaling pathway  (IEA)
negative regulation of T cell receptor signaling pathway  (IEA)
negative regulation of vascular permeability  (IEA)
obsolete calcium-mediated signaling using intracellular calcium source  (ISO)
oligodendrocyte differentiation  (IEA,ISO)
platelet formation  (ISO)
platelet-derived growth factor receptor signaling pathway  (IEA)
positive chemotaxis  (IEA)
positive regulation of cell adhesion  (IEA)
positive regulation of cell-matrix adhesion  (IEA)
positive regulation of Fc receptor mediated stimulatory signaling pathway  (IEA)
positive regulation of focal adhesion assembly  (IEA)
positive regulation of macrophage chemotaxis  (IEA)
positive regulation of MAPK cascade  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of phagocytosis  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of platelet activation  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
regulation of cell adhesion  (IEA)
vasculogenesis  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202   PMID:30188888  


Genomics

Comparative Map Data
PTPRJ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11841,586,262 - 41,635,386 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1841,586,112 - 41,635,308 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,315,308 - 40,366,352 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,238,579 - 42,289,675 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,238,586 - 42,285,426 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11841,727,516 - 41,778,615 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,280,105 - 41,331,461 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,009,997 - 42,061,288 (-)NCBIUU_Cfam_GSD_1.0
PTPRJ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,980,559 - 48,170,839 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,980,425 - 48,170,839 (+)EnsemblGRCh38hg38GRCh38
GRCh371148,002,111 - 48,192,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,958,686 - 48,148,970 (+)NCBINCBI36Build 36hg18NCBI36
Build 341147,958,688 - 48,146,246NCBI
Celera1148,154,504 - 48,344,533 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1147,683,384 - 47,903,543 (+)NCBIHuRef
CHM1_11148,001,881 - 48,191,974 (+)NCBICHM1_1
T2T-CHM13v2.01148,150,119 - 48,340,376 (+)NCBIT2T-CHM13v2.0
Ptprj
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,260,100 - 90,411,102 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,260,098 - 90,410,939 (-)EnsemblGRCm39 Ensembl
GRCm38290,429,756 - 90,580,694 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl290,429,754 - 90,580,647 (-)EnsemblGRCm38mm10GRCm38
MGSCv37290,269,913 - 90,420,804 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,233,731 - 90,381,407 (-)NCBIMGSCv36mm8
Celera291,810,313 - 91,967,158 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.19NCBI
Ptprj
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8396,861,785 - 97,017,702 (-)NCBIGRCr8
mRatBN7.2376,405,917 - 76,561,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl376,405,927 - 76,562,260 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx379,890,269 - 80,046,200 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0388,488,786 - 88,644,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0386,341,245 - 86,497,188 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,233,519 - 79,390,956 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,233,525 - 79,390,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0385,947,682 - 86,099,287 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4374,796,764 - 74,935,540 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1374,693,135 - 74,831,912 (-)NCBI
Celera375,621,921 - 75,777,388 (-)NCBICelera
Cytogenetic Map3q24NCBI
Ptprj
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422399,357 - 443,054 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955422396,266 - 438,792 (-)NCBIChiLan1.0ChiLan1.0
PTPRJ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2950,196,084 - 50,386,550 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11150,215,619 - 50,406,485 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,941,134 - 48,130,538 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11148,518,844 - 48,672,844 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,613,761 - 48,670,494 (+)Ensemblpanpan1.1panPan2
Ptprj
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,050,113 - 19,123,158 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,165,304 - 1,211,817 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,161,764 - 1,234,800 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRJ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl214,548,428 - 14,724,474 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1214,548,489 - 14,724,823 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2215,632,255 - 16,007,397 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRJ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,137,896 - 17,328,836 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,135,907 - 17,328,590 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038114,433,977 - 114,653,560 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptprj
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624767945,553 - 1,051,138 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624767942,786 - 1,051,112 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTPRJ
653 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 11 6 8 10
Low 5 5 11 6 6 6 4 6
Below cutoff 6 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000013154   ⟹   ENSCAFP00000012172
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1841,586,112 - 41,635,308 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000048676   ⟹   ENSCAFP00000036908
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1841,586,112 - 41,635,308 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845033310   ⟹   ENSCAFP00845026074
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1842,238,586 - 42,285,426 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845033512   ⟹   ENSCAFP00845026236
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1842,238,586 - 42,285,373 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845033652   ⟹   ENSCAFP00845026345
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1842,238,586 - 42,285,249 (-)Ensembl
RefSeq Acc Id: XM_022405426   ⟹   XP_022261134
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11841,586,262 - 41,635,386 (-)NCBI
Dog10K_Boxer_Tasha1840,315,308 - 40,366,352 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022405427   ⟹   XP_022261135
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11841,586,262 - 41,635,386 (-)NCBI
Dog10K_Boxer_Tasha1840,315,308 - 40,366,352 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038424325   ⟹   XP_038280253
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01842,238,579 - 42,289,675 (-)NCBI
RefSeq Acc Id: XM_038424326   ⟹   XP_038280254
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01842,238,579 - 42,289,675 (-)NCBI
RefSeq Acc Id: XM_038500675   ⟹   XP_038356603
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11841,727,516 - 41,778,615 (-)NCBI
RefSeq Acc Id: XM_038500676   ⟹   XP_038356604
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11841,727,516 - 41,778,615 (-)NCBI
RefSeq Acc Id: XM_038563264   ⟹   XP_038419192
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01842,009,997 - 42,061,288 (-)NCBI
RefSeq Acc Id: XM_038563265   ⟹   XP_038419193
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01842,009,997 - 42,061,288 (-)NCBI
RefSeq Acc Id: XM_038627377   ⟹   XP_038483305
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01841,280,105 - 41,331,461 (-)NCBI
RefSeq Acc Id: XM_038627378   ⟹   XP_038483306
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01841,280,105 - 41,331,461 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_022261135   ⟸   XM_022405427
- Peptide Label: isoform X2
- UniProtKB: A0A8C0R810 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022261134   ⟸   XM_022405426
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SLH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000036908   ⟸   ENSCAFT00000048676
RefSeq Acc Id: ENSCAFP00000012172   ⟸   ENSCAFT00000013154
RefSeq Acc Id: XP_038356604   ⟸   XM_038500676
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038356603   ⟸   XM_038500675
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038483306   ⟸   XM_038627378
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038483305   ⟸   XM_038627377
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038280254   ⟸   XM_038424326
- Peptide Label: isoform X2
- UniProtKB: A0A8C0R810 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038280253   ⟸   XM_038424325
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SLH7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038419193   ⟸   XM_038563265
- Peptide Label: isoform X2
- UniProtKB: A0A8C0R810 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038419192   ⟸   XM_038563264
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SLH7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845026345   ⟸   ENSCAFT00845033652
RefSeq Acc Id: ENSCAFP00845026236   ⟸   ENSCAFT00845033512
RefSeq Acc Id: ENSCAFP00845026074   ⟸   ENSCAFT00845033310
Protein Domains
Fibronectin type-III   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008279 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040014646 UniProtKB/TrEMBL
  ENSCAFG00845018509 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000013154.5 UniProtKB/TrEMBL
  ENSCAFT00000048676.3 UniProtKB/TrEMBL
  ENSCAFT00040026983.1 UniProtKB/TrEMBL
  ENSCAFT00845033310 ENTREZGENE
  ENSCAFT00845033310.1 UniProtKB/TrEMBL
  ENSCAFT00845033512 ENTREZGENE
  ENSCAFT00845033512.1 UniProtKB/TrEMBL
  ENSCAFT00845033652.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTP_cat UniProtKB/TrEMBL
  PTPRJ_TM UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL
NCBI Gene PTPRJ ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/TrEMBL
  PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, H UniProtKB/TrEMBL
Pfam PTP_tm UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
UniProt A0A8C0R810 ENTREZGENE
  A0A8C0SLH7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P598_CANLF UniProtKB/TrEMBL
  A0A8I3P7Y1_CANLF UniProtKB/TrEMBL
  A0A8I3S3R1_CANLF UniProtKB/TrEMBL
  A0A8P0NAP5_CANLF UniProtKB/TrEMBL
  A0A8P0NP06_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:45190 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 PTPRJ  protein tyrosine phosphatase receptor type J    protein tyrosine phosphatase, receptor type J  Symbol and/or name change 5135510 APPROVED